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The map label for this gene is serA [H]

Identifier: 138895505

GI number: 138895505

Start: 1978592

End: 1979596

Strand: Reverse

Name: serA [H]

Synonym: GTNG_1853

Alternate gene names: 138895505

Gene position: 1979596-1978592 (Counterclockwise)

Preceding gene: 138895506

Following gene: 138895504

Centisome position: 55.76

GC content: 42.89

Gene sequence:

>1005_bases
ATGAAAAAGTACAAAGTAGTAGTGACAGACTATGAATTTCAAACATTGAAACCCGAGCAGGAAGTGCTTTCGCCGCTTAA
TGTCGATTTCGTAGTCGCTCAGTGTTACACAGAGGAAGAAGTCATCGCCGTTTGCAAGGATGCCGATGCTATTATCAACC
AATATGCTCCGATATCTGCAAAGGTGATTGACCAATTAGAGAAATGTAAAGTGATTTCTCGGTACGGAGTCGGTGTCAAC
ACTGTCGATGTGGACGCCGCCACTGAGAAGGGCATTATTGTAGCCAATGTAACGGACTATTCAGTGGATGAAGTATCAGA
TCATGCATTAGCATTGCTGCTTTCGTTAGCCCGAAAAATTGTTAAGTTAAATGACGAAGTGAAAAGCGGAGTATGGAATT
TCAATGTCGGCAAACCAATTTACCGGTTAAGGGGAAGAACGCTCGGTCTTGTAGGGTTTGGAAGAATTCCTCAAGCGTTA
GCGAAAAAGGCTCAATCTCTCGGCTTATATGTCATCGCCTATGATCCATATATTCCTGCGAAAGTGGCTAGGCAGTTCAA
TGTTCATTTAGTGGAACTCAACGATTTATTCCGGCAATCGGACTACAATTCTGTGCATGCCCCCTTAACCAAAGAGACAA
AAGGTATGATCAGTGATGAACAGTTTCATCTAGCAAAAAAGGAACTAATCATTGTCAATACAGCCCGCGGTCCCGTTATT
GATGAGTCATCTCTAATTCGCGCCTTGCAAGATGGGAAGATTTCCGGTGCGGGACTTGATGTCACCGAATACGAGCCGAT
TCACCCTGATAATCCTCTTCTTCAGATGGAGAATGTGGTGATTACACCGCATATTGCTTGGTATTCTGAGGAATCCGAAA
TGGAATTAAAACGAAAAACAGCTCAGAATGTTGCCGATGTACTATCAGGATGTTACCCAAGATATTTAGTCAATCCTCGT
GTGAAAGAAAAGGTGCGCTTGAAAGTGAAAGAATCATACGTATAG

Upstream 100 bases:

>100_bases
TTGGCGCCATGTTGACGGTTCAGTTGCTGAGTGGTAGGGATACAGTGCCTACAGCAGCCCTCTAACTTCTACCGTTTTGT
AGGGAATAGGGGAGGACAAA

Downstream 100 bases:

>100_bases
GAAGATTTATTTCTCAATATATTCAATACGCAAATATCACCAGCACCTTCATCGGCGCCAGCTGTCCGTAACAAGTGGAA
GAAAACGTCAAGGCGGTCGA

Product: putative dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 334; Mature: 334

Protein sequence:

>334_residues
MKKYKVVVTDYEFQTLKPEQEVLSPLNVDFVVAQCYTEEEVIAVCKDADAIINQYAPISAKVIDQLEKCKVISRYGVGVN
TVDVDAATEKGIIVANVTDYSVDEVSDHALALLLSLARKIVKLNDEVKSGVWNFNVGKPIYRLRGRTLGLVGFGRIPQAL
AKKAQSLGLYVIAYDPYIPAKVARQFNVHLVELNDLFRQSDYNSVHAPLTKETKGMISDEQFHLAKKELIIVNTARGPVI
DESSLIRALQDGKISGAGLDVTEYEPIHPDNPLLQMENVVITPHIAWYSEESEMELKRKTAQNVADVLSGCYPRYLVNPR
VKEKVRLKVKESYV

Sequences:

>Translated_334_residues
MKKYKVVVTDYEFQTLKPEQEVLSPLNVDFVVAQCYTEEEVIAVCKDADAIINQYAPISAKVIDQLEKCKVISRYGVGVN
TVDVDAATEKGIIVANVTDYSVDEVSDHALALLLSLARKIVKLNDEVKSGVWNFNVGKPIYRLRGRTLGLVGFGRIPQAL
AKKAQSLGLYVIAYDPYIPAKVARQFNVHLVELNDLFRQSDYNSVHAPLTKETKGMISDEQFHLAKKELIIVNTARGPVI
DESSLIRALQDGKISGAGLDVTEYEPIHPDNPLLQMENVVITPHIAWYSEESEMELKRKTAQNVADVLSGCYPRYLVNPR
VKEKVRLKVKESYV
>Mature_334_residues
MKKYKVVVTDYEFQTLKPEQEVLSPLNVDFVVAQCYTEEEVIAVCKDADAIINQYAPISAKVIDQLEKCKVISRYGVGVN
TVDVDAATEKGIIVANVTDYSVDEVSDHALALLLSLARKIVKLNDEVKSGVWNFNVGKPIYRLRGRTLGLVGFGRIPQAL
AKKAQSLGLYVIAYDPYIPAKVARQFNVHLVELNDLFRQSDYNSVHAPLTKETKGMISDEQFHLAKKELIIVNTARGPVI
DESSLIRALQDGKISGAGLDVTEYEPIHPDNPLLQMENVVITPHIAWYSEESEMELKRKTAQNVADVLSGCYPRYLVNPR
VKEKVRLKVKESYV

Specific function: Unknown

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=310, Percent_Identity=34.5161290322581, Blast_Score=185, Evalue=4e-47,
Organism=Homo sapiens, GI145580578, Length=304, Percent_Identity=34.2105263157895, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI4557499, Length=304, Percent_Identity=34.2105263157895, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI145580575, Length=300, Percent_Identity=34, Blast_Score=170, Evalue=1e-42,
Organism=Homo sapiens, GI4557497, Length=300, Percent_Identity=32.3333333333333, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI61743967, Length=300, Percent_Identity=32.3333333333333, Blast_Score=169, Evalue=3e-42,
Organism=Homo sapiens, GI6912396, Length=246, Percent_Identity=33.739837398374, Blast_Score=139, Evalue=5e-33,
Organism=Escherichia coli, GI87082289, Length=311, Percent_Identity=35.048231511254, Blast_Score=182, Evalue=2e-47,
Organism=Escherichia coli, GI1787645, Length=268, Percent_Identity=32.4626865671642, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1789279, Length=261, Percent_Identity=32.183908045977, Blast_Score=128, Evalue=4e-31,
Organism=Escherichia coli, GI87081824, Length=223, Percent_Identity=24.6636771300448, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17532191, Length=300, Percent_Identity=31.6666666666667, Blast_Score=147, Evalue=6e-36,
Organism=Caenorhabditis elegans, GI25147481, Length=272, Percent_Identity=31.6176470588235, Blast_Score=138, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6320925, Length=279, Percent_Identity=32.9749103942652, Blast_Score=150, Evalue=3e-37,
Organism=Saccharomyces cerevisiae, GI6322116, Length=274, Percent_Identity=32.1167883211679, Blast_Score=143, Evalue=4e-35,
Organism=Saccharomyces cerevisiae, GI6324055, Length=241, Percent_Identity=31.5352697095436, Blast_Score=117, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6324964, Length=355, Percent_Identity=27.6056338028169, Blast_Score=102, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6324980, Length=194, Percent_Identity=25.7731958762887, Blast_Score=66, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24646446, Length=305, Percent_Identity=33.7704918032787, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI24646448, Length=305, Percent_Identity=33.7704918032787, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI24646452, Length=305, Percent_Identity=33.7704918032787, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI24646450, Length=305, Percent_Identity=33.7704918032787, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI62472511, Length=305, Percent_Identity=33.7704918032787, Blast_Score=158, Evalue=6e-39,
Organism=Drosophila melanogaster, GI19921140, Length=283, Percent_Identity=31.095406360424, Blast_Score=139, Evalue=3e-33,
Organism=Drosophila melanogaster, GI24585516, Length=318, Percent_Identity=27.9874213836478, Blast_Score=139, Evalue=4e-33,
Organism=Drosophila melanogaster, GI28571528, Length=281, Percent_Identity=34.1637010676157, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI45552429, Length=321, Percent_Identity=28.3489096573209, Blast_Score=131, Evalue=5e-31,
Organism=Drosophila melanogaster, GI45551003, Length=321, Percent_Identity=28.3489096573209, Blast_Score=131, Evalue=6e-31,
Organism=Drosophila melanogaster, GI24585514, Length=321, Percent_Identity=28.3489096573209, Blast_Score=131, Evalue=7e-31,
Organism=Drosophila melanogaster, GI28574282, Length=321, Percent_Identity=28.3489096573209, Blast_Score=131, Evalue=7e-31,
Organism=Drosophila melanogaster, GI28574284, Length=321, Percent_Identity=28.3489096573209, Blast_Score=131, Evalue=7e-31,
Organism=Drosophila melanogaster, GI28574286, Length=323, Percent_Identity=27.5541795665635, Blast_Score=128, Evalue=4e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 37378; Mature: 37378

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKYKVVVTDYEFQTLKPEQEVLSPLNVDFVVAQCYTEEEVIAVCKDADAIINQYAPISA
CCCEEEEEEECCCEECCCHHHHHCCCCEEEEEEECCCCCHHHEECCCHHHHHHCCCCCHH
KVIDQLEKCKVISRYGVGVNTVDVDAATEKGIIVANVTDYSVDEVSDHALALLLSLARKI
HHHHHHHHHHHHHHCCCCCCEEECCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHH
VKLNDEVKSGVWNFNVGKPIYRLRGRTLGLVGFGRIPQALAKKAQSLGLYVIAYDPYIPA
HHCCHHHHCCCEECCCCCHHHHHCCCEEEEEECCCCHHHHHHHHHHCCEEEEEECCCCCH
KVARQFNVHLVELNDLFRQSDYNSVHAPLTKETKGMISDEQFHLAKKELIIVNTARGPVI
HHHHHHCEEEEEHHHHHHCCCCCCCCCCCCHHHCCCCCCHHHHEECEEEEEEECCCCCCC
DESSLIRALQDGKISGAGLDVTEYEPIHPDNPLLQMENVVITPHIAWYSEESEMELKRKT
CHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEECCEEEECEEEEECCCHHHHHHHHH
AQNVADVLSGCYPRYLVNPRVKEKVRLKVKESYV
HHHHHHHHHCCCCHHCCCCCCCHHHEEEEECCCC
>Mature Secondary Structure
MKKYKVVVTDYEFQTLKPEQEVLSPLNVDFVVAQCYTEEEVIAVCKDADAIINQYAPISA
CCCEEEEEEECCCEECCCHHHHHCCCCEEEEEEECCCCCHHHEECCCHHHHHHCCCCCHH
KVIDQLEKCKVISRYGVGVNTVDVDAATEKGIIVANVTDYSVDEVSDHALALLLSLARKI
HHHHHHHHHHHHHHCCCCCCEEECCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHH
VKLNDEVKSGVWNFNVGKPIYRLRGRTLGLVGFGRIPQALAKKAQSLGLYVIAYDPYIPA
HHCCHHHHCCCEECCCCCHHHHHCCCEEEEEECCCCHHHHHHHHHHCCEEEEEECCCCCH
KVARQFNVHLVELNDLFRQSDYNSVHAPLTKETKGMISDEQFHLAKKELIIVNTARGPVI
HHHHHHCEEEEEHHHHHHCCCCCCCCCCCCHHHCCCCCCHHHHEECEEEEEEECCCCCCC
DESSLIRALQDGKISGAGLDVTEYEPIHPDNPLLQMENVVITPHIAWYSEESEMELKRKT
CHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEECCEEEECEEEEECCCHHHHHHHHH
AQNVADVLSGCYPRYLVNPRVKEKVRLKVKESYV
HHHHHHHHHCCCCHHCCCCCCCHHHEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]