Click here to switch to the map view.

The map label for this gene is proW [H]

Identifier: 13476102

GI number: 13476102

Start: 6061448

End: 6063427

Strand: Reverse

Name: proW [H]

Synonym: mll7329

Alternate gene names: 13476102

Gene position: 6063427-6061448 (Counterclockwise)

Preceding gene: 13476103

Following gene: 13476100

Centisome position: 86.18

GC content: 65.25

Gene sequence:

>1980_bases
ATGACGGTGACGGCAAGCACCAGCGAGCCGAGGCCGCCGCTTCAGCGGTGGCTGCTTGTCTGGGCGCTCGCCCTCGCCGC
CGTGCTCGTGGTGTTCCTGCTGCAGGACAGCGTCCCTTGGGCAGTCGACTATCCGGCCAGCGCCGTCGTGCCCTTCGCCG
ACTGGGTCAGCGCGCTGATGGGCTGGATCAAATCGAACCTGTCATGGCTGACCCGCTCGATCACCGCGGTGCTCGGCGTG
CCGCTCGATTTCGCGCTCAATCTCCTGGCCAAGAATTTCAAGATCGGCCATGGCGCGGACGCCTATGTCCTGCCGCGCCT
CTCCTGGGTTGGCGTCTGCGCTGTCGCCTTCATCGCCGGCCATGCCGTGGGCGGCCGTAAACTCAGCCTGCTGGTCGGCG
GTTGCTTCCTCTACATCGCGCTGTTCGGCCAATGGACCAGCGCCATGCTGACGCTGGCGCTGATCTCGATCGCCGTGCCG
TTTTGCATTGTCACTGGCCTGTTCGCCGGCATCTGGGCCTGGCGCAAGCCATGGGCGGAAAGGCTCATCGTCTCTCCTGC
CCTCGACCTGATGCAGACGATCCCGACCTTCGCCTATCTCATCCCGATGCTGCTCCTGTTCGGCAACAGCCCGGTGTCGG
CGATGATCGCCACAGCTATTTTCGCCACGCCGCCGATGGTTCGGGCGACGATGCTCGGCCTGACGCGCGTGCCCCTGGAG
ATCGGCGAATTCAGCGACATGGCCGGCTGCACGGCGCGGCAGAAACTGTGGCGGGTGCTGCTGCCCTCCGCACGGCCGAC
GCTGATGGTCGGCGTCAACCAGGTTATCATGCTGGCGCTCAACATGGTGATCATCGCCTCGATGATCGGCGCCGGCGGCC
TCGGCTATGACGTGCTCCTGGCGCTGCGCGCGCTGAAGGTCGGCGAGGCGATGGAGGCGGGTCTCGCCATCGTGGCGCTG
GCAATCGCGCTCGACCGGCTGAGTCAGGCCATAGCCCACAAGCAGGCGAAGGGCCATGTTCATCAGGCGGTGGACCCGAG
CTTCTGGCGGCGCTACCCCAATCTGACGCTGGCGATCGCCATCCTTTCCGTCACCACGCTGCTCGGCCTGCTCGTGCCGG
CTTTCGCGGCGGTGCCGAAGGCGATCACCTTCACCACAGCGCCGCTGTGGAAGGCGGCGGTGAACTGGGTGACGATCAAC
TTCTTCGATGCGATCGAAGCCTTTCGCGTGGCGCTGATCCTCAATGTGCTCAATCCGGTGCGTGCCTTCTGCGAAGGCTT
TCCGTGGCTGGGCGCGGTGTTCCTGCTCGGCCTTGCCGGCTATCAGCTCTCGGGCCTGCGCTTGGCGGCCCTGGTCGCCG
CGCTGACCGTCTTCTGCGCCGTCACCGGCCTGTGGGAAAAGACCATGGCCACCGTCTATCTCTGCGGCATCTCGGCCTTC
ATCGCCTGCCTGATCGGCATCCCGATCGGGCTGATGGCGGCGCGCAGCGACCGTTTCGAGAAGATCGTCACACCCATCAT
CGACACGCTGCAGGTGCTTCCATCCTTCTGCTTCATCATTCCGGTGGTGATGCTGTTCCGCGTCGGCGATGTGACCGCCA
TGATCGCAACGATAGCCTTCGCCGTGGTGCCGGCGATCCGCTACACCAATCACGGCATAAGACAGGTGCCGCCGGCGCTG
ATCGAGGCGGCCAAGGTGTCGGGCTGCACGCCGCGCCAGACCTTCTTTCGCGTGCAATTGCCGCTGGCGCTGCCGGAGAT
CATGCTCGGCGTCAACCAGACCATCCTGATGGCGCTAGCGATGATCATCATCTGCGCCATGGTCGGCACGCGCGATCTCG
GCCAGGAAGTGTTCATTGCACTGTCCAAAGCCGATTCCGGCCGCGGCATTGTCGCGGGCCTGGCAATCGCCTTCATCGGC
ATCGTCGCCGACCGGCTGTTCAACGCCTGGACGGCGAAGGCGCGGGCAAGGCTGGGATAG

Upstream 100 bases:

>100_bases
CGTTCGCCGTGGTCAACGGCACCGGCAAGCCGATCGGCGAAGTGACGCCGCAAGCGGTCATCGACCTGCTGGCCGGCATC
GAGCACGCGAGGGCCGGCGC

Downstream 100 bases:

>100_bases
GCAGGACGATGCGTCGCGGCTATTCCGCCGCGACGCCCTTCACTTCGAGATAGCTCTCCATGGAATCGTCCAGCGCCTGC
AGCCAGGGCGTATGGTGCAG

Product: ABC transporter permease protein

Products: ADP; phosphate; L-proline [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 659; Mature: 658

Protein sequence:

>659_residues
MTVTASTSEPRPPLQRWLLVWALALAAVLVVFLLQDSVPWAVDYPASAVVPFADWVSALMGWIKSNLSWLTRSITAVLGV
PLDFALNLLAKNFKIGHGADAYVLPRLSWVGVCAVAFIAGHAVGGRKLSLLVGGCFLYIALFGQWTSAMLTLALISIAVP
FCIVTGLFAGIWAWRKPWAERLIVSPALDLMQTIPTFAYLIPMLLLFGNSPVSAMIATAIFATPPMVRATMLGLTRVPLE
IGEFSDMAGCTARQKLWRVLLPSARPTLMVGVNQVIMLALNMVIIASMIGAGGLGYDVLLALRALKVGEAMEAGLAIVAL
AIALDRLSQAIAHKQAKGHVHQAVDPSFWRRYPNLTLAIAILSVTTLLGLLVPAFAAVPKAITFTTAPLWKAAVNWVTIN
FFDAIEAFRVALILNVLNPVRAFCEGFPWLGAVFLLGLAGYQLSGLRLAALVAALTVFCAVTGLWEKTMATVYLCGISAF
IACLIGIPIGLMAARSDRFEKIVTPIIDTLQVLPSFCFIIPVVMLFRVGDVTAMIATIAFAVVPAIRYTNHGIRQVPPAL
IEAAKVSGCTPRQTFFRVQLPLALPEIMLGVNQTILMALAMIIICAMVGTRDLGQEVFIALSKADSGRGIVAGLAIAFIG
IVADRLFNAWTAKARARLG

Sequences:

>Translated_659_residues
MTVTASTSEPRPPLQRWLLVWALALAAVLVVFLLQDSVPWAVDYPASAVVPFADWVSALMGWIKSNLSWLTRSITAVLGV
PLDFALNLLAKNFKIGHGADAYVLPRLSWVGVCAVAFIAGHAVGGRKLSLLVGGCFLYIALFGQWTSAMLTLALISIAVP
FCIVTGLFAGIWAWRKPWAERLIVSPALDLMQTIPTFAYLIPMLLLFGNSPVSAMIATAIFATPPMVRATMLGLTRVPLE
IGEFSDMAGCTARQKLWRVLLPSARPTLMVGVNQVIMLALNMVIIASMIGAGGLGYDVLLALRALKVGEAMEAGLAIVAL
AIALDRLSQAIAHKQAKGHVHQAVDPSFWRRYPNLTLAIAILSVTTLLGLLVPAFAAVPKAITFTTAPLWKAAVNWVTIN
FFDAIEAFRVALILNVLNPVRAFCEGFPWLGAVFLLGLAGYQLSGLRLAALVAALTVFCAVTGLWEKTMATVYLCGISAF
IACLIGIPIGLMAARSDRFEKIVTPIIDTLQVLPSFCFIIPVVMLFRVGDVTAMIATIAFAVVPAIRYTNHGIRQVPPAL
IEAAKVSGCTPRQTFFRVQLPLALPEIMLGVNQTILMALAMIIICAMVGTRDLGQEVFIALSKADSGRGIVAGLAIAFIG
IVADRLFNAWTAKARARLG
>Mature_658_residues
TVTASTSEPRPPLQRWLLVWALALAAVLVVFLLQDSVPWAVDYPASAVVPFADWVSALMGWIKSNLSWLTRSITAVLGVP
LDFALNLLAKNFKIGHGADAYVLPRLSWVGVCAVAFIAGHAVGGRKLSLLVGGCFLYIALFGQWTSAMLTLALISIAVPF
CIVTGLFAGIWAWRKPWAERLIVSPALDLMQTIPTFAYLIPMLLLFGNSPVSAMIATAIFATPPMVRATMLGLTRVPLEI
GEFSDMAGCTARQKLWRVLLPSARPTLMVGVNQVIMLALNMVIIASMIGAGGLGYDVLLALRALKVGEAMEAGLAIVALA
IALDRLSQAIAHKQAKGHVHQAVDPSFWRRYPNLTLAIAILSVTTLLGLLVPAFAAVPKAITFTTAPLWKAAVNWVTINF
FDAIEAFRVALILNVLNPVRAFCEGFPWLGAVFLLGLAGYQLSGLRLAALVAALTVFCAVTGLWEKTMATVYLCGISAFI
ACLIGIPIGLMAARSDRFEKIVTPIIDTLQVLPSFCFIIPVVMLFRVGDVTAMIATIAFAVVPAIRYTNHGIRQVPPALI
EAAKVSGCTPRQTFFRVQLPLALPEIMLGVNQTILMALAMIIICAMVGTRDLGQEVFIALSKADSGRGIVAGLAIAFIGI
VADRLFNAWTAKARARLG

Specific function: Involved in a multicomponent binding-protein-dependent transport system for glycine betaine/L-proline [H]

COG id: COG4176

COG function: function code E; ABC-type proline/glycine betaine transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1789033, Length=265, Percent_Identity=36.9811320754717, Blast_Score=180, Evalue=3e-46,
Organism=Escherichia coli, GI1788449, Length=182, Percent_Identity=30.7692307692308, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1788451, Length=183, Percent_Identity=25.1366120218579, Blast_Score=66, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 70668; Mature: 70537

Theoretical pI: Translated: 9.91; Mature: 9.91

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVTASTSEPRPPLQRWLLVWALALAAVLVVFLLQDSVPWAVDYPASAVVPFADWVSALM
CEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCHHHCCHHHHHHHHH
GWIKSNLSWLTRSITAVLGVPLDFALNLLAKNFKIGHGADAYVLPRLSWVGVCAVAFIAG
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCHHHCCHHHHHHHHHHHHHH
HAVGGRKLSLLVGGCFLYIALFGQWTSAMLTLALISIAVPFCIVTGLFAGIWAWRKPWAE
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLIVSPALDLMQTIPTFAYLIPMLLLFGNSPVSAMIATAIFATPPMVRATMLGLTRVPLE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCHH
IGEFSDMAGCTARQKLWRVLLPSARPTLMVGVNQVIMLALNMVIIASMIGAGGLGYDVLL
HCCCCHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
ALRALKVGEAMEAGLAIVALAIALDRLSQAIAHKQAKGHVHQAVDPSFWRRYPNLTLAIA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCHHHHHHCCCHHHHHH
ILSVTTLLGLLVPAFAAVPKAITFTTAPLWKAAVNWVTINFFDAIEAFRVALILNVLNPV
HHHHHHHHHHHHHHHHHCCCHHEEECCHHHHHHHHHHEEHHHHHHHHHHHHHHHHHHHHH
RAFCEGFPWLGAVFLLGLAGYQLSGLRLAALVAALTVFCAVTGLWEKTMATVYLCGISAF
HHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IACLIGIPIGLMAARSDRFEKIVTPIIDTLQVLPSFCFIIPVVMLFRVGDVTAMIATIAF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVVPAIRYTNHGIRQVPPALIEAAKVSGCTPRQTFFRVQLPLALPEIMLGVNQTILMALA
HHHHHHHHCCCCHHHCCHHHHHHHHCCCCCCCHHHEEEECCHHHHHHHHCCCHHHHHHHH
MIIICAMVGTRDLGQEVFIALSKADSGRGIVAGLAIAFIGIVADRLFNAWTAKARARLG
HHHHHHHHCCHHCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TVTASTSEPRPPLQRWLLVWALALAAVLVVFLLQDSVPWAVDYPASAVVPFADWVSALM
EECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCHHHCCHHHHHHHHH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HHHHHHHHCCHHCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-proline [Periplasm]; H2O [C]

Specific reaction: ATP + L-proline [Periplasm] + H2O = ADP + phosphate + L-proline [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2649479; 9205837; 9278503 [H]