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The map label for this gene is uvrC [H]

Identifier: 13507864

GI number: 13507864

Start: 161817

End: 163577

Strand: Direct

Name: uvrC [H]

Synonym: MPN125

Alternate gene names: 13507864

Gene position: 161817-163577 (Clockwise)

Preceding gene: 13507862

Following gene: 13507865

Centisome position: 19.82

GC content: 41.4

Gene sequence:

>1761_bases
TTGATCATCGTGAACAATACGCTCGCTTTTAAGTTAAAGAACGCACCCCATAAGCCAGGCTGCTATTTGTGAAAGGATGA
CGCTGGTCAAGTTTTGTATGTCGGGAAGGCTAAGGACATCTTTAAGCGGGTACACCATTACTTTAATCCAAACCGTTCCT
TTAAAACACGGGCACTAGTGGAACGAATTGCGGATGTCGAATACGTCATTTTGAAAAATGAAAATGATGCTTTGAACTTA
GAGGCCAAACTAATTAAACAGTACAAACCGCGCTTTAATTTAGTTTTAAAGGAAAATAATGGTTATCTCTATTTCTTTAT
TACCGCCAGTGTTAAACCCACCTTGGAATTGGGCCGCCGGTATGAGTTTTCCAAGAATAAGTACTTCGGTCCGTTTGCAT
CGAGTAAGTTTCGACTGCGTGACATTTATGACCTGTTGTTAAAGCTGTTTCCATTACGCAAGTGCGCGCCCCATGAACGG
GGTCACCCCTGCTTTTACTATCAGCTTAAAATGTGCATGGGTCAGTGTATGGGCGAGGATACACCGGAACGTTACCAGAC
CACCGTCAAGGGAATTGAACAGTTTTTTAACCACGGTCCCGAGCAGGTTTTAAACCACTTGCAACAGCAAGAAATCAAGG
CTAGTGAACAACAAAACTTTGAAGCAGCACGCCACTTCTTGGACTTACAGAAAGCCGTTTTAGAACTAGTGAACATGCAA
CAAACGGCCTTCATTAAAGCAAAGCAAAGCCATGACTTTATTGGTTATGTCTTTGAGAAAAATGTGTTAGCCATTACCGT
CTTTGCTTACGTTGATAACCAACTAATAGGCAAAAACCAGCAGGTCTTTGAACTACCACAGGACGATGAAAAGGAAGTTG
AAAGTGCTTTGGTTACCTTTATTTACCACTATTATTCCACCAATAAGATACCCAAAACCCTTACAGTTTCTTTAAGCGAA
GAGAATTTGAGCTTACTGGCCAACAGTCTTAAAATTAATGTTACGCAACCAAAAAACGGCGAGCAAAAATCCATTTTGCA
AACCGTGATTGACAACGCCCGTTATGCCTTAAACACCAAGTGAACTGGGTTTATCAATAACCTTAACCGTGCCGAAGTGC
ACCAGCAATTAGCGCAGCTTTTACAAGTTCCTTCGATTCAAAGTCTGGAAATTATTGACATCTCCTTTTATGACAAAGAC
CACGTGGTGGGGGCGATGTTACGGTACGAAAATGGCAAACGGATGAAAGCGTTATCACGCCGTTACAACATTAACATTGA
CCATAAGGGTGACACTAACTATATGGCTGATGTGGTGTACCGCCGGATTATTTCGTCCATCCAAACCCATAAACAGCTAC
CTTTAAGTGATCTTTTAATTGTCGATGGTGGGATTGCCCAAATTAATACGGTAACCAAGGTGTTTGCCTCTTTCCCTAAC
GTTACCCAACCGATCATTATTGGCTTAGCGAAAAACACCCGTCACCAAACTGACCACATTGTGTTAACGGATAACACTAC
CATTAACATTGACAAAAATACGCCTTTGTTTGCTTATCTTACCACCATTCAAGAAGAGGTCGATAGCTTTGCCAAACACA
ATGCCTTTAAGCGAGTTAGTCGCGCTCGCTTCCAAAATCCACTCTTACAAATTGAAGGGGTTGGGCGAAAAACTGTCCAA
ATATTACTTGATAATTTTCAAACAAATGCAAAACATTGAAGCTGCTTCTTTGAGCGAATTATCACAGTTTATTCCTGCTA
A

Upstream 100 bases:

>100_bases
TGGATAGGCAATATATTCGTTGATGATGGCCTTGAGAATTTGGGCTTGTCGGGTAGTTAAATTTTTCATTAGGTTATCCT
AATTTTATTTTGTTAGCCGC

Downstream 100 bases:

>100_bases
TTTAGCACAAAAAATTAAAACTTTTCTAAAGGAAAATGACTAAAGTATTAGTGTTATCAGACACCCATGGCTATAACGAT
AGGTGACTAGCCGTTATGAA

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C [H]

Number of amino acids: Translated: 586; Mature: 586

Protein sequence:

>586_residues
MIIVNNTLAFKLKNAPHKPGCYLWKDDAGQVLYVGKAKDIFKRVHHYFNPNRSFKTRALVERIADVEYVILKNENDALNL
EAKLIKQYKPRFNLVLKENNGYLYFFITASVKPTLELGRRYEFSKNKYFGPFASSKFRLRDIYDLLLKLFPLRKCAPHER
GHPCFYYQLKMCMGQCMGEDTPERYQTTVKGIEQFFNHGPEQVLNHLQQQEIKASEQQNFEAARHFLDLQKAVLELVNMQ
QTAFIKAKQSHDFIGYVFEKNVLAITVFAYVDNQLIGKNQQVFELPQDDEKEVESALVTFIYHYYSTNKIPKTLTVSLSE
ENLSLLANSLKINVTQPKNGEQKSILQTVIDNARYALNTKWTGFINNLNRAEVHQQLAQLLQVPSIQSLEIIDISFYDKD
HVVGAMLRYENGKRMKALSRRYNINIDHKGDTNYMADVVYRRIISSIQTHKQLPLSDLLIVDGGIAQINTVTKVFASFPN
VTQPIIIGLAKNTRHQTDHIVLTDNTTINIDKNTPLFAYLTTIQEEVDSFAKHNAFKRVSRARFQNPLLQIEGVGRKTVQ
ILLDNFQTNAKHWSCFFERIITVYSC

Sequences:

>Translated_586_residues
MIIVNNTLAFKLKNAPHKPGCYL*KDDAGQVLYVGKAKDIFKRVHHYFNPNRSFKTRALVERIADVEYVILKNENDALNL
EAKLIKQYKPRFNLVLKENNGYLYFFITASVKPTLELGRRYEFSKNKYFGPFASSKFRLRDIYDLLLKLFPLRKCAPHER
GHPCFYYQLKMCMGQCMGEDTPERYQTTVKGIEQFFNHGPEQVLNHLQQQEIKASEQQNFEAARHFLDLQKAVLELVNMQ
QTAFIKAKQSHDFIGYVFEKNVLAITVFAYVDNQLIGKNQQVFELPQDDEKEVESALVTFIYHYYSTNKIPKTLTVSLSE
ENLSLLANSLKINVTQPKNGEQKSILQTVIDNARYALNTK*TGFINNLNRAEVHQQLAQLLQVPSIQSLEIIDISFYDKD
HVVGAMLRYENGKRMKALSRRYNINIDHKGDTNYMADVVYRRIISSIQTHKQLPLSDLLIVDGGIAQINTVTKVFASFPN
VTQPIIIGLAKNTRHQTDHIVLTDNTTINIDKNTPLFAYLTTIQEEVDSFAKHNAFKRVSRARFQNPLLQIEGVGRKTVQ
ILLDNFQTNAKH*SCFFERIITVYSC
>Mature_586_residues
MIIVNNTLAFKLKNAPHKPGCYL*KDDAGQVLYVGKAKDIFKRVHHYFNPNRSFKTRALVERIADVEYVILKNENDALNL
EAKLIKQYKPRFNLVLKENNGYLYFFITASVKPTLELGRRYEFSKNKYFGPFASSKFRLRDIYDLLLKLFPLRKCAPHER
GHPCFYYQLKMCMGQCMGEDTPERYQTTVKGIEQFFNHGPEQVLNHLQQQEIKASEQQNFEAARHFLDLQKAVLELVNMQ
QTAFIKAKQSHDFIGYVFEKNVLAITVFAYVDNQLIGKNQQVFELPQDDEKEVESALVTFIYHYYSTNKIPKTLTVSLSE
ENLSLLANSLKINVTQPKNGEQKSILQTVIDNARYALNTK*TGFINNLNRAEVHQQLAQLLQVPSIQSLEIIDISFYDKD
HVVGAMLRYENGKRMKALSRRYNINIDHKGDTNYMADVVYRRIISSIQTHKQLPLSDLLIVDGGIAQINTVTKVFASFPN
VTQPIIIGLAKNTRHQTDHIVLTDNTTINIDKNTPLFAYLTTIQEEVDSFAKHNAFKRVSRARFQNPLLQIEGVGRKTVQ
ILLDNFQTNAKH*SCFFERIITVYSC

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision [H]

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI87081999, Length=577, Percent_Identity=28.9428076256499, Blast_Score=226, Evalue=4e-60,
Organism=Escherichia coli, GI1788037, Length=185, Percent_Identity=28.1081081081081, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001943
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305 [H]

Pfam domain/function: PF01541 GIY-YIG; PF08459 UvrC_HhH_N [H]

EC number: NA

Molecular weight: Translated: 67159; Mature: 67159

Theoretical pI: Translated: 9.52; Mature: 9.52

Prosite motif: PS50151 UVR ; PS50164 UVRC_1 ; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIVNNTLAFKLKNAPHKPGCYLKDDAGQVLYVGKAKDIFKRVHHYFNPNRSFKTRALVE
CEEECCEEEEEECCCCCCCCCEEECCCCCEEEECCHHHHHHHHHHHHCCCCCHHHHHHHH
RIADVEYVILKNENDALNLEAKLIKQYKPRFNLVLKENNGYLYFFITASVKPTLELGRRY
HHCCCEEEEEECCCCCCCHHHHHHHHCCCCEEEEEEECCCEEEEEEECCCCHHHHHCCCE
EFSKNKYFGPFASSKFRLRDIYDLLLKLFPLRKCAPHERGHPCFYYQLKMCMGQCMGEDT
ECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEHHHHHHHHHHCCCCC
PERYQTTVKGIEQFFNHGPEQVLNHLQQQEIKASEQQNFEAARHFLDLQKAVLELVNMQQ
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
TAFIKAKQSHDFIGYVFEKNVLAITVFAYVDNQLIGKNQQVFELPQDDEKEVESALVTFI
HHEEEECCCCCEEEEEEECCEEEEEEEEHHCCHHCCCCCCEEECCCCCHHHHHHHHHHHH
YHYYSTNKIPKTLTVSLSEENLSLLANSLKINVTQPKNGEQKSILQTVIDNARYALNTKT
HHHHHCCCCCCEEEEEECCCHHHHHEECEEEEEECCCCCCHHHHHHHHHHCCCEEEECCC
GFINNLNRAEVHQQLAQLLQVPSIQSLEIIDISFYDKDHVVGAMLRYENGKRMKALSRRY
CCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCHHHHHHHEECCCCHHHHHHHHH
NINIDHKGDTNYMADVVYRRIISSIQTHKQLPLSDLLIVDGGIAQINTVTKVFASFPNVT
CEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHCCCCCC
QPIIIGLAKNTRHQTDHIVLTDNTTINIDKNTPLFAYLTTIQEEVDSFAKHNAFKRVSRA
CCEEEEEECCCCCCCCEEEEECCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RFQNPLLQIEGVGRKTVQILLDNFQTNAKHSCFFERIITVYSC
HHCCCCEEEECCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIIVNNTLAFKLKNAPHKPGCYLKDDAGQVLYVGKAKDIFKRVHHYFNPNRSFKTRALVE
CEEECCEEEEEECCCCCCCCCEEECCCCCEEEECCHHHHHHHHHHHHCCCCCHHHHHHHH
RIADVEYVILKNENDALNLEAKLIKQYKPRFNLVLKENNGYLYFFITASVKPTLELGRRY
HHCCCEEEEEECCCCCCCHHHHHHHHCCCCEEEEEEECCCEEEEEEECCCCHHHHHCCCE
EFSKNKYFGPFASSKFRLRDIYDLLLKLFPLRKCAPHERGHPCFYYQLKMCMGQCMGEDT
ECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEHHHHHHHHHHCCCCC
PERYQTTVKGIEQFFNHGPEQVLNHLQQQEIKASEQQNFEAARHFLDLQKAVLELVNMQQ
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
TAFIKAKQSHDFIGYVFEKNVLAITVFAYVDNQLIGKNQQVFELPQDDEKEVESALVTFI
HHEEEECCCCCEEEEEEECCEEEEEEEEHHCCHHCCCCCCEEECCCCCHHHHHHHHHHHH
YHYYSTNKIPKTLTVSLSEENLSLLANSLKINVTQPKNGEQKSILQTVIDNARYALNTKT
HHHHHCCCCCCEEEEEECCCHHHHHEECEEEEEECCCCCCHHHHHHHHHHCCCEEEECCC
GFINNLNRAEVHQQLAQLLQVPSIQSLEIIDISFYDKDHVVGAMLRYENGKRMKALSRRY
CCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCHHHHHHHEECCCCHHHHHHHHH
NINIDHKGDTNYMADVVYRRIISSIQTHKQLPLSDLLIVDGGIAQINTVTKVFASFPNVT
CEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHCCCCCC
QPIIIGLAKNTRHQTDHIVLTDNTTINIDKNTPLFAYLTTIQEEVDSFAKHNAFKRVSRA
CCEEEEEECCCCCCCCEEEEECCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RFQNPLLQIEGVGRKTVQILLDNFQTNAKHSCFFERIITVYSC
HHCCCCEEEECCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8948633 [H]