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The map label for this gene is ghrA [H]

Identifier: 13475870

GI number: 13475870

Start: 5811855

End: 5812778

Strand: Reverse

Name: ghrA [H]

Synonym: mll7048

Alternate gene names: 13475870

Gene position: 5812778-5811855 (Counterclockwise)

Preceding gene: 13475871

Following gene: 13475869

Centisome position: 82.61

GC content: 66.56

Gene sequence:

>924_bases
ATGACATTCCTGTTCAATTCCGATGCGCGCCGCGGGGCGATCTTCGCCGAGGCGTTCGCGAGAGAACTGCCGGAGGTCCC
CTTCACGATGGATGCCGCAAAGGTCGACCCCGACGCCGTGCGGTATCTCATTACCTGGACCGCACCAGATAACCTCGCGC
GCTACAGGAACCTGGAGATCCTGTTTTCCATTGGCGCCGGCGTCGACCAGTTCCGCCTCGATGGCGTACCGGAGCGGGTG
AAGATTGTGCGTACGATCGAGGAAGGCATCGTGCGCATGATGCAGGAATATGCGGCGCTTGCCGTGCTCGCGCTGCATCG
CAACCTGCCGGCCTATCTGGCGCAGCAGCGCGCAGGCGAATGGCGCGATATCCCGCAGTTGCAGGCCGGGTCGCGCCGGA
TCGGCGTGCTCGGCCTCGGGCAGCTCGGCCAGGCCGTCCTCGGCCGGCTGAAGCCCTTCGGCTTCCCGCTCGCAGGATGG
AGCAGATCGCCGCGGCGGATCGAAGGCGTGACCTGCCATCATGGCGAGCCAGGGTTGGAGGGGATGCTCGCGGTCAGCGA
CATCGTGATCTGCCTGCTGCCATTGACCGAGGATACGCGCGGTTTCCTCAATGCCGGCCTGTTTGCGAAGCTACCCAGGG
GCGCCGCCCTCGTCCACACGGGCCGGGGGCCGCAGCTCGATCACGAGGCGCTTGTCGCGGCTCTCGACCACGGCCACCTT
TCGGCGGCGATGATCGACGTGACCGATCCCGAACCGCTGCCGACCAGTCATCCTTTCTGGCGGCATCCGAAGATCATCCT
GACCCCGCATGTCGCCAGCGTCACCCAGCCCGTGACAGCCGCGCGGGCCGTCATCGAAAACATCCGCCGCCACCGCGCCG
GCCTCGACCCCATCGGGCTCGTTGACCGGTCGCGCGGCTATTGA

Upstream 100 bases:

>100_bases
GCCCACAAGCCGAACGAATACATCCTTGCCAGCGAACTCACCGCCTGCCAGCGCTTGATCGAGTTGCTGGGCGCCCGTTG
CGCGGCTTGAAGGGAGCGGA

Downstream 100 bases:

>100_bases
AATCCAACCTGAAAGGCCATCCTTTGTCCCTGCTCAAGACCGTCGACACCAGCCCCGCCTTCCCGCCGCGTGAATCCCAG
GCGCTGCCCGAACGGCTGAT

Product: dehydrogenase

Products: NA

Alternate protein names: 2-ketoacid reductase [H]

Number of amino acids: Translated: 307; Mature: 306

Protein sequence:

>307_residues
MTFLFNSDARRGAIFAEAFARELPEVPFTMDAAKVDPDAVRYLITWTAPDNLARYRNLEILFSIGAGVDQFRLDGVPERV
KIVRTIEEGIVRMMQEYAALAVLALHRNLPAYLAQQRAGEWRDIPQLQAGSRRIGVLGLGQLGQAVLGRLKPFGFPLAGW
SRSPRRIEGVTCHHGEPGLEGMLAVSDIVICLLPLTEDTRGFLNAGLFAKLPRGAALVHTGRGPQLDHEALVAALDHGHL
SAAMIDVTDPEPLPTSHPFWRHPKIILTPHVASVTQPVTAARAVIENIRRHRAGLDPIGLVDRSRGY

Sequences:

>Translated_307_residues
MTFLFNSDARRGAIFAEAFARELPEVPFTMDAAKVDPDAVRYLITWTAPDNLARYRNLEILFSIGAGVDQFRLDGVPERV
KIVRTIEEGIVRMMQEYAALAVLALHRNLPAYLAQQRAGEWRDIPQLQAGSRRIGVLGLGQLGQAVLGRLKPFGFPLAGW
SRSPRRIEGVTCHHGEPGLEGMLAVSDIVICLLPLTEDTRGFLNAGLFAKLPRGAALVHTGRGPQLDHEALVAALDHGHL
SAAMIDVTDPEPLPTSHPFWRHPKIILTPHVASVTQPVTAARAVIENIRRHRAGLDPIGLVDRSRGY
>Mature_306_residues
TFLFNSDARRGAIFAEAFARELPEVPFTMDAAKVDPDAVRYLITWTAPDNLARYRNLEILFSIGAGVDQFRLDGVPERVK
IVRTIEEGIVRMMQEYAALAVLALHRNLPAYLAQQRAGEWRDIPQLQAGSRRIGVLGLGQLGQAVLGRLKPFGFPLAGWS
RSPRRIEGVTCHHGEPGLEGMLAVSDIVICLLPLTEDTRGFLNAGLFAKLPRGAALVHTGRGPQLDHEALVAALDHGHLS
AAMIDVTDPEPLPTSHPFWRHPKIILTPHVASVTQPVTAARAVIENIRRHRAGLDPIGLVDRSRGY

Specific function: Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively [H]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrA subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=226, Percent_Identity=30.5309734513274, Blast_Score=111, Evalue=8e-25,
Organism=Homo sapiens, GI23308577, Length=236, Percent_Identity=26.6949152542373, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI61743967, Length=245, Percent_Identity=30.2040816326531, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI4557497, Length=245, Percent_Identity=30.2040816326531, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI145580578, Length=274, Percent_Identity=28.4671532846715, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI4557499, Length=274, Percent_Identity=28.4671532846715, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI145580575, Length=274, Percent_Identity=28.4671532846715, Blast_Score=78, Evalue=9e-15,
Organism=Escherichia coli, GI87081824, Length=278, Percent_Identity=37.410071942446, Blast_Score=184, Evalue=6e-48,
Organism=Escherichia coli, GI87082289, Length=239, Percent_Identity=28.0334728033473, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1789279, Length=229, Percent_Identity=26.6375545851528, Blast_Score=65, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17532191, Length=263, Percent_Identity=26.615969581749, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI25147481, Length=258, Percent_Identity=25.5813953488372, Blast_Score=67, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6324055, Length=163, Percent_Identity=31.9018404907975, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI28574286, Length=165, Percent_Identity=33.9393939393939, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI28571528, Length=142, Percent_Identity=33.8028169014084, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI45552429, Length=166, Percent_Identity=32.5301204819277, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI28574284, Length=166, Percent_Identity=32.5301204819277, Blast_Score=85, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24585514, Length=166, Percent_Identity=32.5301204819277, Blast_Score=85, Evalue=6e-17,
Organism=Drosophila melanogaster, GI28574282, Length=166, Percent_Identity=32.5301204819277, Blast_Score=85, Evalue=6e-17,
Organism=Drosophila melanogaster, GI45551003, Length=166, Percent_Identity=32.5301204819277, Blast_Score=85, Evalue=6e-17,
Organism=Drosophila melanogaster, GI19921140, Length=264, Percent_Identity=26.1363636363636, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24585516, Length=146, Percent_Identity=30.8219178082192, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24646446, Length=236, Percent_Identity=27.9661016949153, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24646448, Length=236, Percent_Identity=27.9661016949153, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24646452, Length=236, Percent_Identity=27.9661016949153, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24646450, Length=236, Percent_Identity=27.9661016949153, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI62472511, Length=236, Percent_Identity=27.9661016949153, Blast_Score=72, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.79; =1.1.1.81 [H]

Molecular weight: Translated: 33704; Mature: 33573

Theoretical pI: Translated: 8.72; Mature: 8.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFLFNSDARRGAIFAEAFARELPEVPFTMDAAKVDPDAVRYLITWTAPDNLARYRNLEI
CEEEECCCCCCCHHHHHHHHHHCCCCCEECCCCCCCHHHEEEEEEECCCHHHHHHCCEEE
LFSIGAGVDQFRLDGVPERVKIVRTIEEGIVRMMQEYAALAVLALHRNLPAYLAQQRAGE
EEEECCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCC
WRDIPQLQAGSRRIGVLGLGQLGQAVLGRLKPFGFPLAGWSRSPRRIEGVTCHHGEPGLE
CCCCCCHHCCCCEEEEEECHHHHHHHHHHCCCCCCCCCCCCCCCCEECCEEEECCCCCHH
GMLAVSDIVICLLPLTEDTRGFLNAGLFAKLPRGAALVHTGRGPQLDHEALVAALDHGHL
HHHHHHHHHHEEECCCCCHHHHHHCCHHHCCCCCCEEEECCCCCCCCHHHHHHHHCCCCC
SAAMIDVTDPEPLPTSHPFWRHPKIILTPHVASVTQPVTAARAVIENIRRHRAGLDPIGL
EEEEEECCCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
VDRSRGY
CCCCCCC
>Mature Secondary Structure 
TFLFNSDARRGAIFAEAFARELPEVPFTMDAAKVDPDAVRYLITWTAPDNLARYRNLEI
EEEECCCCCCCHHHHHHHHHHCCCCCEECCCCCCCHHHEEEEEEECCCHHHHHHCCEEE
LFSIGAGVDQFRLDGVPERVKIVRTIEEGIVRMMQEYAALAVLALHRNLPAYLAQQRAGE
EEEECCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCC
WRDIPQLQAGSRRIGVLGLGQLGQAVLGRLKPFGFPLAGWSRSPRRIEGVTCHHGEPGLE
CCCCCCHHCCCCEEEEEECHHHHHHHHHHCCCCCCCCCCCCCCCCEECCEEEECCCCCHH
GMLAVSDIVICLLPLTEDTRGFLNAGLFAKLPRGAALVHTGRGPQLDHEALVAALDHGHL
HHHHHHHHHHEEECCCCCHHHHHHCCHHHCCCCCCEEEECCCCCCCCHHHHHHHHCCCCC
SAAMIDVTDPEPLPTSHPFWRHPKIILTPHVASVTQPVTAARAVIENIRRHRAGLDPIGL
EEEEEECCCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
VDRSRGY
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA