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The map label for this gene is gmk

Identifier: 13476519

GI number: 13476519

Start: 6502013

End: 6502624

Strand: Direct

Name: gmk

Synonym: mlr7857

Alternate gene names: 13476519

Gene position: 6502013-6502624 (Clockwise)

Preceding gene: 13476518

Following gene: 13476527

Centisome position: 92.41

GC content: 62.75

Gene sequence:

>612_bases
ATGCTCGTCCTGTCGTCGCCATCCGGTGCCGGCAAGTCGACGATCGCGCGCAACCTCCTGGAAAGCGATTCCAGCCTCGA
ATTGTCGGTCTCGGTCACGACCAGACCGCGCCGCGGCAGTGAGATCGAGGGGGTTCATTACCATTTCCGTACGATGCGCG
AGTTCGAGCGGTTGCGCGATTCCGACGCTCTGCTCGAGTGGGCGGAGGTGCACGGCAATTGCTATGCGACACCGCGCGAA
CCTGCGGAACTGGCGCTGGCGCAGGGCCGCGACATGCTGTTCGACATCGACTGGCAAGGCGCTCAGCAGTTGAAGGAGAA
GATGCGCGCCGACATCGTCTCGATCTTCATCCTGCCGCCGTCGATGAAGGAATTGAAGGCCCGCCTGAAGCGCCGCGCCG
AGGACCAGGAAGCGGTGATCGAGACGCGGCTGAAGAACGCCCGCAACGAGATCGAGCACTGGAAGGAATATGATTTCGTC
ATCGTCAATGACGATCTCGACCGTGCCTTCGCCGAGGTGCGGGGCATCGTCGTCGCCGAGCGGTTGCGCCGCGACCGCCG
GCCGGGTCTCTTCGATTTCGTCTCGGGGTTGCTGGACGAGAAAACTGTCTAG

Upstream 100 bases:

>100_bases
CCAGTTTCGTGAACAGGTCCAGAATCTGGAGTAGCCGATGGTCGCCAAGGAACCGATGGTTCCCAGGGATTTGGGATCCC
GCATCCGCCGCCGGGGGCTG

Downstream 100 bases:

>100_bases
AGCAATTCCAGGAAAAGTGTGAGCGGTTTTCCCTGGAAAAGCGCGTAGCGCTTTCCCTTGGGAATTGCGTCAAAACAAAG
AGTTAGAGGGTTTCCGCGTT

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase

Number of amino acids: Translated: 203; Mature: 203

Protein sequence:

>203_residues
MLVLSSPSGAGKSTIARNLLESDSSLELSVSVTTRPRRGSEIEGVHYHFRTMREFERLRDSDALLEWAEVHGNCYATPRE
PAELALAQGRDMLFDIDWQGAQQLKEKMRADIVSIFILPPSMKELKARLKRRAEDQEAVIETRLKNARNEIEHWKEYDFV
IVNDDLDRAFAEVRGIVVAERLRRDRRPGLFDFVSGLLDEKTV

Sequences:

>Translated_203_residues
MLVLSSPSGAGKSTIARNLLESDSSLELSVSVTTRPRRGSEIEGVHYHFRTMREFERLRDSDALLEWAEVHGNCYATPRE
PAELALAQGRDMLFDIDWQGAQQLKEKMRADIVSIFILPPSMKELKARLKRRAEDQEAVIETRLKNARNEIEHWKEYDFV
IVNDDLDRAFAEVRGIVVAERLRRDRRPGLFDFVSGLLDEKTV
>Mature_203_residues
MLVLSSPSGAGKSTIARNLLESDSSLELSVSVTTRPRRGSEIEGVHYHFRTMREFERLRDSDALLEWAEVHGNCYATPRE
PAELALAQGRDMLFDIDWQGAQQLKEKMRADIVSIFILPPSMKELKARLKRRAEDQEAVIETRLKNARNEIEHWKEYDFV
IVNDDLDRAFAEVRGIVVAERLRRDRRPGLFDFVSGLLDEKTV

Specific function: Essential for recycling GMP and indirectly, cGMP

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain

Homologues:

Organism=Homo sapiens, GI226874831, Length=194, Percent_Identity=36.5979381443299, Blast_Score=108, Evalue=3e-24,
Organism=Homo sapiens, GI226874833, Length=194, Percent_Identity=36.5979381443299, Blast_Score=108, Evalue=4e-24,
Organism=Homo sapiens, GI4504221, Length=194, Percent_Identity=36.5979381443299, Blast_Score=108, Evalue=4e-24,
Organism=Homo sapiens, GI14780902, Length=184, Percent_Identity=28.804347826087, Blast_Score=78, Evalue=4e-15,
Organism=Homo sapiens, GI38570142, Length=175, Percent_Identity=27.4285714285714, Blast_Score=65, Evalue=3e-11,
Organism=Homo sapiens, GI111154074, Length=174, Percent_Identity=29.3103448275862, Blast_Score=64, Evalue=7e-11,
Organism=Escherichia coli, GI1790080, Length=201, Percent_Identity=47.2636815920398, Blast_Score=173, Evalue=7e-45,
Organism=Caenorhabditis elegans, GI193203132, Length=176, Percent_Identity=36.3636363636364, Blast_Score=102, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17508835, Length=176, Percent_Identity=36.3636363636364, Blast_Score=101, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6320662, Length=183, Percent_Identity=36.6120218579235, Blast_Score=125, Evalue=3e-30,
Organism=Drosophila melanogaster, GI21356141, Length=195, Percent_Identity=37.9487179487179, Blast_Score=115, Evalue=2e-26,
Organism=Drosophila melanogaster, GI161077626, Length=189, Percent_Identity=25.9259259259259, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI116007136, Length=174, Percent_Identity=25.8620689655172, Blast_Score=64, Evalue=5e-11,
Organism=Drosophila melanogaster, GI85724806, Length=174, Percent_Identity=25.8620689655172, Blast_Score=64, Evalue=6e-11,
Organism=Drosophila melanogaster, GI45554481, Length=174, Percent_Identity=25.8620689655172, Blast_Score=64, Evalue=6e-11,
Organism=Drosophila melanogaster, GI45554489, Length=174, Percent_Identity=25.8620689655172, Blast_Score=64, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24640542, Length=174, Percent_Identity=25.8620689655172, Blast_Score=64, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KGUA_RHILO (Q984S9)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_108089.1
- ProteinModelPortal:   Q984S9
- GeneID:   1230741
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mlr7857
- NMPDR:   fig|266835.1.peg.6188
- HOGENOM:   HBG671982
- ProtClustDB:   PRK00300
- BRENDA:   2.7.4.8
- GO:   GO:0005737
- HAMAP:   MF_00328
- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665
- SMART:   SM00072
- TIGRFAMs:   TIGR03263

Pfam domain/function: PF00625 Guanylate_kin

EC number: =2.7.4.8

Molecular weight: Translated: 23341; Mature: 23341

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: PS00856 GUANYLATE_KINASE_1; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVLSSPSGAGKSTIARNLLESDSSLELSVSVTTRPRRGSEIEGVHYHFRTMREFERLRD
CEEECCCCCCCHHHHHHHHHCCCCCEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCC
SDALLEWAEVHGNCYATPREPAELALAQGRDMLFDIDWQGAQQLKEKMRADIVSIFILPP
HHHHHHHHHHCCCEECCCCCHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHEEEEECC
SMKELKARLKRRAEDQEAVIETRLKNARNEIEHWKEYDFVIVNDDLDRAFAEVRGIVVAE
CHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHH
RLRRDRRPGLFDFVSGLLDEKTV
HHHHCCCCCHHHHHHHHHHCCCC
>Mature Secondary Structure
MLVLSSPSGAGKSTIARNLLESDSSLELSVSVTTRPRRGSEIEGVHYHFRTMREFERLRD
CEEECCCCCCCHHHHHHHHHCCCCCEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCC
SDALLEWAEVHGNCYATPREPAELALAQGRDMLFDIDWQGAQQLKEKMRADIVSIFILPP
HHHHHHHHHHCCCEECCCCCHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHEEEEECC
SMKELKARLKRRAEDQEAVIETRLKNARNEIEHWKEYDFVIVNDDLDRAFAEVRGIVVAE
CHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHH
RLRRDRRPGLFDFVSGLLDEKTV
HHHHCCCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968