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The map label for this gene is mutL

Identifier: 138894827

GI number: 138894827

Start: 1228056

End: 1229993

Strand: Direct

Name: mutL

Synonym: GTNG_1161

Alternate gene names: 138894827

Gene position: 1228056-1229993 (Clockwise)

Preceding gene: 138894826

Following gene: 138894828

Centisome position: 34.59

GC content: 55.47

Gene sequence:

>1938_bases
ATGGGACGCATTCATAAGCTCGACGATCAGCTAGCAAACAAAATCGCCGCTGGCGAAGTTGTCGAACGGCCGGCTTCGGT
GGTAAAAGAGCTCGTCGAGAACGCCATCGATGCCCACAGTACGGCGGTCGAAATTGAACTCGAGGAAGCTGGGATGACGA
AAATCCGCGTCATCGACAACGGCGACGGAATGGAAGAAGAGGATTGCCTTCTTGCTTTTGAACGGCATGCGACAAGCAAA
ATTCAAGACGAGCACGACTTGTTCCGCATTCGCACGCTCGGCTTTCGCGGTGAGGCGTTGCCGAGCATTGCTTCAGTGTC
CGAAGTGGAGCTTGTGACAAGCACCGGCAGCGGCCCGGGGACGAAGCTCGTGTTAAAAGGCGGTGCGCTCGTGGCCCGCG
AGCGGGCGGCCGGGCGCAAAGGAACCGATATCACGGTATCCAACTTATTTTTCAACACCCCGGCGAGGTTGAAATATATG
AAAACGATCCATACCGAGCTCGGTCATGCGGCTGATGTCGTCAACCGGCTGGCGCTCGCTCACCCGGATGTGTCATTCCG
GCTTCGCCATCACGGCAAAACGTTGCTTGCGACAAACGGCAGCGGCGATGTCCGGCATGTGCTCGCTGCCATTTACGGTA
TGGAAACGGCAAAACAAATGATCCCGATTGAGGCGGAATCGCTCGATTTTACTGTCCGTGGCTATATTTCACTGCCGGAA
GTGACACGCGCTTCGCGCAATTATATGTCGCTCATTGTCAACGGGCGCTATGTGCGCAATATACCGCTGATGAAGGCCAT
TGAAGCCGGCTATCATACGCTCTTGCCGATCGGTCGCTATCCGATTGTATTTCTGGCGATTGAAATGGACCCGGTGCTCG
TTGATGTGAACGTTCACCCGGCGAAACTGGAAGTCCGTTTCAGCAAAGAAGCGGAGTTAAACGAGCTCATTACCGCGACA
ATCCGCCAAGCGTTCCGCCAGCGGACGCTCATTCCATCCGTATCTGCCGACAGCAAAACGGTCAAAGCGAAGGCGGAGCA
AGCATCTTGGACGTTTGCCCATCGCGTTCATGAACCGCCCGCCCAGCCCGACGGAAAGGCAGAGGGAACTAGCGATGTGA
CCGCAGCAGCGTCCCTGGCCAGTGAAGGATCGCTTTCCCCGTTGCCTGCAGCCGCCCAGGCTGATGCGCCTGCCGTTTCG
GAAGAAGCCGAAGCGTCGGTGTTTTCGGAAAGAAGGACAGGCGTTGTCAACGATTTGCCTGCTGCTGAGTTGAAGCGGGA
TGCCGAGGTGGAGGAGGAACCGACCGAGGCGTGCCTGCCGGCTGATGAGCAAGCAGAGGAGAAACGAGCAGTCGACCGCC
TCCCGCCGCTTTATCCGATCGGGCAGTTGCACGGCACTTATATTTTGGCGGAGAACGAACACGGACTCTATATGATCGAC
CAACATGCGGCGCAAGAACGGATCAACTACGAATATTTCCGGGAAAAACTTGGCGAAGTCACCAATGAGGTGCAAGAGCT
GCTCGTCCCGCTAACGTTTGAATATCCGGCCGACGAATATGAGCGAATCGCCGCTTGCCGCGACGAGCTCGCCCGTTGCG
GCGTGTTTCTTGAACCGTTCGGCCCGCGGGCGTTTCTCGTTCGTTCCCACCCTGTGTGGTTTCCAAAAGGGAAAGAAAAA
GAGATCATCGAGGAAATGATCGAACACGTACTGACCGCCAAAACGGTCGATATAAAGCAGCTGCGCGAGCAAGCCGCTAT
CGTCATGAGCTGTAAGCGCGCCATTAAAGCGAATCAACATTTGCGCACCGACGAAATCTTCGCCTTGCTCGAAACGCTGC
GGCAAACGACCGATCCGTTCACTTGCCCGCACGGCCGGCCGATCATCGTCCATTTTTCAACATATGAAATTGAAAAGTTA
TTTAAACGAGTAATGTAA

Upstream 100 bases:

>100_bases
CGGCATTGAAGGAGGTCAACTTGCTTGAGATGACGCCGCTTGAGGCGTTAAACAAGCTATATGAACTGCAAAAACTCCTT
AAGTAACGGAGGTGGGGGGG

Downstream 100 bases:

>100_bases
ATGGCGAGGGTGTCTTAACAGCAACGAGACCCCCTTTCTTCACTTGTATATGGGCGGCGAATGAATTCACCATTCTATTG
TTTTACTAAAGGACAGGCTC

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 645; Mature: 644

Protein sequence:

>645_residues
MGRIHKLDDQLANKIAAGEVVERPASVVKELVENAIDAHSTAVEIELEEAGMTKIRVIDNGDGMEEEDCLLAFERHATSK
IQDEHDLFRIRTLGFRGEALPSIASVSEVELVTSTGSGPGTKLVLKGGALVARERAAGRKGTDITVSNLFFNTPARLKYM
KTIHTELGHAADVVNRLALAHPDVSFRLRHHGKTLLATNGSGDVRHVLAAIYGMETAKQMIPIEAESLDFTVRGYISLPE
VTRASRNYMSLIVNGRYVRNIPLMKAIEAGYHTLLPIGRYPIVFLAIEMDPVLVDVNVHPAKLEVRFSKEAELNELITAT
IRQAFRQRTLIPSVSADSKTVKAKAEQASWTFAHRVHEPPAQPDGKAEGTSDVTAAASLASEGSLSPLPAAAQADAPAVS
EEAEASVFSERRTGVVNDLPAAELKRDAEVEEEPTEACLPADEQAEEKRAVDRLPPLYPIGQLHGTYILAENEHGLYMID
QHAAQERINYEYFREKLGEVTNEVQELLVPLTFEYPADEYERIAACRDELARCGVFLEPFGPRAFLVRSHPVWFPKGKEK
EIIEEMIEHVLTAKTVDIKQLREQAAIVMSCKRAIKANQHLRTDEIFALLETLRQTTDPFTCPHGRPIIVHFSTYEIEKL
FKRVM

Sequences:

>Translated_645_residues
MGRIHKLDDQLANKIAAGEVVERPASVVKELVENAIDAHSTAVEIELEEAGMTKIRVIDNGDGMEEEDCLLAFERHATSK
IQDEHDLFRIRTLGFRGEALPSIASVSEVELVTSTGSGPGTKLVLKGGALVARERAAGRKGTDITVSNLFFNTPARLKYM
KTIHTELGHAADVVNRLALAHPDVSFRLRHHGKTLLATNGSGDVRHVLAAIYGMETAKQMIPIEAESLDFTVRGYISLPE
VTRASRNYMSLIVNGRYVRNIPLMKAIEAGYHTLLPIGRYPIVFLAIEMDPVLVDVNVHPAKLEVRFSKEAELNELITAT
IRQAFRQRTLIPSVSADSKTVKAKAEQASWTFAHRVHEPPAQPDGKAEGTSDVTAAASLASEGSLSPLPAAAQADAPAVS
EEAEASVFSERRTGVVNDLPAAELKRDAEVEEEPTEACLPADEQAEEKRAVDRLPPLYPIGQLHGTYILAENEHGLYMID
QHAAQERINYEYFREKLGEVTNEVQELLVPLTFEYPADEYERIAACRDELARCGVFLEPFGPRAFLVRSHPVWFPKGKEK
EIIEEMIEHVLTAKTVDIKQLREQAAIVMSCKRAIKANQHLRTDEIFALLETLRQTTDPFTCPHGRPIIVHFSTYEIEKL
FKRVM
>Mature_644_residues
GRIHKLDDQLANKIAAGEVVERPASVVKELVENAIDAHSTAVEIELEEAGMTKIRVIDNGDGMEEEDCLLAFERHATSKI
QDEHDLFRIRTLGFRGEALPSIASVSEVELVTSTGSGPGTKLVLKGGALVARERAAGRKGTDITVSNLFFNTPARLKYMK
TIHTELGHAADVVNRLALAHPDVSFRLRHHGKTLLATNGSGDVRHVLAAIYGMETAKQMIPIEAESLDFTVRGYISLPEV
TRASRNYMSLIVNGRYVRNIPLMKAIEAGYHTLLPIGRYPIVFLAIEMDPVLVDVNVHPAKLEVRFSKEAELNELITATI
RQAFRQRTLIPSVSADSKTVKAKAEQASWTFAHRVHEPPAQPDGKAEGTSDVTAAASLASEGSLSPLPAAAQADAPAVSE
EAEASVFSERRTGVVNDLPAAELKRDAEVEEEPTEACLPADEQAEEKRAVDRLPPLYPIGQLHGTYILAENEHGLYMIDQ
HAAQERINYEYFREKLGEVTNEVQELLVPLTFEYPADEYERIAACRDELARCGVFLEPFGPRAFLVRSHPVWFPKGKEKE
IIEEMIEHVLTAKTVDIKQLREQAAIVMSCKRAIKANQHLRTDEIFALLETLRQTTDPFTCPHGRPIIVHFSTYEIEKLF
KRVM

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family

Homologues:

Organism=Homo sapiens, GI4557757, Length=565, Percent_Identity=29.9115044247788, Blast_Score=216, Evalue=4e-56,
Organism=Homo sapiens, GI4505913, Length=350, Percent_Identity=28.2857142857143, Blast_Score=135, Evalue=2e-31,
Organism=Homo sapiens, GI310128478, Length=350, Percent_Identity=28.2857142857143, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI4505911, Length=308, Percent_Identity=29.2207792207792, Blast_Score=129, Evalue=8e-30,
Organism=Homo sapiens, GI189458898, Length=308, Percent_Identity=29.2207792207792, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI263191589, Length=469, Percent_Identity=26.4392324093817, Blast_Score=120, Evalue=6e-27,
Organism=Homo sapiens, GI189458896, Length=299, Percent_Identity=29.7658862876254, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI91992160, Length=363, Percent_Identity=28.9256198347107, Blast_Score=113, Evalue=7e-25,
Organism=Homo sapiens, GI91992162, Length=363, Percent_Identity=28.9256198347107, Blast_Score=113, Evalue=7e-25,
Organism=Homo sapiens, GI310128480, Length=307, Percent_Identity=27.0358306188925, Blast_Score=103, Evalue=5e-22,
Organism=Escherichia coli, GI1790612, Length=538, Percent_Identity=33.457249070632, Blast_Score=226, Evalue=4e-60,
Organism=Caenorhabditis elegans, GI71991825, Length=322, Percent_Identity=36.6459627329193, Blast_Score=194, Evalue=9e-50,
Organism=Caenorhabditis elegans, GI17562796, Length=360, Percent_Identity=28.3333333333333, Blast_Score=133, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6323819, Length=324, Percent_Identity=35.4938271604938, Blast_Score=188, Evalue=3e-48,
Organism=Saccharomyces cerevisiae, GI6324247, Length=416, Percent_Identity=26.9230769230769, Blast_Score=147, Evalue=7e-36,
Organism=Saccharomyces cerevisiae, GI6325093, Length=563, Percent_Identity=21.3143872113677, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI17136968, Length=338, Percent_Identity=34.0236686390533, Blast_Score=196, Evalue=6e-50,
Organism=Drosophila melanogaster, GI17136970, Length=357, Percent_Identity=29.4117647058824, Blast_Score=124, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MUTL_GEOTN (A4IMI1)

Other databases:

- EMBL:   CP000557
- RefSeq:   YP_001125280.1
- ProteinModelPortal:   A4IMI1
- SMR:   A4IMI1
- STRING:   A4IMI1
- GeneID:   4966102
- GenomeReviews:   CP000557_GR
- KEGG:   gtn:GTNG_1161
- NMPDR:   fig|420246.5.peg.1129
- eggNOG:   COG0323
- HOGENOM:   HBG520262
- OMA:   FLFINNR
- PhylomeDB:   A4IMI1
- ProtClustDB:   PRK00095
- BioCyc:   GTHE420246:GTNG_1161-MONOMER
- HAMAP:   MF_00149
- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.565.10
- Gene3D:   G3DSA:3.30.230.10
- PANTHER:   PTHR10073
- SMART:   SM00387
- SMART:   SM00853
- TIGRFAMs:   TIGR00585

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C; SSF55874 ATP_bd_ATPase; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: NA

Molecular weight: Translated: 71546; Mature: 71415

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGRIHKLDDQLANKIAAGEVVERPASVVKELVENAIDAHSTAVEIELEEAGMTKIRVIDN
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCEEEEEEEC
GDGMEEEDCLLAFERHATSKIQDEHDLFRIRTLGFRGEALPSIASVSEVELVTSTGSGPG
CCCCCCHHHHHHHHHHHHHHCCCHHHEEEEEEECCCCCCCCCHHCCCCEEEEEECCCCCC
TKLVLKGGALVARERAAGRKGTDITVSNLFFNTPARLKYMKTIHTELGHAADVVNRLALA
CEEEEECCCEEEHHHHCCCCCCEEEEEHEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHC
HPDVSFRLRHHGKTLLATNGSGDVRHVLAAIYGMETAKQMIPIEAESLDFTVRGYISLPE
CCCCEEEEEECCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCH
VTRASRNYMSLIVNGRYVRNIPLMKAIEAGYHTLLPIGRYPIVFLAIEMDPVLVDVNVHP
HHHHHCCEEEEEECCEEEECCCHHHHHHCCCHHCCCCCCCCEEEEEEECCCEEEEEECCC
AKLEVRFSKEAELNELITATIRQAFRQRTLIPSVSADSKTVKAKAEQASWTFAHRVHEPP
EEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCHHHHHHCCCCC
AQPDGKAEGTSDVTAAASLASEGSLSPLPAAAQADAPAVSEEAEASVFSERRTGVVNDLP
CCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCC
AAELKRDAEVEEEPTEACLPADEQAEEKRAVDRLPPLYPIGQLHGTYILAENEHGLYMID
HHHHHCCCCCCCCCHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCEEEEE
QHAAQERINYEYFREKLGEVTNEVQELLVPLTFEYPADEYERIAACRDELARCGVFLEPF
CHHHHHHCCHHHHHHHHHHHHHHHHHHHHCEEECCCCHHHHHHHHHHHHHHHCCCEEECC
GPRAFLVRSHPVWFPKGKEKEIIEEMIEHVLTAKTVDIKQLREQAAIVMSCKRAIKANQH
CCEEEEEECCCEECCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCC
LRTDEIFALLETLRQTTDPFTCPHGRPIIVHFSTYEIEKLFKRVM
CCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECHHHHHHHHHHCC
>Mature Secondary Structure 
GRIHKLDDQLANKIAAGEVVERPASVVKELVENAIDAHSTAVEIELEEAGMTKIRVIDN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCEEEEEEEC
GDGMEEEDCLLAFERHATSKIQDEHDLFRIRTLGFRGEALPSIASVSEVELVTSTGSGPG
CCCCCCHHHHHHHHHHHHHHCCCHHHEEEEEEECCCCCCCCCHHCCCCEEEEEECCCCCC
TKLVLKGGALVARERAAGRKGTDITVSNLFFNTPARLKYMKTIHTELGHAADVVNRLALA
CEEEEECCCEEEHHHHCCCCCCEEEEEHEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHC
HPDVSFRLRHHGKTLLATNGSGDVRHVLAAIYGMETAKQMIPIEAESLDFTVRGYISLPE
CCCCEEEEEECCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCH
VTRASRNYMSLIVNGRYVRNIPLMKAIEAGYHTLLPIGRYPIVFLAIEMDPVLVDVNVHP
HHHHHCCEEEEEECCEEEECCCHHHHHHCCCHHCCCCCCCCEEEEEEECCCEEEEEECCC
AKLEVRFSKEAELNELITATIRQAFRQRTLIPSVSADSKTVKAKAEQASWTFAHRVHEPP
EEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCHHHHHHCCCCC
AQPDGKAEGTSDVTAAASLASEGSLSPLPAAAQADAPAVSEEAEASVFSERRTGVVNDLP
CCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCC
AAELKRDAEVEEEPTEACLPADEQAEEKRAVDRLPPLYPIGQLHGTYILAENEHGLYMID
HHHHHCCCCCCCCCHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCEEEEE
QHAAQERINYEYFREKLGEVTNEVQELLVPLTFEYPADEYERIAACRDELARCGVFLEPF
CHHHHHHCCHHHHHHHHHHHHHHHHHHHHCEEECCCCHHHHHHHHHHHHHHHCCCEEECC
GPRAFLVRSHPVWFPKGKEKEIIEEMIEHVLTAKTVDIKQLREQAAIVMSCKRAIKANQH
CCEEEEEECCCEECCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCC
LRTDEIFALLETLRQTTDPFTCPHGRPIIVHFSTYEIEKLFKRVM
CCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA