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The map label for this gene is fghA [H]

Identifier: 13475915

GI number: 13475915

Start: 5860100

End: 5860972

Strand: Direct

Name: fghA [H]

Synonym: mlr7099

Alternate gene names: 13475915

Gene position: 5860100-5860972 (Clockwise)

Preceding gene: 13475914

Following gene: 13475917

Centisome position: 83.29

GC content: 62.89

Gene sequence:

>873_bases
ATGTCGGATCTGATGAAGACCATCTCCTCGGCCAGGTCGCATGGCGGCGTGCAGGGCGTCTACTCTCACGCGTCGGATGC
CTGCGCCTGTGACATGGTTTTCGCCGTCTTCGTGCCGCCGCAGGCCCGTGAGAAACCTTGCCCGGTCGTCTGGTACCTCT
CCGGCCTCACCTGCACACATGCCAATGTCATGGACAAGGGTGAGTACAGGCGCATGGCCGCGGAGCTTGGCCTGATCGTC
GTCTGTCCCGACACCAGCCCGCGCGGCGGCGATATTCCCGACGAGAAGGACAATTGGCAGTTCGGCAGCGGCGCCGGCTT
CTACCTCGACGCCACGCAAGCGCCTTACGCCACGAACTACCGCATGTATTCCTATGTCACCGAGGAATTGCCGGCGTTGA
TCGCCAAGGTATTTCCGGCCGATATGACGCGCCAGGCGATCTTCGGTCACTCGATGGGCGGGCATGGTGCGCTGACGATC
GCGCTCAAAAATCCCGAGCGCTTCAAAAGCTGCTCGGCCTTCGCGCCGATCGTGCAGCCGAGCACCGCTGGCTGGTCACG
GCCGGCCCTCGAAAAGTACCTTGGCGCGGACGAGGCATCGTGGCGGAGCTACGATGCCACCTTGCTGATCGAGGATGGCC
ACCGTTTCCCCGAGCTTTTCGTCGACCAGGGAACGTCGGACGGCTTTCTCAGGGACGGGCTGAGGCCCTGGCTGCTGGAA
GCAGCCTGCACCAGGGCCGGCATTGCGCTGACCCTGCGCATGCAGGATGGCTACGACCACTCGTATTTCTTCATCTCGAC
ATTCATGGACGACCATCTGAGATGGCACGCCGAAAGATTGTCCGGCCCGGTTCGTGGCACCGGGTCACGCTGA

Upstream 100 bases:

>100_bases
TCGGGAATCATGGTCCAATCCATCAGGGTTGCCGCGGTCCTGGCCCGTGCCGTAGACAGGCGGCCGTGAAGGGCGTTTGC
CGATGGCGGAGCAGAAGAAC

Downstream 100 bases:

>100_bases
AGCAACGGCATATCCCCCAGCGGGCTAATCCCGCAACAGGTCGAACATCAGCTTGAAGAAGCGGTCGGCATCGACTTCGT
GAGCGATGCGCGCATTGTCC

Product: esterase

Products: NA

Alternate protein names: FGH [H]

Number of amino acids: Translated: 290; Mature: 289

Protein sequence:

>290_residues
MSDLMKTISSARSHGGVQGVYSHASDACACDMVFAVFVPPQAREKPCPVVWYLSGLTCTHANVMDKGEYRRMAAELGLIV
VCPDTSPRGGDIPDEKDNWQFGSGAGFYLDATQAPYATNYRMYSYVTEELPALIAKVFPADMTRQAIFGHSMGGHGALTI
ALKNPERFKSCSAFAPIVQPSTAGWSRPALEKYLGADEASWRSYDATLLIEDGHRFPELFVDQGTSDGFLRDGLRPWLLE
AACTRAGIALTLRMQDGYDHSYFFISTFMDDHLRWHAERLSGPVRGTGSR

Sequences:

>Translated_290_residues
MSDLMKTISSARSHGGVQGVYSHASDACACDMVFAVFVPPQAREKPCPVVWYLSGLTCTHANVMDKGEYRRMAAELGLIV
VCPDTSPRGGDIPDEKDNWQFGSGAGFYLDATQAPYATNYRMYSYVTEELPALIAKVFPADMTRQAIFGHSMGGHGALTI
ALKNPERFKSCSAFAPIVQPSTAGWSRPALEKYLGADEASWRSYDATLLIEDGHRFPELFVDQGTSDGFLRDGLRPWLLE
AACTRAGIALTLRMQDGYDHSYFFISTFMDDHLRWHAERLSGPVRGTGSR
>Mature_289_residues
SDLMKTISSARSHGGVQGVYSHASDACACDMVFAVFVPPQAREKPCPVVWYLSGLTCTHANVMDKGEYRRMAAELGLIVV
CPDTSPRGGDIPDEKDNWQFGSGAGFYLDATQAPYATNYRMYSYVTEELPALIAKVFPADMTRQAIFGHSMGGHGALTIA
LKNPERFKSCSAFAPIVQPSTAGWSRPALEKYLGADEASWRSYDATLLIEDGHRFPELFVDQGTSDGFLRDGLRPWLLEA
ACTRAGIALTLRMQDGYDHSYFFISTFMDDHLRWHAERLSGPVRGTGSR

Specific function: Serine hydrolase involved in the detoxification of formaldehyde. Hydrolyzes S-formylglutathione to glutathione and formate (Probable) [H]

COG id: COG0627

COG function: function code R; Predicted esterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the esterase D family [H]

Homologues:

Organism=Homo sapiens, GI33413400, Length=280, Percent_Identity=52.8571428571429, Blast_Score=308, Evalue=3e-84,
Organism=Escherichia coli, GI1786551, Length=277, Percent_Identity=45.4873646209386, Blast_Score=263, Evalue=9e-72,
Organism=Escherichia coli, GI1788477, Length=278, Percent_Identity=46.4028776978417, Blast_Score=244, Evalue=5e-66,
Organism=Caenorhabditis elegans, GI17510185, Length=278, Percent_Identity=46.4028776978417, Blast_Score=259, Evalue=8e-70,
Organism=Saccharomyces cerevisiae, GI6322393, Length=296, Percent_Identity=39.527027027027, Blast_Score=207, Evalue=1e-54,
Organism=Drosophila melanogaster, GI45551932, Length=281, Percent_Identity=47.6868327402135, Blast_Score=266, Evalue=1e-71,
Organism=Drosophila melanogaster, GI24648347, Length=281, Percent_Identity=47.6868327402135, Blast_Score=266, Evalue=2e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000801
- InterPro:   IPR014186 [H]

Pfam domain/function: PF00756 Esterase [H]

EC number: =3.1.2.12 [H]

Molecular weight: Translated: 31969; Mature: 31838

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDLMKTISSARSHGGVQGVYSHASDACACDMVFAVFVPPQAREKPCPVVWYLSGLTCTH
CHHHHHHHHHHHHCCCCHHHHHCCCCHHHHHEEEEEECCCCCCCCCCCEEEEECCCEEEC
ANVMDKGEYRRMAAELGLIVVCPDTSPRGGDIPDEKDNWQFGSGAGFYLDATQAPYATNY
CCHHCCHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCC
RMYSYVTEELPALIAKVFPADMTRQAIFGHSMGGHGALTIALKNPERFKSCSAFAPIVQP
HHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCEEEEEEECCHHHHHHHHHCCCCCCC
STAGWSRPALEKYLGADEASWRSYDATLLIEDGHRFPELFVDQGTSDGFLRDGLRPWLLE
CCCCCCCHHHHHHHCCCCCCCCCCCEEEEEECCCCCCHHHCCCCCCCCHHHCCCHHHHHH
AACTRAGIALTLRMQDGYDHSYFFISTFMDDHLRWHAERLSGPVRGTGSR
HHHHCCCEEEEEEECCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
SDLMKTISSARSHGGVQGVYSHASDACACDMVFAVFVPPQAREKPCPVVWYLSGLTCTH
HHHHHHHHHHHHCCCCHHHHHCCCCHHHHHEEEEEECCCCCCCCCCCEEEEECCCEEEC
ANVMDKGEYRRMAAELGLIVVCPDTSPRGGDIPDEKDNWQFGSGAGFYLDATQAPYATNY
CCHHCCHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCC
RMYSYVTEELPALIAKVFPADMTRQAIFGHSMGGHGALTIALKNPERFKSCSAFAPIVQP
HHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCEEEEEEECCHHHHHHHHHCCCCCCC
STAGWSRPALEKYLGADEASWRSYDATLLIEDGHRFPELFVDQGTSDGFLRDGLRPWLLE
CCCCCCCHHHHHHHCCCCCCCCCCCEEEEEECCCCCCHHHCCCCCCCCHHHCCCHHHHHH
AACTRAGIALTLRMQDGYDHSYFFISTFMDDHLRWHAERLSGPVRGTGSR
HHHHCCCEEEEEEECCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8892832 [H]