Click here to switch to the map view.

The map label for this gene is glmU

Identifier: 138893722

GI number: 138893722

Start: 53014

End: 54393

Strand: Direct

Name: glmU

Synonym: GTNG_0043

Alternate gene names: 138893722

Gene position: 53014-54393 (Clockwise)

Preceding gene: 138893721

Following gene: 138893723

Centisome position: 1.49

GC content: 50.72

Gene sequence:

>1380_bases
ATGGTAAAGCGATATGCAGTCATTTTGGCGGCCGGACAAGGAACGAGGATGAAATCCAAGTTGTATAAGGTACTTCATCC
CGTTTGCGGCAAGCCAATGGTTCAGCACGTAGTGGACCAAGTGTCCAAGCTTGGGGTAGAAAAAACGATTGCAGTAGTGG
GATTTGGGGCGGAGCAAGTGAAAGAACAGCTCGGCGCCCAGTGTGAATACGCCTTGCAAGAAAAGCAGCTCGGGACAGCA
CACGCGGTAATGCAGGCCGCGCCTCATTTGCAAAACCTTGAAGGGATCACCATCGTGGTCTGTGGTGATACACCGCTCAT
CACCGCTGAGACGATGGAAGCGCTCCTCGAGCACCATATGACCGCTGGGGCGAAGGCGACCGTATTGACGGCCATCGCTG
ACGATCCGACCGGATATGGCCGCATTGTTCGCAACAGTGATGGCCATGTTGAAAAAATTGTTGAGCATAAAGATGCGAAT
GAACAAGAGCGGGAAATCCGCGAGATTAACACGGGAACGTATTGCTTCGATAATCGAATGTTGTTTCAAGCGCTTACAAA
AGTAACAAACAATAATGCCCAAGGCGAATATTATTTAACCGATGTGATCGAAATTATAAAAGCGGATGGTGGCATTGTCT
CCGCTTATCAGGCACCGTCGTTTGACGAAACGATCGGTATCAATGACCGCATCGCGCTTGCTGAGGCGGAACGGATTATG
CGCGATCGCATTTGCCGCCAACATATGAAAAACGGGGTGACGATCATCGACCCGGCTTGCACTTATATTTCAGCTGAAGC
GACGATCGGGCGCGATACGGTCATTTATCCTGGTACGGTCATCGAGGGAAAGACAGTGATCGGCGAAGATTGTACGATCG
GGCCCCATTCAGAAATTAAAAACTGTCACATCGGCCACCGCACATCTATTCGCCACTCGGTCGCCCATGACAGCGAGATC
GGCGACGATGTGACGATCGGTCCGTTCGCCCATATTCGTCCGCTGTCGAAAATTGACGATGAGGTACGAATCGGTAACTT
TGTCGAGGTGAAAAAATCGACATTCGGTAAAGGAAGCAAAGCTTCGCATTTAAGCTATATTGGGGATGCAGAAGTCGGAG
CCGATGTCAACCTTGGCTGTGGATCGATTACGGTCAATTACGATGGTGTGCATAAGTATCGGACGAAAATTGAAGACGGT
GCATTTATTGGCTGCAACGCCAACTTGATTGCGCCGGTCACGATCGGCCAAGGCGCTTACGTCGCCGCTGGATCGACGGT
CACCGATGATGTTCCCGGCCGTGCGCTCGCTATTGGTCGCGCTCGACAAGTGAACAAAGAAAATTATGTGGATCGCCTGC
GAGGCAAGAAAAAATCTTAA

Upstream 100 bases:

>100_bases
AAGCTCTCTATTTTTTTGGCAAATGCATTGTTTCCTTGAAATGAGCAGCCAATTCATATATATTCAATTATGGATAAAAG
GGTAATTGGGGGCCTTTCAC

Downstream 100 bases:

>100_bases
TGGAGGTTTATCATGTCTGAATGCCAACACCAATTAAAGTTGTTCGCCCTGAACTCGAACATGAAGCTAGCGAAACAAAT
TGCTGAAACCATGGGGATCG

Product: bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase

Number of amino acids: Translated: 459; Mature: 459

Protein sequence:

>459_residues
MVKRYAVILAAGQGTRMKSKLYKVLHPVCGKPMVQHVVDQVSKLGVEKTIAVVGFGAEQVKEQLGAQCEYALQEKQLGTA
HAVMQAAPHLQNLEGITIVVCGDTPLITAETMEALLEHHMTAGAKATVLTAIADDPTGYGRIVRNSDGHVEKIVEHKDAN
EQEREIREINTGTYCFDNRMLFQALTKVTNNNAQGEYYLTDVIEIIKADGGIVSAYQAPSFDETIGINDRIALAEAERIM
RDRICRQHMKNGVTIIDPACTYISAEATIGRDTVIYPGTVIEGKTVIGEDCTIGPHSEIKNCHIGHRTSIRHSVAHDSEI
GDDVTIGPFAHIRPLSKIDDEVRIGNFVEVKKSTFGKGSKASHLSYIGDAEVGADVNLGCGSITVNYDGVHKYRTKIEDG
AFIGCNANLIAPVTIGQGAYVAAGSTVTDDVPGRALAIGRARQVNKENYVDRLRGKKKS

Sequences:

>Translated_459_residues
MVKRYAVILAAGQGTRMKSKLYKVLHPVCGKPMVQHVVDQVSKLGVEKTIAVVGFGAEQVKEQLGAQCEYALQEKQLGTA
HAVMQAAPHLQNLEGITIVVCGDTPLITAETMEALLEHHMTAGAKATVLTAIADDPTGYGRIVRNSDGHVEKIVEHKDAN
EQEREIREINTGTYCFDNRMLFQALTKVTNNNAQGEYYLTDVIEIIKADGGIVSAYQAPSFDETIGINDRIALAEAERIM
RDRICRQHMKNGVTIIDPACTYISAEATIGRDTVIYPGTVIEGKTVIGEDCTIGPHSEIKNCHIGHRTSIRHSVAHDSEI
GDDVTIGPFAHIRPLSKIDDEVRIGNFVEVKKSTFGKGSKASHLSYIGDAEVGADVNLGCGSITVNYDGVHKYRTKIEDG
AFIGCNANLIAPVTIGQGAYVAAGSTVTDDVPGRALAIGRARQVNKENYVDRLRGKKKS
>Mature_459_residues
MVKRYAVILAAGQGTRMKSKLYKVLHPVCGKPMVQHVVDQVSKLGVEKTIAVVGFGAEQVKEQLGAQCEYALQEKQLGTA
HAVMQAAPHLQNLEGITIVVCGDTPLITAETMEALLEHHMTAGAKATVLTAIADDPTGYGRIVRNSDGHVEKIVEHKDAN
EQEREIREINTGTYCFDNRMLFQALTKVTNNNAQGEYYLTDVIEIIKADGGIVSAYQAPSFDETIGINDRIALAEAERIM
RDRICRQHMKNGVTIIDPACTYISAEATIGRDTVIYPGTVIEGKTVIGEDCTIGPHSEIKNCHIGHRTSIRHSVAHDSEI
GDDVTIGPFAHIRPLSKIDDEVRIGNFVEVKKSTFGKGSKASHLSYIGDAEVGADVNLGCGSITVNYDGVHKYRTKIEDG
AFIGCNANLIAPVTIGQGAYVAAGSTVTDDVPGRALAIGRARQVNKENYVDRLRGKKKS

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc

COG id: COG1207

COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family

Homologues:

Organism=Homo sapiens, GI11761621, Length=345, Percent_Identity=22.6086956521739, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI11761619, Length=340, Percent_Identity=22.3529411764706, Blast_Score=75, Evalue=2e-13,
Organism=Escherichia coli, GI1790168, Length=445, Percent_Identity=44.4943820224719, Blast_Score=358, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI133931050, Length=355, Percent_Identity=25.9154929577465, Blast_Score=90, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLMU_GEOTN (A4IJC6)

Other databases:

- EMBL:   CP000557
- RefSeq:   YP_001124175.1
- ProteinModelPortal:   A4IJC6
- SMR:   A4IJC6
- STRING:   A4IJC6
- GeneID:   4965169
- GenomeReviews:   CP000557_GR
- KEGG:   gtn:GTNG_0043
- NMPDR:   fig|420246.5.peg.43
- eggNOG:   COG1207
- HOGENOM:   HBG688195
- OMA:   GSKVNHL
- PhylomeDB:   A4IJC6
- ProtClustDB:   PRK14354
- BioCyc:   GTHE420246:GTNG_0043-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01631
- InterPro:   IPR005882
- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR005835
- InterPro:   IPR011004
- TIGRFAMs:   TIGR01173

Pfam domain/function: PF00132 Hexapep; PF00483 NTP_transferase; SSF51161 Trimer_LpxA_like

EC number: =2.7.7.23; =2.3.1.157

Molecular weight: Translated: 49704; Mature: 49704

Theoretical pI: Translated: 6.75; Mature: 6.75

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: ACT_SITE 363-363 BINDING 73-73 BINDING 140-140 BINDING 155-155 BINDING 170-170 BINDING 387-387 BINDING 423-423 BINDING 440-440

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKRYAVILAAGQGTRMKSKLYKVLHPVCGKPMVQHVVDQVSKLGVEKTIAVVGFGAEQV
CCCEEEEEEECCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHEEEEEECCHHHH
KEQLGAQCEYALQEKQLGTAHAVMQAAPHLQNLEGITIVVCGDTPLITAETMEALLEHHM
HHHHCCHHHHHHHHHHCCHHHHHHHHCCHHCCCCCEEEEEECCCCEEEHHHHHHHHHHHH
TAGAKATVLTAIADDPTGYGRIVRNSDGHVEKIVEHKDANEQEREIREINTGTYCFDNRM
CCCCCEEEEEEECCCCCCCCEEEECCCCHHHHHHHHCCCCHHHHHHHHCCCCEEEECCHH
LFQALTKVTNNNAQGEYYLTDVIEIIKADGGIVSAYQAPSFDETIGINDRIALAEAERIM
HHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHH
RDRICRQHMKNGVTIIDPACTYISAEATIGRDTVIYPGTVIEGKTVIGEDCTIGPHSEIK
HHHHHHHHHHCCCEEEECCCCEEECCCCCCCCEEEECCEEECCCEEECCCCCCCCCHHHC
NCHIGHRTSIRHSVAHDSEIGDDVTIGPFAHIRPLSKIDDEVRIGNFVEVKKSTFGKGSK
CCCCCCCCHHHHHHCCCCCCCCCEEECCHHHHCCHHHCCCCCCCCCEEEEHHHHCCCCCC
ASHLSYIGDAEVGADVNLGCGSITVNYDGVHKYRTKIEDGAFIGCNANLIAPVTIGQGAY
CCHHEECCCCCCCCCEECCCCEEEEECCCHHHHHHHCCCCCEEECCCCEEEEEEECCCCE
VAAGSTVTDDVPGRALAIGRARQVNKENYVDRLRGKKKS
EECCCCCCCCCCCCEEEECCHHHCCHHHHHHHHCCCCCC
>Mature Secondary Structure
MVKRYAVILAAGQGTRMKSKLYKVLHPVCGKPMVQHVVDQVSKLGVEKTIAVVGFGAEQV
CCCEEEEEEECCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHEEEEEECCHHHH
KEQLGAQCEYALQEKQLGTAHAVMQAAPHLQNLEGITIVVCGDTPLITAETMEALLEHHM
HHHHCCHHHHHHHHHHCCHHHHHHHHCCHHCCCCCEEEEEECCCCEEEHHHHHHHHHHHH
TAGAKATVLTAIADDPTGYGRIVRNSDGHVEKIVEHKDANEQEREIREINTGTYCFDNRM
CCCCCEEEEEEECCCCCCCCEEEECCCCHHHHHHHHCCCCHHHHHHHHCCCCEEEECCHH
LFQALTKVTNNNAQGEYYLTDVIEIIKADGGIVSAYQAPSFDETIGINDRIALAEAERIM
HHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHH
RDRICRQHMKNGVTIIDPACTYISAEATIGRDTVIYPGTVIEGKTVIGEDCTIGPHSEIK
HHHHHHHHHHCCCEEEECCCCEEECCCCCCCCEEEECCEEECCCEEECCCCCCCCCHHHC
NCHIGHRTSIRHSVAHDSEIGDDVTIGPFAHIRPLSKIDDEVRIGNFVEVKKSTFGKGSK
CCCCCCCCHHHHHHCCCCCCCCCEEECCHHHHCCHHHCCCCCCCCCEEEEHHHHCCCCCC
ASHLSYIGDAEVGADVNLGCGSITVNYDGVHKYRTKIEDGAFIGCNANLIAPVTIGQGAY
CCHHEECCCCCCCCCEECCCCEEEEECCCHHHHHHHCCCCCEEECCCCEEEEEEECCCCE
VAAGSTVTDDVPGRALAIGRARQVNKENYVDRLRGKKKS
EECCCCCCCCCCCCEEEECCHHHCCHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA