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The map label for this gene is cobB2 [H]

Identifier: 138895164

GI number: 138895164

Start: 1586672

End: 1587505

Strand: Direct

Name: cobB2 [H]

Synonym: GTNG_1502

Alternate gene names: 138895164

Gene position: 1586672-1587505 (Clockwise)

Preceding gene: 138895163

Following gene: 138895165

Centisome position: 44.69

GC content: 48.56

Gene sequence:

>834_bases
ATGGAGTTTCAGCTATACATTATGGCCTCGAAAAGAACCAAAGGCGACATTAGAAAAACCAAGCGATTGATAGGAAGGGA
GAGAAACAACATGAATCCCATCGAACAGTTTGGACAGTGGATTCGAGAGGCTAACACGATCGCCGTCTTGACTGGAGCGG
GGATGAGCACGGAGTCCGGCATCCCTGATTTCCGTAGCGAAAACGGCATTTACGCTCAAGAGGAACGTGTGGAATATTAT
TTGTCTGAGCATTATTATCAAAAAAATCCGGTTGATTTTTGGCGGCGGTTCAAGCGGATGTTTTCATTGAAACTGATGGG
AGACTTTGCACCGAACGCCGGGCATCGGTTTCTTCGTTGGCTGGAGGATATTGGGAAAACAGTGGTGATTTTGACGCAAA
ATATCGATGGGCTGCACACAAAAGCAGGAAACACGAACGTCATTGAGCTGCACGGTACGTTGCAGACAGCGACGTGCCCA
TCGTGCGGCAAAACGTATGACTTGGCGTTTGTCAACCGCACCGATGTGCCGTGCTGCGGTGAGTGTGGGACGATTTTGAA
ACCGGATGTTGTTTTGTTTGGCGGACTCGTTCCCCATATCGAAGAAGCGTTTGCTAGGGCGGCGGAGAGCGACTTGTTGT
TGGCTATGGGGACGAGTTTAGAGGTGGCGCCTGTGAATCAAATTCCGTTTTACGTTGCTGCTGAATCTCCGGCAACACGG
AAAGTGTTAATTAACAAAACGGCGACAAGGATGGACGGAATATTTGATCTTATCATTTATGGTGGAATCGGTGAAACGGT
TGCCGCTGTACGAGAGCGACTCGAGCAAAAATAA

Upstream 100 bases:

>100_bases
TTTTGTGGGGGATGGTTTGGTTTGCTGATGATGTGTCAAAAGCACAACAGCTGCTCGTGATGGCGGGCCGTTGGACGTTG
GTGTTGGTGATTGATTTTGT

Downstream 100 bases:

>100_bases
ATAAGGAGTAGAGCTGAAAACAGAAATGATTGGAAAAGGAAAGGACGATCATGGAGAAGCTACAATCGGTCTTGGGGCGA
TGGAATACTGCCAGCCAACG

Product: NAD-dependent deacetylase

Products: NA

Alternate protein names: Regulatory protein SIR2 homolog 2 [H]

Number of amino acids: Translated: 277; Mature: 277

Protein sequence:

>277_residues
MEFQLYIMASKRTKGDIRKTKRLIGRERNNMNPIEQFGQWIREANTIAVLTGAGMSTESGIPDFRSENGIYAQEERVEYY
LSEHYYQKNPVDFWRRFKRMFSLKLMGDFAPNAGHRFLRWLEDIGKTVVILTQNIDGLHTKAGNTNVIELHGTLQTATCP
SCGKTYDLAFVNRTDVPCCGECGTILKPDVVLFGGLVPHIEEAFARAAESDLLLAMGTSLEVAPVNQIPFYVAAESPATR
KVLINKTATRMDGIFDLIIYGGIGETVAAVRERLEQK

Sequences:

>Translated_277_residues
MEFQLYIMASKRTKGDIRKTKRLIGRERNNMNPIEQFGQWIREANTIAVLTGAGMSTESGIPDFRSENGIYAQEERVEYY
LSEHYYQKNPVDFWRRFKRMFSLKLMGDFAPNAGHRFLRWLEDIGKTVVILTQNIDGLHTKAGNTNVIELHGTLQTATCP
SCGKTYDLAFVNRTDVPCCGECGTILKPDVVLFGGLVPHIEEAFARAAESDLLLAMGTSLEVAPVNQIPFYVAAESPATR
KVLINKTATRMDGIFDLIIYGGIGETVAAVRERLEQK
>Mature_277_residues
MEFQLYIMASKRTKGDIRKTKRLIGRERNNMNPIEQFGQWIREANTIAVLTGAGMSTESGIPDFRSENGIYAQEERVEYY
LSEHYYQKNPVDFWRRFKRMFSLKLMGDFAPNAGHRFLRWLEDIGKTVVILTQNIDGLHTKAGNTNVIELHGTLQTATCP
SCGKTYDLAFVNRTDVPCCGECGTILKPDVVLFGGLVPHIEEAFARAAESDLLLAMGTSLEVAPVNQIPFYVAAESPATR
KVLINKTATRMDGIFDLIIYGGIGETVAAVRERLEQK

Specific function: Modulates the activities of several enzymes which are inactive in their acetylated form [H]

COG id: COG0846

COG function: function code K; NAD-dependent protein deacetylases, SIR2 family

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 deacetylase sirtuin-type domain [H]

Homologues:

Organism=Homo sapiens, GI7657575, Length=243, Percent_Identity=35.8024691358025, Blast_Score=126, Evalue=2e-29,
Organism=Homo sapiens, GI6912660, Length=222, Percent_Identity=36.4864864864865, Blast_Score=117, Evalue=9e-27,
Organism=Homo sapiens, GI13775602, Length=219, Percent_Identity=35.1598173515982, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI63054862, Length=214, Percent_Identity=36.9158878504673, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI13775600, Length=219, Percent_Identity=35.1598173515982, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI300795542, Length=212, Percent_Identity=36.3207547169811, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI6912662, Length=273, Percent_Identity=30.4029304029304, Blast_Score=111, Evalue=8e-25,
Organism=Homo sapiens, GI13787215, Length=231, Percent_Identity=34.6320346320346, Blast_Score=108, Evalue=5e-24,
Organism=Homo sapiens, GI6912664, Length=231, Percent_Identity=34.6320346320346, Blast_Score=108, Evalue=6e-24,
Organism=Homo sapiens, GI300797705, Length=194, Percent_Identity=36.0824742268041, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI215982798, Length=177, Percent_Identity=35.5932203389831, Blast_Score=91, Evalue=9e-19,
Organism=Homo sapiens, GI300797577, Length=258, Percent_Identity=26.7441860465116, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI300797597, Length=244, Percent_Identity=25.8196721311475, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI7706712, Length=272, Percent_Identity=26.1029411764706, Blast_Score=81, Evalue=1e-15,
Organism=Escherichia coli, GI308199517, Length=237, Percent_Identity=32.4894514767932, Blast_Score=107, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI17541892, Length=236, Percent_Identity=33.4745762711864, Blast_Score=126, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI71990482, Length=260, Percent_Identity=29.6153846153846, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71990487, Length=232, Percent_Identity=30.6034482758621, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17567771, Length=259, Percent_Identity=28.5714285714286, Blast_Score=91, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6324504, Length=289, Percent_Identity=29.0657439446367, Blast_Score=104, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6320163, Length=320, Percent_Identity=27.5, Blast_Score=102, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6325242, Length=216, Percent_Identity=29.6296296296296, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6324599, Length=299, Percent_Identity=26.0869565217391, Blast_Score=91, Evalue=2e-19,
Organism=Drosophila melanogaster, GI17137536, Length=265, Percent_Identity=32.8301886792453, Blast_Score=121, Evalue=6e-28,
Organism=Drosophila melanogaster, GI24648389, Length=222, Percent_Identity=36.036036036036, Blast_Score=117, Evalue=6e-27,
Organism=Drosophila melanogaster, GI28571445, Length=206, Percent_Identity=32.0388349514563, Blast_Score=98, Evalue=6e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003000 [H]

Pfam domain/function: PF02146 SIR2 [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 31089; Mature: 31089

Theoretical pI: Translated: 7.46; Mature: 7.46

Prosite motif: PS50305 SIRTUIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFQLYIMASKRTKGDIRKTKRLIGRERNNMNPIEQFGQWIREANTIAVLTGAGMSTESG
CCEEEEEEECCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCC
IPDFRSENGIYAQEERVEYYLSEHYYQKNPVDFWRRFKRMFSLKLMGDFAPNAGHRFLRW
CCCCCCCCCCEEHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
LEDIGKTVVILTQNIDGLHTKAGNTNVIELHGTLQTATCPSCGKTYDLAFVNRTDVPCCG
HHHHCCEEEEEEECCCCCEECCCCCCEEEEECCEEECCCCCCCCEEEEEEEECCCCCCCC
ECGTILKPDVVLFGGLVPHIEEAFARAAESDLLLAMGTSLEVAPVNQIPFYVAAESPATR
CCCCCCCCCHHEECCHHHHHHHHHHHHCCCCEEEEECCCEEEEECCCCCEEEEECCCCCE
KVLINKTATRMDGIFDLIIYGGIGETVAAVRERLEQK
EEEEECHHHHHHHHEEEEEECCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MEFQLYIMASKRTKGDIRKTKRLIGRERNNMNPIEQFGQWIREANTIAVLTGAGMSTESG
CCEEEEEEECCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCC
IPDFRSENGIYAQEERVEYYLSEHYYQKNPVDFWRRFKRMFSLKLMGDFAPNAGHRFLRW
CCCCCCCCCCEEHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
LEDIGKTVVILTQNIDGLHTKAGNTNVIELHGTLQTATCPSCGKTYDLAFVNRTDVPCCG
HHHHCCEEEEEEECCCCCEECCCCCCEEEEECCEEECCCCCCCCEEEEEEEECCCCCCCC
ECGTILKPDVVLFGGLVPHIEEAFARAAESDLLLAMGTSLEVAPVNQIPFYVAAESPATR
CCCCCCCCCHHEECCHHHHHHHHHHHHCCCCEEEEECCCEEEEECCCCCEEEEECCCCCE
KVLINKTATRMDGIFDLIIYGGIGETVAAVRERLEQK
EEEEECHHHHHHHHEEEEEECCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA