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The map label for this gene is sul [H]

Identifier: 138893748

GI number: 138893748

Start: 81579

End: 82433

Strand: Direct

Name: sul [H]

Synonym: GTNG_0069

Alternate gene names: 138893748

Gene position: 81579-82433 (Clockwise)

Preceding gene: 138893747

Following gene: 138893749

Centisome position: 2.3

GC content: 50.53

Gene sequence:

>855_bases
ATGATGATAACAATGACGCGTTCGCGTGTGCTTCAATGCCGCGGGCATGAGTTGGATTTAGGCAAAAAAACATTGATCAT
GGGTATTGTCAACGTCACACCGGATTCATTTTCTGACGGCGGACGATTTTACGATGTAGAAAAAGCCGTTGAGCATGCGA
AGCGGCTTGTGGCTGAGGGAGCGGACATCATTGACATCGGCGGCGAGTCGACACGTCCGGGAGCGGAACAGGTTCCGCTC
GATGAAGAATTACGGCGCGTCATTCCAGCGGTAAGAGCGATTGCCAGTGAGGTGAATGTGCCGATTTCCATTGATACATA
TAAAGCGGAGGTGGCACGCCAAGCCATCGAAGCCGGGGCACATATCATTAACGATGTTTGGGGAGCCAAAGCTGATCCGG
ATATGGCACATGTTGCTGCTTCGTACGGAGTGCCAATTATTTTAATGCACAATCGACACGATATGGCATACCGCGACCTT
ATTTCCGATATGATCGTCGACCTAGAGGAGAGCATCTGCATTGTCAAACAAGCCGGAGTGAAAGATGAAAATATTATTTT
AGATCCAGGTATCGGGTTTGCCAAAACGTTCGAGCATAATTTGGAGGTGATGCGGCGTCTTGATGAGTTTGCTGCCCTTG
GCTATCCGCTGTTGCTTGGAACGTCGCGCAAACGGTTTATCGGCCATGTGCTTGACGTGCCAGTTGAAGAGCGTGTCGAA
GGAACGGGAGCTACTGTTTGTCTTGGTATCGTGAAAGGGGCGAATATCGTCCGCGTTCACGATGTATTGCCGATCGCCCG
CATGGCGAAAATGATGGATGCGATGCTTGGGAAAGGGGAGAGCGGCCATCGATAA

Upstream 100 bases:

>100_bases
TTGGACAAAACGGCCCGGTGACCTGTGCGCTGCAACGCCATTATCGCCGCTTTACGGACACGTTATGGACGAGGAATGAA
TTGTCAGAAAGGATGAATCG

Downstream 100 bases:

>100_bases
AATCTATGTGCGAGAGATGGAGTTTTATGGCTATCATGGAGTGCTTCCCGAAGAAAATGTCCTCGGTCAGAAGTTCGTGA
TTGATGTGACGATGGAGCTT

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 284; Mature: 284

Protein sequence:

>284_residues
MMITMTRSRVLQCRGHELDLGKKTLIMGIVNVTPDSFSDGGRFYDVEKAVEHAKRLVAEGADIIDIGGESTRPGAEQVPL
DEELRRVIPAVRAIASEVNVPISIDTYKAEVARQAIEAGAHIINDVWGAKADPDMAHVAASYGVPIILMHNRHDMAYRDL
ISDMIVDLEESICIVKQAGVKDENIILDPGIGFAKTFEHNLEVMRRLDEFAALGYPLLLGTSRKRFIGHVLDVPVEERVE
GTGATVCLGIVKGANIVRVHDVLPIARMAKMMDAMLGKGESGHR

Sequences:

>Translated_284_residues
MMITMTRSRVLQCRGHELDLGKKTLIMGIVNVTPDSFSDGGRFYDVEKAVEHAKRLVAEGADIIDIGGESTRPGAEQVPL
DEELRRVIPAVRAIASEVNVPISIDTYKAEVARQAIEAGAHIINDVWGAKADPDMAHVAASYGVPIILMHNRHDMAYRDL
ISDMIVDLEESICIVKQAGVKDENIILDPGIGFAKTFEHNLEVMRRLDEFAALGYPLLLGTSRKRFIGHVLDVPVEERVE
GTGATVCLGIVKGANIVRVHDVLPIARMAKMMDAMLGKGESGHR
>Mature_284_residues
MMITMTRSRVLQCRGHELDLGKKTLIMGIVNVTPDSFSDGGRFYDVEKAVEHAKRLVAEGADIIDIGGESTRPGAEQVPL
DEELRRVIPAVRAIASEVNVPISIDTYKAEVARQAIEAGAHIINDVWGAKADPDMAHVAASYGVPIILMHNRHDMAYRDL
ISDMIVDLEESICIVKQAGVKDENIILDPGIGFAKTFEHNLEVMRRLDEFAALGYPLLLGTSRKRFIGHVLDVPVEERVE
GTGATVCLGIVKGANIVRVHDVLPIARMAKMMDAMLGKGESGHR

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=278, Percent_Identity=43.8848920863309, Blast_Score=218, Evalue=3e-58,
Organism=Saccharomyces cerevisiae, GI6324073, Length=316, Percent_Identity=35.126582278481, Blast_Score=162, Evalue=7e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 31067; Mature: 31067

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMITMTRSRVLQCRGHELDLGKKTLIMGIVNVTPDSFSDGGRFYDVEKAVEHAKRLVAEG
CEEEECHHHHHHHCCCCCCCCCCEEEEEEEECCCCCCCCCCCEEEHHHHHHHHHHHHHCC
ADIIDIGGESTRPGAEQVPLDEELRRVIPAVRAIASEVNVPISIDTYKAEVARQAIEAGA
CCEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHH
HIINDVWGAKADPDMAHVAASYGVPIILMHNRHDMAYRDLISDMIVDLEESICIVKQAGV
HHHHHHHCCCCCCHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHEEEHHHCCC
KDENIILDPGIGFAKTFEHNLEVMRRLDEFAALGYPLLLGTSRKRFIGHVLDVPVEERVE
CCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHCCCHHHHHC
GTGATVCLGIVKGANIVRVHDVLPIARMAKMMDAMLGKGESGHR
CCCCEEEEEECCCCCEEEEHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MMITMTRSRVLQCRGHELDLGKKTLIMGIVNVTPDSFSDGGRFYDVEKAVEHAKRLVAEG
CEEEECHHHHHHHCCCCCCCCCCEEEEEEEECCCCCCCCCCCEEEHHHHHHHHHHHHHCC
ADIIDIGGESTRPGAEQVPLDEELRRVIPAVRAIASEVNVPISIDTYKAEVARQAIEAGA
CCEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHH
HIINDVWGAKADPDMAHVAASYGVPIILMHNRHDMAYRDLISDMIVDLEESICIVKQAGV
HHHHHHHCCCCCCHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHEEEHHHCCC
KDENIILDPGIGFAKTFEHNLEVMRRLDEFAALGYPLLLGTSRKRFIGHVLDVPVEERVE
CCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHCCCHHHHHC
GTGATVCLGIVKGANIVRVHDVLPIARMAKMMDAMLGKGESGHR
CCCCEEEEEECCCCCEEEEHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2123867; 7584024; 9384377 [H]