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The map label for this gene is yieO [C]

Identifier: 13475703

GI number: 13475703

Start: 5631367

End: 5632956

Strand: Direct

Name: yieO [C]

Synonym: mlr6842

Alternate gene names: 13475703

Gene position: 5631367-5632956 (Clockwise)

Preceding gene: 13475691

Following gene: 13475704

Centisome position: 80.04

GC content: 64.34

Gene sequence:

>1590_bases
TTGATATTGACATATATCTGCTGCGGGCACATAAACCGCCCCCGAACGTCGGAGACACCCATGAGCATTGACTCGACCCT
CCCGGATGCGCCGCCCGCAGAGTCCGGGGCCAAGCCCGACATCACGACGCTGGTCGTCTATTCCGGCGCGCTGATCGCCA
TGTTCATGGCCACCATCGACATGCAGATCGTCGTCACCGCCTTGCCGACCATTGCCGGCGAACTCGGCAATTTGCATCTG
TTCGGCTGGGTCGGCGCCGCCTATCTGCTGTCGACCGCCGCCGTCGCGCCGTTCTACGGCAAACTTGGCGACATGTATGG
CCGCAAGAATGTGGTGCTGACGGCGATCGCCTTGTTCCTGCTGGGCTCGCTGGTCTGCGGCATGGCCTGGTCGATGGAAA
GCCTGATCGCGGCGCGTGTCCTGCAAGGCATCGGCGGCGGCGGCCTGATGGTCTCGGCCTTTGCCATGATCGGCGAACTG
TTCGGGCCGCGCGACCGCGCCAAATACCAGGGCTACAGCTCGGCGGTGTTCGCGCTGTCGTCGGTCCTCGGCCCGTTGGC
CGGCGGCTATATCACCAGCCTGTTCGGCTGGCGCTGGGTGTTTTTGGTCAACCTGCCGATTGGCATCGTCGTGCTGGCGA
TCCTGGCGTTCGCCATGCGCAGCCGGTTCAACGAGAAGAGGCACAGCATCGACTATCTGGGCGGCTTGCTGCTGGCCATC
GGCACCACCGCAATCGTCTATTGGGGCTATCATCTGCTCGACCCCGCCGGACCGGACCTGCTCACCTTCGCGCTGCCGGT
CGTCGCGCTGGCGGCAATCGCCTCGTTCATCCTGGTCGAGCGGCGGGCCGAAGAGCCGATCGTGCCCTTGCGGCTGTTCG
GCTCCTCGACGGTGCGCATCGTCTCGGGCGTGTCGGTGGTCGCCGGGTCTGTGACGCTTGGCATGTTCTTCTATTTCGCG
CTCTACATGCAGACGTTGACCGGGCTCAGTCCGGCCGAAGTCGGCTTCCTGTTCCTGCCGGCTTCCTTGACCTCGATGGT
CATCTCGATCGTGGCCGGGCGGGTGATTGCCGCGACCGGCCGCTACAAATGGATGCCGGTGGTGGCGATGGGTATTGGCG
GGCTGTTGATGATAGGTTTTGTCTTCATCAATTCGCACACGCCGATCTGGGTTCTGGCGGTGATGATGGGCCTGTTCGGC
ATCAGCATGGGCCTGCAGTTCCAGGTGCTGATCGTGGCGATCCAGGCCGCAGCACCCCTGCAGGACATCGGCGCGGTGAC
GTCGCTGATCACCCAGGCGCGCACGATCGGCGCATCGCTGGGGCTGGCGCTGAACGGCGCGGTGATGACCTGGGCCCTGA
ACCGGCAGACTTCGGAGCTTCCCGCCGATGCCGCCGCCCTGCTGCCGGATGGCCTGACCGGGCTGAACCCGCATCTGGCG
TCAAGCCTGCCGGCCGCGATCCGCGACGTGGTGCTCGCCCACTATTCGAGTGGTTTCAACGTGATGTTCATCTGGGTGGC
GGCGCTTTACTTCGTTGCCATGGCGCTGACGCTTCTGCTGGAGGATATCCAGATCCCGAAGCGGGGCTGA

Upstream 100 bases:

>100_bases
AAATCGGTCGGGCTTGTCCGGCCTGGTATCGTCGCTGCTCATGTCACAGCGCGCTAGCAAAAATATATGTCGGTGTCAAT
TGCATGCTGATAGCATATAT

Downstream 100 bases:

>100_bases
GCCGAGCATCCCCGGTGGTGACTTTACCGTCTCCAACCATGCGGTCGCAGTTGGTGAATCCGACGAAGACCTTTGCATTC
AGACGACAGTATAAGGGGTC

Product: efflux transporter

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 529; Mature: 529

Protein sequence:

>529_residues
MILTYICCGHINRPRTSETPMSIDSTLPDAPPAESGAKPDITTLVVYSGALIAMFMATIDMQIVVTALPTIAGELGNLHL
FGWVGAAYLLSTAAVAPFYGKLGDMYGRKNVVLTAIALFLLGSLVCGMAWSMESLIAARVLQGIGGGGLMVSAFAMIGEL
FGPRDRAKYQGYSSAVFALSSVLGPLAGGYITSLFGWRWVFLVNLPIGIVVLAILAFAMRSRFNEKRHSIDYLGGLLLAI
GTTAIVYWGYHLLDPAGPDLLTFALPVVALAAIASFILVERRAEEPIVPLRLFGSSTVRIVSGVSVVAGSVTLGMFFYFA
LYMQTLTGLSPAEVGFLFLPASLTSMVISIVAGRVIAATGRYKWMPVVAMGIGGLLMIGFVFINSHTPIWVLAVMMGLFG
ISMGLQFQVLIVAIQAAAPLQDIGAVTSLITQARTIGASLGLALNGAVMTWALNRQTSELPADAAALLPDGLTGLNPHLA
SSLPAAIRDVVLAHYSSGFNVMFIWVAALYFVAMALTLLLEDIQIPKRG

Sequences:

>Translated_529_residues
MILTYICCGHINRPRTSETPMSIDSTLPDAPPAESGAKPDITTLVVYSGALIAMFMATIDMQIVVTALPTIAGELGNLHL
FGWVGAAYLLSTAAVAPFYGKLGDMYGRKNVVLTAIALFLLGSLVCGMAWSMESLIAARVLQGIGGGGLMVSAFAMIGEL
FGPRDRAKYQGYSSAVFALSSVLGPLAGGYITSLFGWRWVFLVNLPIGIVVLAILAFAMRSRFNEKRHSIDYLGGLLLAI
GTTAIVYWGYHLLDPAGPDLLTFALPVVALAAIASFILVERRAEEPIVPLRLFGSSTVRIVSGVSVVAGSVTLGMFFYFA
LYMQTLTGLSPAEVGFLFLPASLTSMVISIVAGRVIAATGRYKWMPVVAMGIGGLLMIGFVFINSHTPIWVLAVMMGLFG
ISMGLQFQVLIVAIQAAAPLQDIGAVTSLITQARTIGASLGLALNGAVMTWALNRQTSELPADAAALLPDGLTGLNPHLA
SSLPAAIRDVVLAHYSSGFNVMFIWVAALYFVAMALTLLLEDIQIPKRG
>Mature_529_residues
MILTYICCGHINRPRTSETPMSIDSTLPDAPPAESGAKPDITTLVVYSGALIAMFMATIDMQIVVTALPTIAGELGNLHL
FGWVGAAYLLSTAAVAPFYGKLGDMYGRKNVVLTAIALFLLGSLVCGMAWSMESLIAARVLQGIGGGGLMVSAFAMIGEL
FGPRDRAKYQGYSSAVFALSSVLGPLAGGYITSLFGWRWVFLVNLPIGIVVLAILAFAMRSRFNEKRHSIDYLGGLLLAI
GTTAIVYWGYHLLDPAGPDLLTFALPVVALAAIASFILVERRAEEPIVPLRLFGSSTVRIVSGVSVVAGSVTLGMFFYFA
LYMQTLTGLSPAEVGFLFLPASLTSMVISIVAGRVIAATGRYKWMPVVAMGIGGLLMIGFVFINSHTPIWVLAVMMGLFG
ISMGLQFQVLIVAIQAAAPLQDIGAVTSLITQARTIGASLGLALNGAVMTWALNRQTSELPADAAALLPDGLTGLNPHLA
SSLPAAIRDVVLAHYSSGFNVMFIWVAALYFVAMALTLLLEDIQIPKRG

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Escherichia coli, GI1790195, Length=407, Percent_Identity=27.027027027027, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI87081983, Length=406, Percent_Identity=27.8325123152709, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI1789042, Length=320, Percent_Identity=30, Blast_Score=106, Evalue=4e-24,
Organism=Escherichia coli, GI1788710, Length=317, Percent_Identity=29.3375394321767, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1788392, Length=403, Percent_Identity=28.7841191066998, Blast_Score=99, Evalue=6e-22,
Organism=Escherichia coli, GI1790146, Length=185, Percent_Identity=32.972972972973, Blast_Score=84, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6323735, Length=319, Percent_Identity=30.7210031347962, Blast_Score=131, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6319770, Length=481, Percent_Identity=23.7006237006237, Blast_Score=112, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6322958, Length=464, Percent_Identity=24.3534482758621, Blast_Score=111, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6321663, Length=201, Percent_Identity=32.3383084577114, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6325455, Length=166, Percent_Identity=33.7349397590361, Blast_Score=91, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6319783, Length=384, Percent_Identity=22.9166666666667, Blast_Score=72, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6324954, Length=402, Percent_Identity=22.1393034825871, Blast_Score=64, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829
- InterPro:   IPR001958
- InterPro:   IPR011991 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 55989; Mature: 55989

Theoretical pI: Translated: 8.06; Mature: 8.06

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILTYICCGHINRPRTSETPMSIDSTLPDAPPAESGAKPDITTLVVYSGALIAMFMATID
CEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
MQIVVTALPTIAGELGNLHLFGWVGAAYLLSTAAVAPFYGKLGDMYGRKNVVLTAIALFL
HHHHHHHHHHHHHHHCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
LGSLVCGMAWSMESLIAARVLQGIGGGGLMVSAFAMIGELFGPRDRAKYQGYSSAVFALS
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHH
SVLGPLAGGYITSLFGWRWVFLVNLPIGIVVLAILAFAMRSRFNEKRHSIDYLGGLLLAI
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GTTAIVYWGYHLLDPAGPDLLTFALPVVALAAIASFILVERRAEEPIVPLRLFGSSTVRI
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHH
VSGVSVVAGSVTLGMFFYFALYMQTLTGLSPAEVGFLFLPASLTSMVISIVAGRVIAATG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHEEEHHHHHHHHHHHHHCHHHEECC
RYKWMPVVAMGIGGLLMIGFVFINSHTPIWVLAVMMGLFGISMGLQFQVLIVAIQAAAPL
CCEEHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCH
QDIGAVTSLITQARTIGASLGLALNGAVMTWALNRQTSELPADAAALLPDGLTGLNPHLA
HHHHHHHHHHHHHHHHHHHHCCEECCCEEEEEECCCCCCCCCCHHHHCCCCCCCCCHHHH
SSLPAAIRDVVLAHYSSGFNVMFIWVAALYFVAMALTLLLEDIQIPKRG
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MILTYICCGHINRPRTSETPMSIDSTLPDAPPAESGAKPDITTLVVYSGALIAMFMATID
CEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
MQIVVTALPTIAGELGNLHLFGWVGAAYLLSTAAVAPFYGKLGDMYGRKNVVLTAIALFL
HHHHHHHHHHHHHHHCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
LGSLVCGMAWSMESLIAARVLQGIGGGGLMVSAFAMIGELFGPRDRAKYQGYSSAVFALS
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHH
SVLGPLAGGYITSLFGWRWVFLVNLPIGIVVLAILAFAMRSRFNEKRHSIDYLGGLLLAI
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GTTAIVYWGYHLLDPAGPDLLTFALPVVALAAIASFILVERRAEEPIVPLRLFGSSTVRI
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHH
VSGVSVVAGSVTLGMFFYFALYMQTLTGLSPAEVGFLFLPASLTSMVISIVAGRVIAATG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHEEEHHHHHHHHHHHHHCHHHEECC
RYKWMPVVAMGIGGLLMIGFVFINSHTPIWVLAVMMGLFGISMGLQFQVLIVAIQAAAPL
CCEEHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCH
QDIGAVTSLITQARTIGASLGLALNGAVMTWALNRQTSELPADAAALLPDGLTGLNPHLA
HHHHHHHHHHHHHHHHHHHHCCEECCCEEEEEECCCCCCCCCCHHHHCCCCCCCCCHHHH
SSLPAAIRDVVLAHYSSGFNVMFIWVAALYFVAMALTLLLEDIQIPKRG
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]