Click here to switch to the map view.

The map label for this gene is hxlA [H]

Identifier: 138895152

GI number: 138895152

Start: 1575588

End: 1576235

Strand: Direct

Name: hxlA [H]

Synonym: GTNG_1490

Alternate gene names: 138895152

Gene position: 1575588-1576235 (Clockwise)

Preceding gene: 138895151

Following gene: 138895153

Centisome position: 44.38

GC content: 45.83

Gene sequence:

>648_bases
ATGTATATTCAGCTTGCGCTTGATCGAATGGATATCAATCAAGCAATTCAAATCACTCAACAAGTTGAGGAGTATATTGA
TTGGATTGAAGTAGGAACCTCGCTGATTAAAGAGTTTGGCATCAAAAGTATTGAAGCGATAAAGCGTGCGTTCCCTGGCA
AAATGATTGTCGCGGATACGAAAACGATGGATAACGCTGTGTATGAATGCAACCTATGTTTCGAGGCGGGGGCGGACGTG
ATGACAGTCATGGGCGTTGCACCGCTAATGACGGTGGAAGCGTGTTTGAAGGAGGCTAGCATCCGCGGAAAAAAAGTCAT
GATCGATTTATTAAATACAAACGAGTCGGTGAGGCAGCAACTATTGCAGTATAAGGAAGCGATTTTTTGCATCCATGTCA
GCAAGGATGAACAGGAGTTTGCACAGCAGCACAAAAACTTCAATTTCGCACATTTTCATCGCCCAACTGGTTGCAATCTA
GCGGTTGCTGGAGGAATTTCAGCTGCTACAATGAAACAAATTCAACCGCTTCACCCCTCGATTGTGATTATCGGTTCGGC
CATCACGCGGGCGGAGCATCCGGAACGGGCGGCGAGAGAATTGAGACAATTGGTTCGAAATAGGGGGATCGATGATGCAT
CCAATTGA

Upstream 100 bases:

>100_bases
AGGCGCAATTATATACGTTTTTCTGTCAGTTAATCGTTCGTGAGTCTTCGGGAACGAAAAAAGCTGATGGCTAACTTACA
GGATGAATGGAGAGTGGAAG

Downstream 100 bases:

>100_bases
AGTCATTTTTTCAGAAATAGAACAAGTATTTGCCGAATTTGACCATATGAGCATTGAGTGTGTAGCGATGCGTCTGGCGA
AAGCGAAGCGGATTTTTGTG

Product: 3-hexulose-6-phosphate synthase

Products: NA

Alternate protein names: HPS; D-arabino-3-hexulose-6-phosphate formaldehyde lyase; HUMPS [H]

Number of amino acids: Translated: 215; Mature: 215

Protein sequence:

>215_residues
MYIQLALDRMDINQAIQITQQVEEYIDWIEVGTSLIKEFGIKSIEAIKRAFPGKMIVADTKTMDNAVYECNLCFEAGADV
MTVMGVAPLMTVEACLKEASIRGKKVMIDLLNTNESVRQQLLQYKEAIFCIHVSKDEQEFAQQHKNFNFAHFHRPTGCNL
AVAGGISAATMKQIQPLHPSIVIIGSAITRAEHPERAARELRQLVRNRGIDDASN

Sequences:

>Translated_215_residues
MYIQLALDRMDINQAIQITQQVEEYIDWIEVGTSLIKEFGIKSIEAIKRAFPGKMIVADTKTMDNAVYECNLCFEAGADV
MTVMGVAPLMTVEACLKEASIRGKKVMIDLLNTNESVRQQLLQYKEAIFCIHVSKDEQEFAQQHKNFNFAHFHRPTGCNL
AVAGGISAATMKQIQPLHPSIVIIGSAITRAEHPERAARELRQLVRNRGIDDASN
>Mature_215_residues
MYIQLALDRMDINQAIQITQQVEEYIDWIEVGTSLIKEFGIKSIEAIKRAFPGKMIVADTKTMDNAVYECNLCFEAGADV
MTVMGVAPLMTVEACLKEASIRGKKVMIDLLNTNESVRQQLLQYKEAIFCIHVSKDEQEFAQQHKNFNFAHFHRPTGCNL
AVAGGISAATMKQIQPLHPSIVIIGSAITRAEHPERAARELRQLVRNRGIDDASN

Specific function: Catalyzes the condensation of ribulose 5-phosphate with formaldehyde to form 3-hexulose 6-phosphate. Together with hxlB, may act as a formaldehyde detoxification system [H]

COG id: COG0269

COG function: function code G; 3-hexulose-6-phosphate synthase and related proteins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPS/KGPDC family. HPS subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790640, Length=206, Percent_Identity=28.1553398058252, Blast_Score=81, Evalue=5e-17,
Organism=Escherichia coli, GI1790006, Length=204, Percent_Identity=27.9411764705882, Blast_Score=80, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017553
- InterPro:   IPR013785
- InterPro:   IPR001754
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00215 OMPdecase [H]

EC number: =4.1.2.43 [H]

Molecular weight: Translated: 24063; Mature: 24063

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYIQLALDRMDINQAIQITQQVEEYIDWIEVGTSLIKEFGIKSIEAIKRAFPGKMIVADT
CEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCEEEECC
KTMDNAVYECNLCFEAGADVMTVMGVAPLMTVEACLKEASIRGKKVMIDLLNTNESVRQQ
CHHCCHHEEEEEHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHH
LLQYKEAIFCIHVSKDEQEFAQQHKNFNFAHFHRPTGCNLAVAGGISAATMKQIQPLHPS
HHHHHHHEEEEEECCCHHHHHHHHCCCCEEEECCCCCCCEEEECCCHHHHHHHHCCCCCC
IVIIGSAITRAEHPERAARELRQLVRNRGIDDASN
EEEEEHHHHHCCCHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MYIQLALDRMDINQAIQITQQVEEYIDWIEVGTSLIKEFGIKSIEAIKRAFPGKMIVADT
CEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCEEEECC
KTMDNAVYECNLCFEAGADVMTVMGVAPLMTVEACLKEASIRGKKVMIDLLNTNESVRQQ
CHHCCHHEEEEEHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHH
LLQYKEAIFCIHVSKDEQEFAQQHKNFNFAHFHRPTGCNLAVAGGISAATMKQIQPLHPS
HHHHHHHEEEEEECCCHHHHHHHHCCCCEEEECCCCCCCEEEECCCHHHHHHHHCCCCCC
IVIIGSAITRAEHPERAARELRQLVRNRGIDDASN
EEEEEHHHHHCCCHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7704255; 8969502; 9384377 [H]