Click here to switch to the map view.

The map label for this gene is uppS [H]

Identifier: 138894773

GI number: 138894773

Start: 1166993

End: 1167766

Strand: Direct

Name: uppS [H]

Synonym: GTNG_1107

Alternate gene names: 138894773

Gene position: 1166993-1167766 (Clockwise)

Preceding gene: 138894772

Following gene: 138894774

Centisome position: 32.87

GC content: 49.22

Gene sequence:

>774_bases
ATGTTCAATAAAATGTGGAAAAATAAAGAGAAAGACGCCCTGTTGACGAAAGAGGATGTGCTTAGTCATCCGATTCCGAA
CCACGTCGCCATCATCATGGACGGGAACGGAAGATGGGCGAAAAAGCGGGCTTTGCCGAGGGTGGCCGGCCATTATGAAG
GGATGCAAGTTGTGCGCAAAATTACCCGTTTTGCTAACGAGCTTGGGGTGCGCGTTTTGTCGCTTTATGCGTTTTCAACA
GAAAATTGGAAACGTCCGAAAAGCGAAGTCGACTATTTAATGAAACTGCCAGAACAGTTTTTGACGACATTTCTTCCCGA
GCTTGTCGCAGAGAATGTGAAAGTGCAAGTGATCGGCCGTACAGACGAGCTCCCGGATCATACACGTCAAGCCGTCAGGA
GAGCCATTCACGAAACGAGTGGCAACACCGGCCTAATTTTAAACTTTGCGCTCAATTATGGAAGCCGGGCGGAAATTACC
GCTGCTGTTCAGCAAATCGCCAAAGACGTCCAACGTGGGGCACTCGCGCCGGGGGACATTACCGAGTCACTCATTTCCTC
CTATTTGATGACGGGTGGGCTTGACGATCCGGATTTGCTCATTCGTACGAGCGGAGAAATTCGTTTAAGCAATTTTATGC
TTTGGCAGTTGGCGTATACGGAGTTTTGGTTTACTGATGTATTATGGCCGGATTTTACTGAACAACATTTCTTGCAGGCG
ATTGCCGCTTACCAGCAGCGCGACCGCCGATTTGGAGGAGTGTCAGCACGATGA

Upstream 100 bases:

>100_bases
AGAAGTGATGGAAGTATAGGAAAACGATGCAAACCCTCTATGTTGATGGAGGGTTTTTTTGCTATAATGGAAAGGCAAAA
CACGTTTGCGGAGGACACGT

Downstream 100 bases:

>100_bases
AACAGCGAATCATTACCGGAGTCATAGCGGCGGCGCTCTTTTTGCCGATTGTTATTTTAGGTGGATTTCCGTTTATAATA
GTAACATATATATTGGCTAC

Product: undecaprenyl pyrophosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 257; Mature: 257

Protein sequence:

>257_residues
MFNKMWKNKEKDALLTKEDVLSHPIPNHVAIIMDGNGRWAKKRALPRVAGHYEGMQVVRKITRFANELGVRVLSLYAFST
ENWKRPKSEVDYLMKLPEQFLTTFLPELVAENVKVQVIGRTDELPDHTRQAVRRAIHETSGNTGLILNFALNYGSRAEIT
AAVQQIAKDVQRGALAPGDITESLISSYLMTGGLDDPDLLIRTSGEIRLSNFMLWQLAYTEFWFTDVLWPDFTEQHFLQA
IAAYQQRDRRFGGVSAR

Sequences:

>Translated_257_residues
MFNKMWKNKEKDALLTKEDVLSHPIPNHVAIIMDGNGRWAKKRALPRVAGHYEGMQVVRKITRFANELGVRVLSLYAFST
ENWKRPKSEVDYLMKLPEQFLTTFLPELVAENVKVQVIGRTDELPDHTRQAVRRAIHETSGNTGLILNFALNYGSRAEIT
AAVQQIAKDVQRGALAPGDITESLISSYLMTGGLDDPDLLIRTSGEIRLSNFMLWQLAYTEFWFTDVLWPDFTEQHFLQA
IAAYQQRDRRFGGVSAR
>Mature_257_residues
MFNKMWKNKEKDALLTKEDVLSHPIPNHVAIIMDGNGRWAKKRALPRVAGHYEGMQVVRKITRFANELGVRVLSLYAFST
ENWKRPKSEVDYLMKLPEQFLTTFLPELVAENVKVQVIGRTDELPDHTRQAVRRAIHETSGNTGLILNFALNYGSRAEIT
AAVQQIAKDVQRGALAPGDITESLISSYLMTGGLDDPDLLIRTSGEIRLSNFMLWQLAYTEFWFTDVLWPDFTEQHFLQA
IAAYQQRDRRFGGVSAR

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580738, Length=225, Percent_Identity=40.8888888888889, Blast_Score=177, Evalue=6e-45,
Organism=Homo sapiens, GI45580742, Length=225, Percent_Identity=40.8888888888889, Blast_Score=177, Evalue=7e-45,
Organism=Escherichia coli, GI1786371, Length=245, Percent_Identity=46.530612244898, Blast_Score=224, Evalue=4e-60,
Organism=Caenorhabditis elegans, GI71993029, Length=231, Percent_Identity=38.961038961039, Blast_Score=157, Evalue=6e-39,
Organism=Saccharomyces cerevisiae, GI6319474, Length=216, Percent_Identity=36.1111111111111, Blast_Score=126, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6323748, Length=222, Percent_Identity=33.3333333333333, Blast_Score=113, Evalue=3e-26,
Organism=Drosophila melanogaster, GI18857969, Length=228, Percent_Identity=41.2280701754386, Blast_Score=168, Evalue=3e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 29324; Mature: 29324

Theoretical pI: Translated: 9.24; Mature: 9.24

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFNKMWKNKEKDALLTKEDVLSHPIPNHVAIIMDGNGRWAKKRALPRVAGHYEGMQVVRK
CCCCHHCCCCCCHHCCHHHHHCCCCCCCEEEEECCCCCCHHHHHCHHHHHHHHHHHHHHH
ITRFANELGVRVLSLYAFSTENWKRPKSEVDYLMKLPEQFLTTFLPELVAENVKVQVIGR
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHCCCEEEEEEC
TDELPDHTRQAVRRAIHETSGNTGLILNFALNYGSRAEITAAVQQIAKDVQRGALAPGDI
CCCCCHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCHH
TESLISSYLMTGGLDDPDLLIRTSGEIRLSNFMLWQLAYTEFWFTDVLWPDFTEQHFLQA
HHHHHHHHHHHCCCCCCCEEEECCCCEEEHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
IAAYQQRDRRFGGVSAR
HHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MFNKMWKNKEKDALLTKEDVLSHPIPNHVAIIMDGNGRWAKKRALPRVAGHYEGMQVVRK
CCCCHHCCCCCCHHCCHHHHHCCCCCCCEEEEECCCCCCHHHHHCHHHHHHHHHHHHHHH
ITRFANELGVRVLSLYAFSTENWKRPKSEVDYLMKLPEQFLTTFLPELVAENVKVQVIGR
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHCCCEEEEEEC
TDELPDHTRQAVRRAIHETSGNTGLILNFALNYGSRAEITAAVQQIAKDVQRGALAPGDI
CCCCCHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCHH
TESLISSYLMTGGLDDPDLLIRTSGEIRLSNFMLWQLAYTEFWFTDVLWPDFTEQHFLQA
HHHHHHHHHHHCCCCCCCEEEECCCCEEEHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
IAAYQQRDRRFGGVSAR
HHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA