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The map label for this gene is rfbD [C]

Identifier: 13476274

GI number: 13476274

Start: 6234573

End: 6235451

Strand: Direct

Name: rfbD [C]

Synonym: mlr7553

Alternate gene names: 13476274

Gene position: 6234573-6235451 (Clockwise)

Preceding gene: 13476273

Following gene: 13476275

Centisome position: 88.61

GC content: 65.76

Gene sequence:

>879_bases
GTGAGGCTCGCTGTCACCGGACGCGACGGCCAGGTTGTGTCGAGCCTTCTGGAGGCAGGCCAGTTTGCCGGTGTAGACGT
CATCGCCATTGGCCGTCCGCAGCTCGACTTGGCAAACCCCGATACCGTGATCGAAGCCATTGCAGCGGCCAGGCCTGACA
TCGTCGTGTCAGCTGCCGCTTACACGGCCGTGGATCAGGCCGAGGATGAGCCCGATCTGGCATTCAGGGTGAATGCCGTC
GGCGCCGGCAAGGTGGCGCAAGCCGCGGCGCGGCTTGGCGTTCCCGTCATCCACCTTTCGACCGACTACGTCTTCGACGG
CAGCGCTTCCGGCGCTTACGTCGAAACCGATGCGACCGCGCCAGCCAGCGTTTACGGCGCCTCCAAGCTCGCCGGCGAAC
AGACGGTGGCCGCCGCCGGCCCGCGCCACCTGATCCTGCGCACCGCCTGGGTCTACAGCCCGTTCGGCAAGAATTTCGTC
AAAACCATGCTGCGGCTGGCCGCCGACCGTGACGAGATTTCCGTGGTGGCCGATCAATGGGGAAATCCCAGCTCAGCGCT
GGATATCGCCGATGCGATCCTGCATGCCGCGGCCACGCTGCACCGCAACAAGGACTTCGGCGCGTTCGGCACCTATCATC
TGGCCGGCACGGGCGAGACCAACTGGAGCGGCTTTGCCCGCCATATCCTCGACACGAGCCGCGTGTCTGGCGGTCCTTCA
GCGCGGGTCCACGACATTATGACGACGGACTACCCGACCAAGGCGCGACGCCCTGCCAATTCCCGGCTTTCGAGCGCGAA
GTTCGCGTCAGCCTTTGGCTGGACCGCGCCGGACTGGCGGCAATCGACGGAAGCCGTGGTGCGTCGGGTCCTGTTCTGA

Upstream 100 bases:

>100_bases
GAACCGTGGACTGGTTCCTCGACAACAAATGGTGGTGGGGGCCGATCCGCGAGCAGCGGTACGCCGGTGAAAGGCTGGGC
GAGGCCCGCAAGGTGGGCGC

Downstream 100 bases:

>100_bases
GAGCCAGATGACCCGTGGGGCCGGACCACGGACGCTCGGCGAAGTACCGCCAAACGCCCGGACAAGGCATACGGCATGGA
GCGCACGATCCTTGAGGCAA

Product: dTDP-6-deoxy-L-mannose-dehydrogenase

Products: NA

Alternate protein names: dTDP-4-keto-L-rhamnose reductase; dTDP-6-deoxy-L-lyxo-4-hexulose reductase; dTDP-6-deoxy-L-mannose dehydrogenase; dTDP-L-rhamnose synthase [H]

Number of amino acids: Translated: 292; Mature: 292

Protein sequence:

>292_residues
MRLAVTGRDGQVVSSLLEAGQFAGVDVIAIGRPQLDLANPDTVIEAIAAARPDIVVSAAAYTAVDQAEDEPDLAFRVNAV
GAGKVAQAAARLGVPVIHLSTDYVFDGSASGAYVETDATAPASVYGASKLAGEQTVAAAGPRHLILRTAWVYSPFGKNFV
KTMLRLAADRDEISVVADQWGNPSSALDIADAILHAAATLHRNKDFGAFGTYHLAGTGETNWSGFARHILDTSRVSGGPS
ARVHDIMTTDYPTKARRPANSRLSSAKFASAFGWTAPDWRQSTEAVVRRVLF

Sequences:

>Translated_292_residues
MRLAVTGRDGQVVSSLLEAGQFAGVDVIAIGRPQLDLANPDTVIEAIAAARPDIVVSAAAYTAVDQAEDEPDLAFRVNAV
GAGKVAQAAARLGVPVIHLSTDYVFDGSASGAYVETDATAPASVYGASKLAGEQTVAAAGPRHLILRTAWVYSPFGKNFV
KTMLRLAADRDEISVVADQWGNPSSALDIADAILHAAATLHRNKDFGAFGTYHLAGTGETNWSGFARHILDTSRVSGGPS
ARVHDIMTTDYPTKARRPANSRLSSAKFASAFGWTAPDWRQSTEAVVRRVLF
>Mature_292_residues
MRLAVTGRDGQVVSSLLEAGQFAGVDVIAIGRPQLDLANPDTVIEAIAAARPDIVVSAAAYTAVDQAEDEPDLAFRVNAV
GAGKVAQAAARLGVPVIHLSTDYVFDGSASGAYVETDATAPASVYGASKLAGEQTVAAAGPRHLILRTAWVYSPFGKNFV
KTMLRLAADRDEISVVADQWGNPSSALDIADAILHAAATLHRNKDFGAFGTYHLAGTGETNWSGFARHILDTSRVSGGPS
ARVHDIMTTDYPTKARRPANSRLSSAKFASAFGWTAPDWRQSTEAVVRRVLF

Specific function: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose. RmlD uses NADH and NADPH nearly equally well [H]

COG id: COG1091

COG function: function code M; dTDP-4-dehydrorhamnose reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dTDP-4-dehydrorhamnose reductase family [H]

Homologues:

Organism=Homo sapiens, GI33519455, Length=282, Percent_Identity=28.7234042553192, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI11034825, Length=282, Percent_Identity=28.7234042553192, Blast_Score=89, Evalue=3e-18,
Organism=Escherichia coli, GI1788352, Length=297, Percent_Identity=42.0875420875421, Blast_Score=229, Evalue=1e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005913
- InterPro:   IPR016040 [H]

Pfam domain/function: PF04321 RmlD_sub_bind [H]

EC number: =1.1.1.133 [H]

Molecular weight: Translated: 30806; Mature: 30806

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLAVTGRDGQVVSSLLEAGQFAGVDVIAIGRPQLDLANPDTVIEAIAAARPDIVVSAAA
CEEEEECCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCCEEEEHHH
YTAVDQAEDEPDLAFRVNAVGAGKVAQAAARLGVPVIHLSTDYVFDGSASGAYVETDATA
HHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHCCEEEEEECCEEECCCCCCCEEECCCCC
PASVYGASKLAGEQTVAAAGPRHLILRTAWVYSPFGKNFVKTMLRLAADRDEISVVADQW
CHHHHHHHHHCCCCHHHHCCCCEEEEEHHHHCCCCCHHHHHHHHHHHCCCCCEEEEECCC
GNPSSALDIADAILHAAATLHRNKDFGAFGTYHLAGTGETNWSGFARHILDTSRVSGGPS
CCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCC
ARVHDIMTTDYPTKARRPANSRLSSAKFASAFGWTAPDWRQSTEAVVRRVLF
CEEEEEEECCCCCHHCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MRLAVTGRDGQVVSSLLEAGQFAGVDVIAIGRPQLDLANPDTVIEAIAAARPDIVVSAAA
CEEEEECCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCCEEEEHHH
YTAVDQAEDEPDLAFRVNAVGAGKVAQAAARLGVPVIHLSTDYVFDGSASGAYVETDATA
HHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHCCEEEEEECCEEECCCCCCCEEECCCCC
PASVYGASKLAGEQTVAAAGPRHLILRTAWVYSPFGKNFVKTMLRLAADRDEISVVADQW
CHHHHHHHHHCCCCHHHHCCCCEEEEEHHHHCCCCCHHHHHHHHHHHCCCCCEEEEECCC
GNPSSALDIADAILHAAATLHRNKDFGAFGTYHLAGTGETNWSGFARHILDTSRVSGGPS
CCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCC
ARVHDIMTTDYPTKARRPANSRLSSAKFASAFGWTAPDWRQSTEAVVRRVLF
CEEEEEEECCCCCHHCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]