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The map label for this gene is trxB

Identifier: 13507979

GI number: 13507979

Start: 292328

End: 293275

Strand: Direct

Name: trxB

Synonym: MPN240

Alternate gene names: 13507979

Gene position: 292328-293275 (Clockwise)

Preceding gene: 13507978

Following gene: 13507980

Centisome position: 35.81

GC content: 42.72

Gene sequence:

>948_bases
ATGCTTAAAGTAAAGTCAGATTTTTTAACTAAAGATCAGGTTATTTACGATGTAGCGATAGTGGGTGCTGGGCCAGCTGG
CATAGCAGCGGGTATTTATGGCAAACGCGCTAACCTCAATCTAGCCATTATTGAAGGTAGTACTCCCGGCGGTAAGGTTG
TCAAAACCAACATTGTCGAGAACTATCCGGGTTACAAGTCAATTACCGGACCTGACTTGGGGTTGGAAATGTACAACCAC
CTAATTGATTTAGAGCCCACCTTTTTCTATGCTAACCTAATTAAGTTAGATAAGGCAGCAGATACCTTTATCTTGTACCT
CGATGACAAAACTGTGGTGTTTGCCAAAACCGTTATTTACGCTACGGGAATGTTGGAGCGTAAACTGGGCGTAGCCAAAG
AAGACCACTTTTACGGTAAGGGAATTAGTTACTGTGCCATTTGTGATGGGTCCTTGTACAAAGACCAGGTGGTGGGTGTT
GTTGGTGGGGGGAACTCTGCCATTCAGGAAGCGTTGTATTTAGCTAGCATGGCTAAAACGGTGCACTTAATCCACCGCCG
TGAGGGCTTTCGTGCTGATGAAACGGCGTTAAATAAACTGAGAAACTTACCGAATGTTGTTTTTCACTTGAACTATACCG
TAAAAGAATTGTTGGGTAACAATACCCTAAACGGCATAGTGCTTCAAAACACGCTCGATCATTCAACAAAACAGATAGAT
CTCAATTGTGTCTTTCCCTATATTGGTTTTGAAAGTATTACCAAACCGGTGGAACACCTCAACTTAAAGTTAGATCCCCA
GGGTTTTTTAATTACCAATGAACAGATGGAAACAAGTTTAAAGGGTCTGTTTGCAGCAGGTGATTGTCGTTCTAAGCACT
TCCGTCAAATTGGTACTGCCATTAATGACGGCATTATCGCGGTGTTAACGATCCGTGATGTCCTTTAG

Upstream 100 bases:

>100_bases
ACTAAGAACTTACTGATCTACGACCTCTTTTATGATGACAACAATAAGTTCATAGTAGCAATGCGCTCTGAATATTTAAA
CCCCCGCATCAAAATTATTA

Downstream 100 bases:

>100_bases
TGTTCAGATTAAGCACGAGTTAGCCACCAACCCTTTAATTAAAACAGAGTGATCCAGCTTTTTAGCTGGTTATTTTCAAA
ACGGGTTAAAACTACTCGCT

Product: thioredoxin reductase

Products: NA

Alternate protein names: TRXR

Number of amino acids: Translated: 315; Mature: 315

Protein sequence:

>315_residues
MLKVKSDFLTKDQVIYDVAIVGAGPAGIAAGIYGKRANLNLAIIEGSTPGGKVVKTNIVENYPGYKSITGPDLGLEMYNH
LIDLEPTFFYANLIKLDKAADTFILYLDDKTVVFAKTVIYATGMLERKLGVAKEDHFYGKGISYCAICDGSLYKDQVVGV
VGGGNSAIQEALYLASMAKTVHLIHRREGFRADETALNKLRNLPNVVFHLNYTVKELLGNNTLNGIVLQNTLDHSTKQID
LNCVFPYIGFESITKPVEHLNLKLDPQGFLITNEQMETSLKGLFAAGDCRSKHFRQIGTAINDGIIAVLTIRDVL

Sequences:

>Translated_315_residues
MLKVKSDFLTKDQVIYDVAIVGAGPAGIAAGIYGKRANLNLAIIEGSTPGGKVVKTNIVENYPGYKSITGPDLGLEMYNH
LIDLEPTFFYANLIKLDKAADTFILYLDDKTVVFAKTVIYATGMLERKLGVAKEDHFYGKGISYCAICDGSLYKDQVVGV
VGGGNSAIQEALYLASMAKTVHLIHRREGFRADETALNKLRNLPNVVFHLNYTVKELLGNNTLNGIVLQNTLDHSTKQID
LNCVFPYIGFESITKPVEHLNLKLDPQGFLITNEQMETSLKGLFAAGDCRSKHFRQIGTAINDGIIAVLTIRDVL
>Mature_315_residues
MLKVKSDFLTKDQVIYDVAIVGAGPAGIAAGIYGKRANLNLAIIEGSTPGGKVVKTNIVENYPGYKSITGPDLGLEMYNH
LIDLEPTFFYANLIKLDKAADTFILYLDDKTVVFAKTVIYATGMLERKLGVAKEDHFYGKGISYCAICDGSLYKDQVVGV
VGGGNSAIQEALYLASMAKTVHLIHRREGFRADETALNKLRNLPNVVFHLNYTVKELLGNNTLNGIVLQNTLDHSTKQID
LNCVFPYIGFESITKPVEHLNLKLDPQGFLITNEQMETSLKGLFAAGDCRSKHFRQIGTAINDGIIAVLTIRDVL

Specific function: Unknown

COG id: COG0492

COG function: function code O; Thioredoxin reductase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family

Homologues:

Organism=Escherichia coli, GI1787114, Length=301, Percent_Identity=36.8770764119601, Blast_Score=180, Evalue=9e-47,
Organism=Escherichia coli, GI87081763, Length=305, Percent_Identity=32.4590163934426, Blast_Score=128, Evalue=5e-31,
Organism=Saccharomyces cerevisiae, GI6321898, Length=307, Percent_Identity=29.3159609120521, Blast_Score=140, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6320560, Length=305, Percent_Identity=28.5245901639344, Blast_Score=125, Evalue=6e-30,

Paralogues:

None

Copy number: 808 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): TRXB_MYCPN (P75531)

Other databases:

- EMBL:   U51988
- EMBL:   U00089
- PIR:   S73917
- RefSeq:   NP_109928.1
- ProteinModelPortal:   P75531
- SMR:   P75531
- GeneID:   877259
- GenomeReviews:   U00089_GR
- KEGG:   mpn:MPN240
- HOGENOM:   HBG669726
- OMA:   ASEVHIF
- ProtClustDB:   CLSK542145
- BioCyc:   MetaCyc:MONOMER-543
- BioCyc:   MPNE272634:MPN240-MONOMER
- BRENDA:   1.8.1.9
- GO:   GO:0005737
- InterPro:   IPR013027
- InterPro:   IPR008255
- InterPro:   IPR001327
- InterPro:   IPR000103
- InterPro:   IPR005982
- PRINTS:   PR00368
- PRINTS:   PR00469
- TIGRFAMs:   TIGR01292

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2

EC number: =1.8.1.9

Molecular weight: Translated: 34532; Mature: 34532

Theoretical pI: Translated: 7.23; Mature: 7.23

Prosite motif: PS00573 PYRIDINE_REDOX_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKVKSDFLTKDQVIYDVAIVGAGPAGIAAGIYGKRANLNLAIIEGSTPGGKVVKTNIVE
CCEECCCCCCCCCEEEEEEEECCCCHHHHHCCCCCCCCCEEEEEECCCCCCCEEEEEEHH
NYPGYKSITGPDLGLEMYNHLIDLEPTFFYANLIKLDKAADTFILYLDDKTVVFAKTVIY
CCCCCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHCCCCCEEEEEECCCEEEEEHHHHH
ATGMLERKLGVAKEDHFYGKGISYCAICDGSLYKDQVVGVVGGGNSAIQEALYLASMAKT
HHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCEEEEEEECCCHHHHHHHHHHHHHHH
VHLIHRREGFRADETALNKLRNLPNVVFHLNYTVKELLGNNTLNGIVLQNTLDHSTKQID
HHHHHHHCCCCCHHHHHHHHHCCCCEEEEECHHHHHHHCCCCCCCEEEECCCCCCCEEEE
LNCVFPYIGFESITKPVEHLNLKLDPQGFLITNEQMETSLKGLFAAGDCRSKHFRQIGTA
EEEEECCCCHHHHHCHHHHCEEEECCCCEEEECHHHHHHHHHEEECCCHHHHHHHHHHHH
INDGIIAVLTIRDVL
HCCCEEEEEEEEECC
>Mature Secondary Structure
MLKVKSDFLTKDQVIYDVAIVGAGPAGIAAGIYGKRANLNLAIIEGSTPGGKVVKTNIVE
CCEECCCCCCCCCEEEEEEEECCCCHHHHHCCCCCCCCCEEEEEECCCCCCCEEEEEEHH
NYPGYKSITGPDLGLEMYNHLIDLEPTFFYANLIKLDKAADTFILYLDDKTVVFAKTVIY
CCCCCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHCCCCCEEEEEECCCEEEEEHHHHH
ATGMLERKLGVAKEDHFYGKGISYCAICDGSLYKDQVVGVVGGGNSAIQEALYLASMAKT
HHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCEEEEEEECCCHHHHHHHHHHHHHHH
VHLIHRREGFRADETALNKLRNLPNVVFHLNYTVKELLGNNTLNGIVLQNTLDHSTKQID
HHHHHHHCCCCCHHHHHHHHHCCCCEEEEECHHHHHHHCCCCCCCEEEECCCCCCCEEEE
LNCVFPYIGFESITKPVEHLNLKLDPQGFLITNEQMETSLKGLFAAGDCRSKHFRQIGTA
EEEEECCCCHHHHHCHHHHCEEEECCCCEEEECHHHHHHHHHEEECCCHHHHHHHHHHHH
INDGIIAVLTIRDVL
HCCCEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9202470; 8948633