Click here to switch to the map view.

The map label for this gene is hisC

Identifier: 138895776

GI number: 138895776

Start: 2263392

End: 2264489

Strand: Reverse

Name: hisC

Synonym: GTNG_2132

Alternate gene names: 138895776

Gene position: 2264489-2263392 (Counterclockwise)

Preceding gene: 138895777

Following gene: 138895775

Centisome position: 63.78

GC content: 53.19

Gene sequence:

>1098_bases
ATGCAAGTAAAGGAGCAACTTCGGGGACTCCCCCCGTACCAACCGGGAAAATCGATTGAGGAAGTGAAGCAGGAATACGG
TCTTTCCGAGATTATTAAACTAGCTTCCAATGAAAATCCATACGGCTCATCGCCGACGGTGAAATCTGCCATCGCTGCTG
AACTTGATCGCCTTGCCGTCTACCCGGACGGTTATGCCCGCGCATTGCGCGAAAAAGTGGCCAACCATCTCGGCGTGAAG
GAAACACAGCTGTTGTTTGGCAACGGTTCGGATGAAGTCGTACAAATTTTTTGCCGCGCCTTTTTAGAGCCGGGCACGAA
CACGGTGATGGCGACGCCAACATTTCCGCAATACCGCCATAACGCGATCATCGAGCGGGCTGAAGTGCGCGAAGTGCCGC
TTGTTGACGGGCGCCATGATTTGGAGGCGATGCTTAAGGAAATCGATGAAAACACGCGCATTGTCTGGGTTTGCAATCCG
AACAACCCGACCGGCACGTATGTGAATGAGACAGAATTGCGCGCCTTTTTAGATCGTGTGCCGTCGCACGTGCTTGTCGT
TTTGGATGAGGCGTATTATGAATACGTAACGGCGGACGATTATCCGCAAACGGTGCCGCTGTTACAAGAATACGAACAGC
TTGTTATTATGCGTACGTTCTCGAAAGCGTATGGGCTTGCTGCGCTTCGCGTCGGCTACGGCATTGCCAGTGAGTCGCTC
ATTCGCGCCGTCGAACCGGCGCGCGAGCCGTTTAACACGTCGACCATCGCCCAAGCGGCTGCTGCGGTCGCGCTTGATGA
CCAAGCGTTCATCCGTGCCTGTGTCGAACAAAACCGTGCCGAGCTTGAACGGTATTATCGTTTCTGTGAAGAACACGGCC
TGAAGTACTATCCGTCGCAAACGAACTTTTTGTTCATTGATTTTGGTATGGACGGCAATGAAGTGTTTCAATATTTGCTC
GAGCGTGGCATTATCGTCCGCTCCGGCAAGGCGCTCGGTTTGCCGACCGGCGTGCGCATCACCGTCGGCACGAAAGAGCA
AAATGACCGGGTGTTTGAAACGATTTCGCACATGCTTCGCGAAAAACAGCTCACCTGA

Upstream 100 bases:

>100_bases
TCGCTGAATTTGCCTCCTATGCCCGTTCGCTCGCCGCGCCGCTTCGGGAGCCGTGTTCTTCGCGCTAAAAAGTTCCGACT
TAAAGGAGTGGGCGATATCC

Downstream 100 bases:

>100_bases
CCAGGTTGACAGTGAATTGGTCAGGAAGGCCAGCCCGTTGCTTTTAGCAAGCAGCGGGCACATTTTTACATAAAGAAGGT
GGGTTGGGTTGGAAGGAAAC

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase

Number of amino acids: Translated: 365; Mature: 365

Protein sequence:

>365_residues
MQVKEQLRGLPPYQPGKSIEEVKQEYGLSEIIKLASNENPYGSSPTVKSAIAAELDRLAVYPDGYARALREKVANHLGVK
ETQLLFGNGSDEVVQIFCRAFLEPGTNTVMATPTFPQYRHNAIIERAEVREVPLVDGRHDLEAMLKEIDENTRIVWVCNP
NNPTGTYVNETELRAFLDRVPSHVLVVLDEAYYEYVTADDYPQTVPLLQEYEQLVIMRTFSKAYGLAALRVGYGIASESL
IRAVEPAREPFNTSTIAQAAAAVALDDQAFIRACVEQNRAELERYYRFCEEHGLKYYPSQTNFLFIDFGMDGNEVFQYLL
ERGIIVRSGKALGLPTGVRITVGTKEQNDRVFETISHMLREKQLT

Sequences:

>Translated_365_residues
MQVKEQLRGLPPYQPGKSIEEVKQEYGLSEIIKLASNENPYGSSPTVKSAIAAELDRLAVYPDGYARALREKVANHLGVK
ETQLLFGNGSDEVVQIFCRAFLEPGTNTVMATPTFPQYRHNAIIERAEVREVPLVDGRHDLEAMLKEIDENTRIVWVCNP
NNPTGTYVNETELRAFLDRVPSHVLVVLDEAYYEYVTADDYPQTVPLLQEYEQLVIMRTFSKAYGLAALRVGYGIASESL
IRAVEPAREPFNTSTIAQAAAAVALDDQAFIRACVEQNRAELERYYRFCEEHGLKYYPSQTNFLFIDFGMDGNEVFQYLL
ERGIIVRSGKALGLPTGVRITVGTKEQNDRVFETISHMLREKQLT
>Mature_365_residues
MQVKEQLRGLPPYQPGKSIEEVKQEYGLSEIIKLASNENPYGSSPTVKSAIAAELDRLAVYPDGYARALREKVANHLGVK
ETQLLFGNGSDEVVQIFCRAFLEPGTNTVMATPTFPQYRHNAIIERAEVREVPLVDGRHDLEAMLKEIDENTRIVWVCNP
NNPTGTYVNETELRAFLDRVPSHVLVVLDEAYYEYVTADDYPQTVPLLQEYEQLVIMRTFSKAYGLAALRVGYGIASESL
IRAVEPAREPFNTSTIAQAAAAVALDDQAFIRACVEQNRAELERYYRFCEEHGLKYYPSQTNFLFIDFGMDGNEVFQYLL
ERGIIVRSGKALGLPTGVRITVGTKEQNDRVFETISHMLREKQLT

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788332, Length=363, Percent_Identity=33.3333333333333, Blast_Score=164, Evalue=6e-42,
Organism=Escherichia coli, GI1788722, Length=380, Percent_Identity=26.3157894736842, Blast_Score=74, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6322075, Length=389, Percent_Identity=28.2776349614396, Blast_Score=123, Evalue=4e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS8_GEOTN (A4IQ80)

Other databases:

- EMBL:   CP000557
- RefSeq:   YP_001126229.1
- ProteinModelPortal:   A4IQ80
- SMR:   A4IQ80
- STRING:   A4IQ80
- GeneID:   4967060
- GenomeReviews:   CP000557_GR
- KEGG:   gtn:GTNG_2132
- NMPDR:   fig|420246.5.peg.2039
- eggNOG:   COG0079
- HOGENOM:   HBG646350
- OMA:   KLIYIAN
- PhylomeDB:   A4IQ80
- ProtClustDB:   PRK03158
- BioCyc:   GTHE420246:GTNG_2132-MONOMER
- HAMAP:   MF_01023
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 41212; Mature: 41212

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQVKEQLRGLPPYQPGKSIEEVKQEYGLSEIIKLASNENPYGSSPTVKSAIAAELDRLAV
CCCHHHHCCCCCCCCCCCHHHHHHHHCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHEEE
YPDGYARALREKVANHLGVKETQLLFGNGSDEVVQIFCRAFLEPGTNTVMATPTFPQYRH
CCCHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCEEECCCCCHHHH
NAIIERAEVREVPLVDGRHDLEAMLKEIDENTRIVWVCNPNNPTGTYVNETELRAFLDRV
HHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHC
PSHVLVVLDEAYYEYVTADDYPQTVPLLQEYEQLVIMRTFSKAYGLAALRVGYGIASESL
CHHEEEEEHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
IRAVEPAREPFNTSTIAQAAAAVALDDQAFIRACVEQNRAELERYYRFCEEHGLKYYPSQ
HHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCC
TNFLFIDFGMDGNEVFQYLLERGIIVRSGKALGLPTGVRITVGTKEQNDRVFETISHMLR
CCEEEEEECCCHHHHHHHHHHCCEEEECCCEECCCCCCEEEECCCCCCHHHHHHHHHHHH
EKQLT
HHCCC
>Mature Secondary Structure
MQVKEQLRGLPPYQPGKSIEEVKQEYGLSEIIKLASNENPYGSSPTVKSAIAAELDRLAV
CCCHHHHCCCCCCCCCCCHHHHHHHHCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHEEE
YPDGYARALREKVANHLGVKETQLLFGNGSDEVVQIFCRAFLEPGTNTVMATPTFPQYRH
CCCHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCEEECCCCCHHHH
NAIIERAEVREVPLVDGRHDLEAMLKEIDENTRIVWVCNPNNPTGTYVNETELRAFLDRV
HHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHC
PSHVLVVLDEAYYEYVTADDYPQTVPLLQEYEQLVIMRTFSKAYGLAALRVGYGIASESL
CHHEEEEEHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
IRAVEPAREPFNTSTIAQAAAAVALDDQAFIRACVEQNRAELERYYRFCEEHGLKYYPSQ
HHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCC
TNFLFIDFGMDGNEVFQYLLERGIIVRSGKALGLPTGVRITVGTKEQNDRVFETISHMLR
CCEEEEEECCCHHHHHHHHHHCCEEEECCCEECCCCCCEEEECCCCCCHHHHHHHHHHHH
EKQLT
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA