Click here to switch to the map view.

The map label for this gene is comA [H]

Identifier: 138895707

GI number: 138895707

Start: 2190943

End: 2191614

Strand: Reverse

Name: comA [H]

Synonym: GTNG_2063

Alternate gene names: 138895707

Gene position: 2191614-2190943 (Counterclockwise)

Preceding gene: 138895708

Following gene: 138895706

Centisome position: 61.73

GC content: 40.62

Gene sequence:

>672_bases
ATGATTCACATTTTGGTTGTCGATGATCATCGTCTTGTTGGTGAAGGGACAAAGAATATGCTCGAGAGCGAACAAGATTT
TCAAGTAGAACTTGTTACATCTGGTACAGAAGCGGAACAGATGATGGAACAACGTACATATGATGTGTTTTTGCTTGATT
GGCGTATGCCGGATATGAGCGGCACCGAATTAAGTAAGCGAATTCTCCAAAAACAACCGAATGCGAAAATTGTCATATAT
ACCGGATATGATGTTGCTCCTTTTTTTAATTATTTGATTGAATCAGGCATTACAGGCTTTGTCAGTAAAACGGCAACAAG
CGAGCAATTGATTACAGCGATTCGCTGTGCGTTAAGAGATGAAGCGGTTATTCCTGTGCATTTACTGCGCCAGTTGCAGC
TTTGTGAAGTCAAAGCTAGGATGGTAGAAAATGAAGAACATGTTGCACTGAGCCAGCTTGAGCAAGAAATATTATTCGAG
GTCGCCAACGGTTTAAGCAATAAAGATATTGCTAAAAAACACTATATAAGCCAACGAAGTGTAGAAAGACATCTATCGCG
AATCTTCACCAAGTTACATGTGTCTTCGAGGATAGAAGCAGTAGAAAAAGCCAGACAGTTAGGGCTTATTCCAGAGCTTC
ATATGTTGTTAACGCCTTCATCGGATCGGTGA

Upstream 100 bases:

>100_bases
GGCTTAGGTGGAACATGCGAGATGACGTCACAACTTGGCGAGGGGCTAGATATACGGATCACCATTCCATTATAAGCATA
GTAAGGAGAAAAATGACTAG

Downstream 100 bases:

>100_bases
GGGCGTTTTCTCTTTTTTATTTAGGACTACGCCATTTCATGTCGGTACTCCGCCAAAAAATGGCGGGGTTCCGACACCAT
GTTGGTGGTGAAGAAGAAGA

Product: two-component response regulator ComA

Products: NA

Alternate protein names: Competence protein A [H]

Number of amino acids: Translated: 223; Mature: 223

Protein sequence:

>223_residues
MIHILVVDDHRLVGEGTKNMLESEQDFQVELVTSGTEAEQMMEQRTYDVFLLDWRMPDMSGTELSKRILQKQPNAKIVIY
TGYDVAPFFNYLIESGITGFVSKTATSEQLITAIRCALRDEAVIPVHLLRQLQLCEVKARMVENEEHVALSQLEQEILFE
VANGLSNKDIAKKHYISQRSVERHLSRIFTKLHVSSRIEAVEKARQLGLIPELHMLLTPSSDR

Sequences:

>Translated_223_residues
MIHILVVDDHRLVGEGTKNMLESEQDFQVELVTSGTEAEQMMEQRTYDVFLLDWRMPDMSGTELSKRILQKQPNAKIVIY
TGYDVAPFFNYLIESGITGFVSKTATSEQLITAIRCALRDEAVIPVHLLRQLQLCEVKARMVENEEHVALSQLEQEILFE
VANGLSNKDIAKKHYISQRSVERHLSRIFTKLHVSSRIEAVEKARQLGLIPELHMLLTPSSDR
>Mature_223_residues
MIHILVVDDHRLVGEGTKNMLESEQDFQVELVTSGTEAEQMMEQRTYDVFLLDWRMPDMSGTELSKRILQKQPNAKIVIY
TGYDVAPFFNYLIESGITGFVSKTATSEQLITAIRCALRDEAVIPVHLLRQLQLCEVKARMVENEEHVALSQLEQEILFE
VANGLSNKDIAKKHYISQRSVERHLSRIFTKLHVSSRIEAVEKARQLGLIPELHMLLTPSSDR

Specific function: Response regulator in the two-component regulatory system ComP/ComA involved in a major quorum response pathway that regulates the development of genetic competence. Regulates directly the expression of over 20 genes, including genes of the srfA operon, d

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788222, Length=210, Percent_Identity=26.6666666666667, Blast_Score=95, Evalue=3e-21,
Organism=Escherichia coli, GI1788521, Length=199, Percent_Identity=30.6532663316583, Blast_Score=87, Evalue=7e-19,
Organism=Escherichia coli, GI1786747, Length=210, Percent_Identity=26.1904761904762, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI1788712, Length=199, Percent_Identity=25.6281407035176, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1790102, Length=207, Percent_Identity=27.536231884058, Blast_Score=71, Evalue=6e-14,
Organism=Escherichia coli, GI1787473, Length=199, Percent_Identity=28.1407035175879, Blast_Score=60, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 25506; Mature: 25506

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIHILVVDDHRLVGEGTKNMLESEQDFQVELVTSGTEAEQMMEQRTYDVFLLDWRMPDMS
CEEEEEECCCEEECCCHHHHHCCCCCCEEEEEECCCHHHHHHHHCCCEEEEEEEECCCCC
GTELSKRILQKQPNAKIVIYTGYDVAPFFNYLIESGITGFVSKTATSEQLITAIRCALRD
CHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHHCC
EAVIPVHLLRQLQLCEVKARMVENEEHVALSQLEQEILFEVANGLSNKDIAKKHYISQRS
CCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
VERHLSRIFTKLHVSSRIEAVEKARQLGLIPELHMLLTPSSDR
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHEEECCCCCC
>Mature Secondary Structure
MIHILVVDDHRLVGEGTKNMLESEQDFQVELVTSGTEAEQMMEQRTYDVFLLDWRMPDMS
CEEEEEECCCEEECCCHHHHHCCCCCCEEEEEECCCHHHHHHHHCCCEEEEEEEECCCCC
GTELSKRILQKQPNAKIVIYTGYDVAPFFNYLIESGITGFVSKTATSEQLITAIRCALRD
CHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHHCC
EAVIPVHLLRQLQLCEVKARMVENEEHVALSQLEQEILFEVANGLSNKDIAKKHYISQRS
CCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
VERHLSRIFTKLHVSSRIEAVEKARQLGLIPELHMLLTPSSDR
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2507523; 9274030; 9384377 [H]