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The map label for this gene is thrC [H]

Identifier: 13476245

GI number: 13476245

Start: 6203238

End: 6204635

Strand: Reverse

Name: thrC [H]

Synonym: mll7517

Alternate gene names: 13476245

Gene position: 6204635-6203238 (Counterclockwise)

Preceding gene: 13476247

Following gene: 13476244

Centisome position: 88.18

GC content: 64.02

Gene sequence:

>1398_bases
ATGCAATATGTGAGTACGCGCGGGGAAGCACCCGCGCTTGGATTTTCCGATGCCGTGCTGGCTGGGCTGGCGCGCGATGG
TGGGCTTTACGTGCCGCGCGAGTGGCCGCAGTTTTCAGCTTCCGAGATCCGCGCCATGCGTGGCCTTGCCTATCCCGATC
TCGCGATCCGCGTGCTGTCGCCGTTCCTTGGCGGTGAAATTCCGGCGCCGGTTTTCGAACGCCTGGTGCGCGAAGCCTAT
GCCACGTTCCGTCACGAGGCGGTCTGCCCGCTTGTCCAGACCGGCACCAATACCTTTGTCCTCGAACTCTTCCATGGGCC
GACGCTGGCATTCAAGGATGTGGCGATGCAGCTGCTCGCCCGGCTGATGGACCATGTGCTTGCCGAACGCGATCAGCATG
CCACCATCGTCGGCGCCACGTCAGGCGACACCGGCGGCGCGGCGATCGACGCCTTTGCCGGGCGCAGCCGCACCGACATC
TTCATCCTGTTCCCGCATGGCCGCGTTTCGCCGGTGCAGCAGCGCCAGATGACGACGTCGAAGGCCGAGAACGTCCATGC
GCTGGCGATCGAAGGCAATTTCGACGACTGCCAGGGCCTGCTCAAGGACATGTTCAACGACCACGCCTTTCGCGACCGGG
TGGCGCTGTCGGGGGTCAATTCGATCAACTGGGCGCGCATCATGGCCCAGATCGTCTATTATTTCTCCTCGGCACTGTCG
CTCGGCGCGCCGGACAGGCCGGTGTCGTTCACCGTCCCGACCGGCAATTTCGGCGATATCTTCGCCGGCTACGCCGCCAA
GAAGATGGGCCTGCCGATCGAGCGGCTGGTCATCGCCACCAACGACAACGACATATTGGCGCGCACCTTCGCCACCGGCG
AGTACCGCACCAAGGGTGTCTTTGCGACCACCTCACCGTCGATGGACATCCAGGTTTCGTCGAATTTCGAACGCCTGCTG
TTCGAGGCCTCCAACCGTGACGCGGCGACCGTGCGGCGCTACATGGACGGCCTGAAGCAGTCCGGCGCCTTCACCATAGA
ATCCCGCGAAATCAATGGGATGCGGTCCGAATTCGACGCCGGCCGCGCCACCATGGACGAGGTCGCCGCCACCATCCGTT
CGACGCTCGCGGCCAGCAATTATCTTCTGGATCCGCACACCGCGGCAGCCATGCATGTGGCGGCCGGCAAGGCATCGGGC
GCCGTGCCGATGGTGGTGCTGGGCACGGCGCACCCGGCAAAATTTCCGGCCGCCGTCGAGGCCGCCAGCGGGGTCTCGCC
GGCCCTGCCCGCATGGCTAGGCGGATTGATGACATTTGAGGAAAAATACACGGTACTTCCATCCGACCTGAAAATGGTGG
AAGATTATGTCAGCCGCCGTGCGCGAGCGGCGCGTTAG

Upstream 100 bases:

>100_bases
GTGACGTATATCAACGCCGCGGCAAAAATGCGACTGGAGCCGGCACAGAAATTAACCACCTTGTGGTGAACGGAAAGCCA
AGCGGCAACGGGACTGAGAC

Downstream 100 bases:

>100_bases
GGAGTACGAACCATATGGGTGTTGAGGTAAGCCGTCTGTCGAACGGCCTGACAGTCGCCACCGAAACCCTTCCAAGTATC
GAATCGGTTGCCTTGGGTGC

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 465; Mature: 465

Protein sequence:

>465_residues
MQYVSTRGEAPALGFSDAVLAGLARDGGLYVPREWPQFSASEIRAMRGLAYPDLAIRVLSPFLGGEIPAPVFERLVREAY
ATFRHEAVCPLVQTGTNTFVLELFHGPTLAFKDVAMQLLARLMDHVLAERDQHATIVGATSGDTGGAAIDAFAGRSRTDI
FILFPHGRVSPVQQRQMTTSKAENVHALAIEGNFDDCQGLLKDMFNDHAFRDRVALSGVNSINWARIMAQIVYYFSSALS
LGAPDRPVSFTVPTGNFGDIFAGYAAKKMGLPIERLVIATNDNDILARTFATGEYRTKGVFATTSPSMDIQVSSNFERLL
FEASNRDAATVRRYMDGLKQSGAFTIESREINGMRSEFDAGRATMDEVAATIRSTLAASNYLLDPHTAAAMHVAAGKASG
AVPMVVLGTAHPAKFPAAVEAASGVSPALPAWLGGLMTFEEKYTVLPSDLKMVEDYVSRRARAAR

Sequences:

>Translated_465_residues
MQYVSTRGEAPALGFSDAVLAGLARDGGLYVPREWPQFSASEIRAMRGLAYPDLAIRVLSPFLGGEIPAPVFERLVREAY
ATFRHEAVCPLVQTGTNTFVLELFHGPTLAFKDVAMQLLARLMDHVLAERDQHATIVGATSGDTGGAAIDAFAGRSRTDI
FILFPHGRVSPVQQRQMTTSKAENVHALAIEGNFDDCQGLLKDMFNDHAFRDRVALSGVNSINWARIMAQIVYYFSSALS
LGAPDRPVSFTVPTGNFGDIFAGYAAKKMGLPIERLVIATNDNDILARTFATGEYRTKGVFATTSPSMDIQVSSNFERLL
FEASNRDAATVRRYMDGLKQSGAFTIESREINGMRSEFDAGRATMDEVAATIRSTLAASNYLLDPHTAAAMHVAAGKASG
AVPMVVLGTAHPAKFPAAVEAASGVSPALPAWLGGLMTFEEKYTVLPSDLKMVEDYVSRRARAAR
>Mature_465_residues
MQYVSTRGEAPALGFSDAVLAGLARDGGLYVPREWPQFSASEIRAMRGLAYPDLAIRVLSPFLGGEIPAPVFERLVREAY
ATFRHEAVCPLVQTGTNTFVLELFHGPTLAFKDVAMQLLARLMDHVLAERDQHATIVGATSGDTGGAAIDAFAGRSRTDI
FILFPHGRVSPVQQRQMTTSKAENVHALAIEGNFDDCQGLLKDMFNDHAFRDRVALSGVNSINWARIMAQIVYYFSSALS
LGAPDRPVSFTVPTGNFGDIFAGYAAKKMGLPIERLVIATNDNDILARTFATGEYRTKGVFATTSPSMDIQVSSNFERLL
FEASNRDAATVRRYMDGLKQSGAFTIESREINGMRSEFDAGRATMDEVAATIRSTLAASNYLLDPHTAAAMHVAAGKASG
AVPMVVLGTAHPAKFPAAVEAASGVSPALPAWLGGLMTFEEKYTVLPSDLKMVEDYVSRRARAAR

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI149193323, Length=479, Percent_Identity=35.9081419624217, Blast_Score=287, Evalue=1e-77,
Organism=Homo sapiens, GI153792148, Length=452, Percent_Identity=36.283185840708, Blast_Score=269, Evalue=5e-72,
Organism=Escherichia coli, GI1786185, Length=434, Percent_Identity=34.7926267281106, Blast_Score=248, Evalue=4e-67,
Organism=Saccharomyces cerevisiae, GI6319901, Length=482, Percent_Identity=41.49377593361, Blast_Score=355, Evalue=7e-99,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 50270; Mature: 50270

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQYVSTRGEAPALGFSDAVLAGLARDGGLYVPREWPQFSASEIRAMRGLAYPDLAIRVLS
CCCCCCCCCCCCCCCHHHHHHHHHCCCCEECCCCCCCCCHHHHHHHHCCCCHHHHHHHHH
PFLGGEIPAPVFERLVREAYATFRHEAVCPLVQTGTNTFVLELFHGPTLAFKDVAMQLLA
HHHCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHCCCCEEEEEEECCCCHHHHHHHHHHHH
RLMDHVLAERDQHATIVGATSGDTGGAAIDAFAGRSRTDIFILFPHGRVSPVQQRQMTTS
HHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHH
KAENVHALAIEGNFDDCQGLLKDMFNDHAFRDRVALSGVNSINWARIMAQIVYYFSSALS
HCCCEEEEEEECCHHHHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
LGAPDRPVSFTVPTGNFGDIFAGYAAKKMGLPIERLVIATNDNDILARTFATGEYRTKGV
CCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCHHHEEEEECCCCEEEEEEECCCCEECCE
FATTSPSMDIQVSSNFERLLFEASNRDAATVRRYMDGLKQSGAFTIESREINGMRSEFDA
EEECCCCEEEEECCCHHHHHHCCCCCCHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHCC
GRATMDEVAATIRSTLAASNYLLDPHTAAAMHVAAGKASGAVPMVVLGTAHPAKFPAAVE
CHHHHHHHHHHHHHHHHHCCCEECCCHHHHHHHCCCCCCCCCCEEEEECCCCCCCCHHHH
AASGVSPALPAWLGGLMTFEEKYTVLPSDLKMVEDYVSRRARAAR
HHCCCCCCHHHHHHHHHHHCCCCEECCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQYVSTRGEAPALGFSDAVLAGLARDGGLYVPREWPQFSASEIRAMRGLAYPDLAIRVLS
CCCCCCCCCCCCCCCHHHHHHHHHCCCCEECCCCCCCCCHHHHHHHHCCCCHHHHHHHHH
PFLGGEIPAPVFERLVREAYATFRHEAVCPLVQTGTNTFVLELFHGPTLAFKDVAMQLLA
HHHCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHCCCCEEEEEEECCCCHHHHHHHHHHHH
RLMDHVLAERDQHATIVGATSGDTGGAAIDAFAGRSRTDIFILFPHGRVSPVQQRQMTTS
HHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHH
KAENVHALAIEGNFDDCQGLLKDMFNDHAFRDRVALSGVNSINWARIMAQIVYYFSSALS
HCCCEEEEEEECCHHHHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
LGAPDRPVSFTVPTGNFGDIFAGYAAKKMGLPIERLVIATNDNDILARTFATGEYRTKGV
CCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCHHHEEEEECCCCEEEEEEECCCCEECCE
FATTSPSMDIQVSSNFERLLFEASNRDAATVRRYMDGLKQSGAFTIESREINGMRSEFDA
EEECCCCEEEEECCCHHHHHHCCCCCCHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHCC
GRATMDEVAATIRSTLAASNYLLDPHTAAAMHVAAGKASGAVPMVVLGTAHPAKFPAAVE
CHHHHHHHHHHHHHHHHHCCCEECCCHHHHHHHCCCCCCCCCCEEEEECCCCCCCCHHHH
AASGVSPALPAWLGGLMTFEEKYTVLPSDLKMVEDYVSRRARAAR
HHCCCCCCHHHHHHHHHHHCCCCEECCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1333566; 10984043 [H]