Click here to switch to the map view.

The map label for this gene is comP [H]

Identifier: 138895708

GI number: 138895708

Start: 2191640

End: 2193904

Strand: Reverse

Name: comP [H]

Synonym: GTNG_2064

Alternate gene names: 138895708

Gene position: 2193904-2191640 (Counterclockwise)

Preceding gene: 138895709

Following gene: 138895707

Centisome position: 61.79

GC content: 36.51

Gene sequence:

>2265_bases
ATGAGACGAACGATTACCGTGATAAGCGTAGCTGCGATTGTGGCACTATATTTAACCATTTTCAATGTGAAGCATCCATT
GATCGGCATGGATGTAGAGAAAAATAAGAACGGTGATATTGTTGTAAGCGATATTTACGAGTTTGGTTGGGCAAAAAAAA
ATGGCATTCATATTAATGATCAAGTGCTGAAAGTGGACGGAAAGCCCCCGCTCTCCCATTTTACTGTCCGGAAATACAAA
ACAATTGAACAAGCGAAAACAATAACGATTCAGAGAGAAAATCAAATCCAAACATTGACGGTTGACTATAAATCGCATGG
AACGGAACAATGGCTGTATTATATCGCCTTGCCGATGGGTTTTTTTCTATTCGCTGTTAGTTTAAGCATTTTTTTGCTTC
GTCTGCGGCCGGATGACAAATCGGCCACCGTGCTTATTTACTTTTTATTATTGATAGGGCTTTGTTATATAAGTGCCAGC
TTATCAGCGAAATATGCACTGTTTGGAAGGCAAATGTTTAACGGTATATTTTTAATATTGCCTGCCGTCTTTTTGCACTT
CGTTCATCATTATTTTGAAAAAGAAAAGAAAGTGTGGTTCGCGAAAAAAATCGTCTTTTCCCTTTATGGGTTTAACTTAG
TGATGTTCGTTGCCTCACTCATATCTTTATCGTTTCGTTCGATAAGTGAAGCGGAAGTGCTATTGGCTACATTTTTTATC
AACATGGTCATCATTCTGGCTTTGTTAGGAAAAGGATTCGTTTATCTTAAAAAAGATGAACAGCAAAATACGGTCAAAGG
TTTGCTTTTAGCCATTGGGCTATCTGCCGCACCATTTGTTTTATTTTATAGTCTCCCGGTTCTAATCATTGGAAAATGGG
TACTACCAGCTGAATTAACCGTTACTTCGCTTTTTGTGTTGCCATCTGTCTTTCTTTATTTAATTTGTACAGATCGGTTA
TTTCGATTGCAGTTTTCCATCAATCGCTTTGTGTACTATGCTTTTTTATCATTCCTCCCAGCTTTTCTTATTACATTGCT
TTATGCCAAATTTGTCAATGAAGCGTGGAGACTTGTTGAATTCGCTTTGTTGTTTTTACTAATTTATATAATAAATATCC
TTGCTCTCTATTTAAAAGAATGTTTCGATCGAACATTAAGAGCTAAGTTATATGTACAAAAAGACTTTTACCAAGAAAGT
ATATATCGAATCGGCGAAACATTAAAAAAACAGAAAAACATGCAAGAAGTGATCCGATGCATGGAAAAAGAAGTGAGAGA
AGTATTAGATATAGAGAATCTGGCTTTTGTACAATTAGAGGTCAAAAATATGCAAGCACCTTTTCATTGCGATGAAAAAG
AGTGGATGAAGTTAATCAAAAAGATGGATGGTCAACCACTTTCGATTGGAAAAATCATTGAAAATAAGCGTTTGTTTGCG
GTCTTTGTAGGCTCGTTCCGCCAAAGTCCTTTACTATTAATAGGAAAAAAGAAACATCCCATTCCATTTCGGGCAGAACA
AAAAGATTGGTTATCCACCATTGTCTATTATGCCAGCGTCACGATTGAAAATATGTTAAAAGTAGAGGATTTCATAAAAG
AGTTAGACAGCTTAAAGGAAAGAAGCAATTCTGTTTGGCTCACTCGTTTGATCTTTCAATGGTCGGAAAAGGAAAGAAGA
AAGTTAGCCATTGACTTGCACGATACGATTCTTCAAGATTTAATTGTTTTAAAACGGAAAGTGGAGAGCTTGCGCTTTCA
AAATATGCGTATGGAAGAAATGAAAAAGCAGCTAAACTACATTGAAGAAGAAATCGTAGATATGATTGATTTAACAAGGG
AGATATGCCATGAATTAAGACCGCCATTTTTTAGTCAAATCGGATTAAAGGAAGCGATTGTACAGTTAATCCAACGATTC
CAATTACGTGCGAATATAAAAGTAGAATTGAATGTTCATTTATCAGCTAAATTGAAGGAAGAACGGGAGCTTGCTATTTA
TCGGATTATCCAAGAATTATTAAACAATGCGCTGAAACATTCGCAGGCATCGTATATTCAACTAACATTGGAGGCTCAAA
ATGAGGAGGTTCAACTTCATTACGTTGACAATGGTATAGGTATAGACATGGAAACATTAAATCATTGTGATGGCAAGCTT
GGTTTGTTTGGCATAAAAGAGCGCGTGCAAGGCTTAGGTGGAACATGCGAGATGACGTCACAACTTGGCGAGGGGCTAGA
TATACGGATCACCATTCCATTATAA

Upstream 100 bases:

>100_bases
TACAGTAAGCTTAGTAGGTTTAGATGAACTCGAAGTTCAAGCGATAATAAAGGTATTTAGCCAATCCGTTACCCCCCTTG
GATATTGGAAGTAGAGAGCG

Downstream 100 bases:

>100_bases
GCATAGTAAGGAGAAAAATGACTAGATGATTCACATTTTGGTTGTCGATGATCATCGTCTTGTTGGTGAAGGGACAAAGA
ATATGCTCGAGAGCGAACAA

Product: sensor protein ComP

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 754; Mature: 754

Protein sequence:

>754_residues
MRRTITVISVAAIVALYLTIFNVKHPLIGMDVEKNKNGDIVVSDIYEFGWAKKNGIHINDQVLKVDGKPPLSHFTVRKYK
TIEQAKTITIQRENQIQTLTVDYKSHGTEQWLYYIALPMGFFLFAVSLSIFLLRLRPDDKSATVLIYFLLLIGLCYISAS
LSAKYALFGRQMFNGIFLILPAVFLHFVHHYFEKEKKVWFAKKIVFSLYGFNLVMFVASLISLSFRSISEAEVLLATFFI
NMVIILALLGKGFVYLKKDEQQNTVKGLLLAIGLSAAPFVLFYSLPVLIIGKWVLPAELTVTSLFVLPSVFLYLICTDRL
FRLQFSINRFVYYAFLSFLPAFLITLLYAKFVNEAWRLVEFALLFLLIYIINILALYLKECFDRTLRAKLYVQKDFYQES
IYRIGETLKKQKNMQEVIRCMEKEVREVLDIENLAFVQLEVKNMQAPFHCDEKEWMKLIKKMDGQPLSIGKIIENKRLFA
VFVGSFRQSPLLLIGKKKHPIPFRAEQKDWLSTIVYYASVTIENMLKVEDFIKELDSLKERSNSVWLTRLIFQWSEKERR
KLAIDLHDTILQDLIVLKRKVESLRFQNMRMEEMKKQLNYIEEEIVDMIDLTREICHELRPPFFSQIGLKEAIVQLIQRF
QLRANIKVELNVHLSAKLKEERELAIYRIIQELLNNALKHSQASYIQLTLEAQNEEVQLHYVDNGIGIDMETLNHCDGKL
GLFGIKERVQGLGGTCEMTSQLGEGLDIRITIPL

Sequences:

>Translated_754_residues
MRRTITVISVAAIVALYLTIFNVKHPLIGMDVEKNKNGDIVVSDIYEFGWAKKNGIHINDQVLKVDGKPPLSHFTVRKYK
TIEQAKTITIQRENQIQTLTVDYKSHGTEQWLYYIALPMGFFLFAVSLSIFLLRLRPDDKSATVLIYFLLLIGLCYISAS
LSAKYALFGRQMFNGIFLILPAVFLHFVHHYFEKEKKVWFAKKIVFSLYGFNLVMFVASLISLSFRSISEAEVLLATFFI
NMVIILALLGKGFVYLKKDEQQNTVKGLLLAIGLSAAPFVLFYSLPVLIIGKWVLPAELTVTSLFVLPSVFLYLICTDRL
FRLQFSINRFVYYAFLSFLPAFLITLLYAKFVNEAWRLVEFALLFLLIYIINILALYLKECFDRTLRAKLYVQKDFYQES
IYRIGETLKKQKNMQEVIRCMEKEVREVLDIENLAFVQLEVKNMQAPFHCDEKEWMKLIKKMDGQPLSIGKIIENKRLFA
VFVGSFRQSPLLLIGKKKHPIPFRAEQKDWLSTIVYYASVTIENMLKVEDFIKELDSLKERSNSVWLTRLIFQWSEKERR
KLAIDLHDTILQDLIVLKRKVESLRFQNMRMEEMKKQLNYIEEEIVDMIDLTREICHELRPPFFSQIGLKEAIVQLIQRF
QLRANIKVELNVHLSAKLKEERELAIYRIIQELLNNALKHSQASYIQLTLEAQNEEVQLHYVDNGIGIDMETLNHCDGKL
GLFGIKERVQGLGGTCEMTSQLGEGLDIRITIPL
>Mature_754_residues
MRRTITVISVAAIVALYLTIFNVKHPLIGMDVEKNKNGDIVVSDIYEFGWAKKNGIHINDQVLKVDGKPPLSHFTVRKYK
TIEQAKTITIQRENQIQTLTVDYKSHGTEQWLYYIALPMGFFLFAVSLSIFLLRLRPDDKSATVLIYFLLLIGLCYISAS
LSAKYALFGRQMFNGIFLILPAVFLHFVHHYFEKEKKVWFAKKIVFSLYGFNLVMFVASLISLSFRSISEAEVLLATFFI
NMVIILALLGKGFVYLKKDEQQNTVKGLLLAIGLSAAPFVLFYSLPVLIIGKWVLPAELTVTSLFVLPSVFLYLICTDRL
FRLQFSINRFVYYAFLSFLPAFLITLLYAKFVNEAWRLVEFALLFLLIYIINILALYLKECFDRTLRAKLYVQKDFYQES
IYRIGETLKKQKNMQEVIRCMEKEVREVLDIENLAFVQLEVKNMQAPFHCDEKEWMKLIKKMDGQPLSIGKIIENKRLFA
VFVGSFRQSPLLLIGKKKHPIPFRAEQKDWLSTIVYYASVTIENMLKVEDFIKELDSLKERSNSVWLTRLIFQWSEKERR
KLAIDLHDTILQDLIVLKRKVESLRFQNMRMEEMKKQLNYIEEEIVDMIDLTREICHELRPPFFSQIGLKEAIVQLIQRF
QLRANIKVELNVHLSAKLKEERELAIYRIIQELLNNALKHSQASYIQLTLEAQNEEVQLHYVDNGIGIDMETLNHCDGKL
GLFGIKERVQGLGGTCEMTSQLGEGLDIRITIPL

Specific function: Sensor in the two-component regulatory system ComP/ComA involved in a major quorum response pathway that regulates the development of genetic competence. Plays a role in sporulation, at least partly interchangeable with that of SpoIIJ. Probably activates

COG id: COG4585

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1787474, Length=202, Percent_Identity=28.7128712871287, Blast_Score=77, Evalue=6e-15,
Organism=Escherichia coli, GI87082311, Length=201, Percent_Identity=27.8606965174129, Blast_Score=68, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011712
- InterPro:   IPR005467 [H]

Pfam domain/function: PF02518 HATPase_c; PF07730 HisKA_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 87605; Mature: 87605

Theoretical pI: Translated: 9.28; Mature: 9.28

Prosite motif: PS50106 PDZ ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRTITVISVAAIVALYLTIFNVKHPLIGMDVEKNKNGDIVVSDIYEFGWAKKNGIHIND
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEHHHCCCCCCCCEEECC
QVLKVDGKPPLSHFTVRKYKTIEQAKTITIQRENQIQTLTVDYKSHGTEQWLYYIALPMG
EEEEECCCCCCCHHHHHHHHHHHHHHEEEEEECCCEEEEEEEHHCCCCHHHHHHHHHHHH
FFLFAVSLSIFLLRLRPDDKSATVLIYFLLLIGLCYISASLSAKYALFGRQMFNGIFLIL
HHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
PAVFLHFVHHYFEKEKKVWFAKKIVFSLYGFNLVMFVASLISLSFRSISEAEVLLATFFI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
NMVIILALLGKGFVYLKKDEQQNTVKGLLLAIGLSAAPFVLFYSLPVLIIGKWVLPAELT
HHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHH
VTSLFVLPSVFLYLICTDRLFRLQFSINRFVYYAFLSFLPAFLITLLYAKFVNEAWRLVE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FALLFLLIYIINILALYLKECFDRTLRAKLYVQKDFYQESIYRIGETLKKQKNMQEVIRC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
MEKEVREVLDIENLAFVQLEVKNMQAPFHCDEKEWMKLIKKMDGQPLSIGKIIENKRLFA
HHHHHHHHHCCCCEEEEEEEEECCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHCCCCEEE
VFVGSFRQSPLLLIGKKKHPIPFRAEQKDWLSTIVYYASVTIENMLKVEDFIKELDSLKE
EEECCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RSNSVWLTRLIFQWSEKERRKLAIDLHDTILQDLIVLKRKVESLRFQNMRMEEMKKQLNY
HCCCHHHHHHHHHHCCHHHHHEEEHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
IEEEIVDMIDLTREICHELRPPFFSQIGLKEAIVQLIQRFQLRANIKVELNVHLSAKLKE
HHHHHHHHHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHHHHHHCCEEEEEEEEEEEHHHH
ERELAIYRIIQELLNNALKHSQASYIQLTLEAQNEEVQLHYVDNGIGIDMETLNHCDGKL
HHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCEEEEEEECCCCCCCHHHHHCCCCCC
GLFGIKERVQGLGGTCEMTSQLGEGLDIRITIPL
CHHHHHHHHHCCCCCHHHHHHHCCCCEEEEEECC
>Mature Secondary Structure
MRRTITVISVAAIVALYLTIFNVKHPLIGMDVEKNKNGDIVVSDIYEFGWAKKNGIHIND
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEHHHCCCCCCCCEEECC
QVLKVDGKPPLSHFTVRKYKTIEQAKTITIQRENQIQTLTVDYKSHGTEQWLYYIALPMG
EEEEECCCCCCCHHHHHHHHHHHHHHEEEEEECCCEEEEEEEHHCCCCHHHHHHHHHHHH
FFLFAVSLSIFLLRLRPDDKSATVLIYFLLLIGLCYISASLSAKYALFGRQMFNGIFLIL
HHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
PAVFLHFVHHYFEKEKKVWFAKKIVFSLYGFNLVMFVASLISLSFRSISEAEVLLATFFI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
NMVIILALLGKGFVYLKKDEQQNTVKGLLLAIGLSAAPFVLFYSLPVLIIGKWVLPAELT
HHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHH
VTSLFVLPSVFLYLICTDRLFRLQFSINRFVYYAFLSFLPAFLITLLYAKFVNEAWRLVE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FALLFLLIYIINILALYLKECFDRTLRAKLYVQKDFYQESIYRIGETLKKQKNMQEVIRC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
MEKEVREVLDIENLAFVQLEVKNMQAPFHCDEKEWMKLIKKMDGQPLSIGKIIENKRLFA
HHHHHHHHHCCCCEEEEEEEEECCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHCCCCEEE
VFVGSFRQSPLLLIGKKKHPIPFRAEQKDWLSTIVYYASVTIENMLKVEDFIKELDSLKE
EEECCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RSNSVWLTRLIFQWSEKERRKLAIDLHDTILQDLIVLKRKVESLRFQNMRMEEMKKQLNY
HCCCHHHHHHHHHHCCHHHHHEEEHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
IEEEIVDMIDLTREICHELRPPFFSQIGLKEAIVQLIQRFQLRANIKVELNVHLSAKLKE
HHHHHHHHHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHHHHHHCCEEEEEEEEEEEHHHH
ERELAIYRIIQELLNNALKHSQASYIQLTLEAQNEEVQLHYVDNGIGIDMETLNHCDGKL
HHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCEEEEEEECCCCCCCHHHHHCCCCCC
GLFGIKERVQGLGGTCEMTSQLGEGLDIRITIPL
CHHHHHHHHHCCCCCHHHHHHHCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2116363; 9274030; 9384377; 1715859 [H]