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The map label for this gene is kdgA [H]

Identifier: 138895508

GI number: 138895508

Start: 1980813

End: 1981469

Strand: Reverse

Name: kdgA [H]

Synonym: GTNG_1856

Alternate gene names: 138895508

Gene position: 1981469-1980813 (Counterclockwise)

Preceding gene: 138895509

Following gene: 138895507

Centisome position: 55.81

GC content: 48.25

Gene sequence:

>657_bases
ATGGATAAAATTTTCCATTTAAACCGGTTAAAAACGGTCAAATTGGTGGCGGTGATCCGAAAACCGAAACGGTCGCAAAT
ATTTCAGATTGCTGAGGCTCTTATCGCTGGAGGAGTCGAGGTACTCGAAGTGACGGTTGATACGCCAGGCAGTTTTGAGA
TGATTGCTGCGCTGAAGGAAACGTTCGGAGCAAAGGCGACCATCGGCGCAGGGACAGTCTTAGATGCCGAGACCGCAAAG
AGAGCCATCGAAGCCGGTTCAGACTTTATTTTTTCACCTATTTTTGATCAAGAGACGATCTCTTTAACGAACCGATACGG
AAAAATTTCCATTCCCGGTGTGATGACGCCGACCGAAATCGTTAAGGCTTATCAGATGGGAGCTGACCTTTTGAAAGTAT
TTCCGGCAGGCTCCTTAGGGCCCCAATATTTTAAAGAGTTAAGAGGACCGTTAGGGCATATTCCGTTGATGCCGACAGGT
GGTGTAACGTTGGAGAATGCAGCGGAGTTTATCCGCAACGGCGCCGCAGCCATAGGAGTCGGCAGCGCTTTACTGGATAA
ACGGGTCATTGAGGAAGGGAGATTCAACCTTCTTACAGAAACGGCAAAGAGATTTGTCGAAACGGTTAGAAACGCAGCCG
TAAGAGAGGGGGAATAG

Upstream 100 bases:

>100_bases
AAACGGGGATGTGGAAGGACTGCCAAACGAGGGAGAGCTCGAAGAATTTTTACAAGGCGCCGTACATCATCGAGATGTGA
AGCGATGAGGGGGAGGGACA

Downstream 100 bases:

>100_bases
GAACGTGAAGATTACGAAGTTCGAGACTTTTCTTGTCCCACCTCGATGGTTGTTCCTAAAAATCAGTACGGATGAAGGAA
TTGCTGGATGGGGTGAACCG

Product: 2-dehydro-3-deoxyphosphogluconate aldolase

Products: NA

Alternate protein names: 4-hydroxy-2-oxoglutarate aldolase; 2-keto-4-hydroxyglutarate aldolase; KHG-aldolase; 2-dehydro-3-deoxy-phosphogluconate aldolase; 2-keto-3-deoxy-6-phosphogluconate aldolase; KDPG-aldolase; Phospho-2-dehydro-3-deoxygluconate aldolase; Phospho-2-keto-3-deoxygluconate aldolase [H]

Number of amino acids: Translated: 218; Mature: 218

Protein sequence:

>218_residues
MDKIFHLNRLKTVKLVAVIRKPKRSQIFQIAEALIAGGVEVLEVTVDTPGSFEMIAALKETFGAKATIGAGTVLDAETAK
RAIEAGSDFIFSPIFDQETISLTNRYGKISIPGVMTPTEIVKAYQMGADLLKVFPAGSLGPQYFKELRGPLGHIPLMPTG
GVTLENAAEFIRNGAAAIGVGSALLDKRVIEEGRFNLLTETAKRFVETVRNAAVREGE

Sequences:

>Translated_218_residues
MDKIFHLNRLKTVKLVAVIRKPKRSQIFQIAEALIAGGVEVLEVTVDTPGSFEMIAALKETFGAKATIGAGTVLDAETAK
RAIEAGSDFIFSPIFDQETISLTNRYGKISIPGVMTPTEIVKAYQMGADLLKVFPAGSLGPQYFKELRGPLGHIPLMPTG
GVTLENAAEFIRNGAAAIGVGSALLDKRVIEEGRFNLLTETAKRFVETVRNAAVREGE
>Mature_218_residues
MDKIFHLNRLKTVKLVAVIRKPKRSQIFQIAEALIAGGVEVLEVTVDTPGSFEMIAALKETFGAKATIGAGTVLDAETAK
RAIEAGSDFIFSPIFDQETISLTNRYGKISIPGVMTPTEIVKAYQMGADLLKVFPAGSLGPQYFKELRGPLGHIPLMPTG
GVTLENAAEFIRNGAAAIGVGSALLDKRVIEEGRFNLLTETAKRFVETVRNAAVREGE

Specific function: KEY ENZYME IN THE ENTNER-DOUDOROFF PATHWAY. PARTICIPATES IN THE REGULATION OF THE INTRACELLULAR LEVEL OF GLYOXYLATE. [C]

COG id: COG0800

COG function: function code G; 2-keto-3-deoxy-6-phosphogluconate aldolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the KHG/KDPG aldolase family [H]

Homologues:

Organism=Escherichia coli, GI48994954, Length=171, Percent_Identity=36.2573099415205, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1788156, Length=182, Percent_Identity=30.2197802197802, Blast_Score=81, Evalue=6e-17,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000887
- InterPro:   IPR013785 [H]

Pfam domain/function: PF01081 Aldolase [H]

EC number: =4.1.3.16; =4.1.2.14 [H]

Molecular weight: Translated: 23461; Mature: 23461

Theoretical pI: Translated: 8.89; Mature: 8.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKIFHLNRLKTVKLVAVIRKPKRSQIFQIAEALIAGGVEVLEVTVDTPGSFEMIAALKE
CCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCEEEEEEEECCCCCHHHHHHHHH
TFGAKATIGAGTVLDAETAKRAIEAGSDFIFSPIFDQETISLTNRYGKISIPGVMTPTEI
HHCCCEECCCCCEECHHHHHHHHHCCCCCEECCCCCCHHHHHHHCCCCEECCCCCCHHHH
VKAYQMGADLLKVFPAGSLGPQYFKELRGPLGHIPLMPTGGVTLENAAEFIRNGAAAIGV
HHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHH
GSALLDKRVIEEGRFNLLTETAKRFVETVRNAAVREGE
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MDKIFHLNRLKTVKLVAVIRKPKRSQIFQIAEALIAGGVEVLEVTVDTPGSFEMIAALKE
CCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCEEEEEEEECCCCCHHHHHHHHH
TFGAKATIGAGTVLDAETAKRAIEAGSDFIFSPIFDQETISLTNRYGKISIPGVMTPTEI
HHCCCEECCCCCEECHHHHHHHHHCCCCCEECCCCCCHHHHHHHCCCCEECCCCCCHHHH
VKAYQMGADLLKVFPAGSLGPQYFKELRGPLGHIPLMPTGGVTLENAAEFIRNGAAAIGV
HHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHH
GSALLDKRVIEEGRFNLLTETAKRFVETVRNAAVREGE
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8760912; 9384377 [H]