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The map label for this gene is hemZ [H]

Identifier: 138894227

GI number: 138894227

Start: 614845

End: 616350

Strand: Direct

Name: hemZ [H]

Synonym: GTNG_0553

Alternate gene names: 138894227

Gene position: 614845-616350 (Clockwise)

Preceding gene: 138894226

Following gene: 138894229

Centisome position: 17.32

GC content: 48.47

Gene sequence:

>1506_bases
ATGAACGTGCGTATCGAAATTCAAGGACTGCCGAATCCTGAACGGTTTCAGCGTCCGCTTGAAGTGATAACCGAGCTGTT
TTTCGAATCGCCTGTGCTTTCGTTTGCGTCGCTTCTTGAAGCGGATGCCTCCGTTTCGTTTACCGTTAACGAAAACGGTC
GCATCACCGTTTCCGGAACGCTTGTCGACAAGGCGACCGGGCGCGTCGAGGAAGCTACGTATGAGTATGATGCACCAATA
GGAGCGGACGGGAAAGCGCGTGAAAAACGGTTGAAAAACGCCATCTTCCATGTGTATGTAACGCTTCTTGAACGCTATAC
CAACATCATTCAGCCATGGGGCATTTTAACCGGGGTCCGTCCGGTGAAACTGCTTCATCAGCTGCTGCGTTCCGGGATGA
CGAAAGAAGAGGCGCATCAGAAGCTAGCGGAAGAATATTTAGTAACAAAAGAAAAAATTGAGCTAATGCAAGCGATCGTT
GACCGCCAGCTCACGGTTGTGCCGGATTTGTACGATTTGTCCCATGAAGTGAGCATTTATATCGGCATTCCATTTTGTCC
GACGAAATGCGCTTATTGCACGTTTCCGGCGTACGCGATCAACGGCCGCCAAGGGTCGGTTGACGCCTTTTTAGCCGGGC
TTCATTACGAAATGGAAGCGGTCGGCCGCTTTTTGCGTGAACGCGGTATCCGGATTACAACGATTTATTACGGCGGCGGG
ACGCCGACGAGCATTACAGCTGAGGAGATGGACCAACTATACGCTCATATGTATAAGGTGTTTCCGGATGTCGACCGCGT
CCGCGAAATTACAGTCGAAGCCGGACGACCAGACACCATTACCCCTGAAAAGCTCGACGTCTTGAAAAAATGGCAGATCG
ATCGCATTAGCATCAACCCGCAGTCATACATTCAAGAGACGTTAAAAGCGATCGGCCGCCATCATACCGTTGAAGAAACG
ATCAACAAGTTTCACTTGGCACGAAAAATGGGGATGAACAACATTAATATGGATTTAATTATCGGTCTGCCTGGCGAAGG
GCTGCGGGAGTTTACGCATACGCTTGCCGAGACAGAACAGCTCATGCCGGAGTCGCTCACCGTTCATACGCTATCGTTCA
AGCGGGCCTCAGAAATGACGAAAAACAAACAAAAGTATAAAGTCGCCGACCGTGAAGAAATACAAGCGATGATGAAAGCG
GCCGAAGAGTGGACGAGCAAGCATGGTTATGTGCCGTATTATTTGTATCGACAAAAAAATATTCTCGGCAATCTCGAAAA
TGTCGGTTACGCCTTGCCAGGACATGAGAGCATTTACAATATTATGATCATGGAAGAGCAGCAGTCGATCATCGGACTCG
GCTGCGGGGCGTCAAGCAAATTTGTCGACCCGAAAACAAGGAAAATCACCCGCCAAGCGAATCCAAAAGAGCCAAAAGTG
TACAACGAACATTTTATGGAATACACAGAAGAAAAACTAAAAATCATGGAAGCCATTTTTGGTTAA

Upstream 100 bases:

>100_bases
GCGGCACCTTTCCACAAAGGGCAGCGAAGGAGGTGTATTCTTCCGCTTGACGAGGGAAACAGCAGTTCTGTACACTGAAA
GAAGTTTGACAGAAAAGGTG

Downstream 100 bases:

>100_bases
ATGAAAACACCCCGGGCGTTCCGGGGTGTTTTGCTTAGCGGTGAAACAAAATCAACTTGCCGCTCGCGTTGACGCAGCGG
TGGGTTTTATCAAAACAGCC

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 501; Mature: 501

Protein sequence:

>501_residues
MNVRIEIQGLPNPERFQRPLEVITELFFESPVLSFASLLEADASVSFTVNENGRITVSGTLVDKATGRVEEATYEYDAPI
GADGKAREKRLKNAIFHVYVTLLERYTNIIQPWGILTGVRPVKLLHQLLRSGMTKEEAHQKLAEEYLVTKEKIELMQAIV
DRQLTVVPDLYDLSHEVSIYIGIPFCPTKCAYCTFPAYAINGRQGSVDAFLAGLHYEMEAVGRFLRERGIRITTIYYGGG
TPTSITAEEMDQLYAHMYKVFPDVDRVREITVEAGRPDTITPEKLDVLKKWQIDRISINPQSYIQETLKAIGRHHTVEET
INKFHLARKMGMNNINMDLIIGLPGEGLREFTHTLAETEQLMPESLTVHTLSFKRASEMTKNKQKYKVADREEIQAMMKA
AEEWTSKHGYVPYYLYRQKNILGNLENVGYALPGHESIYNIMIMEEQQSIIGLGCGASSKFVDPKTRKITRQANPKEPKV
YNEHFMEYTEEKLKIMEAIFG

Sequences:

>Translated_501_residues
MNVRIEIQGLPNPERFQRPLEVITELFFESPVLSFASLLEADASVSFTVNENGRITVSGTLVDKATGRVEEATYEYDAPI
GADGKAREKRLKNAIFHVYVTLLERYTNIIQPWGILTGVRPVKLLHQLLRSGMTKEEAHQKLAEEYLVTKEKIELMQAIV
DRQLTVVPDLYDLSHEVSIYIGIPFCPTKCAYCTFPAYAINGRQGSVDAFLAGLHYEMEAVGRFLRERGIRITTIYYGGG
TPTSITAEEMDQLYAHMYKVFPDVDRVREITVEAGRPDTITPEKLDVLKKWQIDRISINPQSYIQETLKAIGRHHTVEET
INKFHLARKMGMNNINMDLIIGLPGEGLREFTHTLAETEQLMPESLTVHTLSFKRASEMTKNKQKYKVADREEIQAMMKA
AEEWTSKHGYVPYYLYRQKNILGNLENVGYALPGHESIYNIMIMEEQQSIIGLGCGASSKFVDPKTRKITRQANPKEPKV
YNEHFMEYTEEKLKIMEAIFG
>Mature_501_residues
MNVRIEIQGLPNPERFQRPLEVITELFFESPVLSFASLLEADASVSFTVNENGRITVSGTLVDKATGRVEEATYEYDAPI
GADGKAREKRLKNAIFHVYVTLLERYTNIIQPWGILTGVRPVKLLHQLLRSGMTKEEAHQKLAEEYLVTKEKIELMQAIV
DRQLTVVPDLYDLSHEVSIYIGIPFCPTKCAYCTFPAYAINGRQGSVDAFLAGLHYEMEAVGRFLRERGIRITTIYYGGG
TPTSITAEEMDQLYAHMYKVFPDVDRVREITVEAGRPDTITPEKLDVLKKWQIDRISINPQSYIQETLKAIGRHHTVEET
INKFHLARKMGMNNINMDLIIGLPGEGLREFTHTLAETEQLMPESLTVHTLSFKRASEMTKNKQKYKVADREEIQAMMKA
AEEWTSKHGYVPYYLYRQKNILGNLENVGYALPGHESIYNIMIMEEQQSIIGLGCGASSKFVDPKTRKITRQANPKEPKV
YNEHFMEYTEEKLKIMEAIFG

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=303, Percent_Identity=23.7623762376238, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI1789325, Length=305, Percent_Identity=27.5409836065574, Blast_Score=115, Evalue=8e-27,
Organism=Escherichia coli, GI87082341, Length=237, Percent_Identity=27.0042194092827, Blast_Score=87, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR007197 [H]

Pfam domain/function: PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 57173; Mature: 57173

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVRIEIQGLPNPERFQRPLEVITELFFESPVLSFASLLEADASVSFTVNENGRITVSGT
CCEEEEEECCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCEEEEECCCCEEEEEEE
LVDKATGRVEEATYEYDAPIGADGKAREKRLKNAIFHVYVTLLERYTNIIQPWGILTGVR
EEECCCCCHHHCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCH
PVKLLHQLLRSGMTKEEAHQKLAEEYLVTKEKIELMQAIVDRQLTVVPDLYDLSHEVSIY
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHCCCCCEEEE
IGIPFCPTKCAYCTFPAYAINGRQGSVDAFLAGLHYEMEAVGRFLRERGIRITTIYYGGG
EECCCCCCCCCEECCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCC
TPTSITAEEMDQLYAHMYKVFPDVDRVREITVEAGRPDTITPEKLDVLKKWQIDRISINP
CCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHEECCCCCCCCHHHHHHHHHCCCCEEECCH
QSYIQETLKAIGRHHTVEETINKFHLARKMGMNNINMDLIIGLPGEGLREFTHTLAETEQ
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHH
LMPESLTVHTLSFKRASEMTKNKQKYKVADREEIQAMMKAAEEWTSKHGYVPYYLYRQKN
HCCCCEEEEEEHHHHHHHHHHCHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECHH
ILGNLENVGYALPGHESIYNIMIMEEQQSIIGLGCGASSKFVDPKTRKITRQANPKEPKV
HHCCHHHCCCCCCCCCCEEEEEEEECCCCEEEEECCCCCCCCCCHHHHHHCCCCCCCCCH
YNEHFMEYTEEKLKIMEAIFG
HHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNVRIEIQGLPNPERFQRPLEVITELFFESPVLSFASLLEADASVSFTVNENGRITVSGT
CCEEEEEECCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCEEEEECCCCEEEEEEE
LVDKATGRVEEATYEYDAPIGADGKAREKRLKNAIFHVYVTLLERYTNIIQPWGILTGVR
EEECCCCCHHHCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCH
PVKLLHQLLRSGMTKEEAHQKLAEEYLVTKEKIELMQAIVDRQLTVVPDLYDLSHEVSIY
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHCCCCCEEEE
IGIPFCPTKCAYCTFPAYAINGRQGSVDAFLAGLHYEMEAVGRFLRERGIRITTIYYGGG
EECCCCCCCCCEECCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCC
TPTSITAEEMDQLYAHMYKVFPDVDRVREITVEAGRPDTITPEKLDVLKKWQIDRISINP
CCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHEECCCCCCCCHHHHHHHHHCCCCEEECCH
QSYIQETLKAIGRHHTVEETINKFHLARKMGMNNINMDLIIGLPGEGLREFTHTLAETEQ
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHH
LMPESLTVHTLSFKRASEMTKNKQKYKVADREEIQAMMKAAEEWTSKHGYVPYYLYRQKN
HCCCCEEEEEEHHHHHHHHHHCHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECHH
ILGNLENVGYALPGHESIYNIMIMEEQQSIIGLGCGASSKFVDPKTRKITRQANPKEPKV
HHCCHHHCCCCCCCCCCEEEEEEEECCCCEEEEECCCCCCCCCCHHHHHHCCCCCCCCCH
YNEHFMEYTEEKLKIMEAIFG
HHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 10568751 [H]