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The map label for this gene is ccrM [H]

Identifier: 13476248

GI number: 13476248

Start: 6206401

End: 6207534

Strand: Direct

Name: ccrM [H]

Synonym: mlr7520

Alternate gene names: 13476248

Gene position: 6206401-6207534 (Clockwise)

Preceding gene: 13476246

Following gene: 13476251

Centisome position: 88.21

GC content: 64.2

Gene sequence:

>1134_bases
ATGTCTGCCGTGCGTCTTCTCCACGAGTTGTCCCACGCTCCCCAGCAATCCGAATGGCTGGACACGATCCTCAAGGGCGA
CTGCGTCGCGGCCCTCGACCGCCTGCCGGAAAAGTCGGTCGACGTCATCTTCGCCGATCCGCCCTACAATCTGCAGCTTG
ACGGCGATCTGCACCGGCCCGACCAGTCCAAGGTCGACGCGGTCGACGATCACTGGGACCAGTTCGAGAATTTTGAGGCC
TATGACGCCTTCACCCGCGCCTGGCTTTTGGCGGCGCGCCGCGTGCTGAAGCCCAACGGCACCATCTGGGTCATCGGCTC
CTATCACAACATCTTCCGGGTCGGCGCCAAGATGCAGGATCTGGGCTTCTGGATCCTCAACGACGTGGTCTGGCGCAAGA
CCAATCCGATGCCGAATTTCCGTGGCCGCCGTTTCCAGAACGCGCATGAGACGATGATCTGGGCTTCTCGCGACCAGAAG
GGCAAGGGCTACACCTTCAACTACGAGGCGCTGAAGGCGTCCAACGACGATATCCAGATGCGTTCGGACTGGCTGTTCCC
GATCTGCACCGGTGGCGAACGGCTGAAGAACGACAACGGCGACAAGCTGCACCCGACACAGAAGCCGGAAGCGTTGCTCG
CCCGCATCATGATGGCCTCGACCAAGCCCGGCGACATCGTGCTCGACCCTTTCTTCGGCTCTGGCACGACAGGTGCGGTC
GCCAAACGCCTCGGCCGTCATTTCGTCGGCATCGAGCGCGAGCAGGCCTATATCGACGCCGCCAACGAGCGTATCGATGC
GGTGCGGCCGCTGGAGGATGCCGATCTGACGGTATTGACCGGCAAGCGCGCCGAGCCGCGCGTCGCCTTCGTCAGCCTGA
TCGACACCGGGTTGATGACGCCCGGCGTCACGCTTTACGACGCCAAGAAGCGCTGGGCCGTCAAGGTGCGCGCCGACGGC
ACGGTCGCGATCGGCGACAGCGCCGGCTCGATCCACAAGATCGGCGCCGAAGTGCAGGGGCTGGACGCCTGCAATGGCTG
GACCTTCTGGCATTATGAGCGCAGCGGCGGGCTGACCCCGATCGACGAACTGCGCCGCATCGCCCGTCTCGGCATGGAGC
GGGCAGGGGGCTGA

Upstream 100 bases:

>100_bases
CGCAAACCTGGCAGGCGATCGCGCCGGCCTTCACCGAATATTTACGCTGATCGGTAACCATAACGGGGAGTAAACAGTAA
CGCGTGCCTTGGGTGTAAAA

Downstream 100 bases:

>100_bases
CCCCCCCGCTGAATTATCGCGTATTGCGTTGAATCAAAATCTCAGCGGATCGCCGCAAGCGATTCAGATCGCGACTTGAT
TCCCAAGCGTTCAAGATCGG

Product: adenine DNA methyltransferase

Products: NA

Alternate protein names: M.BabI; Adenine-specific methyltransferase BabI; DNA methyltransferase CcrM; M.CcrMI ortholog [H]

Number of amino acids: Translated: 377; Mature: 376

Protein sequence:

>377_residues
MSAVRLLHELSHAPQQSEWLDTILKGDCVAALDRLPEKSVDVIFADPPYNLQLDGDLHRPDQSKVDAVDDHWDQFENFEA
YDAFTRAWLLAARRVLKPNGTIWVIGSYHNIFRVGAKMQDLGFWILNDVVWRKTNPMPNFRGRRFQNAHETMIWASRDQK
GKGYTFNYEALKASNDDIQMRSDWLFPICTGGERLKNDNGDKLHPTQKPEALLARIMMASTKPGDIVLDPFFGSGTTGAV
AKRLGRHFVGIEREQAYIDAANERIDAVRPLEDADLTVLTGKRAEPRVAFVSLIDTGLMTPGVTLYDAKKRWAVKVRADG
TVAIGDSAGSIHKIGAEVQGLDACNGWTFWHYERSGGLTPIDELRRIARLGMERAGG

Sequences:

>Translated_377_residues
MSAVRLLHELSHAPQQSEWLDTILKGDCVAALDRLPEKSVDVIFADPPYNLQLDGDLHRPDQSKVDAVDDHWDQFENFEA
YDAFTRAWLLAARRVLKPNGTIWVIGSYHNIFRVGAKMQDLGFWILNDVVWRKTNPMPNFRGRRFQNAHETMIWASRDQK
GKGYTFNYEALKASNDDIQMRSDWLFPICTGGERLKNDNGDKLHPTQKPEALLARIMMASTKPGDIVLDPFFGSGTTGAV
AKRLGRHFVGIEREQAYIDAANERIDAVRPLEDADLTVLTGKRAEPRVAFVSLIDTGLMTPGVTLYDAKKRWAVKVRADG
TVAIGDSAGSIHKIGAEVQGLDACNGWTFWHYERSGGLTPIDELRRIARLGMERAGG
>Mature_376_residues
SAVRLLHELSHAPQQSEWLDTILKGDCVAALDRLPEKSVDVIFADPPYNLQLDGDLHRPDQSKVDAVDDHWDQFENFEAY
DAFTRAWLLAARRVLKPNGTIWVIGSYHNIFRVGAKMQDLGFWILNDVVWRKTNPMPNFRGRRFQNAHETMIWASRDQKG
KGYTFNYEALKASNDDIQMRSDWLFPICTGGERLKNDNGDKLHPTQKPEALLARIMMASTKPGDIVLDPFFGSGTTGAVA
KRLGRHFVGIEREQAYIDAANERIDAVRPLEDADLTVLTGKRAEPRVAFVSLIDTGLMTPGVTLYDAKKRWAVKVRADGT
VAIGDSAGSIHKIGAEVQGLDACNGWTFWHYERSGGLTPIDELRRIARLGMERAGG

Specific function: This methylase recognizes the double-stranded sequence GANTC and causes specific methylation on A-2 on both strands. CcrM-mediated methylation has important cellular functions. Appears to contribute to the accurate cell-cycle control of DNA replication an

COG id: COG0863

COG function: function code L; DNA modification methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the N(4)/N(6)-methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI87082238, Length=270, Percent_Identity=34.0740740740741, Blast_Score=122, Evalue=5e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002941
- InterPro:   IPR002052
- InterPro:   IPR001091 [H]

Pfam domain/function: PF01555 N6_N4_Mtase [H]

EC number: =2.1.1.72 [H]

Molecular weight: Translated: 42274; Mature: 42143

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: PS00092 N6_MTASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAVRLLHELSHAPQQSEWLDTILKGDCVAALDRLPEKSVDVIFADPPYNLQLDGDLHRP
CHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHCCCCCCEEEECCCCCCEEECCCCCCC
DQSKVDAVDDHWDQFENFEAYDAFTRAWLLAARRVLKPNGTIWVIGSYHNIFRVGAKMQD
CCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHCCCHHH
LGFWILNDVVWRKTNPMPNFRGRRFQNAHETMIWASRDQKGKGYTFNYEALKASNDDIQM
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCEEEEEHEEECCCCCEEE
RSDWLFPICTGGERLKNDNGDKLHPTQKPEALLARIMMASTKPGDIVLDPFFGSGTTGAV
ECCCEEEEECCCHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEECCCCCCCHHHH
AKRLGRHFVGIEREQAYIDAANERIDAVRPLEDADLTVLTGKRAEPRVAFVSLIDTGLMT
HHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHCCCC
PGVTLYDAKKRWAVKVRADGTVAIGDSAGSIHKIGAEVQGLDACNGWTFWHYERSGGLTP
CCEEEEECCCEEEEEEECCCEEEECCCCCCHHHHCCCCCCCCCCCCCEEEEEECCCCCCC
IDELRRIARLGMERAGG
HHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SAVRLLHELSHAPQQSEWLDTILKGDCVAALDRLPEKSVDVIFADPPYNLQLDGDLHRP
HHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHCCCCCCEEEECCCCCCEEECCCCCCC
DQSKVDAVDDHWDQFENFEAYDAFTRAWLLAARRVLKPNGTIWVIGSYHNIFRVGAKMQD
CCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHCCCHHH
LGFWILNDVVWRKTNPMPNFRGRRFQNAHETMIWASRDQKGKGYTFNYEALKASNDDIQM
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCEEEEEHEEECCCCCEEE
RSDWLFPICTGGERLKNDNGDKLHPTQKPEALLARIMMASTKPGDIVLDPFFGSGTTGAV
ECCCEEEEECCCHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEECCCCCCCHHHH
AKRLGRHFVGIEREQAYIDAANERIDAVRPLEDADLTVLTGKRAEPRVAFVSLIDTGLMT
HHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHCCCC
PGVTLYDAKKRWAVKVRADGTVAIGDSAGSIHKIGAEVQGLDACNGWTFWHYERSGGLTP
CCEEEEECCCEEEEEEECCCEEEECCCCCCHHHHCCCCCCCCCCCCCEEEEEECCCCCCC
IDELRRIARLGMERAGG
HHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11756688 [H]