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The map label for this gene is galK [H]

Identifier: 138895730

GI number: 138895730

Start: 2220214

End: 2221398

Strand: Reverse

Name: galK [H]

Synonym: GTNG_2086

Alternate gene names: 138895730

Gene position: 2221398-2220214 (Counterclockwise)

Preceding gene: 138895732

Following gene: 138895729

Centisome position: 62.57

GC content: 52.49

Gene sequence:

>1185_bases
ATGATCTCCACGTTAAAACAGCAATTTACCAAGCTTTTCGGCGGGCTAGAAGAAGACATCCGCATGTTTTTCGCCCCTGG
CCGCGTCAATTTGATTGGCGAGCATACTGATTATAACGGCGGGCACGTGTTGCCGTGTGCGCTTACGATTGGCACATATG
CGCTTGTGCGACAAACGAAAGTGCCGCTCGTGCGGCTGTATTCAAAAAACTTCCCAGAAACTGGCGTCATTACTGTGCCG
TATGATGATTTGTCATATCGGAGAGAGCATAGCTGGGCGAACTACCCGAAAGGGATCATCGCTGCCTTTCAAGCGCTCGG
CCCGCTAGGGACCGGATTAGACATTTTGTATTACGGCACGATTCCAAACGGCGCGGGATTGTCGTCATCGGCGTCGATTG
AGCTTGTGACGGCCGTCGCCTTAAACAACTTGTTTGAGCGGCAGCTCGATCAGTTGGAGCTTGTGAAAATGAGCCAGAAC
GTAGAAAACAAATACGTTGGCGTCAATTGTGGCATTATGGACCAGTTTGCCGTCGGCATGGGGAAACAAAACTCGGCGAT
CTTATTAAACTGCCAAACGCTTGAGTATCGCTATTTGCCGCTTGCGCTCGACGACTATTTCATTGTTATTGCGAACACGA
ACAAAAAACGGGGCTTGGCGGATTCAGCGTACAATGAGCGGCGGACGACGTGCGAAACGGCGCTCGCGAAACTGCAAACG
GTGCGGAACATCGCCTCGCTTGGTGAACTGACGAGCGCAGAGCTGACTCAATATGCTCATCTTCTTTCCCCGCTTGAGCA
AAAGCGGGCCCGCCATGCGGTGACGGAAAACGAGCGTACGCTCGAGGCGGCCACAGCGCTTGAGCAAGGAGATCTCGTTC
GTTTTGGCGAGCTGATGAAGCAGTCGCATATGTCACTGCGTGACGACTATGAAGTGACGGGCATTGAGCTCGATACGCTC
GTTGAAGCGGCGTGGGCGCACGAAGGAACGATTGGGGCGCGCATGACCGGCGCCGGGTTTGGTGGCTGCACGGTGAACGT
GGTGAAAAAAGCATCTATTCAAGATTTCGTTAAACAAGTTGGAAGGACATATGCCGAAAAAATCGGCTATGAAGCGAGCT
TTTATGTCGTTGACGTTGGCAATGGGGCGCGTGAACTGATAGAAATGGAGGAGATGTGCCGATGA

Upstream 100 bases:

>100_bases
AAAAAAAGATCGTGTTTCACAATTGATTTTAAATAAAATATTTACTAAAATATTTACAAAAAAGAGAATAACTCAATTTG
ATTTTTAAGGAGGCCCTTCC

Downstream 100 bases:

>100_bases
TTTTGATTTGTGGCGGGGCAGGGTATATCGGCAGTCATGCGGTGTACCGTCTGCTCGAAAAAGGGGAAGAGGTCATTGTT
GTTGATAACTTGCAGACCGG

Product: galactokinase

Products: NA

Alternate protein names: Galactose kinase [H]

Number of amino acids: Translated: 394; Mature: 394

Protein sequence:

>394_residues
MISTLKQQFTKLFGGLEEDIRMFFAPGRVNLIGEHTDYNGGHVLPCALTIGTYALVRQTKVPLVRLYSKNFPETGVITVP
YDDLSYRREHSWANYPKGIIAAFQALGPLGTGLDILYYGTIPNGAGLSSSASIELVTAVALNNLFERQLDQLELVKMSQN
VENKYVGVNCGIMDQFAVGMGKQNSAILLNCQTLEYRYLPLALDDYFIVIANTNKKRGLADSAYNERRTTCETALAKLQT
VRNIASLGELTSAELTQYAHLLSPLEQKRARHAVTENERTLEAATALEQGDLVRFGELMKQSHMSLRDDYEVTGIELDTL
VEAAWAHEGTIGARMTGAGFGGCTVNVVKKASIQDFVKQVGRTYAEKIGYEASFYVVDVGNGARELIEMEEMCR

Sequences:

>Translated_394_residues
MISTLKQQFTKLFGGLEEDIRMFFAPGRVNLIGEHTDYNGGHVLPCALTIGTYALVRQTKVPLVRLYSKNFPETGVITVP
YDDLSYRREHSWANYPKGIIAAFQALGPLGTGLDILYYGTIPNGAGLSSSASIELVTAVALNNLFERQLDQLELVKMSQN
VENKYVGVNCGIMDQFAVGMGKQNSAILLNCQTLEYRYLPLALDDYFIVIANTNKKRGLADSAYNERRTTCETALAKLQT
VRNIASLGELTSAELTQYAHLLSPLEQKRARHAVTENERTLEAATALEQGDLVRFGELMKQSHMSLRDDYEVTGIELDTL
VEAAWAHEGTIGARMTGAGFGGCTVNVVKKASIQDFVKQVGRTYAEKIGYEASFYVVDVGNGARELIEMEEMCR
>Mature_394_residues
MISTLKQQFTKLFGGLEEDIRMFFAPGRVNLIGEHTDYNGGHVLPCALTIGTYALVRQTKVPLVRLYSKNFPETGVITVP
YDDLSYRREHSWANYPKGIIAAFQALGPLGTGLDILYYGTIPNGAGLSSSASIELVTAVALNNLFERQLDQLELVKMSQN
VENKYVGVNCGIMDQFAVGMGKQNSAILLNCQTLEYRYLPLALDDYFIVIANTNKKRGLADSAYNERRTTCETALAKLQT
VRNIASLGELTSAELTQYAHLLSPLEQKRARHAVTENERTLEAATALEQGDLVRFGELMKQSHMSLRDDYEVTGIELDTL
VEAAWAHEGTIGARMTGAGFGGCTVNVVKKASIQDFVKQVGRTYAEKIGYEASFYVVDVGNGARELIEMEEMCR

Specific function: Galactose metabolism; first step. [C]

COG id: COG0153

COG function: function code G; Galactokinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. GalK subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503895, Length=391, Percent_Identity=39.386189258312, Blast_Score=238, Evalue=7e-63,
Organism=Homo sapiens, GI4503897, Length=448, Percent_Identity=29.2410714285714, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI48527957, Length=448, Percent_Identity=29.2410714285714, Blast_Score=122, Evalue=4e-28,
Organism=Escherichia coli, GI1786972, Length=363, Percent_Identity=41.5977961432507, Blast_Score=269, Evalue=3e-73,
Organism=Caenorhabditis elegans, GI71989053, Length=418, Percent_Identity=27.0334928229665, Blast_Score=112, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6319494, Length=237, Percent_Identity=30.8016877637131, Blast_Score=70, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24661292, Length=431, Percent_Identity=28.0742459396752, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI21355577, Length=431, Percent_Identity=28.0742459396752, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24661285, Length=431, Percent_Identity=28.0742459396752, Blast_Score=100, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000705
- InterPro:   IPR022963
- InterPro:   IPR019741
- InterPro:   IPR019539
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR006206
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF10509 GalKase_gal_bdg; PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.6 [H]

Molecular weight: Translated: 43538; Mature: 43538

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: PS00012 PHOSPHOPANTETHEINE ; PS00106 GALACTOKINASE ; PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISTLKQQFTKLFGGLEEDIRMFFAPGRVNLIGEHTDYNGGHVLPCALTIGTYALVRQTK
CCCHHHHHHHHHHCCCCHHHHEEECCCCEEEEECCCCCCCCEEEEHHHHHHHHHHHHHCC
VPLVRLYSKNFPETGVITVPYDDLSYRREHSWANYPKGIIAAFQALGPLGTGLDILYYGT
CCHHHHHHCCCCCCCEEEECCCCCHHHHHCCCCCCCHHHHHHHHHHCCCCCCCEEEEEEC
IPNGAGLSSSASIELVTAVALNNLFERQLDQLELVKMSQNVENKYVGVNCGIMDQFAVGM
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHCC
GKQNSAILLNCQTLEYRYLPLALDDYFIVIANTNKKRGLADSAYNERRTTCETALAKLQT
CCCCCEEEEEEEEEEEEEEEEEECCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHH
VRNIASLGELTSAELTQYAHLLSPLEQKRARHAVTENERTLEAATALEQGDLVRFGELMK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHH
QSHMSLRDDYEVTGIELDTLVEAAWAHEGTIGARMTGAGFGGCTVNVVKKASIQDFVKQV
HHHCCCCCCCEECCEEHHHHHHHHHHCCCCCCCEECCCCCCCCEEEHHHHHHHHHHHHHH
GRTYAEKIGYEASFYVVDVGNGARELIEMEEMCR
HHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHCC
>Mature Secondary Structure
MISTLKQQFTKLFGGLEEDIRMFFAPGRVNLIGEHTDYNGGHVLPCALTIGTYALVRQTK
CCCHHHHHHHHHHCCCCHHHHEEECCCCEEEEECCCCCCCCEEEEHHHHHHHHHHHHHCC
VPLVRLYSKNFPETGVITVPYDDLSYRREHSWANYPKGIIAAFQALGPLGTGLDILYYGT
CCHHHHHHCCCCCCCEEEECCCCCHHHHHCCCCCCCHHHHHHHHHHCCCCCCCEEEEEEC
IPNGAGLSSSASIELVTAVALNNLFERQLDQLELVKMSQNVENKYVGVNCGIMDQFAVGM
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHCC
GKQNSAILLNCQTLEYRYLPLALDDYFIVIANTNKKRGLADSAYNERRTTCETALAKLQT
CCCCCEEEEEEEEEEEEEEEEEECCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHH
VRNIASLGELTSAELTQYAHLLSPLEQKRARHAVTENERTLEAATALEQGDLVRFGELMK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHH
QSHMSLRDDYEVTGIELDTLVEAAWAHEGTIGARMTGAGFGGCTVNVVKKASIQDFVKQV
HHHCCCCCCCEECCEEHHHHHHHHHHCCCCCCCEECCCCCCCCEEEHHHHHHHHHHHHHH
GRTYAEKIGYEASFYVVDVGNGARELIEMEEMCR
HHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA