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The map label for this gene is dhaT [H]

Identifier: 138895503

GI number: 138895503

Start: 1974794

End: 1975981

Strand: Reverse

Name: dhaT [H]

Synonym: GTNG_1851

Alternate gene names: 138895503

Gene position: 1975981-1974794 (Counterclockwise)

Preceding gene: 138895504

Following gene: 138895502

Centisome position: 55.66

GC content: 55.05

Gene sequence:

>1188_bases
ATGTACGAGTTATTAGTACCGAATCGGGTCATTTATGGGCGCGATACGTTTCGCGAAGTCGGCCGTCAAGCGAAAGCACT
TGGAACGAAAGCGCTCATTGTCAGTGACCCGGTGATGGAGAACATCGGTCTTGTCGCGCGCTGTGAGCAATATTTGCGGG
AAGCGGGGCTGCCGTTGGCCACGTACACAAGGGTCGACACGGAACCGACGGATGTTCATGTGAAAGAAGCGCTTGATGTC
TGCCGGAGCGAACAATGCGATGTCATCGTTGCCATCGGCGGCGGCAGCAGCATTGATGCCGCCAAGGCGGTGGCGGTGAT
GATGACGAATGAGGGAACGATCAGTGACTACGTTGGCAACGCCAAGATGTTCACGAAAAAACCAGTGCCGCTCATTGCTA
TTCCGACGACGGCCGGTACCGGTTCAGAAGTGACGAAAGTGACAGTTATTATTGATACGAAAACGGATGTCAAAATGATG
ATTTCCCAGCCGGCGCTCCTTCCGGCGGTGGCCATCGTTGACCCGCTTCTTACCGTTTCCTGTCCGCCTTCTGTGACCGC
AGCGACTGGTGTCGATGCGCTCTGCCACTCGATCGAGGCATATATTTCCCGTCGCGCCCACCCGGTGACCGATGTGTTGG
CGCTATCCGCCATTGAAGCGATCATCGGCCATTTGCGCCGGGCGTACGAAAACGGACAAGACATTGAAGCGCGAGAGAAA
ATGGCGATCGCCGCCATGAAGGCTGGCATGGCGTTTTCCAACGCCTCAGTGACGCTTGTACACGGCATGTCGCGGCCGAT
CGGCGCGCTCTTCCACGTGCCGCACGGCGTGTCCAATGCGATGCTTTTGCCGGGAGTACTCGAATTTACGAAAGAGAGCG
CCATAGAACGGTTGGCGGTAATTGCCCGGCTCATTAATCCACAACTTAAAGACGTTTCCAACGCCGAAGCAGCCGATGCG
CTCGTTGAGGAAGTGAAGCAGCTTTGCCGGGATTTGCACATCCCGAATATGAAAACATGGGGCATTGACAAAACGGCGTT
TGACAAAGCGGTCGATAAAATGGCGGCCGACGCGCTTGCGAGCGGCAGCCCTAGCAACAACCCGAGAGTGCCGACTCATG
AGGAAATTGTCGCGCTGTATCATATTTGTTACGACTATCGGTATGATACGAACACGGTCAGTCATTAA

Upstream 100 bases:

>100_bases
AGAAGATGAAAAATTCTTAATTGTGGCTCTACTATAGCTTGGCACGAAGTTTGCATACAGAATGTGTTGAAAGCGCTGTC
AATTTAAAGGAGGGGAAATC

Downstream 100 bases:

>100_bases
TGAAGAGACGGTCAAACGAGGGGGAAGAAGATGTTGGGGATGATTGGTTTATTGGCCTCATTAGGGTTGTTGATCTTTTT
GACAATGAGGGGGATCAATA

Product: 1,3-propanediol dehydrogenase

Products: NA

Alternate protein names: 1,3-propanediol oxidoreductase; 3-hydroxypropionaldehyde reductase [H]

Number of amino acids: Translated: 395; Mature: 395

Protein sequence:

>395_residues
MYELLVPNRVIYGRDTFREVGRQAKALGTKALIVSDPVMENIGLVARCEQYLREAGLPLATYTRVDTEPTDVHVKEALDV
CRSEQCDVIVAIGGGSSIDAAKAVAVMMTNEGTISDYVGNAKMFTKKPVPLIAIPTTAGTGSEVTKVTVIIDTKTDVKMM
ISQPALLPAVAIVDPLLTVSCPPSVTAATGVDALCHSIEAYISRRAHPVTDVLALSAIEAIIGHLRRAYENGQDIEAREK
MAIAAMKAGMAFSNASVTLVHGMSRPIGALFHVPHGVSNAMLLPGVLEFTKESAIERLAVIARLINPQLKDVSNAEAADA
LVEEVKQLCRDLHIPNMKTWGIDKTAFDKAVDKMAADALASGSPSNNPRVPTHEEIVALYHICYDYRYDTNTVSH

Sequences:

>Translated_395_residues
MYELLVPNRVIYGRDTFREVGRQAKALGTKALIVSDPVMENIGLVARCEQYLREAGLPLATYTRVDTEPTDVHVKEALDV
CRSEQCDVIVAIGGGSSIDAAKAVAVMMTNEGTISDYVGNAKMFTKKPVPLIAIPTTAGTGSEVTKVTVIIDTKTDVKMM
ISQPALLPAVAIVDPLLTVSCPPSVTAATGVDALCHSIEAYISRRAHPVTDVLALSAIEAIIGHLRRAYENGQDIEAREK
MAIAAMKAGMAFSNASVTLVHGMSRPIGALFHVPHGVSNAMLLPGVLEFTKESAIERLAVIARLINPQLKDVSNAEAADA
LVEEVKQLCRDLHIPNMKTWGIDKTAFDKAVDKMAADALASGSPSNNPRVPTHEEIVALYHICYDYRYDTNTVSH
>Mature_395_residues
MYELLVPNRVIYGRDTFREVGRQAKALGTKALIVSDPVMENIGLVARCEQYLREAGLPLATYTRVDTEPTDVHVKEALDV
CRSEQCDVIVAIGGGSSIDAAKAVAVMMTNEGTISDYVGNAKMFTKKPVPLIAIPTTAGTGSEVTKVTVIIDTKTDVKMM
ISQPALLPAVAIVDPLLTVSCPPSVTAATGVDALCHSIEAYISRRAHPVTDVLALSAIEAIIGHLRRAYENGQDIEAREK
MAIAAMKAGMAFSNASVTLVHGMSRPIGALFHVPHGVSNAMLLPGVLEFTKESAIERLAVIARLINPQLKDVSNAEAADA
LVEEVKQLCRDLHIPNMKTWGIDKTAFDKAVDKMAADALASGSPSNNPRVPTHEEIVALYHICYDYRYDTNTVSH

Specific function: Most active with substrates containing two primary alcohol groups separated by one or two carbon atoms. In the physiological direction, 3-hydroxypropionaldehyde is the preferred substrate [H]

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=388, Percent_Identity=31.9587628865979, Blast_Score=162, Evalue=4e-40,
Organism=Escherichia coli, GI1789163, Length=389, Percent_Identity=39.3316195372751, Blast_Score=233, Evalue=1e-62,
Organism=Escherichia coli, GI48994951, Length=380, Percent_Identity=36.5789473684211, Blast_Score=233, Evalue=2e-62,
Organism=Escherichia coli, GI87082107, Length=376, Percent_Identity=38.8297872340425, Blast_Score=223, Evalue=1e-59,
Organism=Escherichia coli, GI1787493, Length=391, Percent_Identity=32.4808184143223, Blast_Score=175, Evalue=4e-45,
Organism=Escherichia coli, GI1789386, Length=361, Percent_Identity=20.4986149584488, Blast_Score=82, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17537053, Length=410, Percent_Identity=29.2682926829268, Blast_Score=163, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6321181, Length=360, Percent_Identity=39.4444444444444, Blast_Score=238, Evalue=1e-63,
Organism=Drosophila melanogaster, GI24657991, Length=415, Percent_Identity=30.3614457831325, Blast_Score=148, Evalue=7e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.202 [H]

Molecular weight: Translated: 42486; Mature: 42486

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS00913 ADH_IRON_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYELLVPNRVIYGRDTFREVGRQAKALGTKALIVSDPVMENIGLVARCEQYLREAGLPLA
CCEEECCCEEEECCHHHHHHHHHHHHHCCEEEEEECHHHHHCCHHHHHHHHHHHCCCCEE
TYTRVDTEPTDVHVKEALDVCRSEQCDVIVAIGGGSSIDAAKAVAVMMTNEGTISDYVGN
EEEECCCCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCCHHHEEEEEEECCCCHHHHCCC
AKMFTKKPVPLIAIPTTAGTGSEVTKVTVIIDTKTDVKMMISQPALLPAVAIVDPLLTVS
CCEEECCCCCEEEECCCCCCCCCEEEEEEEEECCCCHHHHHCCCCHHHHHHHHHHHHEEC
CPPSVTAATGVDALCHSIEAYISRRAHPVTDVLALSAIEAIIGHLRRAYENGQDIEAREK
CCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
MAIAAMKAGMAFSNASVTLVHGMSRPIGALFHVPHGVSNAMLLPGVLEFTKESAIERLAV
HHHHHHHHCCEECCCCEEEEECCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
IARLINPQLKDVSNAEAADALVEEVKQLCRDLHIPNMKTWGIDKTAFDKAVDKMAADALA
HHHHHCCHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
SGSPSNNPRVPTHEEIVALYHICYDYRYDTNTVSH
CCCCCCCCCCCCHHHHHHHHHHHHHEEECCCCCCC
>Mature Secondary Structure
MYELLVPNRVIYGRDTFREVGRQAKALGTKALIVSDPVMENIGLVARCEQYLREAGLPLA
CCEEECCCEEEECCHHHHHHHHHHHHHCCEEEEEECHHHHHCCHHHHHHHHHHHCCCCEE
TYTRVDTEPTDVHVKEALDVCRSEQCDVIVAIGGGSSIDAAKAVAVMMTNEGTISDYVGN
EEEECCCCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCCHHHEEEEEEECCCCHHHHCCC
AKMFTKKPVPLIAIPTTAGTGSEVTKVTVIIDTKTDVKMMISQPALLPAVAIVDPLLTVS
CCEEECCCCCEEEECCCCCCCCCEEEEEEEEECCCCHHHHHCCCCHHHHHHHHHHHHEEC
CPPSVTAATGVDALCHSIEAYISRRAHPVTDVLALSAIEAIIGHLRRAYENGQDIEAREK
CCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
MAIAAMKAGMAFSNASVTLVHGMSRPIGALFHVPHGVSNAMLLPGVLEFTKESAIERLAV
HHHHHHHHCCEECCCCEEEEECCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
IARLINPQLKDVSNAEAADALVEEVKQLCRDLHIPNMKTWGIDKTAFDKAVDKMAADALA
HHHHHCCHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
SGSPSNNPRVPTHEEIVALYHICYDYRYDTNTVSH
CCCCCCCCCCCCHHHHHHHHHHHHHEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7721705 [H]