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The map label for this gene is pepA

Identifier: 13476527

GI number: 13476527

Start: 6511067

End: 6512578

Strand: Direct

Name: pepA

Synonym: mlr7868

Alternate gene names: 13476527

Gene position: 6511067-6512578 (Clockwise)

Preceding gene: 13476519

Following gene: 13476528

Centisome position: 92.54

GC content: 64.29

Gene sequence:

>1512_bases
ATGAACCCGAGACCATCGATCGCCTTTGCAAAATTCGCCGCGCCTCAGACGGCGGCGAACAGGAAGGGCACGGTCTTCGT
GCTGTCGGCGGATGACGGCGGCCTGAGCGATGCGGCCAGGGCTTACGATCCCGGCAAGACATTGGAACGAGCCTTTCCGG
TGGCCGAATTCACCGGCAAGTTCGCCGGCGTCGTCGAGATACTGGCGCCGGAAGGAACGTCGCTCGACAGGTTGGTCGCG
ATCGGCGCGGGCAAGGCGGCCGGGCTCGATGAATATGCCTGGCTGAAACTCGGTGGCACCATTGCGGCGTCGCTGCGCAA
GGCAACCGATGTCGCCGTGGTCCTCGACCTGGTCGGCGCTTCGATTGACGGCAAGGACGCCGCCAACCTTGCGGCAGGCA
TTCTCCTGCGCAGCTATTCCTTCGACAAATACAAGACCAGCAAGGACAAGGATGACGCAAAGGCCGATCCGAAGAAGCCG
GTCAAGATAACCATCCACACCGCCGACCCGGCAGGCGCCAAGAAGGCCTTCGCCGATGCCGAGGCGGTGATCGACGGCGT
GCTTCTGGCGCGCGACCTTGTCAACGAACCGGCAAATATACTGGGACCGGTCGAGTTCGCGGCCCGCGCCAAGGAACTCG
AGACGCTCGGCGTCAAGGTCGAGATCCTGACCGAGAAGGAAATGAAGAAGCTCGGCATGGGCTCGCTGCTCGGCGTCGCG
CAAGGCTCGCCGCGCGGCGCGCGCATGGCCGTCATGCAGTGGAACGGCGGCAAACCCAAGGACGGGCCGATCGCTTTCGT
CGGCAAGGGCGTCACTTTCGACACCGGCGGCAATTCGATGAAGCCGGCTTCGGGCATGGAGGATATGAAGGGCGATATGG
GTGGCGCTGCCGCCGTGACCGGCCTCATGCATGCGCTGGCCGCGCGCAAGGCAAAGGCCAATGTCGTCGGCATTATCGGC
CTGGTCGAAAACGCCGTCGATGGCCATGCCCAGCGTCCCGGCGACATCGTCACCTCGATGTCGGGCCAGACCATCGAGGT
GCTCAACACCGACGCCGAGGGGCGTCTCGTGCTGGCCGATGCGCTGTGGTACTGCAACGACCGCTTCCAGCCGAAATTCA
TGGTCAATCTGGCGACGCTGACCGGCGCCATCATGGTCGCGCTCGGCCTGCACTATGCCGGCCTGTTCTCCAACAATGAC
GAATTGGCGGAGAGGCTTGCGGCGGCAGGGCAGGCGACGCAGGAGCGGCTGTGGCGCATGCCGCTCGGCGCCGAATACGA
CAAGCTGATCGATTCCAAGAACGCCGACATGAAGAACATTGGCGGCCGCTATGGCGGCGCCATCATCGCGGCACAATTCC
TGCAGCGTTTCGTCAAGGACACGCCCTGGGCGCATCTCGACATTGCCGGCACGGCCATGGGCTCGCCGTCGAGCGAGATC
AACCAGTCCTGGGGCTCAGGCTTCGGCGTGCGGCTGCTCGACCGGCTGGTGCGCGATCACTACGAGAGCTGA

Upstream 100 bases:

>100_bases
GGGTAGCCATTTTGGCAAAGTCTTGCCAAATGCCGGAAAACGACCAAATGTCGCGGATCGCTTCAAACGCTTCGCGCGCC
ATCCCCGAAAGCAGGACATG

Downstream 100 bases:

>100_bases
CCCTGATCCATGGCCGACGTGCTGTTCTACCATCTGACCGAATCGACCCTGGAGGAGGCGCTGCCAGGCCTGCTCGAGCG
CAGCGTCGATCGTGGCTGGC

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase

Number of amino acids: Translated: 503; Mature: 503

Protein sequence:

>503_residues
MNPRPSIAFAKFAAPQTAANRKGTVFVLSADDGGLSDAARAYDPGKTLERAFPVAEFTGKFAGVVEILAPEGTSLDRLVA
IGAGKAAGLDEYAWLKLGGTIAASLRKATDVAVVLDLVGASIDGKDAANLAAGILLRSYSFDKYKTSKDKDDAKADPKKP
VKITIHTADPAGAKKAFADAEAVIDGVLLARDLVNEPANILGPVEFAARAKELETLGVKVEILTEKEMKKLGMGSLLGVA
QGSPRGARMAVMQWNGGKPKDGPIAFVGKGVTFDTGGNSMKPASGMEDMKGDMGGAAAVTGLMHALAARKAKANVVGIIG
LVENAVDGHAQRPGDIVTSMSGQTIEVLNTDAEGRLVLADALWYCNDRFQPKFMVNLATLTGAIMVALGLHYAGLFSNND
ELAERLAAAGQATQERLWRMPLGAEYDKLIDSKNADMKNIGGRYGGAIIAAQFLQRFVKDTPWAHLDIAGTAMGSPSSEI
NQSWGSGFGVRLLDRLVRDHYES

Sequences:

>Translated_503_residues
MNPRPSIAFAKFAAPQTAANRKGTVFVLSADDGGLSDAARAYDPGKTLERAFPVAEFTGKFAGVVEILAPEGTSLDRLVA
IGAGKAAGLDEYAWLKLGGTIAASLRKATDVAVVLDLVGASIDGKDAANLAAGILLRSYSFDKYKTSKDKDDAKADPKKP
VKITIHTADPAGAKKAFADAEAVIDGVLLARDLVNEPANILGPVEFAARAKELETLGVKVEILTEKEMKKLGMGSLLGVA
QGSPRGARMAVMQWNGGKPKDGPIAFVGKGVTFDTGGNSMKPASGMEDMKGDMGGAAAVTGLMHALAARKAKANVVGIIG
LVENAVDGHAQRPGDIVTSMSGQTIEVLNTDAEGRLVLADALWYCNDRFQPKFMVNLATLTGAIMVALGLHYAGLFSNND
ELAERLAAAGQATQERLWRMPLGAEYDKLIDSKNADMKNIGGRYGGAIIAAQFLQRFVKDTPWAHLDIAGTAMGSPSSEI
NQSWGSGFGVRLLDRLVRDHYES
>Mature_503_residues
MNPRPSIAFAKFAAPQTAANRKGTVFVLSADDGGLSDAARAYDPGKTLERAFPVAEFTGKFAGVVEILAPEGTSLDRLVA
IGAGKAAGLDEYAWLKLGGTIAASLRKATDVAVVLDLVGASIDGKDAANLAAGILLRSYSFDKYKTSKDKDDAKADPKKP
VKITIHTADPAGAKKAFADAEAVIDGVLLARDLVNEPANILGPVEFAARAKELETLGVKVEILTEKEMKKLGMGSLLGVA
QGSPRGARMAVMQWNGGKPKDGPIAFVGKGVTFDTGGNSMKPASGMEDMKGDMGGAAAVTGLMHALAARKAKANVVGIIG
LVENAVDGHAQRPGDIVTSMSGQTIEVLNTDAEGRLVLADALWYCNDRFQPKFMVNLATLTGAIMVALGLHYAGLFSNND
ELAERLAAAGQATQERLWRMPLGAEYDKLIDSKNADMKNIGGRYGGAIIAAQFLQRFVKDTPWAHLDIAGTAMGSPSSEI
NQSWGSGFGVRLLDRLVRDHYES

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family

Homologues:

Organism=Homo sapiens, GI41393561, Length=406, Percent_Identity=38.423645320197, Blast_Score=226, Evalue=5e-59,
Organism=Homo sapiens, GI47155554, Length=319, Percent_Identity=34.7962382445141, Blast_Score=142, Evalue=7e-34,
Organism=Escherichia coli, GI1790710, Length=412, Percent_Identity=41.747572815534, Blast_Score=299, Evalue=3e-82,
Organism=Escherichia coli, GI87082123, Length=351, Percent_Identity=35.8974358974359, Blast_Score=184, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI17556903, Length=313, Percent_Identity=32.2683706070287, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17565172, Length=156, Percent_Identity=34.6153846153846, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24662227, Length=355, Percent_Identity=33.5211267605634, Blast_Score=189, Evalue=3e-48,
Organism=Drosophila melanogaster, GI20129969, Length=357, Percent_Identity=32.4929971988796, Blast_Score=185, Evalue=5e-47,
Organism=Drosophila melanogaster, GI24661038, Length=321, Percent_Identity=35.8255451713396, Blast_Score=181, Evalue=8e-46,
Organism=Drosophila melanogaster, GI21355725, Length=455, Percent_Identity=31.8681318681319, Blast_Score=178, Evalue=9e-45,
Organism=Drosophila melanogaster, GI21355645, Length=289, Percent_Identity=32.8719723183391, Blast_Score=171, Evalue=1e-42,
Organism=Drosophila melanogaster, GI24662223, Length=289, Percent_Identity=32.8719723183391, Blast_Score=171, Evalue=1e-42,
Organism=Drosophila melanogaster, GI161077148, Length=287, Percent_Identity=32.404181184669, Blast_Score=168, Evalue=7e-42,
Organism=Drosophila melanogaster, GI20130057, Length=287, Percent_Identity=32.404181184669, Blast_Score=168, Evalue=7e-42,
Organism=Drosophila melanogaster, GI19922386, Length=334, Percent_Identity=32.9341317365269, Blast_Score=165, Evalue=7e-41,
Organism=Drosophila melanogaster, GI20129963, Length=333, Percent_Identity=31.8318318318318, Blast_Score=159, Evalue=3e-39,
Organism=Drosophila melanogaster, GI221379063, Length=322, Percent_Identity=31.9875776397516, Blast_Score=139, Evalue=3e-33,
Organism=Drosophila melanogaster, GI221379062, Length=322, Percent_Identity=31.9875776397516, Blast_Score=139, Evalue=3e-33,
Organism=Drosophila melanogaster, GI21357381, Length=322, Percent_Identity=31.9875776397516, Blast_Score=139, Evalue=4e-33,
Organism=Drosophila melanogaster, GI24646701, Length=276, Percent_Identity=29.7101449275362, Blast_Score=89, Evalue=7e-18,
Organism=Drosophila melanogaster, GI24646703, Length=276, Percent_Identity=29.7101449275362, Blast_Score=89, Evalue=7e-18,
Organism=Drosophila melanogaster, GI21358201, Length=276, Percent_Identity=29.7101449275362, Blast_Score=89, Evalue=7e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AMPA_RHILO (Q984S1)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_108097.1
- ProteinModelPortal:   Q984S1
- SMR:   Q984S1
- MEROPS:   M17.003
- GeneID:   1230749
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mlr7868
- NMPDR:   fig|266835.1.peg.6196
- HOGENOM:   HBG742580
- OMA:   NMHLMRY
- ProtClustDB:   PRK00913
- BRENDA:   3.4.11.1
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00181
- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283
- PANTHER:   PTHR11963:SF3
- PRINTS:   PR00481

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N

EC number: =3.4.11.1; =3.4.11.10

Molecular weight: Translated: 52902; Mature: 52902

Theoretical pI: Translated: 7.17; Mature: 7.17

Prosite motif: PS00631 CYTOSOL_AP

Important sites: ACT_SITE 281-281 ACT_SITE 355-355

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPRPSIAFAKFAAPQTAANRKGTVFVLSADDGGLSDAARAYDPGKTLERAFPVAEFTGK
CCCCCCEEEEECCCCCCCCCCCCEEEEEECCCCCCCHHHHHCCCCHHHHHHCCHHHHHCC
FAGVVEILAPEGTSLDRLVAIGAGKAAGLDEYAWLKLGGTIAASLRKATDVAVVLDLVGA
HHCEEEEECCCCCCCCCEEEECCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHCC
SIDGKDAANLAAGILLRSYSFDKYKTSKDKDDAKADPKKPVKITIHTADPAGAKKAFADA
CCCCCHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHH
EAVIDGVLLARDLVNEPANILGPVEFAARAKELETLGVKVEILTEKEMKKLGMGSLLGVA
HHHHHHHHHHHHHHCCCHHHHCHHHHHHHHHHHHHHCEEEEEECHHHHHHCCCCHHHHCC
QGSPRGARMAVMQWNGGKPKDGPIAFVGKGVTFDTGGNSMKPASGMEDMKGDMGGAAAVT
CCCCCCCEEEEEEECCCCCCCCCEEEEECCEEEECCCCCCCCCCCHHHHCCCCCHHHHHH
GLMHALAARKAKANVVGIIGLVENAVDGHAQRPGDIVTSMSGQTIEVLNTDAEGRLVLAD
HHHHHHHHHHHCCCEEEEHHHHHHHHCCCCCCCCHHHCCCCCCEEEEEECCCCCCEEEEE
ALWYCNDRFQPKFMVNLATLTGAIMVALGLHYAGLFSNNDELAERLAAAGQATQERLWRM
HHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHCC
PLGAEYDKLIDSKNADMKNIGGRYGGAIIAAQFLQRFVKDTPWAHLDIAGTAMGSPSSEI
CCCCCHHHHHCCCCCCHHHCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHH
NQSWGSGFGVRLLDRLVRDHYES
HHHHCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNPRPSIAFAKFAAPQTAANRKGTVFVLSADDGGLSDAARAYDPGKTLERAFPVAEFTGK
CCCCCCEEEEECCCCCCCCCCCCEEEEEECCCCCCCHHHHHCCCCHHHHHHCCHHHHHCC
FAGVVEILAPEGTSLDRLVAIGAGKAAGLDEYAWLKLGGTIAASLRKATDVAVVLDLVGA
HHCEEEEECCCCCCCCCEEEECCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHCC
SIDGKDAANLAAGILLRSYSFDKYKTSKDKDDAKADPKKPVKITIHTADPAGAKKAFADA
CCCCCHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHH
EAVIDGVLLARDLVNEPANILGPVEFAARAKELETLGVKVEILTEKEMKKLGMGSLLGVA
HHHHHHHHHHHHHHCCCHHHHCHHHHHHHHHHHHHHCEEEEEECHHHHHHCCCCHHHHCC
QGSPRGARMAVMQWNGGKPKDGPIAFVGKGVTFDTGGNSMKPASGMEDMKGDMGGAAAVT
CCCCCCCEEEEEEECCCCCCCCCEEEEECCEEEECCCCCCCCCCCHHHHCCCCCHHHHHH
GLMHALAARKAKANVVGIIGLVENAVDGHAQRPGDIVTSMSGQTIEVLNTDAEGRLVLAD
HHHHHHHHHHHCCCEEEEHHHHHHHHCCCCCCCCHHHCCCCCCEEEEEECCCCCCEEEEE
ALWYCNDRFQPKFMVNLATLTGAIMVALGLHYAGLFSNNDELAERLAAAGQATQERLWRM
HHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHCC
PLGAEYDKLIDSKNADMKNIGGRYGGAIIAAQFLQRFVKDTPWAHLDIAGTAMGSPSSEI
CCCCCHHHHHCCCCCCHHHCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHH
NQSWGSGFGVRLLDRLVRDHYES
HHHHCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11214968