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The map label for this gene is phoQ [H]

Identifier: 13476382

GI number: 13476382

Start: 6360818

End: 6362239

Strand: Direct

Name: phoQ [H]

Synonym: mlr7686

Alternate gene names: 13476382

Gene position: 6360818-6362239 (Clockwise)

Preceding gene: 13476381

Following gene: 13476383

Centisome position: 90.4

GC content: 63.43

Gene sequence:

>1422_bases
GTGAGCCGGAGGCGTAACTCGGAACCGCTCAAACCAATCGCAAGGGCGCCGCTTTCGCTGCGTTTGTGGCCGCGTTCGCT
GACGTTCCGCGTGATCGCCTTTTCGACGGTGTGGGCGATCCTGACGCTTGTCGTCATTTTCACCCTGATCACCACGCTCT
ACCGCCAGGCCAGCGAGCGCGGCTTCGACAGCCTGCTTTCTGCGCATCTGTTCAACCTGATCGGCTCCGTCGGCATTTCC
GACACGGGTGCGCTCATCGGCGCCCCGGACCTTGGCGACCTCCGCTTCTCCGAGCCGAAGTCTGGTTGGTACTGGTCGGT
CGAGCCTGCCTCGGAGGGCGTGCATGGCGACCTTCATTCGTCGTCGATGACGAGCAAAATCCCGTCGCCAAGCGTCGCCG
AGGTGCCATTCAATGCCAGCTTCCAACGCAGCTATTCTGCGGAAGGCATAGACGGCGAGCAACTCGAAGTGTTCGAGAGC
GAATTCGTGCTCGATGCCAAGAACCGTGCCGCGCGTTTTCGCGTGATGGGCAACCAGAGCGAGCTCGAACAGGAAATCGT
CACCTTCCAGCGCCGCCTGCTGACCTATCTCAGCCTGTTCGGCGTCGGCATGATCGCCATCAACGCCATTGCCATCCTGC
TCGGCCTGCAGCCGCTGCGCCGGGTGCGCAACGCCCTTGCCATGGTGCGCGAAGGCACCGCGCAGCGGCTCGACGGCCGC
TTCCCGGCCGAGATCGAGCCGTTAGCCAACGAAACCAACGCCTTGATCGAAAACAACAAACGCATCGTCGAGCGCTCGCG
CACCCAGGTCGGCAATCTCGCCCATTCGCTGAAGACGCCGCTGGCGGTGCTGCTCAACGAAGGCAGGGCGCTTGGCGGCG
CCAAGGGACAATTGATCGCCGAGCAGGCCGCCTCGATGCAGAAGCAGGTGGACCACTATTTGCAGCGCGCCCGCGTCGCG
GCGCAACGCGACAGCGTCGTCTACCGCACGCCGGTGGCGCCACTGGTGCAGCGCATGGTGCGGGTCCTGCAGAAGCTCAA
CCCGCAGACCAGCCTGTCGCTGTCCCTGCCGGCCACCGAGATCGTCTTTGCCGGCGAGCGCGAGGACCTCGAGGAGTTGC
TCGGCAACCTTCTCGAAAACGCTATGAAATGGGCAAAAAGCGCGGTGTCGGTCACCGTCGCGCCCGGCAAGGACGATAAT
CTTTTCGAGATCAGCATCGACGACGACGGTCCTGGCATTCCCGAGGACAAGGCGCGCGACGCGCTGAAGCGTGGAAGGCG
CCTGGACGAGACAAAACCGGGAACAGGTCTGGGACTTGCCATTGTCGCCGACCTCGTCAACGAGTATGGAGGCATTCTCG
CGCTCGAACGGTCCGGCCTGGGTGGATTGAAGGCAGTCGTGCGCTTGCGGAGCCTTCAGTGA

Upstream 100 bases:

>100_bases
GACCGCGATTCCAACACCATCGAGGTGTTTGTCGGGCGATTGCGCAAGAAGATGGGCATCGACATGATCGAAACCGTGCG
TGGCATGGGCTACCGCATGC

Downstream 100 bases:

>100_bases
CGCTTAACTGGCCAATCGACAGCGGTGCAAGGCGTATGTTATGGCGGCATATCGATTGATTTTGAGCTGGCCGGCAGCGG
CCAAATTTCCGACAAATATC

Product: two-component system, sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 473; Mature: 472

Protein sequence:

>473_residues
MSRRRNSEPLKPIARAPLSLRLWPRSLTFRVIAFSTVWAILTLVVIFTLITTLYRQASERGFDSLLSAHLFNLIGSVGIS
DTGALIGAPDLGDLRFSEPKSGWYWSVEPASEGVHGDLHSSSMTSKIPSPSVAEVPFNASFQRSYSAEGIDGEQLEVFES
EFVLDAKNRAARFRVMGNQSELEQEIVTFQRRLLTYLSLFGVGMIAINAIAILLGLQPLRRVRNALAMVREGTAQRLDGR
FPAEIEPLANETNALIENNKRIVERSRTQVGNLAHSLKTPLAVLLNEGRALGGAKGQLIAEQAASMQKQVDHYLQRARVA
AQRDSVVYRTPVAPLVQRMVRVLQKLNPQTSLSLSLPATEIVFAGEREDLEELLGNLLENAMKWAKSAVSVTVAPGKDDN
LFEISIDDDGPGIPEDKARDALKRGRRLDETKPGTGLGLAIVADLVNEYGGILALERSGLGGLKAVVRLRSLQ

Sequences:

>Translated_473_residues
MSRRRNSEPLKPIARAPLSLRLWPRSLTFRVIAFSTVWAILTLVVIFTLITTLYRQASERGFDSLLSAHLFNLIGSVGIS
DTGALIGAPDLGDLRFSEPKSGWYWSVEPASEGVHGDLHSSSMTSKIPSPSVAEVPFNASFQRSYSAEGIDGEQLEVFES
EFVLDAKNRAARFRVMGNQSELEQEIVTFQRRLLTYLSLFGVGMIAINAIAILLGLQPLRRVRNALAMVREGTAQRLDGR
FPAEIEPLANETNALIENNKRIVERSRTQVGNLAHSLKTPLAVLLNEGRALGGAKGQLIAEQAASMQKQVDHYLQRARVA
AQRDSVVYRTPVAPLVQRMVRVLQKLNPQTSLSLSLPATEIVFAGEREDLEELLGNLLENAMKWAKSAVSVTVAPGKDDN
LFEISIDDDGPGIPEDKARDALKRGRRLDETKPGTGLGLAIVADLVNEYGGILALERSGLGGLKAVVRLRSLQ
>Mature_472_residues
SRRRNSEPLKPIARAPLSLRLWPRSLTFRVIAFSTVWAILTLVVIFTLITTLYRQASERGFDSLLSAHLFNLIGSVGISD
TGALIGAPDLGDLRFSEPKSGWYWSVEPASEGVHGDLHSSSMTSKIPSPSVAEVPFNASFQRSYSAEGIDGEQLEVFESE
FVLDAKNRAARFRVMGNQSELEQEIVTFQRRLLTYLSLFGVGMIAINAIAILLGLQPLRRVRNALAMVREGTAQRLDGRF
PAEIEPLANETNALIENNKRIVERSRTQVGNLAHSLKTPLAVLLNEGRALGGAKGQLIAEQAASMQKQVDHYLQRARVAA
QRDSVVYRTPVAPLVQRMVRVLQKLNPQTSLSLSLPATEIVFAGEREDLEELLGNLLENAMKWAKSAVSVTVAPGKDDNL
FEISIDDDGPGIPEDKARDALKRGRRLDETKPGTGLGLAIVADLVNEYGGILALERSGLGGLKAVVRLRSLQ

Specific function: Member of the two-component regulatory system phoQ/phoP which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides. In presence of low periplasmic Mg(2+) concentrations, phoQ functions as a membrane

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1787374, Length=271, Percent_Identity=31.3653136531365, Blast_Score=131, Evalue=1e-31,
Organism=Escherichia coli, GI1788393, Length=279, Percent_Identity=27.5985663082437, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI1790551, Length=339, Percent_Identity=26.8436578171091, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI1790346, Length=270, Percent_Identity=28.1481481481481, Blast_Score=75, Evalue=9e-15,
Organism=Escherichia coli, GI1787894, Length=286, Percent_Identity=24.8251748251748, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1790861, Length=208, Percent_Identity=28.3653846153846, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1786912, Length=207, Percent_Identity=29.4685990338164, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI1786783, Length=291, Percent_Identity=23.3676975945017, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1786600, Length=206, Percent_Identity=26.2135922330097, Blast_Score=63, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR015014
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF08918 PhoQ_Sensor [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 51821; Mature: 51690

Theoretical pI: Translated: 9.48; Mature: 9.48

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRRRNSEPLKPIARAPLSLRLWPRSLTFRVIAFSTVWAILTLVVIFTLITTLYRQASER
CCCCCCCCCCCHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GFDSLLSAHLFNLIGSVGISDTGALIGAPDLGDLRFSEPKSGWYWSVEPASEGVHGDLHS
HHHHHHHHHHHHHHHCCCCCCCCCEECCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCC
SSMTSKIPSPSVAEVPFNASFQRSYSAEGIDGEQLEVFESEFVLDAKNRAARFRVMGNQS
CHHHHCCCCCCCCCCCCCCCHHCCCCCCCCCCHHHHHHHHHHHEECCCCCEEEEEECCHH
ELEQEIVTFQRRLLTYLSLFGVGMIAINAIAILLGLQPLRRVRNALAMVREGTAQRLDGR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCC
FPAEIEPLANETNALIENNKRIVERSRTQVGNLAHSLKTPLAVLLNEGRALGGAKGQLIA
CCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHH
EQAASMQKQVDHYLQRARVAAQRDSVVYRTPVAPLVQRMVRVLQKLNPQTSLSLSLPATE
HHHHHHHHHHHHHHHHHHHHHHHCCEEEECCHHHHHHHHHHHHHHCCCCCCEEEECCCEE
IVFAGEREDLEELLGNLLENAMKWAKSAVSVTVAPGKDDNLFEISIDDDGPGIPEDKARD
EEECCCHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCEEEEEECCCCCCCCCHHHHH
ALKRGRRLDETKPGTGLGLAIVADLVNEYGGILALERSGLGGLKAVVRLRSLQ
HHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCC
>Mature Secondary Structure 
SRRRNSEPLKPIARAPLSLRLWPRSLTFRVIAFSTVWAILTLVVIFTLITTLYRQASER
CCCCCCCCCCHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GFDSLLSAHLFNLIGSVGISDTGALIGAPDLGDLRFSEPKSGWYWSVEPASEGVHGDLHS
HHHHHHHHHHHHHHHCCCCCCCCCEECCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCC
SSMTSKIPSPSVAEVPFNASFQRSYSAEGIDGEQLEVFESEFVLDAKNRAARFRVMGNQS
CHHHHCCCCCCCCCCCCCCCHHCCCCCCCCCCHHHHHHHHHHHEECCCCCEEEEEECCHH
ELEQEIVTFQRRLLTYLSLFGVGMIAINAIAILLGLQPLRRVRNALAMVREGTAQRLDGR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCC
FPAEIEPLANETNALIENNKRIVERSRTQVGNLAHSLKTPLAVLLNEGRALGGAKGQLIA
CCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHH
EQAASMQKQVDHYLQRARVAAQRDSVVYRTPVAPLVQRMVRVLQKLNPQTSLSLSLPATE
HHHHHHHHHHHHHHHHHHHHHHHCCEEEECCHHHHHHHHHHHHHHCCCCCCEEEECCCEE
IVFAGEREDLEELLGNLLENAMKWAKSAVSVTVAPGKDDNLFEISIDDDGPGIPEDKARD
EEECCCHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCEEEEEECCCCCCCCCHHHHH
ALKRGRRLDETKPGTGLGLAIVADLVNEYGGILALERSGLGGLKAVVRLRSLQ
HHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA