Click here to switch to the map view.

The map label for this gene is murQ

Identifier: 13476039

GI number: 13476039

Start: 5988290

End: 5989213

Strand: Reverse

Name: murQ

Synonym: mll7248

Alternate gene names: 13476039

Gene position: 5989213-5988290 (Counterclockwise)

Preceding gene: 13476040

Following gene: 13476038

Centisome position: 85.12

GC content: 64.18

Gene sequence:

>924_bases
ATGACCGAGCACGGGTTGATGTCTGAGCTGGACCTGTTGGTTTCCGAAGGCCGCAACCCGCGGACGATGGATATCGACCT
GCTGCCGACCATCGATGTGCTGCGCAAGATCAATGACGAAGACAGGCTTGTGCCTGTGGCTGTCGAAAAGGTGCTGCCGG
AAATCGCCGCCGCGGTCGACCGGATCGTGCTTGCCTTCCAGAAGGGCGCGCGGCTGATCTATGTCGGCGCCGGCACCAGC
GGCCGGCTCGGCGTTCTCGACGCTTCGGAATGCCCGCCCACTTTCGGCGTGCCCGAAGACATGGTGATCGGCCTGATCGC
CGGCGGTCCGGACGCTCTGGTGCGGTCGACGGAAGGTGCTGAGGATGACCCGAAAATGGGCGCGCAGGCGTTGCAGGAGA
TCGGGCTCACACCGGACGACGTCGTGATGGGCATCGCGGTCAGCGGGCGCACGCCTTACGTCATCGGCGGGCTGAACTAC
GCCAAGCAGGTCGGCGCGACCACGGTTGCCTTGTCCTGCAATCCGGCATCGACCATTGCCGGCATCGCCGACATTGCCAT
CTCGCCGGTCGTCGGCCCCGAAGTGCTGACCGGCTCGACCCGGCTGAAGTCGGGAACCGCGCAGAAGCTGGTGCTCAACA
TGCTGACCACGGCCTCGATGATCCGCATCGGCAAGAGTTTTCAGAATCTGATGGTCGACCTCAACCCGTCCAACAAGAAA
CTGGTGGCGAGGGCAACCAGGATGGTCATGCAGACGACGGGCTGCACGGCGCAGCAGGCCAAACAGGCGCTCCACCAAAC
AAGCAACGATGTGAAGCTGGCGATCCTGGTGACGATCACCGGCCTCGATGTCGAGGCGGCGCGGGCTGCCCTCGGCAAGG
CCGGAGGCTTCCTGCGAAAGGCGATCAGTGACCCGACGGCATGA

Upstream 100 bases:

>100_bases
TTAACAAAGAAAAACTGCGATGACGGACCCGAGGTCCGTGTGCCCTGGCGTTCGTTGAGCCATACCGGACGCCGGCAGCA
GAATTTTTGAAGGCACTGGA

Downstream 100 bases:

>100_bases
AACCGCCTGGGACAAGACGGCAAGAAGCCGCTTTAGACAAGACGGCGCGAAGCCGCATAGACTGGGCCGATACTCCAAAG
CATGTGTGTCTTGGAAGCGG

Product: N-acetylmuramic acid-6-phosphate etherase

Products: NA

Alternate protein names: MurNAc-6-P etherase; N-acetylmuramic acid 6-phosphate hydrolase; N-acetylmuramic acid 6-phosphate lyase

Number of amino acids: Translated: 307; Mature: 306

Protein sequence:

>307_residues
MTEHGLMSELDLLVSEGRNPRTMDIDLLPTIDVLRKINDEDRLVPVAVEKVLPEIAAAVDRIVLAFQKGARLIYVGAGTS
GRLGVLDASECPPTFGVPEDMVIGLIAGGPDALVRSTEGAEDDPKMGAQALQEIGLTPDDVVMGIAVSGRTPYVIGGLNY
AKQVGATTVALSCNPASTIAGIADIAISPVVGPEVLTGSTRLKSGTAQKLVLNMLTTASMIRIGKSFQNLMVDLNPSNKK
LVARATRMVMQTTGCTAQQAKQALHQTSNDVKLAILVTITGLDVEAARAALGKAGGFLRKAISDPTA

Sequences:

>Translated_307_residues
MTEHGLMSELDLLVSEGRNPRTMDIDLLPTIDVLRKINDEDRLVPVAVEKVLPEIAAAVDRIVLAFQKGARLIYVGAGTS
GRLGVLDASECPPTFGVPEDMVIGLIAGGPDALVRSTEGAEDDPKMGAQALQEIGLTPDDVVMGIAVSGRTPYVIGGLNY
AKQVGATTVALSCNPASTIAGIADIAISPVVGPEVLTGSTRLKSGTAQKLVLNMLTTASMIRIGKSFQNLMVDLNPSNKK
LVARATRMVMQTTGCTAQQAKQALHQTSNDVKLAILVTITGLDVEAARAALGKAGGFLRKAISDPTA
>Mature_306_residues
TEHGLMSELDLLVSEGRNPRTMDIDLLPTIDVLRKINDEDRLVPVAVEKVLPEIAAAVDRIVLAFQKGARLIYVGAGTSG
RLGVLDASECPPTFGVPEDMVIGLIAGGPDALVRSTEGAEDDPKMGAQALQEIGLTPDDVVMGIAVSGRTPYVIGGLNYA
KQVGATTVALSCNPASTIAGIADIAISPVVGPEVLTGSTRLKSGTAQKLVLNMLTTASMIRIGKSFQNLMVDLNPSNKKL
VARATRMVMQTTGCTAQQAKQALHQTSNDVKLAILVTITGLDVEAARAALGKAGGFLRKAISDPTA

Specific function: Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate. Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported

COG id: COG2103

COG function: function code R; Predicted sugar phosphate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SIS domain

Homologues:

Organism=Escherichia coli, GI1788768, Length=294, Percent_Identity=52.7210884353742, Blast_Score=316, Evalue=1e-87,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURQ_RHILO (Q986Q8)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_107609.1
- HSSP:   P44862
- ProteinModelPortal:   Q986Q8
- SMR:   Q986Q8
- GeneID:   1230264
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mll7248
- NMPDR:   fig|266835.1.peg.5710
- HOGENOM:   HBG703490
- OMA:   SMIGVGK
- ProtClustDB:   PRK12570
- HAMAP:   MF_00068
- InterPro:   IPR005486
- InterPro:   IPR005488
- InterPro:   IPR001347
- TIGRFAMs:   TIGR00274

Pfam domain/function: PF01380 SIS

EC number: NA

Molecular weight: Translated: 32022; Mature: 31890

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: PS01272 GCKR; PS51464 SIS

Important sites: ACT_SITE 90-90 ACT_SITE 121-121

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEHGLMSELDLLVSEGRNPRTMDIDLLPTIDVLRKINDEDRLVPVAVEKVLPEIAAAVD
CCCCCHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHH
RIVLAFQKGARLIYVGAGTSGRLGVLDASECPPTFGVPEDMVIGLIAGGPDALVRSTEGA
HHHHHHHCCCEEEEEECCCCCCEEEEECCCCCCCCCCCHHHEEEEEECCCHHHHCCCCCC
EDDPKMGAQALQEIGLTPDDVVMGIAVSGRTPYVIGGLNYAKQVGATTVALSCNPASTIA
CCCHHHHHHHHHHCCCCCCCEEEEEEECCCCCEEEECCHHHHHCCCEEEEEECCCHHHHH
GIADIAISPVVGPEVLTGSTRLKSGTAQKLVLNMLTTASMIRIGKSFQNLMVDLNPSNKK
HHHHHHCCCCCCCHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCHH
LVARATRMVMQTTGCTAQQAKQALHQTSNDVKLAILVTITGLDVEAARAALGKAGGFLRK
HHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEEEEEECCCHHHHHHHHHHHHHHHHH
AISDPTA
HHCCCCC
>Mature Secondary Structure 
TEHGLMSELDLLVSEGRNPRTMDIDLLPTIDVLRKINDEDRLVPVAVEKVLPEIAAAVD
CCCCHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHH
RIVLAFQKGARLIYVGAGTSGRLGVLDASECPPTFGVPEDMVIGLIAGGPDALVRSTEGA
HHHHHHHCCCEEEEEECCCCCCEEEEECCCCCCCCCCCHHHEEEEEECCCHHHHCCCCCC
EDDPKMGAQALQEIGLTPDDVVMGIAVSGRTPYVIGGLNYAKQVGATTVALSCNPASTIA
CCCHHHHHHHHHHCCCCCCCEEEEEEECCCCCEEEECCHHHHHCCCEEEEEECCCHHHHH
GIADIAISPVVGPEVLTGSTRLKSGTAQKLVLNMLTTASMIRIGKSFQNLMVDLNPSNKK
HHHHHHCCCCCCCHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCHH
LVARATRMVMQTTGCTAQQAKQALHQTSNDVKLAILVTITGLDVEAARAALGKAGGFLRK
HHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEEEEEECCCHHHHHHHHHHHHHHHHH
AISDPTA
HHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968