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The map label for this gene is ribBA [H]

Identifier: 13476204

GI number: 13476204

Start: 6165157

End: 6166257

Strand: Direct

Name: ribBA [H]

Synonym: mlr7463

Alternate gene names: 13476204

Gene position: 6165157-6166257 (Clockwise)

Preceding gene: 13476203

Following gene: 13476205

Centisome position: 87.62

GC content: 63.31

Gene sequence:

>1101_bases
ATGCCTTACGACCAGAAGAAGATTGTCGAAGCCATCCGCGCTTTCGAACGCGGCGAGATCGTCGTCGTCATGGATGATGA
CGGGCGCGAGAATGAGGGCGACCTGATCGTCGCCGCCGTTCACTGCACGCCGGAAAAGATGGCCTTCATCGTGCGCAACA
CCTCCGGCATCGTCTGCACGCCGATGCCACGCGAGGAAGCCAAGCGGCTCAACCTGCAGCCGATGGTCGCCGACAATGAT
TCAGCCCACACCACCGCCTTTACCGTCAGCGTCGATTTCAAGCATGGCACGACGACAGGCATTTCGGCCGACGACCGCAC
GCTCACCGTGCGCAACCTCGCCAACGGCAATGTCGGCGCCTCCGATTTCGTCCGTCCGGGTCACATCTTTCCGCTGATCG
CGCGCGAAGGCGGCGTCCTGATGCGTTCGGGCCATACCGAAGCGGCGGTCGATCTCTGCAAGCTCGCCGGCCTGCCGCCG
ATCGGCGTCATTTCCGAACTGGTCAATGATGACGGTACCGTCAAGCGCGGCCCCCAGGTGCAGGCTTTCGCCGAAGAGCA
TGGCCTGAAGCAGGTATCGGTCGCCGACCTCATCGCCTACCGCCAGCGCAAGGAAACGCTGGTCGAACGCGTCGCCTGCT
CCGATATCGACACGCTTGGCGGCAAGGCGCAGGTCTTCACCTACACGCTGCCCTGGGACACGATGCATCACGTTGCCGTC
GTCTTCGGCGACATCCGCGATGGCGAGGAGGTGCCGGTGCGGCTGCATTCCGAGGATGTGGTGACCGATGTCTTCGGCAC
CAGTCATCGCCTGGACGGCATCATGAAAGCGATGGGCGAGCGCAAGCGCGGCGTCATCGTCTATCTCAGAGAGGGCTCCG
TCGGTGTCGCGCATCAGGAGCGCAAGCGCCCGCTGAGCGGCGACCGCGAGGATCATGAAGAGGCCCGCCGGCGCGAGAAC
GAATGGCGCGAGATCGGCCTCGGCGCGCAGATCCTGAAGGATCTCGGCATTTCCTCGATCAACCTGATCGCCTCGCGCGA
GCGTCATTATGTCGGCCTCGAAGGGTTTGGCATCCACATCGCCAAGACCGAGATCCTCTGA

Upstream 100 bases:

>100_bases
AAGGGAATAGGCAGTAGGGAATAGGCAGTAGGCCGCCCGAAACAGCCTTTTTCTTCCCTACTGCCTACTCCCTAATCCCT
GCGAGCGAAGCGAGCATCCC

Downstream 100 bases:

>100_bases
GGGGTAACCGACCCCTTGCCGGGAGATGACGGCATGAACGCGTCATTGCCTCTGAGCCAGCGCAACGGACGGCTTTTGCT
GCGCCGACCAACGAAGGCCG

Product: GTP cyclohydrolase II

Products: NA

Alternate protein names: 3,4-dihydroxy-2-butanone 4-phosphate synthase; DHBP synthase; GTP cyclohydrolase-2; GTP cyclohydrolase II [H]

Number of amino acids: Translated: 366; Mature: 365

Protein sequence:

>366_residues
MPYDQKKIVEAIRAFERGEIVVVMDDDGRENEGDLIVAAVHCTPEKMAFIVRNTSGIVCTPMPREEAKRLNLQPMVADND
SAHTTAFTVSVDFKHGTTTGISADDRTLTVRNLANGNVGASDFVRPGHIFPLIAREGGVLMRSGHTEAAVDLCKLAGLPP
IGVISELVNDDGTVKRGPQVQAFAEEHGLKQVSVADLIAYRQRKETLVERVACSDIDTLGGKAQVFTYTLPWDTMHHVAV
VFGDIRDGEEVPVRLHSEDVVTDVFGTSHRLDGIMKAMGERKRGVIVYLREGSVGVAHQERKRPLSGDREDHEEARRREN
EWREIGLGAQILKDLGISSINLIASRERHYVGLEGFGIHIAKTEIL

Sequences:

>Translated_366_residues
MPYDQKKIVEAIRAFERGEIVVVMDDDGRENEGDLIVAAVHCTPEKMAFIVRNTSGIVCTPMPREEAKRLNLQPMVADND
SAHTTAFTVSVDFKHGTTTGISADDRTLTVRNLANGNVGASDFVRPGHIFPLIAREGGVLMRSGHTEAAVDLCKLAGLPP
IGVISELVNDDGTVKRGPQVQAFAEEHGLKQVSVADLIAYRQRKETLVERVACSDIDTLGGKAQVFTYTLPWDTMHHVAV
VFGDIRDGEEVPVRLHSEDVVTDVFGTSHRLDGIMKAMGERKRGVIVYLREGSVGVAHQERKRPLSGDREDHEEARRREN
EWREIGLGAQILKDLGISSINLIASRERHYVGLEGFGIHIAKTEIL
>Mature_365_residues
PYDQKKIVEAIRAFERGEIVVVMDDDGRENEGDLIVAAVHCTPEKMAFIVRNTSGIVCTPMPREEAKRLNLQPMVADNDS
AHTTAFTVSVDFKHGTTTGISADDRTLTVRNLANGNVGASDFVRPGHIFPLIAREGGVLMRSGHTEAAVDLCKLAGLPPI
GVISELVNDDGTVKRGPQVQAFAEEHGLKQVSVADLIAYRQRKETLVERVACSDIDTLGGKAQVFTYTLPWDTMHHVAVV
FGDIRDGEEVPVRLHSEDVVTDVFGTSHRLDGIMKAMGERKRGVIVYLREGSVGVAHQERKRPLSGDREDHEEARRRENE
WREIGLGAQILKDLGISSINLIASRERHYVGLEGFGIHIAKTEIL

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0108

COG function: function code H; 3,4-dihydroxy-2-butanone 4-phosphate synthase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1789420, Length=200, Percent_Identity=48, Blast_Score=190, Evalue=2e-49,
Organism=Saccharomyces cerevisiae, GI6320695, Length=205, Percent_Identity=50.2439024390244, Blast_Score=201, Evalue=1e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12; =3.5.4.25 [H]

Molecular weight: Translated: 40312; Mature: 40181

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPYDQKKIVEAIRAFERGEIVVVMDDDGRENEGDLIVAAVHCTPEKMAFIVRNTSGIVCT
CCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEEEECCCCCEEEEEECCCCEEEC
PMPREEAKRLNLQPMVADNDSAHTTAFTVSVDFKHGTTTGISADDRTLTVRNLANGNVGA
CCCHHHHHHCCCCEEEECCCCCCEEEEEEEEEECCCCCCCCCCCCCEEEEEECCCCCCCH
SDFVRPGHIFPLIAREGGVLMRSGHTEAAVDLCKLAGLPPIGVISELVNDDGTVKRGPQV
HHCCCCCCEEEEEECCCCEEEECCCCHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCH
QAFAEEHGLKQVSVADLIAYRQRKETLVERVACSDIDTLGGKAQVFTYTLPWDTMHHVAV
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCEEEEEEECCCCHHHEEEE
VFGDIRDGEEVPVRLHSEDVVTDVFGTSHRLDGIMKAMGERKRGVIVYLREGSVGVAHQE
EEECCCCCCCCCEEECCCHHHHHHHCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHH
RKRPLSGDREDHEEARRRENEWREIGLGAQILKDLGISSINLIASRERHYVGLEGFGIHI
HCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHCCCCEEEEEECCCCCEEEECCCEEEE
AKTEIL
EEEECC
>Mature Secondary Structure 
PYDQKKIVEAIRAFERGEIVVVMDDDGRENEGDLIVAAVHCTPEKMAFIVRNTSGIVCT
CCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEEEECCCCCEEEEEECCCCEEEC
PMPREEAKRLNLQPMVADNDSAHTTAFTVSVDFKHGTTTGISADDRTLTVRNLANGNVGA
CCCHHHHHHCCCCEEEECCCCCCEEEEEEEEEECCCCCCCCCCCCCEEEEEECCCCCCCH
SDFVRPGHIFPLIAREGGVLMRSGHTEAAVDLCKLAGLPPIGVISELVNDDGTVKRGPQV
HHCCCCCCEEEEEECCCCEEEECCCCHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCH
QAFAEEHGLKQVSVADLIAYRQRKETLVERVACSDIDTLGGKAQVFTYTLPWDTMHHVAV
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCEEEEEEECCCCHHHEEEE
VFGDIRDGEEVPVRLHSEDVVTDVFGTSHRLDGIMKAMGERKRGVIVYLREGSVGVAHQE
EEECCCCCCCCCEEECCCHHHHHHHCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHH
RKRPLSGDREDHEEARRRENEWREIGLGAQILKDLGISSINLIASRERHYVGLEGFGIHI
HCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHCCCCEEEEEECCCCCEEEECCCEEEE
AKTEIL
EEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9784136 [H]