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The map label for this gene is argE [H]

Identifier: 13475871

GI number: 13475871

Start: 5812789

End: 5813913

Strand: Reverse

Name: argE [H]

Synonym: mll7049

Alternate gene names: 13475871

Gene position: 5813913-5812789 (Counterclockwise)

Preceding gene: 13475873

Following gene: 13475870

Centisome position: 82.63

GC content: 66.84

Gene sequence:

>1125_bases
ATGGACGTCTTCGACATCCTCGACCGTCTCGTCGCCTTTCCATCGGTGGCCGGCAAGCCGAATGGCGATATCGCCGGCTG
GATCGCGGCCTATCTCGCGGAACACGGAACTCAGGTCAGAGTGCTTCCAGGGCCAGAAGGCGACCGTTCCAATCTTTTCG
CCACAATCGGGCCTGCCGATATTCCGGGCTACATCCTATCCGGTCACACGGACGTCGTCCCCGCTGGGGAGCCGCAATGG
AGTTCGGCCCCTTTCGCGCTGCGCCGGGAGGGCGAGCAGCTCTACGGACGCGGCACCACGGACATGAAGGGGTTTCTTGC
CGCGGTGCTTGCGGCCGTGCCCACATTGGCGGGACTGCCCCTCGCCAGGCCGATCCATCTCGCCTTTTCCTATGACGAGG
AGGTGGGATGTCGCGGCGTGCCGCATTTGATCGCCCGCCTTCCCGACCTTTGCGCGAAGCCGCTCGGCGTGATCGTCGGC
GAGCCGAGCGGCATGCGCGCCGTGCGCGGCCATAAGGGCAAGGCAGCCGCCCGCGTGACGATCAACGGGCGCTCCGGCCA
TTCCTCGCGACCCGATCTCGGGCTCAACGCGATCCACGCTATGTCTGGTGCGCTCAGCGCGGCGGTAAGCGAAGCCGCAC
GGCTGACGCACGGTCCATTCGATGCTGCCTTCGAGCCACCCTATTCCTCGCTGCAAGCAGGCGTCGTGGCCGGCGGACAT
CAGGTCAACATCATTCCCGAAACCTGCACTCTGGACCTCGAGGCGCGCGCCATACCCGGTGTCGACCCGGCAGGCCTGCT
CGCGCCGGTCAAGGCTCGGGCCGAGGCTCTTGCGGACGACGGCTTTCGTGTCGAGTGGACGCCGATGAGCGCCTATCCGG
CGCTGTCGCTGCGGCGCGATGCGGCACTGGCGGCACTGTTGACCGAACTGACCGGTGAAGCGTCGCTCGCCGCCGTCAGC
TACGGCACGGAGGCCGGGCTCTACCAGGCCGCCGGGCTCGATGCGATCATTTGCGGCCCCGGCGACATCGATCGCGCCCA
CAAGCCGAACGAATACATCCTTGCCAGCGAACTCACCGCCTGCCAGCGCTTGATCGAGTTGCTGGGCGCCCGTTGCGCGG
CTTGA

Upstream 100 bases:

>100_bases
TCCGCTTTCGGCACGCAATCGCGAATGAACGCCTCCATCCTCGACGTTACCGGTCCGGCGAACCCGGAATGCCAAATCCC
CAACTGCCTTGAGGGCTGGA

Downstream 100 bases:

>100_bases
AGGGAGCGGAATGACATTCCTGTTCAATTCCGATGCGCGCCGCGGGGCGATCTTCGCCGAGGCGTTCGCGAGAGAACTGC
CGGAGGTCCCCTTCACGATG

Product: acetylornithine deacetylase

Products: NA

Alternate protein names: AO; Acetylornithinase; N-acetylornithinase; NAO [H]

Number of amino acids: Translated: 374; Mature: 374

Protein sequence:

>374_residues
MDVFDILDRLVAFPSVAGKPNGDIAGWIAAYLAEHGTQVRVLPGPEGDRSNLFATIGPADIPGYILSGHTDVVPAGEPQW
SSAPFALRREGEQLYGRGTTDMKGFLAAVLAAVPTLAGLPLARPIHLAFSYDEEVGCRGVPHLIARLPDLCAKPLGVIVG
EPSGMRAVRGHKGKAAARVTINGRSGHSSRPDLGLNAIHAMSGALSAAVSEAARLTHGPFDAAFEPPYSSLQAGVVAGGH
QVNIIPETCTLDLEARAIPGVDPAGLLAPVKARAEALADDGFRVEWTPMSAYPALSLRRDAALAALLTELTGEASLAAVS
YGTEAGLYQAAGLDAIICGPGDIDRAHKPNEYILASELTACQRLIELLGARCAA

Sequences:

>Translated_374_residues
MDVFDILDRLVAFPSVAGKPNGDIAGWIAAYLAEHGTQVRVLPGPEGDRSNLFATIGPADIPGYILSGHTDVVPAGEPQW
SSAPFALRREGEQLYGRGTTDMKGFLAAVLAAVPTLAGLPLARPIHLAFSYDEEVGCRGVPHLIARLPDLCAKPLGVIVG
EPSGMRAVRGHKGKAAARVTINGRSGHSSRPDLGLNAIHAMSGALSAAVSEAARLTHGPFDAAFEPPYSSLQAGVVAGGH
QVNIIPETCTLDLEARAIPGVDPAGLLAPVKARAEALADDGFRVEWTPMSAYPALSLRRDAALAALLTELTGEASLAAVS
YGTEAGLYQAAGLDAIICGPGDIDRAHKPNEYILASELTACQRLIELLGARCAA
>Mature_374_residues
MDVFDILDRLVAFPSVAGKPNGDIAGWIAAYLAEHGTQVRVLPGPEGDRSNLFATIGPADIPGYILSGHTDVVPAGEPQW
SSAPFALRREGEQLYGRGTTDMKGFLAAVLAAVPTLAGLPLARPIHLAFSYDEEVGCRGVPHLIARLPDLCAKPLGVIVG
EPSGMRAVRGHKGKAAARVTINGRSGHSSRPDLGLNAIHAMSGALSAAVSEAARLTHGPFDAAFEPPYSSLQAGVVAGGH
QVNIIPETCTLDLEARAIPGVDPAGLLAPVKARAEALADDGFRVEWTPMSAYPALSLRRDAALAALLTELTGEASLAAVS
YGTEAGLYQAAGLDAIICGPGDIDRAHKPNEYILASELTACQRLIELLGARCAA

Specific function: Displays A Broad Specificity And Can Also Deacylate Substrates Such As Acetylarginine, Acetylhistidine Or Acetylglutamate Semialdehyde. [C]

COG id: COG0624

COG function: function code E; Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20A family. ArgE subfamily [H]

Homologues:

Organism=Homo sapiens, GI4501901, Length=248, Percent_Identity=28.6290322580645, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1790395, Length=380, Percent_Identity=32.3684210526316, Blast_Score=164, Evalue=1e-41,
Organism=Escherichia coli, GI1788816, Length=347, Percent_Identity=28.8184438040346, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1789236, Length=323, Percent_Identity=25.3869969040248, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17551016, Length=380, Percent_Identity=27.6315789473684, Blast_Score=96, Evalue=4e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010169
- InterPro:   IPR001261
- InterPro:   IPR002933
- InterPro:   IPR011650 [H]

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20 [H]

EC number: =3.5.1.16 [H]

Molecular weight: Translated: 38821; Mature: 38821

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: PS00759 ARGE_DAPE_CPG2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDVFDILDRLVAFPSVAGKPNGDIAGWIAAYLAEHGTQVRVLPGPEGDRSNLFATIGPAD
CCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCCCCEEEEECCCC
IPGYILSGHTDVVPAGEPQWSSAPFALRREGEQLYGRGTTDMKGFLAAVLAAVPTLAGLP
CCCEEECCCCCCCCCCCCCCCCCCHHHHHCCHHHHCCCCCHHHHHHHHHHHHHHHHHCCC
LARPIHLAFSYDEEVGCRGVPHLIARLPDLCAKPLGVIVGEPSGMRAVRGHKGKAAARVT
CCCEEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCHHHCCCCCCEEEEEE
INGRSGHSSRPDLGLNAIHAMSGALSAAVSEAARLTHGPFDAAFEPPYSSLQAGVVAGGH
EECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHEEECCE
QVNIIPETCTLDLEARAIPGVDPAGLLAPVKARAEALADDGFRVEWTPMSAYPALSLRRD
EEEEECCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHH
AALAALLTELTGEASLAAVSYGTEAGLYQAAGLDAIICGPGDIDRAHKPNEYILASELTA
HHHHHHHHHHCCCCCEEEEECCCCCCCEECCCCCEEEECCCCCCCCCCCCCEEEHHHHHH
CQRLIELLGARCAA
HHHHHHHHHHHCCC
>Mature Secondary Structure
MDVFDILDRLVAFPSVAGKPNGDIAGWIAAYLAEHGTQVRVLPGPEGDRSNLFATIGPAD
CCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCCCCEEEEECCCC
IPGYILSGHTDVVPAGEPQWSSAPFALRREGEQLYGRGTTDMKGFLAAVLAAVPTLAGLP
CCCEEECCCCCCCCCCCCCCCCCCHHHHHCCHHHHCCCCCHHHHHHHHHHHHHHHHHCCC
LARPIHLAFSYDEEVGCRGVPHLIARLPDLCAKPLGVIVGEPSGMRAVRGHKGKAAARVT
CCCEEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCHHHCCCCCCEEEEEE
INGRSGHSSRPDLGLNAIHAMSGALSAAVSEAARLTHGPFDAAFEPPYSSLQAGVVAGGH
EECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHEEECCE
QVNIIPETCTLDLEARAIPGVDPAGLLAPVKARAEALADDGFRVEWTPMSAYPALSLRRD
EEEEECCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHH
AALAALLTELTGEASLAAVSYGTEAGLYQAAGLDAIICGPGDIDRAHKPNEYILASELTA
HHHHHHHHHHCCCCCEEEEECCCCCCCEECCCCCEEEECCCCCCCCCCCCCEEEHHHHHH
CQRLIELLGARCAA
HHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10692366 [H]