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The map label for this gene is regB [H]

Identifier: 13475711

GI number: 13475711

Start: 5640736

End: 5642088

Strand: Direct

Name: regB [H]

Synonym: mlr6852

Alternate gene names: 13475711

Gene position: 5640736-5642088 (Clockwise)

Preceding gene: 13475710

Following gene: 13475712

Centisome position: 80.17

GC content: 63.93

Gene sequence:

>1353_bases
ATGAGCGCCCCGACGCAAACGCTTCGCAACGACAAATCATTCGCGGCCGCATCGCTTGCGGGCAAGAACGGCGCGGCCCC
CGATCCCGACGCGGCGAACAGGAAGAACCTGCTCCTGCTTATCCAGCTGCGCTGGCTGGCGGTGGCGGGTCAGGTGCTCA
CCATCCTGGTGACGCAATACTGGTTCGACATCCCGCTGCCGCTGGGGGAGATGGCCGGGGTGGTGGTTTTCCTGGTCGGG
CTGAACATCTTCAGCCTGCTCGCTTTGCGCGGCCAGCGGCCGATCAGCAACGCGCAGCTGTTCGTCGCGCTCATCTTCGA
CATGGCGGCACTGACGACGCAGCTTTACCTCAGCGGCGGTGCCTCGAACCCGTTCGTGTCGCTTTATCTCTTGCAGATCA
CCCTTGGCGCCGCGCTTTTGACACCCTGGTCCACCTGGAGCCTGGTGGCCGCCGCTTCCGCGTGCTTCGTCTTCCTCACC
TTCCAGTTCCAGCCGATCGCGATTCCGCATCACGGCGGCAGCGACCTGTTGGCCCTGCATATCAGGGGCATGTTCATCTG
CTTCGTGCTGGCGGCCGGCCTGATCGTCATCTTCATGACGCGCATCAACCGTAATCTTCGTGAGCGCGACGCCTATCTCG
CCGATCTGCGCCAGCACTCGGCCGAGGAGGACCACATCGTGCGCATGGGCTTGCTCGCCTCCGGAGCCGCGCATGAACTG
GGCACGCCGCTGTCGACCATCTCCGTCATCCTCTCCGACTGGCGCCAGATCCGCAGCGTCACCCGCAACCGCGAATTGGC
CGGGGACGTCGCCGAAATGCAGGCGCAGATCGAACGCTGCAAAAGCATCGTCTCGGGCATCCTGATGTCGTCGGGGCAGG
CACGGGGCGAGGGCACGATCCGCACCAGCATCCGCCATTTCCTCGGCGATCTGGTCCAGGAATGGCGGGTCAGCCGCCAG
CCGCTCAATCTGGAGTACAAGAACGATTTCGAACCTGACGAGCAGATCGTCTCCGACACGGCGCTGAAGCAGGTCATCTT
CAATGTGTTCGACAATGCTCTGGAGGCATCGCAGGATTGGGTCGGCGTCGCCGCCGGGCGGCAGGGCGAGAAACTGGTGA
TTTCGGTGCGTGACCGCGGGCCGGGCTTTGACGAGGGTATTCTGGCCGCGCTCGGCCAGCCCTATATGTCGAGCAAGGGA
CGACCCGGCGGCGGCCTTGGCCTTTTCCTCGTCGTCAACGTGGTCCGAAAGCTGGGAGGCGACTTTTCGGCGCGCAACAT
GGAGCAGGGGGCCTGTGTTACGCTTTCGCTGCCGCTCGCGGCGCTGACTGATGGAGATGATCATGAGGCCTGA

Upstream 100 bases:

>100_bases
ACCTCGTCTATGCTTTGACCTGGTTCACGCTCGCTGCGATGCTCGCTGCGGCCCTGGCCGCGCCGATGATCGGCGCCCGC
TGGCGGCGAGGACCGGCACG

Downstream 100 bases:

>100_bases
TCGATCCCTGTTTATCGTCGAGGACGACGCCACTTTCGCGAAGACGCTGAAGCGCTCCTTCGAAAAGCGCGACTACGACG
TCGTGGTCTGCCACGGCAGG

Product: two-component, sensor histidine protein kinase

Products: NA

Alternate protein names: Protein prrB [H]

Number of amino acids: Translated: 450; Mature: 449

Protein sequence:

>450_residues
MSAPTQTLRNDKSFAAASLAGKNGAAPDPDAANRKNLLLLIQLRWLAVAGQVLTILVTQYWFDIPLPLGEMAGVVVFLVG
LNIFSLLALRGQRPISNAQLFVALIFDMAALTTQLYLSGGASNPFVSLYLLQITLGAALLTPWSTWSLVAAASACFVFLT
FQFQPIAIPHHGGSDLLALHIRGMFICFVLAAGLIVIFMTRINRNLRERDAYLADLRQHSAEEDHIVRMGLLASGAAHEL
GTPLSTISVILSDWRQIRSVTRNRELAGDVAEMQAQIERCKSIVSGILMSSGQARGEGTIRTSIRHFLGDLVQEWRVSRQ
PLNLEYKNDFEPDEQIVSDTALKQVIFNVFDNALEASQDWVGVAAGRQGEKLVISVRDRGPGFDEGILAALGQPYMSSKG
RPGGGLGLFLVVNVVRKLGGDFSARNMEQGACVTLSLPLAALTDGDDHEA

Sequences:

>Translated_450_residues
MSAPTQTLRNDKSFAAASLAGKNGAAPDPDAANRKNLLLLIQLRWLAVAGQVLTILVTQYWFDIPLPLGEMAGVVVFLVG
LNIFSLLALRGQRPISNAQLFVALIFDMAALTTQLYLSGGASNPFVSLYLLQITLGAALLTPWSTWSLVAAASACFVFLT
FQFQPIAIPHHGGSDLLALHIRGMFICFVLAAGLIVIFMTRINRNLRERDAYLADLRQHSAEEDHIVRMGLLASGAAHEL
GTPLSTISVILSDWRQIRSVTRNRELAGDVAEMQAQIERCKSIVSGILMSSGQARGEGTIRTSIRHFLGDLVQEWRVSRQ
PLNLEYKNDFEPDEQIVSDTALKQVIFNVFDNALEASQDWVGVAAGRQGEKLVISVRDRGPGFDEGILAALGQPYMSSKG
RPGGGLGLFLVVNVVRKLGGDFSARNMEQGACVTLSLPLAALTDGDDHEA
>Mature_449_residues
SAPTQTLRNDKSFAAASLAGKNGAAPDPDAANRKNLLLLIQLRWLAVAGQVLTILVTQYWFDIPLPLGEMAGVVVFLVGL
NIFSLLALRGQRPISNAQLFVALIFDMAALTTQLYLSGGASNPFVSLYLLQITLGAALLTPWSTWSLVAAASACFVFLTF
QFQPIAIPHHGGSDLLALHIRGMFICFVLAAGLIVIFMTRINRNLRERDAYLADLRQHSAEEDHIVRMGLLASGAAHELG
TPLSTISVILSDWRQIRSVTRNRELAGDVAEMQAQIERCKSIVSGILMSSGQARGEGTIRTSIRHFLGDLVQEWRVSRQP
LNLEYKNDFEPDEQIVSDTALKQVIFNVFDNALEASQDWVGVAAGRQGEKLVISVRDRGPGFDEGILAALGQPYMSSKGR
PGGGLGLFLVVNVVRKLGGDFSARNMEQGACVTLSLPLAALTDGDDHEA

Specific function: Member of the two-component regulatory system RegB/RegA. Involved in the positive regulation of photosynthesis gene expression in response to anaerobiosis. Also involved in positive regulation of the cbbI and cbbII Calvin cycle CO2 fixation operons, as we

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=266, Percent_Identity=31.203007518797, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI87081816, Length=105, Percent_Identity=35.2380952380952, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 48778; Mature: 48647

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAPTQTLRNDKSFAAASLAGKNGAAPDPDAANRKNLLLLIQLRWLAVAGQVLTILVTQY
CCCCHHHHHCCCHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHH
WFDIPLPLGEMAGVVVFLVGLNIFSLLALRGQRPISNAQLFVALIFDMAALTTQLYLSGG
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
ASNPFVSLYLLQITLGAALLTPWSTWSLVAAASACFVFLTFQFQPIAIPHHGGSDLLALH
CCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHEEEEEEEEEEEECCCCCCCHHHHH
IRGMFICFVLAAGLIVIFMTRINRNLRERDAYLADLRQHSAEEDHIVRMGLLASGAAHEL
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCEEHHHHHHCCCHHHH
GTPLSTISVILSDWRQIRSVTRNRELAGDVAEMQAQIERCKSIVSGILMSSGQARGEGTI
CCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHH
RTSIRHFLGDLVQEWRVSRQPLNLEYKNDFEPDEQIVSDTALKQVIFNVFDNALEASQDW
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
VGVAAGRQGEKLVISVRDRGPGFDEGILAALGQPYMSSKGRPGGGLGLFLVVNVVRKLGG
EEEECCCCCCEEEEEEECCCCCCCHHHHHHHCCCHHCCCCCCCCCHHHHHHHHHHHHHCC
DFSARNMEQGACVTLSLPLAALTDGDDHEA
CCCCCCCCCCCEEEEECCHHEECCCCCCCC
>Mature Secondary Structure 
SAPTQTLRNDKSFAAASLAGKNGAAPDPDAANRKNLLLLIQLRWLAVAGQVLTILVTQY
CCCHHHHHCCCHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHH
WFDIPLPLGEMAGVVVFLVGLNIFSLLALRGQRPISNAQLFVALIFDMAALTTQLYLSGG
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
ASNPFVSLYLLQITLGAALLTPWSTWSLVAAASACFVFLTFQFQPIAIPHHGGSDLLALH
CCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHEEEEEEEEEEEECCCCCCCHHHHH
IRGMFICFVLAAGLIVIFMTRINRNLRERDAYLADLRQHSAEEDHIVRMGLLASGAAHEL
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCEEHHHHHHCCCHHHH
GTPLSTISVILSDWRQIRSVTRNRELAGDVAEMQAQIERCKSIVSGILMSSGQARGEGTI
CCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHH
RTSIRHFLGDLVQEWRVSRQPLNLEYKNDFEPDEQIVSDTALKQVIFNVFDNALEASQDW
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
VGVAAGRQGEKLVISVRDRGPGFDEGILAALGQPYMSSKGRPGGGLGLFLVVNVVRKLGG
EEEECCCCCCEEEEEEECCCCCCCHHHHHHHCCCHHCCCCCCCCCHHHHHHHHHHHHHCC
DFSARNMEQGACVTLSLPLAALTDGDDHEA
CCCCCCCCCCCEEEEECCHHEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7751278; 10358089 [H]