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The map label for this gene is gcp [H]

Identifier: 13507798

GI number: 13507798

Start: 75243

End: 76202

Strand: Direct

Name: gcp [H]

Synonym: MPN059

Alternate gene names: 13507798

Gene position: 75243-76202 (Clockwise)

Preceding gene: 13507797

Following gene: 13507799

Centisome position: 9.22

GC content: 43.33

Gene sequence:

>960_bases
ATGGAACAACCTTTGTGTATCTTGGGAATTGAAACCACTTGTGATGACACTAGCATAGGGGTAATCACTGAGAGTAAGGT
ACAAGCACACATTGTTTTATCATCCGCCAAATTACACGCCCAAACTGGTGGCGTAGTGCCCGAAGTTGCAGCTAGGAGTC
ACGAACAAAACTTGCTTAAAGCACTGCAACAATCAGGGGTTGTTTTAGAACAAATTACTCACATTGCTTATGCCGCTAAT
CCGGGATTACCCGGTTGTCTGCATGTGGGAGCTACCTTTGCGCGCAGTTTAAGCTTCTTATTGGACAAACCCTTATTGCC
CATCAACCACCTTTATGCCCACATCTTCTCGGCCTTAATTGACCAAGATATTAATCAGTTAAAACTCCCCGCTTTAGGCT
TAGTGGTGTCCGGGGGGCACACTGCCATTTACCTAATTAAGTCCTTGTTTGACTTGGAGTTAATTGCTGAGACTAGCGAT
GATGCGATTGGCGAAGTTTATGATAAGGTGGGCCGCGCTATGGGTTTTCCTTATCCAGCTGGACCCCAGTTAGATAGTTT
GTTTCAACCGGAGTTAGTTAAGTCACATTATTTCTTTCGTCCTTCCACGAAGTGAACGAAATTTTCCTACTCGGGGTTGA
AGTCACAGTGTTTTACCAAGATTAAACAGTTAAGGGAAAGGAAAGGCTTTAATCCCCAAACCCACGATTGGAATGAGTTT
GCTTCTAACTTCCAGGCCACCATTATTGATCACTACATCAATCATGTCAAGGATGCCATTCAGCAACACCAACCGCAAAT
GTTGCTGTTAGGTGGTGGGGTAAGTGCTAATAAATACTTAAGAGAACAGGTAACACAGTTACAGCTGCCTTACTTAATTG
CGCCGCTCAAGTACACGAGCGATAACGGGGCGATGATTGGTTTTTATGCTAATCTTTTAATTAATGGCAAAAACAATTAA

Upstream 100 bases:

>100_bases
ACAATATTAATTGGGCTAACTTAATCGAGAAACCAATTACCCCATTACAAAGGAGTAATTTAACATTATCGTGGCTTGAC
TTTAAGCAACGCTTTTGATA

Downstream 100 bases:

>100_bases
ACATCCCCGATGGGGTAGATATGTAGCAGAAGCAGTTGGTCGTGGTCACCCCGATAAGATCTGTGACCAGATTGCGGACA
GTATCTTAGATGAATGCATT

Product: DNA-binding/iron metalloprotein/AP endonuclease

Products: NA

Alternate protein names: Glycoprotease [H]

Number of amino acids: Translated: 319; Mature: 319

Protein sequence:

>319_residues
MEQPLCILGIETTCDDTSIGVITESKVQAHIVLSSAKLHAQTGGVVPEVAARSHEQNLLKALQQSGVVLEQITHIAYAAN
PGLPGCLHVGATFARSLSFLLDKPLLPINHLYAHIFSALIDQDINQLKLPALGLVVSGGHTAIYLIKSLFDLELIAETSD
DAIGEVYDKVGRAMGFPYPAGPQLDSLFQPELVKSHYFFRPSTKWTKFSYSGLKSQCFTKIKQLRERKGFNPQTHDWNEF
ASNFQATIIDHYINHVKDAIQQHQPQMLLLGGGVSANKYLREQVTQLQLPYLIAPLKYTSDNGAMIGFYANLLINGKNN

Sequences:

>Translated_319_residues
MEQPLCILGIETTCDDTSIGVITESKVQAHIVLSSAKLHAQTGGVVPEVAARSHEQNLLKALQQSGVVLEQITHIAYAAN
PGLPGCLHVGATFARSLSFLLDKPLLPINHLYAHIFSALIDQDINQLKLPALGLVVSGGHTAIYLIKSLFDLELIAETSD
DAIGEVYDKVGRAMGFPYPAGPQLDSLFQPELVKSHYFFRPSTK*TKFSYSGLKSQCFTKIKQLRERKGFNPQTHDWNEF
ASNFQATIIDHYINHVKDAIQQHQPQMLLLGGGVSANKYLREQVTQLQLPYLIAPLKYTSDNGAMIGFYANLLINGKNN
>Mature_319_residues
MEQPLCILGIETTCDDTSIGVITESKVQAHIVLSSAKLHAQTGGVVPEVAARSHEQNLLKALQQSGVVLEQITHIAYAAN
PGLPGCLHVGATFARSLSFLLDKPLLPINHLYAHIFSALIDQDINQLKLPALGLVVSGGHTAIYLIKSLFDLELIAETSD
DAIGEVYDKVGRAMGFPYPAGPQLDSLFQPELVKSHYFFRPSTK*TKFSYSGLKSQCFTKIKQLRERKGFNPQTHDWNEF
ASNFQATIIDHYINHVKDAIQQHQPQMLLLGGGVSANKYLREQVTQLQLPYLIAPLKYTSDNGAMIGFYANLLINGKNN

Specific function: Could Be A Metalloprotease. [C]

COG id: COG0533

COG function: function code O; Metal-dependent proteases with possible chaperone activity

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M22 family [H]

Homologues:

Organism=Homo sapiens, GI116812636, Length=332, Percent_Identity=30.1204819277108, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI8923380, Length=312, Percent_Identity=26.6025641025641, Blast_Score=74, Evalue=1e-13,
Organism=Escherichia coli, GI1789445, Length=313, Percent_Identity=35.7827476038339, Blast_Score=193, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI17557464, Length=339, Percent_Identity=26.2536873156342, Blast_Score=114, Evalue=9e-26,
Organism=Caenorhabditis elegans, GI71995670, Length=328, Percent_Identity=28.3536585365854, Blast_Score=97, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6320099, Length=336, Percent_Identity=27.3809523809524, Blast_Score=118, Evalue=1e-27,
Organism=Drosophila melanogaster, GI20129063, Length=335, Percent_Identity=30.1492537313433, Blast_Score=142, Evalue=3e-34,
Organism=Drosophila melanogaster, GI21357207, Length=321, Percent_Identity=26.1682242990654, Blast_Score=84, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022450
- InterPro:   IPR000905
- InterPro:   IPR017860
- InterPro:   IPR017861 [H]

Pfam domain/function: PF00814 Peptidase_M22 [H]

EC number: =3.4.24.57 [H]

Molecular weight: Translated: 35007; Mature: 35007

Theoretical pI: Translated: 7.19; Mature: 7.19

Prosite motif: PS01016 GLYCOPROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQPLCILGIETTCDDTSIGVITESKVQAHIVLSSAKLHAQTGGVVPEVAARSHEQNLLK
CCCCEEEEEECCCCCCCCEEEEECCCEEEEEEEECHHHHHCCCCCCHHHHHHHHHHHHHH
ALQQSGVVLEQITHIAYAANPGLPGCLHVGATFARSLSFLLDKPLLPINHLYAHIFSALI
HHHHCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
DQDINQLKLPALGLVVSGGHTAIYLIKSLFDLELIAETSDDAIGEVYDKVGRAMGFPYPA
HCCHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHCCCCCC
GPQLDSLFQPELVKSHYFFRPSTKTKFSYSGLKSQCFTKIKQLRERKGFNPQTHDWNEFA
CCCHHHHCCHHHHHHCEEECCCCCCEEECCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
SNFQATIIDHYINHVKDAIQQHQPQMLLLGGGVSANKYLREQVTQLQLPYLIAPLKYTSD
HHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHCCCCEEECEEEECC
NGAMIGFYANLLINGKNN
CCCEEEEEEEEEEECCCC
>Mature Secondary Structure
MEQPLCILGIETTCDDTSIGVITESKVQAHIVLSSAKLHAQTGGVVPEVAARSHEQNLLK
CCCCEEEEEECCCCCCCCEEEEECCCEEEEEEEECHHHHHCCCCCCHHHHHHHHHHHHHH
ALQQSGVVLEQITHIAYAANPGLPGCLHVGATFARSLSFLLDKPLLPINHLYAHIFSALI
HHHHCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
DQDINQLKLPALGLVVSGGHTAIYLIKSLFDLELIAETSDDAIGEVYDKVGRAMGFPYPA
HCCHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHCCCCCC
GPQLDSLFQPELVKSHYFFRPSTKTKFSYSGLKSQCFTKIKQLRERKGFNPQTHDWNEFA
CCCHHHHCCHHHHHHCEEECCCCCCEEECCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
SNFQATIIDHYINHVKDAIQQHQPQMLLLGGGVSANKYLREQVTQLQLPYLIAPLKYTSD
HHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHCCCCEEECEEEECC
NGAMIGFYANLLINGKNN
CCCEEEEEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8948633 [H]