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The map label for this gene is saeR [H]

Identifier: 13475584

GI number: 13475584

Start: 5487224

End: 5487619

Strand: Direct

Name: saeR [H]

Synonym: mlr6690

Alternate gene names: 13475584

Gene position: 5487224-5487619 (Clockwise)

Preceding gene: 13475583

Following gene: 13475585

Centisome position: 77.99

GC content: 64.39

Gene sequence:

>396_bases
GTGACGATCATGCCGGCAAGGATCCTCTACGTGGATGACGAGGACGATATCCGCGAAATCGCTCAGATGTCGCTGGAGCT
CGATCCGGAATTCGAGGTGCGGTCTTGCTCTTCGGGCGCCGCGGCGCTGACCGATGCCGCCGCATGGCATCCCGATCTCA
TCTTGCTCGACGTGATGATGCCGGACATGGACGGGCCGGAGACGCTGAAGCGCCTGGCTGCTTCACCGCTGACGGCGTCG
ATACCCGTGGCCTTTATCACCGCGCGCACCCAGACGCATCAGGTCGAGCGCTATCTCGCCATGGGAGCGGTCGGGGTCAT
CGCCAAACCCTTCGATCCGCTGGCCCTCGCCGGCGAAGTCAGGAAGCTGCTCTCGGAGCATCCCGGGCGCGCATAG

Upstream 100 bases:

>100_bases
TGACCAAGACCAGGGCGTCGGAGATCGATGTCGCAAAGCTGGTCAGAACCATGTTGGCCTCATCGCGAGATGGCACCAGA
CCCGCCGGCCGCGCCAAGGA

Downstream 100 bases:

>100_bases
CCGCTGGGTCGAAGGCAGTGGCAACAAGCCTGTCAGCAAGCTCCGTTTGCCGTTTACGGCACCTGTACCATACCCCAATA
TTCATCTACTGATTGTATCG

Product: two-component response regulator

Products: NA

Alternate protein names: Staphylococcus exoprotein expression protein R [H]

Number of amino acids: Translated: 131; Mature: 130

Protein sequence:

>131_residues
MTIMPARILYVDDEDDIREIAQMSLELDPEFEVRSCSSGAAALTDAAAWHPDLILLDVMMPDMDGPETLKRLAASPLTAS
IPVAFITARTQTHQVERYLAMGAVGVIAKPFDPLALAGEVRKLLSEHPGRA

Sequences:

>Translated_131_residues
MTIMPARILYVDDEDDIREIAQMSLELDPEFEVRSCSSGAAALTDAAAWHPDLILLDVMMPDMDGPETLKRLAASPLTAS
IPVAFITARTQTHQVERYLAMGAVGVIAKPFDPLALAGEVRKLLSEHPGRA
>Mature_130_residues
TIMPARILYVDDEDDIREIAQMSLELDPEFEVRSCSSGAAALTDAAAWHPDLILLDVMMPDMDGPETLKRLAASPLTASI
PVAFITARTQTHQVERYLAMGAVGVIAKPFDPLALAGEVRKLLSEHPGRA

Specific function: Member of the two-component regulatory system saeR/saeS involved in the regulation of staphylococcal virulence factors in a strain-dependent fashion. Probably functions as a transcriptional regulator via a specific DNA-binding domain, recognizing motifs n

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=106, Percent_Identity=36.7924528301887, Blast_Score=69, Evalue=1e-13,
Organism=Escherichia coli, GI1786599, Length=121, Percent_Identity=36.3636363636364, Blast_Score=66, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 14229; Mature: 14097

Theoretical pI: Translated: 4.38; Mature: 4.38

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIMPARILYVDDEDDIREIAQMSLELDPEFEVRSCSSGAAALTDAAAWHPDLILLDVMM
CCCCCCEEEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHCCCCCCCEEEEEEEC
PDMDGPETLKRLAASPLTASIPVAFITARTQTHQVERYLAMGAVGVIAKPFDPLALAGEV
CCCCCHHHHHHHHCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
RKLLSEHPGRA
HHHHHCCCCCC
>Mature Secondary Structure 
TIMPARILYVDDEDDIREIAQMSLELDPEFEVRSCSSGAAALTDAAAWHPDLILLDVMM
CCCCCEEEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHCCCCCCCEEEEEEEC
PDMDGPETLKRLAASPLTASIPVAFITARTQTHQVERYLAMGAVGVIAKPFDPLALAGEV
CCCCCHHHHHHHHCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
RKLLSEHPGRA
HHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA