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The map label for this gene is php [H]

Identifier: 13476366

GI number: 13476366

Start: 6345696

End: 6346784

Strand: Reverse

Name: php [H]

Synonym: mll7664

Alternate gene names: 13476366

Gene position: 6346784-6345696 (Counterclockwise)

Preceding gene: 13476367

Following gene: 13476365

Centisome position: 90.2

GC content: 60.97

Gene sequence:

>1089_bases
ATGGATCATTTGTTCGACAACAGGCCAAGGCAAAGAGTGCCGATCGGTGTTCGCTCCGGGACCGTGATGACCGTTACCGG
CCCGGTCGCGATCGCCGACATGGGCGTGACGCTGATGCACGAGCATATCCTGCTCGATGGCTCGACATCCTGGAAATGCC
CCTGCCATCCCGACGACAGGAAGATCGCCGAGCAGCCGGTCAGCATGGAGATCATCGGCGAATTGCGGATGAACCCCTAC
ATGAACCGCGACAATGTCTCGCTCGACGACAGCGACCTGGCGCTTTCCGAGCTCGCCAGGTACCGGGCGCTGGGCGGCCA
TACGGTTGTCGACGCGACCAATATCGGCATCGGCCGCGATCCGGTGAAGCTGGCACGTATTGCCCGCGCCTCCGGATTGC
GCATCGTCATGGGCACGGGCTTCTATCTGCAGCACACCCATCCGGACTGGCTGAAGGCGATGGACGTCGATGCCGCTACG
GAATTTCTCGTCAACGATGTCGGCGGCGGCTCGACGCAGCCCGAAATCATGGCCGGCATCATCGGCGAAGTCGGCATCAG
CAAGGATTTCACCGAAGAGGAACGCAAATCACTGCGGGCTTCAGCGCGCGCGGCCAGGATCACCGGCGTCCCGCTGACCA
TCCACCTGCCCGGCTGGGAACGGCTGGCGCATGACGTGCTCGACGTGGTCGAAGCCGAAGGCGCGGATCTGAGACATACG
ATCCTTTGCCATATGAATCCGAGCCACAATGACCTTGCCTACCAGAGAAGCCTCGCCGCGCGTGGCGCCTTCCTGGAATA
CGACATGATCGGCATGGATTTCTATTATGCCGACCAGGATGCGCAATCGCCTTCCGACGAGCAGAACGCGCAGGCGATCC
GTTCGTTGATCGACATGGGGCTGGTCGACAGGATCCTGCTGTCGCAGGACGTCTTCCTGAAGATCATGCTGACGCGCTTC
GGCGGCTTCGGCTACGGCTTCATCCTCAAACATTTCGTGCCAAGGCTGAAACGCCATGGTGTCGAGCAATCGGCAATCGA
CCGCATGCTCATCGACAACCCAAAGACCGTGTTCGCCGCGAGCCTCTGA

Upstream 100 bases:

>100_bases
ATGTCGCCCTTCCTGACGCCGATCGTCACCGGCACTATCATCCTCGTTGCCATCTGGCTGAATTTCCGCCTGTTCAAGGG
CGCGACGCGGAGCCGCTGAC

Downstream 100 bases:

>100_bases
GCTGCCGGCCACAGCAAAAAACAGGGAGTTTACATGTCCAGGAAGAAAGTTCTTCTCGCCGGCGAGTCCTGGGTTTCGAC
CGCGACCCACATCAAGGGCT

Product: resiniferotoxin-binding, phosphotriesterase-related protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 362; Mature: 362

Protein sequence:

>362_residues
MDHLFDNRPRQRVPIGVRSGTVMTVTGPVAIADMGVTLMHEHILLDGSTSWKCPCHPDDRKIAEQPVSMEIIGELRMNPY
MNRDNVSLDDSDLALSELARYRALGGHTVVDATNIGIGRDPVKLARIARASGLRIVMGTGFYLQHTHPDWLKAMDVDAAT
EFLVNDVGGGSTQPEIMAGIIGEVGISKDFTEEERKSLRASARAARITGVPLTIHLPGWERLAHDVLDVVEAEGADLRHT
ILCHMNPSHNDLAYQRSLAARGAFLEYDMIGMDFYYADQDAQSPSDEQNAQAIRSLIDMGLVDRILLSQDVFLKIMLTRF
GGFGYGFILKHFVPRLKRHGVEQSAIDRMLIDNPKTVFAASL

Sequences:

>Translated_362_residues
MDHLFDNRPRQRVPIGVRSGTVMTVTGPVAIADMGVTLMHEHILLDGSTSWKCPCHPDDRKIAEQPVSMEIIGELRMNPY
MNRDNVSLDDSDLALSELARYRALGGHTVVDATNIGIGRDPVKLARIARASGLRIVMGTGFYLQHTHPDWLKAMDVDAAT
EFLVNDVGGGSTQPEIMAGIIGEVGISKDFTEEERKSLRASARAARITGVPLTIHLPGWERLAHDVLDVVEAEGADLRHT
ILCHMNPSHNDLAYQRSLAARGAFLEYDMIGMDFYYADQDAQSPSDEQNAQAIRSLIDMGLVDRILLSQDVFLKIMLTRF
GGFGYGFILKHFVPRLKRHGVEQSAIDRMLIDNPKTVFAASL
>Mature_362_residues
MDHLFDNRPRQRVPIGVRSGTVMTVTGPVAIADMGVTLMHEHILLDGSTSWKCPCHPDDRKIAEQPVSMEIIGELRMNPY
MNRDNVSLDDSDLALSELARYRALGGHTVVDATNIGIGRDPVKLARIARASGLRIVMGTGFYLQHTHPDWLKAMDVDAAT
EFLVNDVGGGSTQPEIMAGIIGEVGISKDFTEEERKSLRASARAARITGVPLTIHLPGWERLAHDVLDVVEAEGADLRHT
ILCHMNPSHNDLAYQRSLAARGAFLEYDMIGMDFYYADQDAQSPSDEQNAQAIRSLIDMGLVDRILLSQDVFLKIMLTRF
GGFGYGFILKHFVPRLKRHGVEQSAIDRMLIDNPKTVFAASL

Specific function: Its real enzymatic activity is not yet known. It was tested for general esterase, aminopeptidase, sulfatase, phosphatase, carbonic anhydrase, phosphodiesterase, and phosphotriesterase activities with the following substrates:P- nitrophenyl acetate, L-alan

COG id: COG1735

COG function: function code R; Predicted metal-dependent hydrolase with the TIM-barrel fold

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphotriesterase family [H]

Homologues:

Organism=Homo sapiens, GI20070186, Length=340, Percent_Identity=33.8235294117647, Blast_Score=205, Evalue=6e-53,
Organism=Homo sapiens, GI47933341, Length=340, Percent_Identity=33.8235294117647, Blast_Score=205, Evalue=6e-53,
Organism=Escherichia coli, GI1789780, Length=283, Percent_Identity=28.2685512367491, Blast_Score=124, Evalue=7e-30,
Organism=Drosophila melanogaster, GI24645325, Length=346, Percent_Identity=25.4335260115607, Blast_Score=140, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017947
- InterPro:   IPR001559 [H]

Pfam domain/function: PF02126 PTE [H]

EC number: NA

Molecular weight: Translated: 40057; Mature: 40057

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: PS01322 PHOSPHOTRIESTERASE_1 ; PS01323 PHOSPHOTRIESTERASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDHLFDNRPRQRVPIGVRSGTVMTVTGPVAIADMGVTLMHEHILLDGSTSWKCPCHPDDR
CCCCCCCCCCCCCCEEECCCEEEEEECCEEEHHCCHHHEEEEEEEECCCCCCCCCCCCCH
KIAEQPVSMEIIGELRMNPYMNRDNVSLDDSDLALSELARYRALGGHTVVDATNIGIGRD
HHHHCCCCCEEHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCC
PVKLARIARASGLRIVMGTGFYLQHTHPDWLKAMDVDAATEFLVNDVGGGSTQPEIMAGI
HHHHHHHHHHCCCEEEEECCEEEECCCCHHHHHHCHHHHHHHHHHCCCCCCCCHHHHHHH
IGEVGISKDFTEEERKSLRASARAARITGVPLTIHLPGWERLAHDVLDVVEAEGADLRHT
HHHCCCCCCCCHHHHHHHHHHHHHHEEECCEEEEECCCHHHHHHHHHHHHHCCCCCCEEE
ILCHMNPSHNDLAYQRSLAARGAFLEYDMIGMDFYYADQDAQSPSDEQNAQAIRSLIDMG
EEEEECCCCCHHHHHHHHHHCCCEEEEEEECCEEEECCCCCCCCCCHHHHHHHHHHHHHH
LVDRILLSQDVFLKIMLTRFGGFGYGFILKHFVPRLKRHGVEQSAIDRMLIDNPKTVFAA
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEE
SL
CC
>Mature Secondary Structure
MDHLFDNRPRQRVPIGVRSGTVMTVTGPVAIADMGVTLMHEHILLDGSTSWKCPCHPDDR
CCCCCCCCCCCCCCEEECCCEEEEEECCEEEHHCCHHHEEEEEEEECCCCCCCCCCCCCH
KIAEQPVSMEIIGELRMNPYMNRDNVSLDDSDLALSELARYRALGGHTVVDATNIGIGRD
HHHHCCCCCEEHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCC
PVKLARIARASGLRIVMGTGFYLQHTHPDWLKAMDVDAATEFLVNDVGGGSTQPEIMAGI
HHHHHHHHHHCCCEEEEECCEEEECCCCHHHHHHCHHHHHHHHHHCCCCCCCCHHHHHHH
IGEVGISKDFTEEERKSLRASARAARITGVPLTIHLPGWERLAHDVLDVVEAEGADLRHT
HHHCCCCCCCCHHHHHHHHHHHHHHEEECCEEEEECCCHHHHHHHHHHHHHCCCCCCEEE
ILCHMNPSHNDLAYQRSLAARGAFLEYDMIGMDFYYADQDAQSPSDEQNAQAIRSLIDMG
EEEEECCCCCHHHHHHHHHHCCCEEEEEEECCEEEECCCCCCCCCCHHHHHHHHHHHHHH
LVDRILLSQDVFLKIMLTRFGGFGYGFILKHFVPRLKRHGVEQSAIDRMLIDNPKTVFAA
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEE
SL
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503; 9548740 [H]