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The map label for this gene is pyrE

Identifier: 13476437

GI number: 13476437

Start: 6425238

End: 6425816

Strand: Direct

Name: pyrE

Synonym: mlr7756

Alternate gene names: 13476437

Gene position: 6425238-6425816 (Clockwise)

Preceding gene: 13476436

Following gene: 13476438

Centisome position: 91.32

GC content: 66.84

Gene sequence:

>579_bases
ATGAAGACCGATGAAGTGCTGGGCATTTTCCGCGAGGCGGGTGCTGTTCTGGAGGGGCATTTCATCCTGACGTCGGGCCT
GCGCAGCCCGGTCTTCCTGCAGAAGGCACGGGTGTTCATGCATGCCGACAAGACCGAGCGGCTTTGCAGGGCGCTGGCCG
AAAAGATCCGGGCAGCGGTGCCAGGCAAGATCGACTATGTCGTCGGCCCTGCGATCGGCGGCCTGATCCCGGCCTACGAA
ACCTCGCGCCATCTCGGCGTGCCGGCGATCTGGGTCGAGCGGGAAGGGGGCGAGTTCCGCCTGCGCCGCTTCGAGATCGC
CAGGGGTGCGCGCGTCGTCATCGTCGAGGATATCGTCACCACCGGCCTGTCGATCCGCGAAACCATCGAGTGCCTGCGCG
AGCTTGGCGCCGAGGTGGTGGCGGCCGCCTGCATCATCGACCGTTCGGCCGGCAAGACCCATGTCGGCGTGCCGCTGATC
GCGCTCGCCGAATACGAGGTTCCGGCCTATCCGCCGGACCGGCTGCCGCCGGAGCTTGCCGCGATACCTGCGGTCAAGCC
TGGCAGCCGCAACATCTGA

Upstream 100 bases:

>100_bases
TCTCAACCGGCTGCTGTCGCAGCTCAAGGACAATTCGAGCGTCAGCGATGCACGGCGCGTGAATGGCTGACATGGCTGAT
CTATTTGGGGGCAGGCGCAG

Downstream 100 bases:

>100_bases
CCGTGGATGTCGCCCAAAAGTGTGCAGCGGTTTTGGGAGTAACGACATGCATGAAAACAAATTCGAAACGATCGTCGGGA
TCGATCATTTCGTGCTGACG

Product: orotate phosphoribosyltransferase

Products: NA

Alternate protein names: OPRT 2; OPRTase 2

Number of amino acids: Translated: 192; Mature: 192

Protein sequence:

>192_residues
MKTDEVLGIFREAGAVLEGHFILTSGLRSPVFLQKARVFMHADKTERLCRALAEKIRAAVPGKIDYVVGPAIGGLIPAYE
TSRHLGVPAIWVEREGGEFRLRRFEIARGARVVIVEDIVTTGLSIRETIECLRELGAEVVAAACIIDRSAGKTHVGVPLI
ALAEYEVPAYPPDRLPPELAAIPAVKPGSRNI

Sequences:

>Translated_192_residues
MKTDEVLGIFREAGAVLEGHFILTSGLRSPVFLQKARVFMHADKTERLCRALAEKIRAAVPGKIDYVVGPAIGGLIPAYE
TSRHLGVPAIWVEREGGEFRLRRFEIARGARVVIVEDIVTTGLSIRETIECLRELGAEVVAAACIIDRSAGKTHVGVPLI
ALAEYEVPAYPPDRLPPELAAIPAVKPGSRNI
>Mature_192_residues
MKTDEVLGIFREAGAVLEGHFILTSGLRSPVFLQKARVFMHADKTERLCRALAEKIRAAVPGKIDYVVGPAIGGLIPAYE
TSRHLGVPAIWVEREGGEFRLRRFEIARGARVVIVEDIVTTGLSIRETIECLRELGAEVVAAACIIDRSAGKTHVGVPLI
ALAEYEVPAYPPDRLPPELAAIPAVKPGSRNI

Specific function: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)

COG id: COG0461

COG function: function code F; Orotate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily

Homologues:

Organism=Caenorhabditis elegans, GI17508631, Length=139, Percent_Identity=34.5323741007194, Blast_Score=66, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRE2_RHILO (Q985B1)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_108007.1
- ProteinModelPortal:   Q985B1
- SMR:   Q985B1
- GeneID:   1230662
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mlr7756
- NMPDR:   fig|266835.1.peg.6108
- HOGENOM:   HBG404341
- OMA:   FYLQSAK
- ProtClustDB:   PRK00455
- BRENDA:   2.4.2.10
- HAMAP:   MF_01208
- InterPro:   IPR023031
- InterPro:   IPR006273
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01367

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.10

Molecular weight: Translated: 20827; Mature: 20827

Theoretical pI: Translated: 8.08; Mature: 8.08

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: BINDING 120-120 BINDING 148-148

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTDEVLGIFREAGAVLEGHFILTSGLRSPVFLQKARVFMHADKTERLCRALAEKIRAAV
CCCHHHHHHHHHCCCCCCCCEEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHC
PGKIDYVVGPAIGGLIPAYETSRHLGVPAIWVEREGGEFRLRRFEIARGARVVIVEDIVT
CCCEEEEECCHHHCCCCCCCCCCCCCCCEEEEECCCCCEEEEEEEECCCCEEEEEEHHHH
TGLSIRETIECLRELGAEVVAAACIIDRSAGKTHVGVPLIALAEYEVPAYPPDRLPPELA
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCHHH
AIPAVKPGSRNI
HCCCCCCCCCCC
>Mature Secondary Structure
MKTDEVLGIFREAGAVLEGHFILTSGLRSPVFLQKARVFMHADKTERLCRALAEKIRAAV
CCCHHHHHHHHHCCCCCCCCEEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHC
PGKIDYVVGPAIGGLIPAYETSRHLGVPAIWVEREGGEFRLRRFEIARGARVVIVEDIVT
CCCEEEEECCHHHCCCCCCCCCCCCCCCEEEEECCCCCEEEEEEEECCCCEEEEEEHHHH
TGLSIRETIECLRELGAEVVAAACIIDRSAGKTHVGVPLIALAEYEVPAYPPDRLPPELA
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCHHH
AIPAVKPGSRNI
HCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968