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The map label for this gene is rsh [H]

Identifier: 13476436

GI number: 13476436

Start: 6422979

End: 6425207

Strand: Direct

Name: rsh [H]

Synonym: mlr7755

Alternate gene names: 13476436

Gene position: 6422979-6425207 (Clockwise)

Preceding gene: 13476435

Following gene: 13476437

Centisome position: 91.29

GC content: 63.39

Gene sequence:

>2229_bases
ATGATGCGTCAGTATGAGCTTGTCGAGCGCGTCCAGCGCTACAAGCCTGACGTCAATGAGGCGTTGCTCAACAAGGCCTA
TGTCTATGCCATGCAGAAGCATGGCCACCAGAAGCGCGCTTCCGGCGATCCCTATTTCTCGCATCCGCTCGAAGTCGCTG
CCATCCTCACCGAAATGCATATGGACGAGGCAACGATCGCTGTCGCTTTGCTGCACGACACCATCGAAGACACAACCGCG
ACGCGGGCCGAGATCGACGATCTGTTCGGCCCCGAAATGGGCAAGCTGGTCGAGGGCCTGACCAAGCTGAAGAAGCTTGA
TCTCGTCTCCAAGAAGGCCGAGCAGGCGGAGAACCTGCGCAAGCTGCTGCTGGCGATCTCGGAAGACGTCCGCGTGCTGC
TGGTCAAGCTCGCCGACCGCCTGCACAACATGCGCACCCTCGACCACATGCCGGAGGCCAAGCGCCTGCGCATCGCCGAG
GAGACGATGGACATCTATGCGCCGCTGGCCGGGCGCATGGGCATGCAAGGCATGCGCGAGGAGCTGGAGGAGATCGCCTT
CCGCTACATCAATCCGGAAGCCTACCGTGCCGTCACCGCGCGGCTTGCCGAGATCTTCGAACGCAACAAGGGCGTGCTGA
CCGACATCGAAAAGGCGCTGTCGGCGCTGTTTGAAAAGCATGCCATCAACGCCGGCGTGAAGAGCCGCCAGAAGAAGCCG
TGGTCGGTGTTCCGCAAGATGGAGGCCAAGGCGCTTTCCTTCGAGCAACTGTCCGACATTTTCGGCTTTCGTGTCGTCGT
CGATACGGTCGAGGACTGCTATCGCGCGCTCGGCGCCATCCACACCACCTGGTCGATGGTGCCCGGCCGCTTCAAGGACT
ACATCTCGACGCCGAAGCAGAACGACTATCGCTCGATCCACACCACCATCGTCGGCCCCTCGCGCCAGCGCGTCGAACTG
CAGATCCGCACCCGCGAGATGAACAAGATCGCCGAATACGGCGTCGCGGCGCACTCGATCTACAAGGACACCGGCGGCAA
GACGAACGGTGCCGGCCATGCGATCTCGAAGGAGACCAACGCCTATGCCTGGCTGCGGCGCACCATCGAGCAGCTTGCCG
AAGGTGACAATCCCGAGGATTTTCTCGAAAACACCAAGCTGGAACTGTTCCAGGACCAGGTGTTCTGCTTCACTCCGAAA
GGCATGCTGATTGCCTTGCCGCGCGGTGCCACGCCCATCGATTTCGCCTATGCGGTGCACACCGATGTCGGCGACACCTG
TGTCGGCGCCAAGGTCAACGGCCGCATCATGCCGTTGATGACGGAACTGAAGAATGGCGACGAGGTCGAGATCATCCGCT
CCAAGGCGCAAGTGCCGCCGGCGGCGTGGGAATCGGTCGTCGTCACCGGCAAGGCGCGCGCCGCCATCCGCCGGGCCACC
AAGAACGCCATTCGCAAGCAGTATTCCGGCCTCGGCGCGCGTATTCTCGAACGCGCCTTCGAACGCGCCGGCAAGAATTT
CACCAAGGAAAGCCTGAAGCCGGTGCTGCACCGGCTGGCGCGCAAGGATATCGAGGACGTGCTGGCGTCCGTCGGCCGTG
GCGAACTCGCCTCCACCGACGTTATGAAGGCGGTCTTCCCCGACTACAAGGACGAGCGTGTCACGCCGGCAGCGCCCAAG
CAGCGCGAGGAGGGCTGGTCGAAGATCCGCAACGCCGCCGGCATGCTGTTCCAGATTCCGGGCCGCGCCGCGCGCAAGGA
CAAGGACCAGCCGCGCGACGGCGCCGTGCCGATCCGCGGCGTACGCGGCGACCTGCCGGTGCGCTTCGCGCCGGAGGGTG
CTGTGCCCGGCGATCGCATCGTTGGCATCGTCCAGCCGGGCACCGGCATCACCATCTATCCGATCCAGTCGCCGGCGCTG
CAGGCTTTCGATGACCAGCCCGAGCGCTGGATCGATGTGCGCTGGGACATTGACGAGCGCACCAAGGAGCGCTTCCCCGC
GCGTGTCTCGGTCACCGCCATCAATGCGCCGGGCTCGCTCGCCGATATCGCCCAGGTCGTTGCGTCCAACGACGCCAACA
TCCATACGCTGTCGATGGTGCGCACCGCGCCCGACTTCACCGAAATGCTGATCGATCTCGAAGTCTGGGATCTGAAGCAT
CTCAACCGGCTGCTGTCGCAGCTCAAGGACAATTCGAGCGTCAGCGATGCACGGCGCGTGAATGGCTGA

Upstream 100 bases:

>100_bases
GTTTCCGGCACTTCCGTCCCGGCAGTTTCGTGGCTATCTATGACATGCGCCGTACAGCAGTGCGGCGCATGATTCATTTC
ATCGCTGAGAGATTCCGCCC

Downstream 100 bases:

>100_bases
CATGGCTGATCTATTTGGGGGCAGGCGCAGATGAAGACCGATGAAGTGCTGGGCATTTTCCGCGAGGCGGGTGCTGTTCT
GGAGGGGCATTTCATCCTGA

Product: GTP pyrophosphokinase

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase [H]

Number of amino acids: Translated: 742; Mature: 742

Protein sequence:

>742_residues
MMRQYELVERVQRYKPDVNEALLNKAYVYAMQKHGHQKRASGDPYFSHPLEVAAILTEMHMDEATIAVALLHDTIEDTTA
TRAEIDDLFGPEMGKLVEGLTKLKKLDLVSKKAEQAENLRKLLLAISEDVRVLLVKLADRLHNMRTLDHMPEAKRLRIAE
ETMDIYAPLAGRMGMQGMREELEEIAFRYINPEAYRAVTARLAEIFERNKGVLTDIEKALSALFEKHAINAGVKSRQKKP
WSVFRKMEAKALSFEQLSDIFGFRVVVDTVEDCYRALGAIHTTWSMVPGRFKDYISTPKQNDYRSIHTTIVGPSRQRVEL
QIRTREMNKIAEYGVAAHSIYKDTGGKTNGAGHAISKETNAYAWLRRTIEQLAEGDNPEDFLENTKLELFQDQVFCFTPK
GMLIALPRGATPIDFAYAVHTDVGDTCVGAKVNGRIMPLMTELKNGDEVEIIRSKAQVPPAAWESVVVTGKARAAIRRAT
KNAIRKQYSGLGARILERAFERAGKNFTKESLKPVLHRLARKDIEDVLASVGRGELASTDVMKAVFPDYKDERVTPAAPK
QREEGWSKIRNAAGMLFQIPGRAARKDKDQPRDGAVPIRGVRGDLPVRFAPEGAVPGDRIVGIVQPGTGITIYPIQSPAL
QAFDDQPERWIDVRWDIDERTKERFPARVSVTAINAPGSLADIAQVVASNDANIHTLSMVRTAPDFTEMLIDLEVWDLKH
LNRLLSQLKDNSSVSDARRVNG

Sequences:

>Translated_742_residues
MMRQYELVERVQRYKPDVNEALLNKAYVYAMQKHGHQKRASGDPYFSHPLEVAAILTEMHMDEATIAVALLHDTIEDTTA
TRAEIDDLFGPEMGKLVEGLTKLKKLDLVSKKAEQAENLRKLLLAISEDVRVLLVKLADRLHNMRTLDHMPEAKRLRIAE
ETMDIYAPLAGRMGMQGMREELEEIAFRYINPEAYRAVTARLAEIFERNKGVLTDIEKALSALFEKHAINAGVKSRQKKP
WSVFRKMEAKALSFEQLSDIFGFRVVVDTVEDCYRALGAIHTTWSMVPGRFKDYISTPKQNDYRSIHTTIVGPSRQRVEL
QIRTREMNKIAEYGVAAHSIYKDTGGKTNGAGHAISKETNAYAWLRRTIEQLAEGDNPEDFLENTKLELFQDQVFCFTPK
GMLIALPRGATPIDFAYAVHTDVGDTCVGAKVNGRIMPLMTELKNGDEVEIIRSKAQVPPAAWESVVVTGKARAAIRRAT
KNAIRKQYSGLGARILERAFERAGKNFTKESLKPVLHRLARKDIEDVLASVGRGELASTDVMKAVFPDYKDERVTPAAPK
QREEGWSKIRNAAGMLFQIPGRAARKDKDQPRDGAVPIRGVRGDLPVRFAPEGAVPGDRIVGIVQPGTGITIYPIQSPAL
QAFDDQPERWIDVRWDIDERTKERFPARVSVTAINAPGSLADIAQVVASNDANIHTLSMVRTAPDFTEMLIDLEVWDLKH
LNRLLSQLKDNSSVSDARRVNG
>Mature_742_residues
MMRQYELVERVQRYKPDVNEALLNKAYVYAMQKHGHQKRASGDPYFSHPLEVAAILTEMHMDEATIAVALLHDTIEDTTA
TRAEIDDLFGPEMGKLVEGLTKLKKLDLVSKKAEQAENLRKLLLAISEDVRVLLVKLADRLHNMRTLDHMPEAKRLRIAE
ETMDIYAPLAGRMGMQGMREELEEIAFRYINPEAYRAVTARLAEIFERNKGVLTDIEKALSALFEKHAINAGVKSRQKKP
WSVFRKMEAKALSFEQLSDIFGFRVVVDTVEDCYRALGAIHTTWSMVPGRFKDYISTPKQNDYRSIHTTIVGPSRQRVEL
QIRTREMNKIAEYGVAAHSIYKDTGGKTNGAGHAISKETNAYAWLRRTIEQLAEGDNPEDFLENTKLELFQDQVFCFTPK
GMLIALPRGATPIDFAYAVHTDVGDTCVGAKVNGRIMPLMTELKNGDEVEIIRSKAQVPPAAWESVVVTGKARAAIRRAT
KNAIRKQYSGLGARILERAFERAGKNFTKESLKPVLHRLARKDIEDVLASVGRGELASTDVMKAVFPDYKDERVTPAAPK
QREEGWSKIRNAAGMLFQIPGRAARKDKDQPRDGAVPIRGVRGDLPVRFAPEGAVPGDRIVGIVQPGTGITIYPIQSPAL
QAFDDQPERWIDVRWDIDERTKERFPARVSVTAINAPGSLADIAQVVASNDANIHTLSMVRTAPDFTEMLIDLEVWDLKH
LNRLLSQLKDNSSVSDARRVNG

Specific function: Functions as a (p)ppGpp synthase. In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. Plays a role in ada

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HD domain [H]

Homologues:

Organism=Homo sapiens, GI38348360, Length=139, Percent_Identity=39.568345323741, Blast_Score=73, Evalue=9e-13,
Organism=Escherichia coli, GI1790082, Length=725, Percent_Identity=36.1379310344828, Blast_Score=474, Evalue=1e-135,
Organism=Escherichia coli, GI1789147, Length=735, Percent_Identity=31.2925170068027, Blast_Score=363, Evalue=1e-101,
Organism=Caenorhabditis elegans, GI25143118, Length=130, Percent_Identity=39.2307692307692, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24650996, Length=123, Percent_Identity=38.2113821138211, Blast_Score=75, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR003607
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5 [H]

Molecular weight: Translated: 83212; Mature: 83212

Theoretical pI: Translated: 9.14; Mature: 9.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMRQYELVERVQRYKPDVNEALLNKAYVYAMQKHGHQKRASGDPYFSHPLEVAAILTEMH
CCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHH
MDEATIAVALLHDTIEDTTATRAEIDDLFGPEMGKLVEGLTKLKKLDLVSKKAEQAENLR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KLLLAISEDVRVLLVKLADRLHNMRTLDHMPEAKRLRIAEETMDIYAPLAGRMGMQGMRE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHH
ELEEIAFRYINPEAYRAVTARLAEIFERNKGVLTDIEKALSALFEKHAINAGVKSRQKKP
HHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHCCCCH
WSVFRKMEAKALSFEQLSDIFGFRVVVDTVEDCYRALGAIHTTWSMVPGRFKDYISTPKQ
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCC
NDYRSIHTTIVGPSRQRVELQIRTREMNKIAEYGVAAHSIYKDTGGKTNGAGHAISKETN
CCCCEEEEEEECCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCH
AYAWLRRTIEQLAEGDNPEDFLENTKLELFQDQVFCFTPKGMLIALPRGATPIDFAYAVH
HHHHHHHHHHHHHCCCCHHHHHHCCHHHHHHCCEEEECCCCEEEEECCCCCCCEEEEEEE
TDVGDTCVGAKVNGRIMPLMTELKNGDEVEIIRSKAQVPPAAWESVVVTGKARAAIRRAT
CCCCCCEECCEECCEEEHHHHHCCCCCHHHHHHHHCCCCCHHHCCEEEECHHHHHHHHHH
KNAIRKQYSGLGARILERAFERAGKNFTKESLKPVLHRLARKDIEDVLASVGRGELASTD
HHHHHHHHHCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
VMKAVFPDYKDERVTPAAPKQREEGWSKIRNAAGMLFQIPGRAARKDKDQPRDGAVPIRG
HHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEECCCCHHCCCCCCCCCCCCCCCC
VRGDLPVRFAPEGAVPGDRIVGIVQPGTGITIYPIQSPALQAFDDQPERWIDVRWDIDER
CCCCCCEEECCCCCCCCCCEEEEEECCCCEEEEECCCCHHHHCCCCCCCEEEEEECCCHH
TKERFPARVSVTAINAPGSLADIAQVVASNDANIHTLSMVRTAPDFTEMLIDLEVWDLKH
HHHHCCCEEEEEEECCCCCHHHHHHHHHCCCCCEEEEHHHHCCCCHHHHHHHHHHHHHHH
LNRLLSQLKDNSSVSDARRVNG
HHHHHHHHCCCCCHHHHHHCCC
>Mature Secondary Structure
MMRQYELVERVQRYKPDVNEALLNKAYVYAMQKHGHQKRASGDPYFSHPLEVAAILTEMH
CCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHH
MDEATIAVALLHDTIEDTTATRAEIDDLFGPEMGKLVEGLTKLKKLDLVSKKAEQAENLR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KLLLAISEDVRVLLVKLADRLHNMRTLDHMPEAKRLRIAEETMDIYAPLAGRMGMQGMRE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHH
ELEEIAFRYINPEAYRAVTARLAEIFERNKGVLTDIEKALSALFEKHAINAGVKSRQKKP
HHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHCCCCH
WSVFRKMEAKALSFEQLSDIFGFRVVVDTVEDCYRALGAIHTTWSMVPGRFKDYISTPKQ
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCC
NDYRSIHTTIVGPSRQRVELQIRTREMNKIAEYGVAAHSIYKDTGGKTNGAGHAISKETN
CCCCEEEEEEECCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCH
AYAWLRRTIEQLAEGDNPEDFLENTKLELFQDQVFCFTPKGMLIALPRGATPIDFAYAVH
HHHHHHHHHHHHHCCCCHHHHHHCCHHHHHHCCEEEECCCCEEEEECCCCCCCEEEEEEE
TDVGDTCVGAKVNGRIMPLMTELKNGDEVEIIRSKAQVPPAAWESVVVTGKARAAIRRAT
CCCCCCEECCEECCEEEHHHHHCCCCCHHHHHHHHCCCCCHHHCCEEEECHHHHHHHHHH
KNAIRKQYSGLGARILERAFERAGKNFTKESLKPVLHRLARKDIEDVLASVGRGELASTD
HHHHHHHHHCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
VMKAVFPDYKDERVTPAAPKQREEGWSKIRNAAGMLFQIPGRAARKDKDQPRDGAVPIRG
HHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEECCCCHHCCCCCCCCCCCCCCCC
VRGDLPVRFAPEGAVPGDRIVGIVQPGTGITIYPIQSPALQAFDDQPERWIDVRWDIDER
CCCCCCEEECCCCCCCCCCEEEEEECCCCEEEEECCCCHHHHCCCCCCCEEEEEECCCHH
TKERFPARVSVTAINAPGSLADIAQVVASNDANIHTLSMVRTAPDFTEMLIDLEVWDLKH
HHHHCCCEEEEEEECCCCCHHHHHHHHHCCCCCEEEEHHHHCCCCHHHHHHHHHHHHHHH
LNRLLSQLKDNSSVSDARRVNG
HHHHHHHHCCCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA