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The map label for this gene is uvrB

Identifier: 13507950

GI number: 13507950

Start: 259641

End: 261614

Strand: Direct

Name: uvrB

Synonym: MPN211

Alternate gene names: 13507950

Gene position: 259641-261614 (Clockwise)

Preceding gene: 13507949

Following gene: 13507951

Centisome position: 31.8

GC content: 44.53

Gene sequence:

>1974_bases
ATGAAAAGTCCAACGAAGGACAGTAAACTGTTCCACCTCAAGAGTAACTTTGCCCCCACTGGGGACCAACCAGCGGCGAT
TGCTAAGTTAGCTGAGTTTCAAACCAATGAACAGGTCTTACTCGGTGCTACGGGTACCGGTAAGACCTTTACGATTGCCA
ACGTTATTCAAAAGGTACAACTGCCTACAGTAGTGATTGCCCACAATAAAACGTTAGCGGGACAGCTTTATCAGGAGTTG
AAGGAGTTATTCCCTAATAATGCGGTGGAGTACTTCATCTCCTACTTTGACTTTTACCAACCAGAGGCTTATCTGCCCGC
TAAGGGGGTTTACATTGAAAAGAGTGCAACTGTTAACGAAGAGATTAAACGGTTACGAGTGTCCACCTTACATTCACTCT
CTACCCGCAAGGATGTGATTGTGGTGGGTTCGGTAGCCAGTATTTACCCAACTTCTTCTCCCGCTGATTTCGCCCAGTAC
TCGCTCTGGTTAGTAGTTGGTAAGGAATACGGTTTAAGTGAGTTAAAAACGCAGTTAATTCACCTAAACTATGTTGTTAA
TAAACAACAGTTAACTCCGGGAAAGTTCCGCTTTCAGGGCGATGTTGTTGAAGTGTTTCCTGGTTATGCGCAGGATTATG
TCTTGCGGCTTTCCTTCTTTGACCAGCAACTAGAACAAATTGCTCGCATCGATCCCTTAACTAACAAGGTATTGGAAACC
CTTAACAGCTTTAAGTTAGGTCCCGCTGATGAGTACATAGTAAACCAAAATGACTTAGGAGTAGCCTTAGACACGATTAA
GGCCGAACTCAAAGATCGCTTAAAGTACTTTGAACGGTTAAACTTCCCCGAACGTGCCCAGCGCTTACAAACGATTACCG
AACACGATTTAGCAGATCTGAAGGCCTGGGGGGTATGTAGTGGCGTGGAAAACTATGCGCGGCATTTAGAACACCGCCCA
CCGCACTCCAAGCCGTATAACATCTTTGATTACTTTACTAAAGGTGAATGGCTATTGGTAGTTGATGAATCCCACCAAAC
GCTACCGCAAATTAAGGGGATGTACAACACCGATATTTCACGGAAACAAAGCCTAATTGAGTACGGTTTTCGCCTCCCTT
CAGCTTTAGACAACCGTCCTTTATCCTATGAGGAATTCCGCCAGGGAATCAACAAGGTCATTTATGTATCCGCTACCCCT
AGGGAAGAGGAAATTCAGTTAAGTCACAACAACGTGGTCGAACAGTTAGTGCGTCCCACCTACCTCTTGGACCCGGAAGT
GATTGTGAAACCGAAGGACAACCAGGTTGAAGACCTAGTGAGTGAAATCATTAACCAAAGAAAACACAACGGTCGTACCT
TTGTCACGGTGTTAACGATTAAGATGGCGGAAAACCTGACTGACTTTTTGAAGGAGCGCAACATTAAGGTAGCGTACATC
CACAAGGATATTAAAGCCTTGGAACGTTTAATTCTGTTAACGGATTTACGCAAAGGTGAGTATGAGTGTTTAGTGGGGAT
TAACTTACTGCGAGAAGGTTTAGATGTTCCTGAAGTTTCACTCGTAGCCATCTTTGACGCTGACATTCCTGGATTACCAC
GCGATGAGCGCAGTTTAATCCAGATAATTGGCCGCGCTGCGCGAAACGTTCATGGCCGGGTGATTATGTATGCCAATACC
ATTAGCGAACAAATGGATAAGGCGATTAAGGAAACGCAACGCCGGCGCACCATCCAAATGGCTTACAACGAACAACACCA
CAAAACACCAATGACGGTGCAAAAACCAATTACCTTAAACCAGCCGATTAAGTTAAAGACCAAAAGCTCAGAGCAGCAAA
AAGCTGCTTTAATTAAGCAGCTAACCAAGGAAATGAAGCAAGCAGCAGCTAACCAAAACTATGAGTTAGCGATTGAGATC
CGCGACTCGATCTTTGAATTGGAAAAGCAATTTCGTGGTAAAATTAAGAGCTAG

Upstream 100 bases:

>100_bases
GTCATTATCCAAATTGCTAACTTAGCGACTCCCGAAGAGTTTGATGAGGAACTAATGAAGGCTAACGCCTTGAAGAAGTT
GCAAGCACTTAGAGAAGCTC

Downstream 100 bases:

>100_bases
CAATGCGTAAACTAATTAAATTAAACGTCATTGTCTTTGTCTTGTTGTACTTGGGCGAGCTGTTTGCCAGCCTTTCGTTC
AAGTTAATCAGTTGCCTCAA

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B

Number of amino acids: Translated: 657; Mature: 657

Protein sequence:

>657_residues
MKSPTKDSKLFHLKSNFAPTGDQPAAIAKLAEFQTNEQVLLGATGTGKTFTIANVIQKVQLPTVVIAHNKTLAGQLYQEL
KELFPNNAVEYFISYFDFYQPEAYLPAKGVYIEKSATVNEEIKRLRVSTLHSLSTRKDVIVVGSVASIYPTSSPADFAQY
SLWLVVGKEYGLSELKTQLIHLNYVVNKQQLTPGKFRFQGDVVEVFPGYAQDYVLRLSFFDQQLEQIARIDPLTNKVLET
LNSFKLGPADEYIVNQNDLGVALDTIKAELKDRLKYFERLNFPERAQRLQTITEHDLADLKAWGVCSGVENYARHLEHRP
PHSKPYNIFDYFTKGEWLLVVDESHQTLPQIKGMYNTDISRKQSLIEYGFRLPSALDNRPLSYEEFRQGINKVIYVSATP
REEEIQLSHNNVVEQLVRPTYLLDPEVIVKPKDNQVEDLVSEIINQRKHNGRTFVTVLTIKMAENLTDFLKERNIKVAYI
HKDIKALERLILLTDLRKGEYECLVGINLLREGLDVPEVSLVAIFDADIPGLPRDERSLIQIIGRAARNVHGRVIMYANT
ISEQMDKAIKETQRRRTIQMAYNEQHHKTPMTVQKPITLNQPIKLKTKSSEQQKAALIKQLTKEMKQAAANQNYELAIEI
RDSIFELEKQFRGKIKS

Sequences:

>Translated_657_residues
MKSPTKDSKLFHLKSNFAPTGDQPAAIAKLAEFQTNEQVLLGATGTGKTFTIANVIQKVQLPTVVIAHNKTLAGQLYQEL
KELFPNNAVEYFISYFDFYQPEAYLPAKGVYIEKSATVNEEIKRLRVSTLHSLSTRKDVIVVGSVASIYPTSSPADFAQY
SLWLVVGKEYGLSELKTQLIHLNYVVNKQQLTPGKFRFQGDVVEVFPGYAQDYVLRLSFFDQQLEQIARIDPLTNKVLET
LNSFKLGPADEYIVNQNDLGVALDTIKAELKDRLKYFERLNFPERAQRLQTITEHDLADLKAWGVCSGVENYARHLEHRP
PHSKPYNIFDYFTKGEWLLVVDESHQTLPQIKGMYNTDISRKQSLIEYGFRLPSALDNRPLSYEEFRQGINKVIYVSATP
REEEIQLSHNNVVEQLVRPTYLLDPEVIVKPKDNQVEDLVSEIINQRKHNGRTFVTVLTIKMAENLTDFLKERNIKVAYI
HKDIKALERLILLTDLRKGEYECLVGINLLREGLDVPEVSLVAIFDADIPGLPRDERSLIQIIGRAARNVHGRVIMYANT
ISEQMDKAIKETQRRRTIQMAYNEQHHKTPMTVQKPITLNQPIKLKTKSSEQQKAALIKQLTKEMKQAAANQNYELAIEI
RDSIFELEKQFRGKIKS
>Mature_657_residues
MKSPTKDSKLFHLKSNFAPTGDQPAAIAKLAEFQTNEQVLLGATGTGKTFTIANVIQKVQLPTVVIAHNKTLAGQLYQEL
KELFPNNAVEYFISYFDFYQPEAYLPAKGVYIEKSATVNEEIKRLRVSTLHSLSTRKDVIVVGSVASIYPTSSPADFAQY
SLWLVVGKEYGLSELKTQLIHLNYVVNKQQLTPGKFRFQGDVVEVFPGYAQDYVLRLSFFDQQLEQIARIDPLTNKVLET
LNSFKLGPADEYIVNQNDLGVALDTIKAELKDRLKYFERLNFPERAQRLQTITEHDLADLKAWGVCSGVENYARHLEHRP
PHSKPYNIFDYFTKGEWLLVVDESHQTLPQIKGMYNTDISRKQSLIEYGFRLPSALDNRPLSYEEFRQGINKVIYVSATP
REEEIQLSHNNVVEQLVRPTYLLDPEVIVKPKDNQVEDLVSEIINQRKHNGRTFVTVLTIKMAENLTDFLKERNIKVAYI
HKDIKALERLILLTDLRKGEYECLVGINLLREGLDVPEVSLVAIFDADIPGLPRDERSLIQIIGRAARNVHGRVIMYANT
ISEQMDKAIKETQRRRTIQMAYNEQHHKTPMTVQKPITLNQPIKLKTKSSEQQKAALIKQLTKEMKQAAANQNYELAIEI
RDSIFELEKQFRGKIKS

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI1786996, Length=670, Percent_Identity=47.3134328358209, Blast_Score=569, Evalue=1e-163,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRB_MYCPN (P75558)

Other databases:

- EMBL:   U00089
- PIR:   S73946
- RefSeq:   NP_109899.1
- ProteinModelPortal:   P75558
- GeneID:   877052
- GenomeReviews:   U00089_GR
- KEGG:   mpn:MPN211
- HOGENOM:   HBG703949
- OMA:   EKDLAIN
- ProtClustDB:   PRK05298
- BioCyc:   MPNE272634:MPN211-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00204
- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055
- SMART:   SM00487
- SMART:   SM00490
- TIGRFAMs:   TIGR00631

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR; SSF46600 UvrB_C

EC number: NA

Molecular weight: Translated: 75194; Mature: 75194

Theoretical pI: Translated: 8.86; Mature: 8.86

Prosite motif: PS51192 HELICASE_ATP_BIND_1; PS51194 HELICASE_CTER; PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSPTKDSKLFHLKSNFAPTGDQPAAIAKLAEFQTNEQVLLGATGTGKTFTIANVIQKVQ
CCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCEEEHHHHHHHHC
LPTVVIAHNKTLAGQLYQELKELFPNNAVEYFISYFDFYQPEAYLPAKGVYIEKSATVNE
CCEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCHHH
EIKRLRVSTLHSLSTRKDVIVVGSVASIYPTSSPADFAQYSLWLVVGKEYGLSELKTQLI
HHHHHHHHHHHHHCCCCCEEEEECHHHHCCCCCCCHHHHEEEEEEEECCCCHHHHHHHHH
HLNYVVNKQQLTPGKFRFQGDVVEVFPGYAQDYVLRLSFFDQQLEQIARIDPLTNKVLET
HEEEEEECCCCCCCCEEECCCHHEECCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
LNSFKLGPADEYIVNQNDLGVALDTIKAELKDRLKYFERLNFPERAQRLQTITEHDLADL
HHHCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
KAWGVCSGVENYARHLEHRPPHSKPYNIFDYFTKGEWLLVVDESHQTLPQIKGMYNTDIS
HHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCEEEEECCCCHHHHHHCCCCCCCHH
RKQSLIEYGFRLPSALDNRPLSYEEFRQGINKVIYVSATPREEEIQLSHNNVVEQLVRPT
HHHHHHHHHCCCCHHHCCCCCCHHHHHHCCCEEEEEECCCCCHHEEEHHHHHHHHHHCCC
YLLDPEVIVKPKDNQVEDLVSEIINQRKHNGRTFVTVLTIKMAENLTDFLKERNIKVAYI
EEECCCEEECCCCCHHHHHHHHHHHHHHCCCCEEEEEEEHHHHHHHHHHHHHCCCEEEEE
HKDIKALERLILLTDLRKGEYECLVGINLLREGLDVPEVSLVAIFDADIPGLPRDERSLI
HHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHCCCCCCCEEEEEEEECCCCCCCCCHHHHH
QIIGRAARNVHGRVIMYANTISEQMDKAIKETQRRRTIQMAYNEQHHKTPMTVQKPITLN
HHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCC
QPIKLKTKSSEQQKAALIKQLTKEMKQAAANQNYELAIEIRDSIFELEKQFRGKIKS
CCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MKSPTKDSKLFHLKSNFAPTGDQPAAIAKLAEFQTNEQVLLGATGTGKTFTIANVIQKVQ
CCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCEEEHHHHHHHHC
LPTVVIAHNKTLAGQLYQELKELFPNNAVEYFISYFDFYQPEAYLPAKGVYIEKSATVNE
CCEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCHHH
EIKRLRVSTLHSLSTRKDVIVVGSVASIYPTSSPADFAQYSLWLVVGKEYGLSELKTQLI
HHHHHHHHHHHHHCCCCCEEEEECHHHHCCCCCCCHHHHEEEEEEEECCCCHHHHHHHHH
HLNYVVNKQQLTPGKFRFQGDVVEVFPGYAQDYVLRLSFFDQQLEQIARIDPLTNKVLET
HEEEEEECCCCCCCCEEECCCHHEECCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
LNSFKLGPADEYIVNQNDLGVALDTIKAELKDRLKYFERLNFPERAQRLQTITEHDLADL
HHHCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
KAWGVCSGVENYARHLEHRPPHSKPYNIFDYFTKGEWLLVVDESHQTLPQIKGMYNTDIS
HHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCEEEEECCCCHHHHHHCCCCCCCHH
RKQSLIEYGFRLPSALDNRPLSYEEFRQGINKVIYVSATPREEEIQLSHNNVVEQLVRPT
HHHHHHHHHCCCCHHHCCCCCCHHHHHHCCCEEEEEECCCCCHHEEEHHHHHHHHHHCCC
YLLDPEVIVKPKDNQVEDLVSEIINQRKHNGRTFVTVLTIKMAENLTDFLKERNIKVAYI
EEECCCEEECCCCCHHHHHHHHHHHHHHCCCCEEEEEEEHHHHHHHHHHHHHCCCEEEEE
HKDIKALERLILLTDLRKGEYECLVGINLLREGLDVPEVSLVAIFDADIPGLPRDERSLI
HHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHCCCCCCCEEEEEEEECCCCCCCCCHHHHH
QIIGRAARNVHGRVIMYANTISEQMDKAIKETQRRRTIQMAYNEQHHKTPMTVQKPITLN
HHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCC
QPIKLKTKSSEQQKAALIKQLTKEMKQAAANQNYELAIEIRDSIFELEKQFRGKIKS
CCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8948633