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The map label for this gene is prs [H]

Identifier: 138893723

GI number: 138893723

Start: 54406

End: 55353

Strand: Direct

Name: prs [H]

Synonym: GTNG_0044

Alternate gene names: 138893723

Gene position: 54406-55353 (Clockwise)

Preceding gene: 138893722

Following gene: 138893724

Centisome position: 1.53

GC content: 49.05

Gene sequence:

>948_bases
ATGTCTGAATGCCAACACCAATTAAAGTTGTTCGCCCTGAACTCGAACATGAAGCTAGCGAAACAAATTGCTGAAACCAT
GGGGATCGAGCTTGGCAAGTGTTCAGTATCCCGTTTTAGCGATGGAGAAATTCAAATTAACATCGAAGAAAGCATCCGCG
GCGACGATGTATTTGTCATCCAATCGACAAGCGTCCCGGTCAATGAGCATTTAATGGAACTGCTCATTATGATCGATGCA
TTAAAACGTGCTTCAGCGCGCACGATCAATATCGTAATGCCATACTACGGTTATGCGCGACAAGACCGGAAAGCGCGCTC
GCGCGAGCCGATTACAGCGAAACTCGTGGCCAACTTGCTGGAAACAGCCGGGGCATCGCGCGTCATTACGCTCGATTTGC
ATGCTCCGCAAATCCAAGGGTTTTTCGATATCCCGATCGATCATTTAATGGGTGTTCCGATTTTAGCGGATTACTTTAAA
AGCAAACAGTTGGATGATGTCGTCATCGTTTCCCCGGACCATGGCGGTGTGACGCGGGCACGCAAGTTGGCTGATCGTCT
GAAGGCACCGCTCGCTATTATTGACAAACGCCGGCCGCGGCCAAACGCTGTTGAAGTAATGAACATCATCGGTCAAGTGA
AAGGAAAGACGGCCATTTTGATTGATGACATTATCGATACAGCTGGGACGATTACGCTGGGGGCGAACGCCCTTGTTGAA
AACGGGGCGAAAGAAGTGTACGCATGCTGTACTCACCCGGTGTTGTCCGGTCCGGCGATTGAGCGTATTCAAAATTCCAA
AATTAAGGAGCTTGTCGTCACCAATTCGATTGCCTTGCCAGAAGAGAAGAAAATTGATAAAATTGTAGAGCTGTCGGTGG
CGCCGCTCATTGCTGAAGCGATTACGCGCGTGTATGAAATGCAATCCGTCAGCGTCCTGTTCGACTAA

Upstream 100 bases:

>100_bases
TCCCGGCCGTGCGCTCGCTATTGGTCGCGCTCGACAAGTGAACAAAGAAAATTATGTGGATCGCCTGCGAGGCAAGAAAA
AATCTTAATGGAGGTTTATC

Downstream 100 bases:

>100_bases
ACACAAAGCATGTTTAACCCTTCTTGTTTTAGGATAAAGTAGACAATAGATTCTAATTCAGGAAGGTGAAGAAACATGGC
GATTGTGTTGGGAGCGAAAG

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 315; Mature: 314

Protein sequence:

>315_residues
MSECQHQLKLFALNSNMKLAKQIAETMGIELGKCSVSRFSDGEIQINIEESIRGDDVFVIQSTSVPVNEHLMELLIMIDA
LKRASARTINIVMPYYGYARQDRKARSREPITAKLVANLLETAGASRVITLDLHAPQIQGFFDIPIDHLMGVPILADYFK
SKQLDDVVIVSPDHGGVTRARKLADRLKAPLAIIDKRRPRPNAVEVMNIIGQVKGKTAILIDDIIDTAGTITLGANALVE
NGAKEVYACCTHPVLSGPAIERIQNSKIKELVVTNSIALPEEKKIDKIVELSVAPLIAEAITRVYEMQSVSVLFD

Sequences:

>Translated_315_residues
MSECQHQLKLFALNSNMKLAKQIAETMGIELGKCSVSRFSDGEIQINIEESIRGDDVFVIQSTSVPVNEHLMELLIMIDA
LKRASARTINIVMPYYGYARQDRKARSREPITAKLVANLLETAGASRVITLDLHAPQIQGFFDIPIDHLMGVPILADYFK
SKQLDDVVIVSPDHGGVTRARKLADRLKAPLAIIDKRRPRPNAVEVMNIIGQVKGKTAILIDDIIDTAGTITLGANALVE
NGAKEVYACCTHPVLSGPAIERIQNSKIKELVVTNSIALPEEKKIDKIVELSVAPLIAEAITRVYEMQSVSVLFD
>Mature_314_residues
SECQHQLKLFALNSNMKLAKQIAETMGIELGKCSVSRFSDGEIQINIEESIRGDDVFVIQSTSVPVNEHLMELLIMIDAL
KRASARTINIVMPYYGYARQDRKARSREPITAKLVANLLETAGASRVITLDLHAPQIQGFFDIPIDHLMGVPILADYFKS
KQLDDVVIVSPDHGGVTRARKLADRLKAPLAIIDKRRPRPNAVEVMNIIGQVKGKTAILIDDIIDTAGTITLGANALVEN
GAKEVYACCTHPVLSGPAIERIQNSKIKELVVTNSIALPEEKKIDKIVELSVAPLIAEAITRVYEMQSVSVLFD

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506129, Length=310, Percent_Identity=46.7741935483871, Blast_Score=285, Evalue=3e-77,
Organism=Homo sapiens, GI4506127, Length=313, Percent_Identity=46.6453674121406, Blast_Score=285, Evalue=4e-77,
Organism=Homo sapiens, GI84875539, Length=313, Percent_Identity=46.3258785942492, Blast_Score=280, Evalue=1e-75,
Organism=Homo sapiens, GI28557709, Length=311, Percent_Identity=45.3376205787781, Blast_Score=279, Evalue=3e-75,
Organism=Homo sapiens, GI4506133, Length=344, Percent_Identity=37.2093023255814, Blast_Score=190, Evalue=1e-48,
Organism=Homo sapiens, GI194018537, Length=350, Percent_Identity=35.7142857142857, Blast_Score=184, Evalue=7e-47,
Organism=Homo sapiens, GI310128524, Length=136, Percent_Identity=36.0294117647059, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI310115209, Length=136, Percent_Identity=36.0294117647059, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI310118259, Length=136, Percent_Identity=36.0294117647059, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI310119946, Length=136, Percent_Identity=36.0294117647059, Blast_Score=90, Evalue=3e-18,
Organism=Escherichia coli, GI1787458, Length=311, Percent_Identity=50.8038585209003, Blast_Score=319, Evalue=2e-88,
Organism=Caenorhabditis elegans, GI25149168, Length=311, Percent_Identity=48.2315112540193, Blast_Score=293, Evalue=8e-80,
Organism=Caenorhabditis elegans, GI17554702, Length=311, Percent_Identity=48.2315112540193, Blast_Score=292, Evalue=1e-79,
Organism=Caenorhabditis elegans, GI71989924, Length=311, Percent_Identity=48.2315112540193, Blast_Score=291, Evalue=3e-79,
Organism=Caenorhabditis elegans, GI17554704, Length=308, Percent_Identity=48.3766233766234, Blast_Score=291, Evalue=4e-79,
Organism=Caenorhabditis elegans, GI17570245, Length=335, Percent_Identity=34.9253731343284, Blast_Score=194, Evalue=4e-50,
Organism=Saccharomyces cerevisiae, GI6320946, Length=312, Percent_Identity=46.1538461538462, Blast_Score=277, Evalue=1e-75,
Organism=Saccharomyces cerevisiae, GI6319403, Length=317, Percent_Identity=45.7413249211356, Blast_Score=274, Evalue=2e-74,
Organism=Saccharomyces cerevisiae, GI6321776, Length=312, Percent_Identity=46.1538461538462, Blast_Score=265, Evalue=7e-72,
Organism=Saccharomyces cerevisiae, GI6322667, Length=198, Percent_Identity=41.9191919191919, Blast_Score=166, Evalue=7e-42,
Organism=Saccharomyces cerevisiae, GI6324511, Length=271, Percent_Identity=32.1033210332103, Blast_Score=127, Evalue=2e-30,
Organism=Drosophila melanogaster, GI21355239, Length=313, Percent_Identity=47.6038338658147, Blast_Score=283, Evalue=9e-77,
Organism=Drosophila melanogaster, GI45551540, Length=336, Percent_Identity=44.6428571428571, Blast_Score=271, Evalue=3e-73,
Organism=Drosophila melanogaster, GI24651458, Length=347, Percent_Identity=36.3112391930836, Blast_Score=198, Evalue=3e-51,
Organism=Drosophila melanogaster, GI24651456, Length=347, Percent_Identity=36.3112391930836, Blast_Score=198, Evalue=3e-51,
Organism=Drosophila melanogaster, GI281362873, Length=347, Percent_Identity=36.3112391930836, Blast_Score=198, Evalue=5e-51,
Organism=Drosophila melanogaster, GI24651454, Length=347, Percent_Identity=36.3112391930836, Blast_Score=198, Evalue=5e-51,
Organism=Drosophila melanogaster, GI24651462, Length=368, Percent_Identity=33.695652173913, Blast_Score=171, Evalue=6e-43,
Organism=Drosophila melanogaster, GI24651464, Length=368, Percent_Identity=33.695652173913, Blast_Score=171, Evalue=6e-43,
Organism=Drosophila melanogaster, GI45552010, Length=368, Percent_Identity=33.695652173913, Blast_Score=171, Evalue=6e-43,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 34633; Mature: 34502

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER ; PS00114 PRPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSECQHQLKLFALNSNMKLAKQIAETMGIELGKCSVSRFSDGEIQINIEESIRGDDVFVI
CCCHHHEEEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEHHCCCCCEEEEE
QSTSVPVNEHLMELLIMIDALKRASARTINIVMPYYGYARQDRKARSREPITAKLVANLL
ECCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHCCCCHHHHHHHHHH
ETAGASRVITLDLHAPQIQGFFDIPIDHLMGVPILADYFKSKQLDDVVIVSPDHGGVTRA
HHCCCCEEEEEEECCCCCCCEEECCHHHHCCCHHHHHHHHCCCCCCEEEECCCCCCHHHH
RKLADRLKAPLAIIDKRRPRPNAVEVMNIIGQVKGKTAILIDDIIDTAGTITLGANALVE
HHHHHHHHCCHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEHHHHCCCCEEEECCHHHHH
NGAKEVYACCTHPVLSGPAIERIQNSKIKELVVTNSIALPEEKKIDKIVELSVAPLIAEA
CCHHHHHHHHCCCCCCCHHHHHHHCCHHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHH
ITRVYEMQSVSVLFD
HHHHHHHHHEEEEEC
>Mature Secondary Structure 
SECQHQLKLFALNSNMKLAKQIAETMGIELGKCSVSRFSDGEIQINIEESIRGDDVFVI
CCHHHEEEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEHHCCCCCEEEEE
QSTSVPVNEHLMELLIMIDALKRASARTINIVMPYYGYARQDRKARSREPITAKLVANLL
ECCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHCCCCHHHHHHHHHH
ETAGASRVITLDLHAPQIQGFFDIPIDHLMGVPILADYFKSKQLDDVVIVSPDHGGVTRA
HHCCCCEEEEEEECCCCCCCEEECCHHHHCCCHHHHHHHHCCCCCCEEEECCCCCCHHHH
RKLADRLKAPLAIIDKRRPRPNAVEVMNIIGQVKGKTAILIDDIIDTAGTITLGANALVE
HHHHHHHHCCHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEHHHHCCCCEEEECCHHHHH
NGAKEVYACCTHPVLSGPAIERIQNSKIKELVVTNSIALPEEKKIDKIVELSVAPLIAEA
CCHHHHHHHHCCCCCCCHHHHHHHCCHHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHH
ITRVYEMQSVSVLFD
HHHHHHHHHEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8918235 [H]