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The map label for this gene is ilvD [H]

Identifier: 138895578

GI number: 138895578

Start: 2054325

End: 2056019

Strand: Reverse

Name: ilvD [H]

Synonym: GTNG_1931

Alternate gene names: 138895578

Gene position: 2056019-2054325 (Counterclockwise)

Preceding gene: 138895581

Following gene: 138895577

Centisome position: 57.91

GC content: 54.04

Gene sequence:

>1695_bases
ATGGAGGGACTCTTCATGAAAACACGGCGCAGCGACATGATTAAAAAAGGATTCGACCGCGCTCCGCACCGAAGTTTATT
GCGGGCGGCTGGCGTGAAAGAAGAAGATTTTGACAAACCGTTTATTGCGGTGGTCAACTCATATATTGACATTATCCCTG
GACACGTCCATTTACAAGAGTTTGGAAAAATCGTCAAGGAAGCGATCCGTGAAGCGGGTGGCGTGCCGTTTGAAATGAAT
ACGATCGGCGTTGATGATGGCATCGCGATGGGGCATATCGGGATGCGCTATTCGCTTCCGAGCCGGGAAATTATCGCCGA
CTCGATTGAAACGGTTGTTTCCGCGCATTGGTTTGACGGTATGGTGTGCATTCCGAACTGCGACAAAATTACGCCAGGAA
TGATGATGGCAGCGATGCGGCTCAACATCCCGACGATTTTTGTCAGCGGCGGGCCGATGAAAGCCGGCGTAACGAAAGAT
GGGCGGAAAATTTCACTCTCGTCCGTGTTTGAAGGAGTCGGGGCGTATTTAGGCGGCTCGCTCGATGAGAAAGGACTGAT
GGAACTCGAACAGTACGGCTGTCCGACGTGCGGGTCGTGTTCGGGCATGTTCACGGCCAATTCGATGAACTGTTTGGCCG
AAGCGCTCGGGCTCGCCTTACCAGGCAACGGGACGATTTTAGCGGTTGACCCGGCGCGTAAAGAGCTTGTCCGCGAATCG
GCGAAACAGCTCATGTATTTGATCGAACATGATATTAAACCGCGCGACATTGTCACGGAAAAAGCAATCGATAACGCGTT
CGCGCTCGATATGGCGCTTGGCGGCTCGACGAATACGGTACTACATACGTTGGCCATCGCCAACGAAGCCGGCATTGACT
ATTCGCTCGAGCGGATTAACGAAGTGGCGTCACGCGTGCCGCATTTAGCGAAGCTCGCTCCGGCATCGGATGTCCATTAT
ATTGAAGACTTGCACGAAGCGGGCGGCGTCTCGGCGGTGCTCAATGAATTGTCGAAAAAAGAAGGCACACTCCATTTAGA
CACGCTCACTGTCACTGGTAAAACGCTTGGCGAAAACATTGCCGGCTGTGAAGTGAAAAACTATGATGTCATCCGGCCAA
TCGATAACCCGTATTCGGAAACGGGCGGGCTCACCATTTTGTTCGGCAACTTAGCACCGGACGGAGCGGTCATTAAAACC
GGCGCGGTTCAAGGCGGCATCACGCGCCATAAAGGGCCAGCCATCGTCTTCGATTCGCAGGAAGAAGCGCTTGAAGGCAT
CGCCAGCGGCAAAATCAAGCCAGGCCATGTCGTCGTCATCCGTTACGAAGGGCCAAAAGGTGGCCCAGGCATGCCGGAAA
TGCTCGCGCCAACCTCACAAATTGTCGGCATGGGGCTCGGCACAAAAGTGGCGCTTGTCACTGACGGGCGGTTCTCCGGT
GCTTCGCGCGGCTTGTCGATCGGGCACGTCTCTCCGGAGGCAGCAGAAGGCGGACCGATCGCGTTCATCGAAGACGGCGA
TATAATCGAAATCGACACGGTCAAGCGGACGATCAATGTCAAATTGTCTGACGAAGAGCTTGAACGGCGCAAAGCGAACT
GGAAAGGCTTTGAGCCGAAAGTAAAAACCGGGTATCTCGCCCGCTACTCGAAGCACGTCACTTCAGCGAGCACAGGGGGG
GTTATGAAGCTTTAA

Upstream 100 bases:

>100_bases
CCTTGCTCTAGACAAAACAATGAAAACGCATTCAGAATAAAGGTAATTGTCAATTTATTAAAAAAAGTGGTACAATACTA
GCAACCTATTAATCTGAACG

Downstream 100 bases:

>100_bases
GGCAGCAGCGGCTTCCGATGAATGAGCGCCCTGCCGTAAAAGAGAAAGCCTGCCTGGACGAGTGAAAACAGGCAGGCTTT
TTCATCATGATATATCGCCC

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 564; Mature: 564

Protein sequence:

>564_residues
MEGLFMKTRRSDMIKKGFDRAPHRSLLRAAGVKEEDFDKPFIAVVNSYIDIIPGHVHLQEFGKIVKEAIREAGGVPFEMN
TIGVDDGIAMGHIGMRYSLPSREIIADSIETVVSAHWFDGMVCIPNCDKITPGMMMAAMRLNIPTIFVSGGPMKAGVTKD
GRKISLSSVFEGVGAYLGGSLDEKGLMELEQYGCPTCGSCSGMFTANSMNCLAEALGLALPGNGTILAVDPARKELVRES
AKQLMYLIEHDIKPRDIVTEKAIDNAFALDMALGGSTNTVLHTLAIANEAGIDYSLERINEVASRVPHLAKLAPASDVHY
IEDLHEAGGVSAVLNELSKKEGTLHLDTLTVTGKTLGENIAGCEVKNYDVIRPIDNPYSETGGLTILFGNLAPDGAVIKT
GAVQGGITRHKGPAIVFDSQEEALEGIASGKIKPGHVVVIRYEGPKGGPGMPEMLAPTSQIVGMGLGTKVALVTDGRFSG
ASRGLSIGHVSPEAAEGGPIAFIEDGDIIEIDTVKRTINVKLSDEELERRKANWKGFEPKVKTGYLARYSKHVTSASTGG
VMKL

Sequences:

>Translated_564_residues
MEGLFMKTRRSDMIKKGFDRAPHRSLLRAAGVKEEDFDKPFIAVVNSYIDIIPGHVHLQEFGKIVKEAIREAGGVPFEMN
TIGVDDGIAMGHIGMRYSLPSREIIADSIETVVSAHWFDGMVCIPNCDKITPGMMMAAMRLNIPTIFVSGGPMKAGVTKD
GRKISLSSVFEGVGAYLGGSLDEKGLMELEQYGCPTCGSCSGMFTANSMNCLAEALGLALPGNGTILAVDPARKELVRES
AKQLMYLIEHDIKPRDIVTEKAIDNAFALDMALGGSTNTVLHTLAIANEAGIDYSLERINEVASRVPHLAKLAPASDVHY
IEDLHEAGGVSAVLNELSKKEGTLHLDTLTVTGKTLGENIAGCEVKNYDVIRPIDNPYSETGGLTILFGNLAPDGAVIKT
GAVQGGITRHKGPAIVFDSQEEALEGIASGKIKPGHVVVIRYEGPKGGPGMPEMLAPTSQIVGMGLGTKVALVTDGRFSG
ASRGLSIGHVSPEAAEGGPIAFIEDGDIIEIDTVKRTINVKLSDEELERRKANWKGFEPKVKTGYLARYSKHVTSASTGG
VMKL
>Mature_564_residues
MEGLFMKTRRSDMIKKGFDRAPHRSLLRAAGVKEEDFDKPFIAVVNSYIDIIPGHVHLQEFGKIVKEAIREAGGVPFEMN
TIGVDDGIAMGHIGMRYSLPSREIIADSIETVVSAHWFDGMVCIPNCDKITPGMMMAAMRLNIPTIFVSGGPMKAGVTKD
GRKISLSSVFEGVGAYLGGSLDEKGLMELEQYGCPTCGSCSGMFTANSMNCLAEALGLALPGNGTILAVDPARKELVRES
AKQLMYLIEHDIKPRDIVTEKAIDNAFALDMALGGSTNTVLHTLAIANEAGIDYSLERINEVASRVPHLAKLAPASDVHY
IEDLHEAGGVSAVLNELSKKEGTLHLDTLTVTGKTLGENIAGCEVKNYDVIRPIDNPYSETGGLTILFGNLAPDGAVIKT
GAVQGGITRHKGPAIVFDSQEEALEGIASGKIKPGHVVVIRYEGPKGGPGMPEMLAPTSQIVGMGLGTKVALVTDGRFSG
ASRGLSIGHVSPEAAEGGPIAFIEDGDIIEIDTVKRTINVKLSDEELERRKANWKGFEPKVKTGYLARYSKHVTSASTGG
VMKL

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=613, Percent_Identity=47.6345840130506, Blast_Score=533, Evalue=1e-152,
Organism=Escherichia coli, GI1788157, Length=543, Percent_Identity=32.5966850828729, Blast_Score=234, Evalue=1e-62,
Organism=Escherichia coli, GI2367371, Length=523, Percent_Identity=34.0344168260038, Blast_Score=218, Evalue=9e-58,
Organism=Escherichia coli, GI1786464, Length=502, Percent_Identity=34.6613545816733, Blast_Score=218, Evalue=1e-57,
Organism=Saccharomyces cerevisiae, GI6322476, Length=548, Percent_Identity=41.7883211678832, Blast_Score=407, Evalue=1e-114,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 60155; Mature: 60155

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2 ; PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEGLFMKTRRSDMIKKGFDRAPHRSLLRAAGVKEEDFDKPFIAVVNSYIDIIPGHVHLQE
CCCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCEEEHHH
FGKIVKEAIREAGGVPFEMNTIGVDDGIAMGHIGMRYSLPSREIIADSIETVVSAHWFDG
HHHHHHHHHHHHCCCCEEEEEECCCCCCEECCCCEEECCCCHHHHHHHHHHHHHHHHCCC
MVCIPNCDKITPGMMMAAMRLNIPTIFVSGGPMKAGVTKDGRKISLSSVFEGVGAYLGGS
EEECCCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCEEEHHHHHHHHHHHHCCC
LDEKGLMELEQYGCPTCGSCSGMFTANSMNCLAEALGLALPGNGTILAVDPARKELVRES
CCHHHHHHHHHCCCCCCCCCCCCEECCHHHHHHHHHCEECCCCCEEEEECHHHHHHHHHH
AKQLMYLIEHDIKPRDIVTEKAIDNAFALDMALGGSTNTVLHTLAIANEAGIDYSLERIN
HHHHHHHHHCCCCCHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHCCCCCCHHHHHHH
EVASRVPHLAKLAPASDVHYIEDLHEAGGVSAVLNELSKKEGTLHLDTLTVTGKTLGENI
HHHHHCCHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEEEEEECHHHCCCC
AGCEVKNYDVIRPIDNPYSETGGLTILFGNLAPDGAVIKTGAVQGGITRHKGPAIVFDSQ
CCCEECCCCEECCCCCCCCCCCCEEEEECCCCCCCCEEEECCCCCCCCCCCCCEEEECCH
EEALEGIASGKIKPGHVVVIRYEGPKGGPGMPEMLAPTSQIVGMGLGTKVALVTDGRFSG
HHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCHHHCCHHHHHCCCCCCEEEEEECCCCCC
ASRGLSIGHVSPEAAEGGPIAFIEDGDIIEIDTVKRTINVKLSDEELERRKANWKGFEPK
CCCCEEECCCCCCCCCCCCEEEECCCCEEEEEEEEEEEEEEECHHHHHHHHCCCCCCCCC
VKTGYLARYSKHVTSASTGGVMKL
CCCHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MEGLFMKTRRSDMIKKGFDRAPHRSLLRAAGVKEEDFDKPFIAVVNSYIDIIPGHVHLQE
CCCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCEEEHHH
FGKIVKEAIREAGGVPFEMNTIGVDDGIAMGHIGMRYSLPSREIIADSIETVVSAHWFDG
HHHHHHHHHHHHCCCCEEEEEECCCCCCEECCCCEEECCCCHHHHHHHHHHHHHHHHCCC
MVCIPNCDKITPGMMMAAMRLNIPTIFVSGGPMKAGVTKDGRKISLSSVFEGVGAYLGGS
EEECCCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCEEEHHHHHHHHHHHHCCC
LDEKGLMELEQYGCPTCGSCSGMFTANSMNCLAEALGLALPGNGTILAVDPARKELVRES
CCHHHHHHHHHCCCCCCCCCCCCEECCHHHHHHHHHCEECCCCCEEEEECHHHHHHHHHH
AKQLMYLIEHDIKPRDIVTEKAIDNAFALDMALGGSTNTVLHTLAIANEAGIDYSLERIN
HHHHHHHHHCCCCCHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHCCCCCCHHHHHHH
EVASRVPHLAKLAPASDVHYIEDLHEAGGVSAVLNELSKKEGTLHLDTLTVTGKTLGENI
HHHHHCCHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEEEEEECHHHCCCC
AGCEVKNYDVIRPIDNPYSETGGLTILFGNLAPDGAVIKTGAVQGGITRHKGPAIVFDSQ
CCCEECCCCEECCCCCCCCCCCCEEEEECCCCCCCCEEEECCCCCCCCCCCCCEEEECCH
EEALEGIASGKIKPGHVVVIRYEGPKGGPGMPEMLAPTSQIVGMGLGTKVALVTDGRFSG
HHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCHHHCCHHHHHCCCCCCEEEEEECCCCCC
ASRGLSIGHVSPEAAEGGPIAFIEDGDIIEIDTVKRTINVKLSDEELERRKANWKGFEPK
CCCCEEECCCCCCCCCCCCEEEECCCCEEEEEEEEEEEEEEECHHHHHHHHCCCCCCCCC
VKTGYLARYSKHVTSASTGGVMKL
CCCHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA