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The map label for this gene is pyrH

Identifier: 13508371

GI number: 13508371

Start: 758768

End: 759475

Strand: Direct

Name: pyrH

Synonym: MPN632

Alternate gene names: 13508371

Gene position: 758768-759475 (Clockwise)

Preceding gene: 13508370

Following gene: 13508372

Centisome position: 92.94

GC content: 42.23

Gene sequence:

>708_bases
ATGCGCCTAAAGATCCTAATCAAACTAAGCGGTGCTGGCATGAGCGCTGATAGTTCCGAACCGTTTTCCAACCAATTTTT
AGAAACTGTCATCGCTCAACTAAAACAACTAGTACCCAACTACCAAATAGGCATTGTGATTGGTGGGGGCAACATTATGC
GCGGTAAGTCTTGTAGTGACTACAACATTACCGAAATAGCAGGGCACCACTTGGGCATTATGGCCACGGTTATTAACGGC
GCTTTTTTAAAGGCTAAGTTTGATAGTCATAAACTTAACAGCACCCTGTTGAGTGCAGTGAGCTGTCCTAGTTTAGCGAC
CCACATTGTGTCCCAGACCACGATTGATGATGCCTTTAAAAACCATGACATTGTCATTTTTGCGGGCGGTACTGGTAACC
CGTACTTTTCGACTGATACCGCTGTGGCGTTGCGTGCTACCCAAATGCAAGCCGATATTATTCTAATTGGCAAGAATGGT
GTTGATGGGGTTTACACTGCGGATCCTAAAAAGGATAAGCATGCTAAGTTTTTAGCTAGCTTAACTTACGCTGAAGCGAT
TAAGAATGACCTGCAAATCATGGACATTACCGCCTTTACAATGTGTAAGGAAAATAACTTAAAGGTGATCATATTTAACA
TCAATGCCGAGCATGCCATCATTAAGGCATTGAGCAAACAAGGTAAATACACCTTAATAGAAAAATAA

Upstream 100 bases:

>100_bases
AGTAAAGTAATCCATTTTGTGCGCTTTGAAGTTGGTGAAGGCATTGTCAAAGAAGCAGTTGACTTCGCTAGTGAAGTAAG
TGCGCAAATGAAAAAATAAG

Downstream 100 bases:

>100_bases
GCAACTGTTTTTTAGATTAATAACATAATTAAAAGCTGGATCGCTGTTTAATCTCCTGCAGCTTTCCAGCTTTTTTATTA
GCCATTTTCAAAATAACTTT

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK

Number of amino acids: Translated: 235; Mature: 235

Protein sequence:

>235_residues
MRLKILIKLSGAGMSADSSEPFSNQFLETVIAQLKQLVPNYQIGIVIGGGNIMRGKSCSDYNITEIAGHHLGIMATVING
AFLKAKFDSHKLNSTLLSAVSCPSLATHIVSQTTIDDAFKNHDIVIFAGGTGNPYFSTDTAVALRATQMQADIILIGKNG
VDGVYTADPKKDKHAKFLASLTYAEAIKNDLQIMDITAFTMCKENNLKVIIFNINAEHAIIKALSKQGKYTLIEK

Sequences:

>Translated_235_residues
MRLKILIKLSGAGMSADSSEPFSNQFLETVIAQLKQLVPNYQIGIVIGGGNIMRGKSCSDYNITEIAGHHLGIMATVING
AFLKAKFDSHKLNSTLLSAVSCPSLATHIVSQTTIDDAFKNHDIVIFAGGTGNPYFSTDTAVALRATQMQADIILIGKNG
VDGVYTADPKKDKHAKFLASLTYAEAIKNDLQIMDITAFTMCKENNLKVIIFNINAEHAIIKALSKQGKYTLIEK
>Mature_235_residues
MRLKILIKLSGAGMSADSSEPFSNQFLETVIAQLKQLVPNYQIGIVIGGGNIMRGKSCSDYNITEIAGHHLGIMATVING
AFLKAKFDSHKLNSTLLSAVSCPSLATHIVSQTTIDDAFKNHDIVIFAGGTGNPYFSTDTAVALRATQMQADIILIGKNG
VDGVYTADPKKDKHAKFLASLTYAEAIKNDLQIMDITAFTMCKENNLKVIIFNINAEHAIIKALSKQGKYTLIEK

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family

Homologues:

Organism=Escherichia coli, GI1786367, Length=231, Percent_Identity=34.1991341991342, Blast_Score=159, Evalue=1e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRH_MYCPN (P75165)

Other databases:

- EMBL:   U00089
- PIR:   S73536
- RefSeq:   NP_110321.1
- ProteinModelPortal:   P75165
- SMR:   P75165
- GeneID:   877000
- GenomeReviews:   U00089_GR
- KEGG:   mpn:MPN632
- HOGENOM:   HBG497552
- OMA:   YRWQRVL
- ProtClustDB:   CLSK335337
- BioCyc:   MetaCyc:MONOMER-570
- BioCyc:   MPNE272634:MPN632-MONOMER
- BRENDA:   2.7.4.22
- GO:   GO:0005737
- HAMAP:   MF_01220_B
- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963
- Gene3D:   G3DSA:3.40.1160.10
- PIRSF:   PIRSF005650
- TIGRFAMs:   TIGR02075

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.4.22

Molecular weight: Translated: 25421; Mature: 25421

Theoretical pI: Translated: 8.78; Mature: 8.78

Prosite motif: NA

Important sites: BINDING 49-49 BINDING 50-50 BINDING 54-54 BINDING 159-159 BINDING 165-165 BINDING 168-168

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLKILIKLSGAGMSADSSEPFSNQFLETVIAQLKQLVPNYQIGIVIGGGNIMRGKSCSD
CEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEECCCCCCC
YNITEIAGHHLGIMATVINGAFLKAKFDSHKLNSTLLSAVSCPSLATHIVSQTTIDDAFK
CCHHHHCCCHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHC
NHDIVIFAGGTGNPYFSTDTAVALRATQMQADIILIGKNGVDGVYTADPKKDKHAKFLAS
CCCEEEEECCCCCCCCCCCCEEEEEEEEEEEEEEEEECCCCCCEEECCCCCCHHHHHHHH
LTYAEAIKNDLQIMDITAFTMCKENNLKVIIFNINAEHAIIKALSKQGKYTLIEK
HHHHHHHHCCCEEEEEEEEEEEECCCCEEEEEECCCCHHHHHHHHCCCCEEEECC
>Mature Secondary Structure
MRLKILIKLSGAGMSADSSEPFSNQFLETVIAQLKQLVPNYQIGIVIGGGNIMRGKSCSD
CEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEECCCCCCC
YNITEIAGHHLGIMATVINGAFLKAKFDSHKLNSTLLSAVSCPSLATHIVSQTTIDDAFK
CCHHHHCCCHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHC
NHDIVIFAGGTGNPYFSTDTAVALRATQMQADIILIGKNGVDGVYTADPKKDKHAKFLAS
CCCEEEEECCCCCCCCCCCCEEEEEEEEEEEEEEEEECCCCCCEEECCCCCCHHHHHHHH
LTYAEAIKNDLQIMDITAFTMCKENNLKVIIFNINAEHAIIKALSKQGKYTLIEK
HHHHHHHHCCCEEEEEEEEEEEECCCCEEEEEECCCCHHHHHHHHCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8948633