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The map label for this gene is acbB [H]

Identifier: 13475647

GI number: 13475647

Start: 5566659

End: 5567663

Strand: Direct

Name: acbB [H]

Synonym: mlr6767

Alternate gene names: 13475647

Gene position: 5566659-5567663 (Clockwise)

Preceding gene: 13475646

Following gene: 13475648

Centisome position: 79.12

GC content: 61.09

Gene sequence:

>1005_bases
ATGAGCTATAGTGGCAAGAAAGTTCTGGTGACGGGCGCGGATGGATTTATCGGTTCGCATCTCACCGAAGCGCTCGTCCG
CAACGGCGCGGATGTCACGGCCCTGGCGCTATACAATTCCTTCGACAGCCATGGATGGCTGGACGATTTGCCGGACAAGA
TCCGCAGCCAGCTGAAGCTCGTCCGCGGTGACGTCCGCGACAGCGCGTTCCTGAACCGGATCGTGCGCGGCCAGGCCGTC
GTGTTTCACCTGGCCGCGCTCATTGCGATTCCATATTCCTACGCGGCTGCCCAGTCCTATGTGGAAACCAACATTCTGGG
CACTGTGAATGTTCTTGAAGCGGCGCGTCAATGGGAGACGGAGCGGGTGGTGCATACCTCCACGAGCGAGGTCTATGGAA
CCGCCCAGACCATGCCCATCCGCGAAACGCATCCGTTACAGGGACAGTCACCCTATTCGGCATCCAAGATCGGCGCCGAC
ATGATGGCCGAGTCCTATGCCAGGTCGTTCGATGTCCCCGTGGTCATCATGCGGCCCTTCAACACCTATGGTCCGCGCCA
GAGTGAACGCGCCATCGTGCCGACCATCGTCCGGCAGGCCCTTGATCCGAAGTGCCCGTCGATCATGGTCGGCGATACGA
GCCCGATCCGCGACCTGACCTTTGTCGAGGACACTGCGGCAGCCTTCCTGACCGCGGGCCTGGCCGGGCTTGAATTCGGC
CACGCCTACAATGCCGGCAGCCAACGCGCCGCGACCATCTCCGACGTATTGGATCTTGTCCTCGAATTGAGCGGTTCCAA
GAAACCGGTCCATCGTGACGAACGCCGTTTGCGACCGCAAAATTCGGAGGTTCGCGCCTTGCTCGCCGATTCTTCGCGTT
TTGAAGGCGAGACCGGATGGCGGGCGCAGACAAGCCTGCGCGATGGACTGGAGCGAACGATCGCATGGTGGCGCGCGCGC
CTTAGTGAAGGCCGGGTACGGCGCGAAATGGGTTATATGACATGA

Upstream 100 bases:

>100_bases
GCGTGGCGTCCTGGCGGTTGTCGGCTGGGTTCCATCGCAGCCGATCGACGTATGAATCCCAAAAGGAAAGCGATCCAGTA
AACCAAGGGAATGCGCAGTC

Downstream 100 bases:

>100_bases
CCCCGTTCCGCCGGCATATGTTTGCGCTGTTGCTGATTGCCGGTGCCATGTTCCCGAATATCTTTATGGCCGGTAGTCGC
GAAAGCAGCGCATCGCAACC

Product: UDP-glucose 4-epimerase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 334; Mature: 333

Protein sequence:

>334_residues
MSYSGKKVLVTGADGFIGSHLTEALVRNGADVTALALYNSFDSHGWLDDLPDKIRSQLKLVRGDVRDSAFLNRIVRGQAV
VFHLAALIAIPYSYAAAQSYVETNILGTVNVLEAARQWETERVVHTSTSEVYGTAQTMPIRETHPLQGQSPYSASKIGAD
MMAESYARSFDVPVVIMRPFNTYGPRQSERAIVPTIVRQALDPKCPSIMVGDTSPIRDLTFVEDTAAAFLTAGLAGLEFG
HAYNAGSQRAATISDVLDLVLELSGSKKPVHRDERRLRPQNSEVRALLADSSRFEGETGWRAQTSLRDGLERTIAWWRAR
LSEGRVRREMGYMT

Sequences:

>Translated_334_residues
MSYSGKKVLVTGADGFIGSHLTEALVRNGADVTALALYNSFDSHGWLDDLPDKIRSQLKLVRGDVRDSAFLNRIVRGQAV
VFHLAALIAIPYSYAAAQSYVETNILGTVNVLEAARQWETERVVHTSTSEVYGTAQTMPIRETHPLQGQSPYSASKIGAD
MMAESYARSFDVPVVIMRPFNTYGPRQSERAIVPTIVRQALDPKCPSIMVGDTSPIRDLTFVEDTAAAFLTAGLAGLEFG
HAYNAGSQRAATISDVLDLVLELSGSKKPVHRDERRLRPQNSEVRALLADSSRFEGETGWRAQTSLRDGLERTIAWWRAR
LSEGRVRREMGYMT
>Mature_333_residues
SYSGKKVLVTGADGFIGSHLTEALVRNGADVTALALYNSFDSHGWLDDLPDKIRSQLKLVRGDVRDSAFLNRIVRGQAVV
FHLAALIAIPYSYAAAQSYVETNILGTVNVLEAARQWETERVVHTSTSEVYGTAQTMPIRETHPLQGQSPYSASKIGADM
MAESYARSFDVPVVIMRPFNTYGPRQSERAIVPTIVRQALDPKCPSIMVGDTSPIRDLTFVEDTAAAFLTAGLAGLEFGH
AYNAGSQRAATISDVLDLVLELSGSKKPVHRDERRLRPQNSEVRALLADSSRFEGETGWRAQTSLRDGLERTIAWWRARL
SEGRVRREMGYMT

Specific function: Probably involved in the biosynthesis of the acarviose moiety of the alpha-glucosidase inhibitor acarbose. Catalyzes the dehydration of dTDP-D-glucose to form dTDP-6-deoxy-D-xylo-4- hexulose via a three-step process involving oxidation, dehydration and re

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family. dTDP-glucose dehydratase subfamily [H]

Homologues:

Organism=Homo sapiens, GI7657641, Length=330, Percent_Identity=28.7878787878788, Blast_Score=138, Evalue=9e-33,
Organism=Homo sapiens, GI42516563, Length=338, Percent_Identity=27.2189349112426, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI56237023, Length=343, Percent_Identity=26.530612244898, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI56118217, Length=343, Percent_Identity=26.530612244898, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI189083684, Length=343, Percent_Identity=26.530612244898, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI4504031, Length=199, Percent_Identity=27.6381909547739, Blast_Score=75, Evalue=6e-14,
Organism=Escherichia coli, GI48994969, Length=341, Percent_Identity=31.0850439882698, Blast_Score=132, Evalue=4e-32,
Organism=Escherichia coli, GI1788353, Length=343, Percent_Identity=29.4460641399417, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1786974, Length=351, Percent_Identity=26.7806267806268, Blast_Score=108, Evalue=6e-25,
Organism=Escherichia coli, GI1788366, Length=355, Percent_Identity=25.6338028169014, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1788365, Length=339, Percent_Identity=24.188790560472, Blast_Score=75, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17568069, Length=323, Percent_Identity=28.1733746130031, Blast_Score=114, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI115532424, Length=332, Percent_Identity=27.710843373494, Blast_Score=106, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17539532, Length=331, Percent_Identity=25.9818731117825, Blast_Score=106, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI71982035, Length=359, Percent_Identity=26.4623955431755, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71982038, Length=361, Percent_Identity=26.3157894736842, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI133901790, Length=351, Percent_Identity=25.6410256410256, Blast_Score=82, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI133901788, Length=343, Percent_Identity=26.530612244898, Blast_Score=81, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17539424, Length=343, Percent_Identity=26.530612244898, Blast_Score=81, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI133901786, Length=343, Percent_Identity=26.530612244898, Blast_Score=81, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17539422, Length=343, Percent_Identity=26.530612244898, Blast_Score=81, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17507723, Length=227, Percent_Identity=27.3127753303965, Blast_Score=72, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6319493, Length=351, Percent_Identity=28.2051282051282, Blast_Score=97, Evalue=3e-21,
Organism=Drosophila melanogaster, GI21356223, Length=335, Percent_Identity=26.5671641791045, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI19923002, Length=340, Percent_Identity=25.5882352941176, Blast_Score=88, Evalue=7e-18,
Organism=Drosophila melanogaster, GI24158427, Length=202, Percent_Identity=26.7326732673267, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005888
- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =4.2.1.46 [H]

Molecular weight: Translated: 36849; Mature: 36718

Theoretical pI: Translated: 7.78; Mature: 7.78

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYSGKKVLVTGADGFIGSHLTEALVRNGADVTALALYNSFDSHGWLDDLPDKIRSQLKL
CCCCCCEEEEECCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHH
VRGDVRDSAFLNRIVRGQAVVFHLAALIAIPYSYAAAQSYVETNILGTVNVLEAARQWET
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH
ERVVHTSTSEVYGTAQTMPIRETHPLQGQSPYSASKIGADMMAESYARSFDVPVVIMRPF
HHEEECCCHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCC
NTYGPRQSERAIVPTIVRQALDPKCPSIMVGDTSPIRDLTFVEDTAAAFLTAGLAGLEFG
CCCCCCCCCCCHHHHHHHHHCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHC
HAYNAGSQRAATISDVLDLVLELSGSKKPVHRDERRLRPQNSEVRALLADSSRFEGETGW
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCHHHEEEECCCCCCCCCCC
RAQTSLRDGLERTIAWWRARLSEGRVRREMGYMT
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SYSGKKVLVTGADGFIGSHLTEALVRNGADVTALALYNSFDSHGWLDDLPDKIRSQLKL
CCCCCEEEEECCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHH
VRGDVRDSAFLNRIVRGQAVVFHLAALIAIPYSYAAAQSYVETNILGTVNVLEAARQWET
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH
ERVVHTSTSEVYGTAQTMPIRETHPLQGQSPYSASKIGADMMAESYARSFDVPVVIMRPF
HHEEECCCHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCC
NTYGPRQSERAIVPTIVRQALDPKCPSIMVGDTSPIRDLTFVEDTAAAFLTAGLAGLEFG
CCCCCCCCCCCHHHHHHHHHCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHC
HAYNAGSQRAATISDVLDLVLELSGSKKPVHRDERRLRPQNSEVRALLADSSRFEGETGW
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCHHHEEEECCCCCCCCCCC
RAQTSLRDGLERTIAWWRARLSEGRVRREMGYMT
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10196166 [H]