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The map label for this gene is ksgA [H]

Identifier: 138893714

GI number: 138893714

Start: 47203

End: 48084

Strand: Direct

Name: ksgA [H]

Synonym: GTNG_0035

Alternate gene names: 138893714

Gene position: 47203-48084 (Clockwise)

Preceding gene: 138893713

Following gene: 138893715

Centisome position: 1.33

GC content: 50.79

Gene sequence:

>882_bases
ATGCATAAAGATATTGCGACACCGGGGCGGACGAAAGAAATTTTGGCACGGTACGGCTTTTCGTTTAAAAAGAGCCTCGG
ACAAAACTTTTTAATCGATACGAATATTTTACGAAAAATTGTTGACGCTGCTGGCATTTCCGGCGACACCGGAGCGATTG
AAATCGGGCCTGGCATTGGGGCGCTGACCGAACAGTTGGCGCGGCGGGCCAAAAAAGTGGTCGCCTTTGAAATCGACAGC
CGGTTGCTGCCGATTTTGGCTGATACGTTATCAGCTTATGATAATGTGCGCATTATCCATCAAGATGTGTTAAAAGCCGA
TTTGCATGCGGTGATTGCCGAAGAGTTTGCTGAGGTGAGTGATCGGATGGTCGTGGCGAATTTGCCGTATTACGTGACGA
CGCCAATCATCATGAAACTGCTCACCGAGAGGCTGCCGATCCGCGGTATGGTCGTTATGATGCAAAAAGAAGTAGCTGAC
CGCCTTGCAGCCAAGCCGGGAACGAAAGATTACGGCTCGCTGACGATCGCTGTGCAATATTATACAGAGGCGGAAGTCGT
CATGACGGTGCCGCGCACTGTATTTATGCCACAGCCGAACGTCGACTCCGCTGTCATCCGATTGACGAAACGATCCCATC
CTCCTGTGGCTGTGGAGGACGAAGAGGTGTTTTTTCAAGTGGTGCGGGCAAGCTTTGCTCAGCGTCGCAAAACGCTGTTG
AATAACTTGCTAAACAATTTGCCAGATGGAAAGGAGAAAAAAGAACAAATTGAACGGGCGCTCGATGCTGTAGGCATTGA
TCCGCGCCGTCGTGGGGAAACGCTCGATATGGCTGAATTCGCTTCGTTAAGCAACGCGCTGATGCCGCTTTTCCGCGTCT
AG

Upstream 100 bases:

>100_bases
GCCAACGGCCGACAGTTTCATAAGCGGCTAAAAGTGTTCCGTATTTCTCGAGATGCCTTTTATGCGGCGTTGGCACAAGT
GATGCAGGAGGAGGCAGGCG

Downstream 100 bases:

>100_bases
ACCGCCGTTAAAAGAAAGCGAGACGTCTATCACCTATTGTCCGCGTATGCATATCGTATGGATGACAACGATTATACAAT
GGAGTGAGTGGTGATGGACG

Product: dimethyladenosine transferase

Products: NA

Alternate protein names: 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase; 16S rRNA dimethyladenosine transferase; 16S rRNA dimethylase; S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase [H]

Number of amino acids: Translated: 293; Mature: 293

Protein sequence:

>293_residues
MHKDIATPGRTKEILARYGFSFKKSLGQNFLIDTNILRKIVDAAGISGDTGAIEIGPGIGALTEQLARRAKKVVAFEIDS
RLLPILADTLSAYDNVRIIHQDVLKADLHAVIAEEFAEVSDRMVVANLPYYVTTPIIMKLLTERLPIRGMVVMMQKEVAD
RLAAKPGTKDYGSLTIAVQYYTEAEVVMTVPRTVFMPQPNVDSAVIRLTKRSHPPVAVEDEEVFFQVVRASFAQRRKTLL
NNLLNNLPDGKEKKEQIERALDAVGIDPRRRGETLDMAEFASLSNALMPLFRV

Sequences:

>Translated_293_residues
MHKDIATPGRTKEILARYGFSFKKSLGQNFLIDTNILRKIVDAAGISGDTGAIEIGPGIGALTEQLARRAKKVVAFEIDS
RLLPILADTLSAYDNVRIIHQDVLKADLHAVIAEEFAEVSDRMVVANLPYYVTTPIIMKLLTERLPIRGMVVMMQKEVAD
RLAAKPGTKDYGSLTIAVQYYTEAEVVMTVPRTVFMPQPNVDSAVIRLTKRSHPPVAVEDEEVFFQVVRASFAQRRKTLL
NNLLNNLPDGKEKKEQIERALDAVGIDPRRRGETLDMAEFASLSNALMPLFRV
>Mature_293_residues
MHKDIATPGRTKEILARYGFSFKKSLGQNFLIDTNILRKIVDAAGISGDTGAIEIGPGIGALTEQLARRAKKVVAFEIDS
RLLPILADTLSAYDNVRIIHQDVLKADLHAVIAEEFAEVSDRMVVANLPYYVTTPIIMKLLTERLPIRGMVVMMQKEVAD
RLAAKPGTKDYGSLTIAVQYYTEAEVVMTVPRTVFMPQPNVDSAVIRLTKRSHPPVAVEDEEVFFQVVRASFAQRRKTLL
NNLLNNLPDGKEKKEQIERALDAVGIDPRRRGETLDMAEFASLSNALMPLFRV

Specific function: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits [H]

COG id: COG0030

COG function: function code J; Dimethyladenosine transferase (rRNA methylation)

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily [H]

Homologues:

Organism=Homo sapiens, GI7657198, Length=225, Percent_Identity=35.1111111111111, Blast_Score=126, Evalue=2e-29,
Organism=Homo sapiens, GI156415992, Length=292, Percent_Identity=30.8219178082192, Blast_Score=124, Evalue=1e-28,
Organism=Escherichia coli, GI1786236, Length=280, Percent_Identity=34.2857142857143, Blast_Score=153, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI25146882, Length=224, Percent_Identity=35.7142857142857, Blast_Score=129, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI25141369, Length=295, Percent_Identity=30.1694915254237, Blast_Score=115, Evalue=4e-26,
Organism=Saccharomyces cerevisiae, GI6324989, Length=224, Percent_Identity=30.3571428571429, Blast_Score=105, Evalue=8e-24,
Organism=Drosophila melanogaster, GI21358017, Length=234, Percent_Identity=33.7606837606838, Blast_Score=128, Evalue=4e-30,
Organism=Drosophila melanogaster, GI21357273, Length=265, Percent_Identity=28.6792452830189, Blast_Score=97, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023165
- InterPro:   IPR020596
- InterPro:   IPR001737
- InterPro:   IPR020598
- InterPro:   IPR011530 [H]

Pfam domain/function: PF00398 RrnaAD [H]

EC number: =2.1.1.182 [H]

Molecular weight: Translated: 32617; Mature: 32617

Theoretical pI: Translated: 9.20; Mature: 9.20

Prosite motif: PS01131 RRNA_A_DIMETH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHKDIATPGRTKEILARYGFSFKKSLGQNFLIDTNILRKIVDAAGISGDTGAIEIGPGIG
CCCCCCCCCHHHHHHHHHCCHHHHHCCCCCEECHHHHHHHHHHCCCCCCCCEEEECCCCH
ALTEQLARRAKKVVAFEIDSRLLPILADTLSAYDNVRIIHQDVLKADLHAVIAEEFAEVS
HHHHHHHHHHHHHEEEECCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
DRMVVANLPYYVTTPIIMKLLTERLPIRGMVVMMQKEVADRLAAKPGTKDYGSLTIAVQY
CCEEEECCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEE
YTEAEVVMTVPRTVFMPQPNVDSAVIRLTKRSHPPVAVEDEEVFFQVVRASFAQRRKTLL
ECCCEEEEECCCEEECCCCCCCHHHHHHHHCCCCCCEECHHHHHHHHHHHHHHHHHHHHH
NNLLNNLPDGKEKKEQIERALDAVGIDPRRRGETLDMAEFASLSNALMPLFRV
HHHHHHCCCCHHHHHHHHHHHHHCCCCCHHCCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MHKDIATPGRTKEILARYGFSFKKSLGQNFLIDTNILRKIVDAAGISGDTGAIEIGPGIG
CCCCCCCCCHHHHHHHHHCCHHHHHCCCCCEECHHHHHHHHHHCCCCCCCCEEEECCCCH
ALTEQLARRAKKVVAFEIDSRLLPILADTLSAYDNVRIIHQDVLKADLHAVIAEEFAEVS
HHHHHHHHHHHHHEEEECCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
DRMVVANLPYYVTTPIIMKLLTERLPIRGMVVMMQKEVADRLAAKPGTKDYGSLTIAVQY
CCEEEECCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEE
YTEAEVVMTVPRTVFMPQPNVDSAVIRLTKRSHPPVAVEDEEVFFQVVRASFAQRRKTLL
ECCCEEEEECCCEEECCCCCCCHHHHHHHHCCCCCCEECHHHHHHHHHHHHHHHHHHHHH
NNLLNNLPDGKEKKEQIERALDAVGIDPRRRGETLDMAEFASLSNALMPLFRV
HHHHHHCCCCHHHHHHHHHHHHHCCCCCHHCCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA