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The map label for this gene is pgm [H]

Identifier: 13476306

GI number: 13476306

Start: 6278247

End: 6279875

Strand: Direct

Name: pgm [H]

Synonym: mlr7590

Alternate gene names: 13476306

Gene position: 6278247-6279875 (Clockwise)

Preceding gene: 13476305

Following gene: 13476307

Centisome position: 89.23

GC content: 63.9

Gene sequence:

>1629_bases
ATGATACGAACCGTCCCCACCAAGCCCTATTCAGACCAGAAGCCCGGCACGTCGGGCCTGCGCAAGAAGGTGCCCGTGTT
CCAGCAGGAGCACTATGCCGAGAACTTCATCCAGTCGATCTTCGATGCACTGGACGGTTTCCAGGGCAAGACGCTGGTGA
TCGGCGGCGACGGCCGCTTCTACAACCGCGAGGTCATCCAGAAGGCGATCGCCATGGCGGCCGCCAACGGCTTCGGCAAG
GTGATGGTCGGGCAGGGCGGCATATTGTCGACGCCGGCCGCCTCGCATGTCATCCGCAAATACAAGACCTTCGGCGGCAT
CATCCTGTCGGCCAGCCACAATCCCGGCGGCCCGCATGAGGATTTCGGCATCAAGTACAATGCCGGCAATGGCGGCCCGG
CCCCGGAAAAGCTGACCGACGCGATCTTCGCCAAGACCAAGGCGATATCGAGCTTCAAGACATCAGACATCGATACGATC
GACATCGATACGATCGGCACCGTCAAGGCCGCCGGCATGACGGTCGAGATCATCGATCCGGTCGCCGATTATGCCGAGCT
GATGGAAAGCCTGTTCGATTTCGACGCGCTGCGCAGACTGTTCAAATCGGGCTTCCGCATGCGCTTCGACGCCATGCATG
CGGTGACCGGTCCCTATGCCAAGGAAATTCTCGAGAACCGGCTTGGCGCGCCCAGCGGCACCTGCCGCAACTTCAAGCCG
CTGCCGGATTTCGGCGGCCATCATCCGGACCCGAACCTGGTGCACGCCAAGCATCTCTATGACGAGATGATGGGGCCGGA
CGCGCCGGATTTTGGTGCCGCCTCCGACGGTGACGGCGACCGCAATTTGATCATCGGCAAGGGCATTTTCGTCACCCCCT
CGGATTCGGTGGCGATGCTTGCCGCCAATGCCCGCCTGGCGCCCGGCTACAAGGACGGGCTGAAGGGCATCGCCCGTTCG
ATGCCGACCAGTGGCGCCGCCGACCGCGTCGCCGAAAAGCTCGGCATCGGCATCTACGAGACGCCGACCGGCTGGAAGTT
CTTCGGCAATCTGCTCGATGCCGGCATGGCGACGATCTGCGGCGAGGAGAGCGCCGGCACCGGCTCCAACCATGTGCGCG
AAAAGGACGGCCTGTGGGCGGTGCTGTTGTGGCTCAACATCCTCGCCGCGCGCGGCGAGAGCTGCAAGCAGGTCGTCACC
GAGCACTGGGCGGCCTACGGGCGCAACTACTATTCGCGCCACGACTATGAGGAGGTCGAGAGCGACCGCGCCAACGCGCT
GGTCGACGAACTCAGGGCCAAGCTCGGTTCGCTGCCCGGCACCAGCGTGCGCGGCTTGAAGATCGCCAAGGCCGACGATT
TCGCCTATCACGACCCGGTCGATGGCTCGACCAGCGAGCACCAGGGCATCAGGATCCTGTTCGAAGGCGGCTCGCGCGTC
GTCTTCCGGCTTTCCGGAACCGGCACGTCCGGCGCGACGCTGCGCGTCTACATCGAGCGCTACGAGCCGGACAAGGCCAG
GCACGATCTCGACACGCAGGCAGCCCTTGCCGACCTCATCGCTGCCGCTGACGACATCGCCGGGATCAAAAGCCACACCG
GCCGCAACAAGCCGAGCGTGATTACTTGA

Upstream 100 bases:

>100_bases
CCAGCGCCAGGGCATGAAGGCCGATGTGTCATGGGACAAGAGCGCGGAAAAATATCTTGAACTCTATCGCCTGCTGCTTT
CGAAAAGGGTTGCCTGAAGC

Downstream 100 bases:

>100_bases
GGGTGGTAGTGAGGGCTTTTCCTTCTCCCCTTGTGGGAGAAGGTGGCCGAGCGAAGCTCGGTCGGATGAGGGGTGCTCCA
GCTTGGCGTAAACCAACGCC

Product: phosphoglucomutase

Products: NA

Alternate protein names: PGM; Glucose phosphomutase [H]

Number of amino acids: Translated: 542; Mature: 542

Protein sequence:

>542_residues
MIRTVPTKPYSDQKPGTSGLRKKVPVFQQEHYAENFIQSIFDALDGFQGKTLVIGGDGRFYNREVIQKAIAMAAANGFGK
VMVGQGGILSTPAASHVIRKYKTFGGIILSASHNPGGPHEDFGIKYNAGNGGPAPEKLTDAIFAKTKAISSFKTSDIDTI
DIDTIGTVKAAGMTVEIIDPVADYAELMESLFDFDALRRLFKSGFRMRFDAMHAVTGPYAKEILENRLGAPSGTCRNFKP
LPDFGGHHPDPNLVHAKHLYDEMMGPDAPDFGAASDGDGDRNLIIGKGIFVTPSDSVAMLAANARLAPGYKDGLKGIARS
MPTSGAADRVAEKLGIGIYETPTGWKFFGNLLDAGMATICGEESAGTGSNHVREKDGLWAVLLWLNILAARGESCKQVVT
EHWAAYGRNYYSRHDYEEVESDRANALVDELRAKLGSLPGTSVRGLKIAKADDFAYHDPVDGSTSEHQGIRILFEGGSRV
VFRLSGTGTSGATLRVYIERYEPDKARHDLDTQAALADLIAAADDIAGIKSHTGRNKPSVIT

Sequences:

>Translated_542_residues
MIRTVPTKPYSDQKPGTSGLRKKVPVFQQEHYAENFIQSIFDALDGFQGKTLVIGGDGRFYNREVIQKAIAMAAANGFGK
VMVGQGGILSTPAASHVIRKYKTFGGIILSASHNPGGPHEDFGIKYNAGNGGPAPEKLTDAIFAKTKAISSFKTSDIDTI
DIDTIGTVKAAGMTVEIIDPVADYAELMESLFDFDALRRLFKSGFRMRFDAMHAVTGPYAKEILENRLGAPSGTCRNFKP
LPDFGGHHPDPNLVHAKHLYDEMMGPDAPDFGAASDGDGDRNLIIGKGIFVTPSDSVAMLAANARLAPGYKDGLKGIARS
MPTSGAADRVAEKLGIGIYETPTGWKFFGNLLDAGMATICGEESAGTGSNHVREKDGLWAVLLWLNILAARGESCKQVVT
EHWAAYGRNYYSRHDYEEVESDRANALVDELRAKLGSLPGTSVRGLKIAKADDFAYHDPVDGSTSEHQGIRILFEGGSRV
VFRLSGTGTSGATLRVYIERYEPDKARHDLDTQAALADLIAAADDIAGIKSHTGRNKPSVIT
>Mature_542_residues
MIRTVPTKPYSDQKPGTSGLRKKVPVFQQEHYAENFIQSIFDALDGFQGKTLVIGGDGRFYNREVIQKAIAMAAANGFGK
VMVGQGGILSTPAASHVIRKYKTFGGIILSASHNPGGPHEDFGIKYNAGNGGPAPEKLTDAIFAKTKAISSFKTSDIDTI
DIDTIGTVKAAGMTVEIIDPVADYAELMESLFDFDALRRLFKSGFRMRFDAMHAVTGPYAKEILENRLGAPSGTCRNFKP
LPDFGGHHPDPNLVHAKHLYDEMMGPDAPDFGAASDGDGDRNLIIGKGIFVTPSDSVAMLAANARLAPGYKDGLKGIARS
MPTSGAADRVAEKLGIGIYETPTGWKFFGNLLDAGMATICGEESAGTGSNHVREKDGLWAVLLWLNILAARGESCKQVVT
EHWAAYGRNYYSRHDYEEVESDRANALVDELRAKLGSLPGTSVRGLKIAKADDFAYHDPVDGSTSEHQGIRILFEGGSRV
VFRLSGTGTSGATLRVYIERYEPDKARHDLDTQAALADLIAAADDIAGIKSHTGRNKPSVIT

Specific function: This enzyme participates in both the breakdown and synthesis of glucose. Required for the synthesis of capsular polysaccharide and normal lipopolysaccharide [H]

COG id: COG0033

COG function: function code G; Phosphoglucomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Homo sapiens, GI21361621, Length=560, Percent_Identity=53.9285714285714, Blast_Score=596, Evalue=1e-170,
Organism=Homo sapiens, GI290463102, Length=560, Percent_Identity=53.2142857142857, Blast_Score=591, Evalue=1e-169,
Organism=Homo sapiens, GI133922562, Length=561, Percent_Identity=47.415329768271, Blast_Score=521, Evalue=1e-148,
Organism=Homo sapiens, GI290463104, Length=366, Percent_Identity=53.551912568306, Blast_Score=399, Evalue=1e-111,
Organism=Homo sapiens, GI239741729, Length=133, Percent_Identity=49.6240601503759, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI239743670, Length=133, Percent_Identity=48.8721804511278, Blast_Score=119, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI17535441, Length=562, Percent_Identity=50.8896797153025, Blast_Score=530, Evalue=1e-151,
Organism=Saccharomyces cerevisiae, GI6323752, Length=570, Percent_Identity=49.2982456140351, Blast_Score=533, Evalue=1e-152,
Organism=Saccharomyces cerevisiae, GI6322722, Length=570, Percent_Identity=46.8421052631579, Blast_Score=498, Evalue=1e-142,
Organism=Drosophila melanogaster, GI17864244, Length=562, Percent_Identity=50.5338078291815, Blast_Score=549, Evalue=1e-156,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2 [H]

Molecular weight: Translated: 58314; Mature: 58314

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: PS00710 PGM_PMM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRTVPTKPYSDQKPGTSGLRKKVPVFQQEHYAENFIQSIFDALDGFQGKTLVIGGDGRF
CCCCCCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCC
YNREVIQKAIAMAAANGFGKVMVGQGGILSTPAASHVIRKYKTFGGIILSASHNPGGPHE
HHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHHHHCCEEEECCCCCCCCCC
DFGIKYNAGNGGPAPEKLTDAIFAKTKAISSFKTSDIDTIDIDTIGTVKAAGMTVEIIDP
CCCEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCEECCCEEEEEHHH
VADYAELMESLFDFDALRRLFKSGFRMRFDAMHAVTGPYAKEILENRLGAPSGTCRNFKP
HHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCC
LPDFGGHHPDPNLVHAKHLYDEMMGPDAPDFGAASDGDGDRNLIIGKGIFVTPSDSVAML
CCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCEEECCCCCEEEE
AANARLAPGYKDGLKGIARSMPTSGAADRVAEKLGIGIYETPTGWKFFGNLLDAGMATIC
EECCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHC
GEESAGTGSNHVREKDGLWAVLLWLNILAARGESCKQVVTEHWAAYGRNYYSRHDYEEVE
CCCCCCCCCCCCHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHCCCHHHHH
SDRANALVDELRAKLGSLPGTSVRGLKIAKADDFAYHDPVDGSTSEHQGIRILFEGGSRV
HHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCEEEEEECCCEE
VFRLSGTGTSGATLRVYIERYEPDKARHDLDTQAALADLIAAADDIAGIKSHTGRNKPSV
EEEEECCCCCCCEEEEEEEECCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
IT
CC
>Mature Secondary Structure
MIRTVPTKPYSDQKPGTSGLRKKVPVFQQEHYAENFIQSIFDALDGFQGKTLVIGGDGRF
CCCCCCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCC
YNREVIQKAIAMAAANGFGKVMVGQGGILSTPAASHVIRKYKTFGGIILSASHNPGGPHE
HHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHHHHCCEEEECCCCCCCCCC
DFGIKYNAGNGGPAPEKLTDAIFAKTKAISSFKTSDIDTIDIDTIGTVKAAGMTVEIIDP
CCCEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCEECCCEEEEEHHH
VADYAELMESLFDFDALRRLFKSGFRMRFDAMHAVTGPYAKEILENRLGAPSGTCRNFKP
HHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCC
LPDFGGHHPDPNLVHAKHLYDEMMGPDAPDFGAASDGDGDRNLIIGKGIFVTPSDSVAML
CCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCEEECCCCCEEEE
AANARLAPGYKDGLKGIARSMPTSGAADRVAEKLGIGIYETPTGWKFFGNLLDAGMATIC
EECCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHC
GEESAGTGSNHVREKDGLWAVLLWLNILAARGESCKQVVTEHWAAYGRNYYSRHDYEEVE
CCCCCCCCCCCCHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHCCCHHHHH
SDRANALVDELRAKLGSLPGTSVRGLKIAKADDFAYHDPVDGSTSEHQGIRILFEGGSRV
HHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCEEEEEECCCEE
VFRLSGTGTSGATLRVYIERYEPDKARHDLDTQAALADLIAAADDIAGIKSHTGRNKPSV
EEEEECCCCCCCEEEEEEEECCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
IT
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7959036; 2307661 [H]