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The map label for this gene is gabT [C]

Identifier: 13475792

GI number: 13475792

Start: 5721876

End: 5723276

Strand: Direct

Name: gabT [C]

Synonym: mlr6963

Alternate gene names: 13475792

Gene position: 5721876-5723276 (Clockwise)

Preceding gene: 13474952

Following gene: 13475793

Centisome position: 81.32

GC content: 57.39

Gene sequence:

>1401_bases
ATGGTTGAACCTGCTCTCTCGCTAAATGAAACCGGCGCCCCCACCAATGAGCGGTTTCATCTGATTCAGGCCGCCCCTCT
GGCCGGCAGTATCGGTGCGGAAGCTCGCGAACTCATCACATCCTCGGAAGATATTTTCGTCACCGATCAGAGCGGAAGAA
AACTGATCGACGGACCGGCAGGCATGTGGTGCATCAACGTGGGACATCGCAACCAAGCGCTGGCCGATACATTGCGCGAC
CAGGCAATGTCGATGACCTATTCAACGCCGTGGTATACAAGCAATGCTCCCGCGGAGAAGCTTGCGCAGATGCTCGCGGA
GCGCGCGCCGGGTGACCTCAACCATGTCTTCTTGACGACTGGCGGTTCATCCGCGGTCGAAACAGCAATACGGCTCGTGC
AATTCTACAACAACGTCCGCGGACTGCCGCAGAAGAAGTTGTTGATCTCACGCCAAGGAAGCTACCACGGCTCGACATAC
CTGACCGCGTCGCTGAACGGCCGCCCGCGTGATCACGACTGGATGGATGGCGCAGGCGATCTCGTCAGAAAGCTGACTTG
CCCCAATCCCTTCCACCGACCGGCAAACTTGTCGCTGGAGGCGTTCGAAGATTTCCTCGTCAATGAGTTTCGCGCGCTCA
TCGAGCACGAGGGCGCCCAGCAGATCGCGGCTTTTATCGCCGAACCGATCCAGGCGAGCGGCGGGGTGTTGATGTCGCCG
CCGAACTATCTCAAGCGCATGCGAGCGCTCTGCACGGAAAATGACATTCTGTTTATCACTGACGAGGTCGTCACCGCTTT
CGGGCGGCTCGGCCATATCTTCGCATCGCAGGACGTGTTCGGAATTCAGCCGGATATGATCACTTTCGCTAAAGGTGTCA
CGTCAGGGTATTTTCCCCTTGGTGGCGTCATGGTGTCGGATCGCTTGCTCAGCGAACTTCGCCGTCTGAACCATCCCAAA
GCAAACTTCGTGCATGGTCTGACCTATTCCAGTCATCCCATCGGCTGCGCGGTGGCAATCCGCAATATCGAACTGCTGGA
AGATGGTCTCCTCCATCACGCGCGTGAAATAGGTCCCTACTTTCAAGAGCAGTTACGGACGCTCGAGGAACTACCCCTCG
TAGGCGAGGTGCGCGGGGCCGGACTGATGGCGGGGATTGAATGTGTTGCCGATGCCAAGACGGAGGATCGTCTTGATCTC
GACCTGACCGTCGGTAAGCGCATCGATTTTCATTGCCAGGAGAATGGATTGCTTGTCCGGCCCCTGATCAATATGTGCGT
GATGTCGCCGCCGCTGACAATCAGCCGTTCGCAAATCGACATGATGACCGATGCTCTTCGCAAGGGGATTGAAGCCACCG
CGGATGACCTGATCCGTGAGGGACTTTGGAAGCCGGCATGA

Upstream 100 bases:

>100_bases
CTGGCTGAGAACTATCTTGCCGCCCTCAAACTCGTCGCAATCCGCATCTGGCTACGCGGTAATGAGTCTACGTCCTAGTC
TTTAGATCGTGAGGATTATT

Downstream 100 bases:

>100_bases
TCCGGCCGCCTGCCTTCCTTTTAGGCAGGGCAGATGGCTAGACGACAACCAACCAGCCTGAACATTTTTGAAGCCGGGCC
TGAAGCTCCATCGGATGCCC

Product: hypothetical protein

Products: L-Glutamate; Succinic semialdehyde [C]

Alternate protein names: NA

Number of amino acids: Translated: 466; Mature: 466

Protein sequence:

>466_residues
MVEPALSLNETGAPTNERFHLIQAAPLAGSIGAEARELITSSEDIFVTDQSGRKLIDGPAGMWCINVGHRNQALADTLRD
QAMSMTYSTPWYTSNAPAEKLAQMLAERAPGDLNHVFLTTGGSSAVETAIRLVQFYNNVRGLPQKKLLISRQGSYHGSTY
LTASLNGRPRDHDWMDGAGDLVRKLTCPNPFHRPANLSLEAFEDFLVNEFRALIEHEGAQQIAAFIAEPIQASGGVLMSP
PNYLKRMRALCTENDILFITDEVVTAFGRLGHIFASQDVFGIQPDMITFAKGVTSGYFPLGGVMVSDRLLSELRRLNHPK
ANFVHGLTYSSHPIGCAVAIRNIELLEDGLLHHAREIGPYFQEQLRTLEELPLVGEVRGAGLMAGIECVADAKTEDRLDL
DLTVGKRIDFHCQENGLLVRPLINMCVMSPPLTISRSQIDMMTDALRKGIEATADDLIREGLWKPA

Sequences:

>Translated_466_residues
MVEPALSLNETGAPTNERFHLIQAAPLAGSIGAEARELITSSEDIFVTDQSGRKLIDGPAGMWCINVGHRNQALADTLRD
QAMSMTYSTPWYTSNAPAEKLAQMLAERAPGDLNHVFLTTGGSSAVETAIRLVQFYNNVRGLPQKKLLISRQGSYHGSTY
LTASLNGRPRDHDWMDGAGDLVRKLTCPNPFHRPANLSLEAFEDFLVNEFRALIEHEGAQQIAAFIAEPIQASGGVLMSP
PNYLKRMRALCTENDILFITDEVVTAFGRLGHIFASQDVFGIQPDMITFAKGVTSGYFPLGGVMVSDRLLSELRRLNHPK
ANFVHGLTYSSHPIGCAVAIRNIELLEDGLLHHAREIGPYFQEQLRTLEELPLVGEVRGAGLMAGIECVADAKTEDRLDL
DLTVGKRIDFHCQENGLLVRPLINMCVMSPPLTISRSQIDMMTDALRKGIEATADDLIREGLWKPA
>Mature_466_residues
MVEPALSLNETGAPTNERFHLIQAAPLAGSIGAEARELITSSEDIFVTDQSGRKLIDGPAGMWCINVGHRNQALADTLRD
QAMSMTYSTPWYTSNAPAEKLAQMLAERAPGDLNHVFLTTGGSSAVETAIRLVQFYNNVRGLPQKKLLISRQGSYHGSTY
LTASLNGRPRDHDWMDGAGDLVRKLTCPNPFHRPANLSLEAFEDFLVNEFRALIEHEGAQQIAAFIAEPIQASGGVLMSP
PNYLKRMRALCTENDILFITDEVVTAFGRLGHIFASQDVFGIQPDMITFAKGVTSGYFPLGGVMVSDRLLSELRRLNHPK
ANFVHGLTYSSHPIGCAVAIRNIELLEDGLLHHAREIGPYFQEQLRTLEELPLVGEVRGAGLMAGIECVADAKTEDRLDL
DLTVGKRIDFHCQENGLLVRPLINMCVMSPPLTISRSQIDMMTDALRKGIEATADDLIREGLWKPA

Specific function: 4-aminobutyrate (GABA) degradation. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI13994255, Length=433, Percent_Identity=27.0207852193995, Blast_Score=139, Evalue=4e-33,
Organism=Homo sapiens, GI4557809, Length=413, Percent_Identity=26.3922518159806, Blast_Score=133, Evalue=4e-31,
Organism=Homo sapiens, GI284507298, Length=333, Percent_Identity=28.2282282282282, Blast_Score=119, Evalue=6e-27,
Organism=Homo sapiens, GI37574042, Length=422, Percent_Identity=24.4075829383886, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI226442709, Length=357, Percent_Identity=25.4901960784314, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI226442705, Length=355, Percent_Identity=25.6338028169014, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI24119277, Length=366, Percent_Identity=24.0437158469945, Blast_Score=102, Evalue=9e-22,
Organism=Escherichia coli, GI1789016, Length=418, Percent_Identity=29.6650717703349, Blast_Score=167, Evalue=2e-42,
Organism=Escherichia coli, GI145693181, Length=420, Percent_Identity=30.4761904761905, Blast_Score=158, Evalue=9e-40,
Organism=Escherichia coli, GI1786991, Length=428, Percent_Identity=28.5046728971963, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI1788044, Length=409, Percent_Identity=29.0953545232274, Blast_Score=139, Evalue=4e-34,
Organism=Escherichia coli, GI1789759, Length=358, Percent_Identity=28.7709497206704, Blast_Score=138, Evalue=7e-34,
Organism=Escherichia coli, GI1787560, Length=446, Percent_Identity=27.5784753363229, Blast_Score=130, Evalue=3e-31,
Organism=Escherichia coli, GI1786349, Length=399, Percent_Identity=25.31328320802, Blast_Score=76, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI32564660, Length=452, Percent_Identity=29.646017699115, Blast_Score=154, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI25144271, Length=416, Percent_Identity=25.4807692307692, Blast_Score=141, Evalue=8e-34,
Organism=Caenorhabditis elegans, GI71992977, Length=417, Percent_Identity=26.1390887290168, Blast_Score=122, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI25144274, Length=267, Percent_Identity=29.2134831460674, Blast_Score=122, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17541228, Length=236, Percent_Identity=27.9661016949153, Blast_Score=81, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6323470, Length=415, Percent_Identity=26.0240963855422, Blast_Score=135, Evalue=9e-33,
Organism=Saccharomyces cerevisiae, GI6324432, Length=416, Percent_Identity=28.125, Blast_Score=124, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6324386, Length=429, Percent_Identity=26.1072261072261, Blast_Score=123, Evalue=8e-29,
Organism=Drosophila melanogaster, GI161085790, Length=429, Percent_Identity=26.8065268065268, Blast_Score=142, Evalue=4e-34,
Organism=Drosophila melanogaster, GI28574759, Length=431, Percent_Identity=27.1461716937355, Blast_Score=142, Evalue=4e-34,
Organism=Drosophila melanogaster, GI21357415, Length=417, Percent_Identity=27.5779376498801, Blast_Score=139, Evalue=6e-33,
Organism=Drosophila melanogaster, GI21356575, Length=445, Percent_Identity=26.0674157303371, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI281366494, Length=390, Percent_Identity=22.8205128205128, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24667139, Length=390, Percent_Identity=22.8205128205128, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24667143, Length=390, Percent_Identity=22.8205128205128, Blast_Score=70, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: 2.6.1.19 [C]

Molecular weight: Translated: 51201; Mature: 51201

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVEPALSLNETGAPTNERFHLIQAAPLAGSIGAEARELITSSEDIFVTDQSGRKLIDGPA
CCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHCCCCCEEEECCCCCEEECCCC
GMWCINVGHRNQALADTLRDQAMSMTYSTPWYTSNAPAEKLAQMLAERAPGDLNHVFLTT
CEEEEECCCCCHHHHHHHHHHHHHEEECCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEC
GGSSAVETAIRLVQFYNNVRGLPQKKLLISRQGSYHGSTYLTASLNGRPRDHDWMDGAGD
CCCHHHHHHHHHHHHHHHHCCCCHHHHHEECCCCCCCCEEEEEECCCCCCCCCCCCCHHH
LVRKLTCPNPFHRPANLSLEAFEDFLVNEFRALIEHEGAQQIAAFIAEPIQASGGVLMSP
HHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEECC
PNYLKRMRALCTENDILFITDEVVTAFGRLGHIFASQDVFGIQPDMITFAKGVTSGYFPL
HHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCCC
GGVMVSDRLLSELRRLNHPKANFVHGLTYSSHPIGCAVAIRNIELLEDGLLHHAREIGPY
CHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHCHH
FQEQLRTLEELPLVGEVRGAGLMAGIECVADAKTEDRLDLDLTVGKRIDFHCQENGLLVR
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCEEEEEEECCEEEEEECCCCEEHH
PLINMCVMSPPLTISRSQIDMMTDALRKGIEATADDLIREGLWKPA
HHHHHHHCCCCCEECHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MVEPALSLNETGAPTNERFHLIQAAPLAGSIGAEARELITSSEDIFVTDQSGRKLIDGPA
CCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHCCCCCEEEECCCCCEEECCCC
GMWCINVGHRNQALADTLRDQAMSMTYSTPWYTSNAPAEKLAQMLAERAPGDLNHVFLTT
CEEEEECCCCCHHHHHHHHHHHHHEEECCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEC
GGSSAVETAIRLVQFYNNVRGLPQKKLLISRQGSYHGSTYLTASLNGRPRDHDWMDGAGD
CCCHHHHHHHHHHHHHHHHCCCCHHHHHEECCCCCCCCEEEEEECCCCCCCCCCCCCHHH
LVRKLTCPNPFHRPANLSLEAFEDFLVNEFRALIEHEGAQQIAAFIAEPIQASGGVLMSP
HHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEECC
PNYLKRMRALCTENDILFITDEVVTAFGRLGHIFASQDVFGIQPDMITFAKGVTSGYFPL
HHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCCC
GGVMVSDRLLSELRRLNHPKANFVHGLTYSSHPIGCAVAIRNIELLEDGLLHHAREIGPY
CHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHCHH
FQEQLRTLEELPLVGEVRGAGLMAGIECVADAKTEDRLDLDLTVGKRIDFHCQENGLLVR
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCEEEEEEECCEEEEEECCCCEEHH
PLINMCVMSPPLTISRSQIDMMTDALRKGIEATADDLIREGLWKPA
HHHHHHHCCCCCEECHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Pyridoxal 5'-phosphate lysine-residue [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 3.3 {4-aminobutanoate}} 1.1 {4-aminobutanoate}} 1.3 {2-oxoglutarate}} 0.7 {2-oxoglutarate}} [C]

Substrates: 4-Aminobutanoate; 2-Oxoglutarate [C]

Specific reaction: 4-Aminobutanoate + 2-Oxoglutarate --> L-Glutamate + Succinic semialdehyde [C]

General reaction: Amino group transfer [C]

Inhibitor: 2-Oxoglutarate; Lysyl reagents; SH-group reagents [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8796346; 9163424 [H]