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The map label for this gene is phoP [H]

Identifier: 13476381

GI number: 13476381

Start: 6360169

End: 6360834

Strand: Direct

Name: phoP [H]

Synonym: mlr7684

Alternate gene names: 13476381

Gene position: 6360169-6360834 (Clockwise)

Preceding gene: 13476380

Following gene: 13476382

Centisome position: 90.39

GC content: 64.41

Gene sequence:

>666_bases
ATGCGCGTACTCGTCGTCGAGGATGACAAGGATCTCAACCGGCAGATAGCGGACGCGTTGGTCGACGCCGGCTATGTCGT
CGACCGTGCCTTTGACGGCGAGGAAGGCCATTTCCTCGGCGACACCGAACCCTATGACGCCGTCGTGCTCGACATCGGCC
TGCCGCAGATCGACGGCATCAGCGTGGTCGAGCGCTGGCGCCGTGGCGGTCGCAAGATGCCGGTGCTGATCCTGACCGCG
CGCGACCGCTGGAGCGACAAGGTCTCGGGCATCGATGCCGGCGCGGACGACTATGTCACCAAGCCGTTCCACATCGAGGA
GGTGCTGGCGCGGCTCAGGGCGCTCATCCGCCGCGCCGCCGGCCATGCCTCGTCGGAGCTTACCTGCGGGCCGCTGCGCC
TCGACACCAAGGCCTCGAAGGCCGATGTCGACGGCGTGCCGTTGAAGCTGACCTCGCACGAATTCCGCCTGCTTGCCTAT
CTGATGCACCATATGGGCGAGGTCGTCTCGCGCACCGAACTGGTCGAGCATCTCTACGACCAGGATTTCGACCGCGATTC
CAACACCATCGAGGTGTTTGTCGGGCGATTGCGCAAGAAGATGGGCATCGACATGATCGAAACCGTGCGTGGCATGGGCT
ACCGCATGCGTGAGCCGGAGGCGTAA

Upstream 100 bases:

>100_bases
CGCAGAACTGACCAATCTTCCATCTCACAGGCCTCCGTTTCCCAGTCCGCCGGAATCGGCCTATATCTGAACAAGTCCTT
CAAAAGGTATCGATCTCCGC

Downstream 100 bases:

>100_bases
CTCGGAACCGCTCAAACCAATCGCAAGGGCGCCGCTTTCGCTGCGTTTGTGGCCGCGTTCGCTGACGTTCCGCGTGATCG
CCTTTTCGACGGTGTGGGCG

Product: two-component system, regulatory protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 221; Mature: 221

Protein sequence:

>221_residues
MRVLVVEDDKDLNRQIADALVDAGYVVDRAFDGEEGHFLGDTEPYDAVVLDIGLPQIDGISVVERWRRGGRKMPVLILTA
RDRWSDKVSGIDAGADDYVTKPFHIEEVLARLRALIRRAAGHASSELTCGPLRLDTKASKADVDGVPLKLTSHEFRLLAY
LMHHMGEVVSRTELVEHLYDQDFDRDSNTIEVFVGRLRKKMGIDMIETVRGMGYRMREPEA

Sequences:

>Translated_221_residues
MRVLVVEDDKDLNRQIADALVDAGYVVDRAFDGEEGHFLGDTEPYDAVVLDIGLPQIDGISVVERWRRGGRKMPVLILTA
RDRWSDKVSGIDAGADDYVTKPFHIEEVLARLRALIRRAAGHASSELTCGPLRLDTKASKADVDGVPLKLTSHEFRLLAY
LMHHMGEVVSRTELVEHLYDQDFDRDSNTIEVFVGRLRKKMGIDMIETVRGMGYRMREPEA
>Mature_221_residues
MRVLVVEDDKDLNRQIADALVDAGYVVDRAFDGEEGHFLGDTEPYDAVVLDIGLPQIDGISVVERWRRGGRKMPVLILTA
RDRWSDKVSGIDAGADDYVTKPFHIEEVLARLRALIRRAAGHASSELTCGPLRLDTKASKADVDGVPLKLTSHEFRLLAY
LMHHMGEVVSRTELVEHLYDQDFDRDSNTIEVFVGRLRKKMGIDMIETVRGMGYRMREPEA

Specific function: Member of the two-component regulatory system phoQ/phoP which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1787375, Length=218, Percent_Identity=43.5779816513761, Blast_Score=182, Evalue=2e-47,
Organism=Escherichia coli, GI1789402, Length=218, Percent_Identity=45.4128440366972, Blast_Score=178, Evalue=3e-46,
Organism=Escherichia coli, GI1786784, Length=226, Percent_Identity=40.2654867256637, Blast_Score=169, Evalue=1e-43,
Organism=Escherichia coli, GI87082012, Length=219, Percent_Identity=38.3561643835616, Blast_Score=157, Evalue=6e-40,
Organism=Escherichia coli, GI1790552, Length=216, Percent_Identity=41.2037037037037, Blast_Score=153, Evalue=9e-39,
Organism=Escherichia coli, GI1786599, Length=223, Percent_Identity=35.4260089686099, Blast_Score=121, Evalue=4e-29,
Organism=Escherichia coli, GI1789809, Length=225, Percent_Identity=33.3333333333333, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1788394, Length=221, Percent_Identity=33.9366515837104, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI1786911, Length=221, Percent_Identity=33.4841628959276, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI1790860, Length=222, Percent_Identity=32.8828828828829, Blast_Score=110, Evalue=9e-26,
Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=34.2105263157895, Blast_Score=107, Evalue=5e-25,
Organism=Escherichia coli, GI1790863, Length=228, Percent_Identity=30.7017543859649, Blast_Score=95, Evalue=3e-21,
Organism=Escherichia coli, GI1787229, Length=220, Percent_Identity=28.1818181818182, Blast_Score=95, Evalue=4e-21,
Organism=Escherichia coli, GI1788550, Length=119, Percent_Identity=31.9327731092437, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI145693140, Length=229, Percent_Identity=26.2008733624454, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 24920; Mature: 24920

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVLVVEDDKDLNRQIADALVDAGYVVDRAFDGEEGHFLGDTEPYDAVVLDIGLPQIDGI
CEEEEECCCHHHHHHHHHHHHHCCHHEEECCCCCCCCCCCCCCCCCEEEEECCCCCCCCH
SVVERWRRGGRKMPVLILTARDRWSDKVSGIDAGADDYVTKPFHIEEVLARLRALIRRAA
HHHHHHHHCCCCCCEEEEECCCCCCHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
GHASSELTCGPLRLDTKASKADVDGVPLKLTSHEFRLLAYLMHHMGEVVSRTELVEHLYD
CCCCCCCCCCCEEECCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QDFDRDSNTIEVFVGRLRKKMGIDMIETVRGMGYRMREPEA
CCCCCCCCHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MRVLVVEDDKDLNRQIADALVDAGYVVDRAFDGEEGHFLGDTEPYDAVVLDIGLPQIDGI
CEEEEECCCHHHHHHHHHHHHHCCHHEEECCCCCCCCCCCCCCCCCEEEEECCCCCCCCH
SVVERWRRGGRKMPVLILTARDRWSDKVSGIDAGADDYVTKPFHIEEVLARLRALIRRAA
HHHHHHHHCCCCCCEEEEECCCCCCHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
GHASSELTCGPLRLDTKASKADVDGVPLKLTSHEFRLLAYLMHHMGEVVSRTELVEHLYD
CCCCCCCCCCCEEECCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QDFDRDSNTIEVFVGRLRKKMGIDMIETVRGMGYRMREPEA
CCCCCCCCHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA