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The map label for this gene is hemN [H]

Identifier: 13475538

GI number: 13475538

Start: 5433838

End: 5435187

Strand: Direct

Name: hemN [H]

Synonym: mlr6633

Alternate gene names: 13475538

Gene position: 5433838-5435187 (Clockwise)

Preceding gene: 13475536

Following gene: 13475543

Centisome position: 77.23

GC content: 62.59

Gene sequence:

>1350_bases
ATGCAACCGGAAGCGGCCGCCAGGCTTGGCGAAAATGTACCGCGCTACACGAGCTATCCGACGGCGCCCCATTTCCACCC
GGGGGTTGATGCGGCTGTCTGTCGGACTTGGCTGGAAGCGCTCAAAGGCGATGACGAGATATCGCTCTATCTGCATATTC
CCTACTGCGACAAGCTGTGCTGGTTCTGTGCGTGCCACACCAAGCAGACCCGGCACTATCAGCCGGTAGCGACCTTTCTG
CACTCCTTGCATAGGGAGATCGAGGCTGTTGGCAGCCTCGTGCGCGGCAAGGGTCGTGTGCGCGCCATCCATTTCGGCGG
TGGCTCGCCGACGATGCTGAAGCCCGAGGACATCCTGTCGCTTGGAGAAGCGCTGCGGGATCGTTTCGATGTGCTCGACG
ATGCCAGCCTCAGTGTCGAAATCGATCCCAGCGACATGGATGAGGCCCGGCTCGACGCCCTCTCCGCGATAGGCATGACG
AGGGCGAGCCTCGGCGTTCAGGATTTCGATCCCAAGGTGCAGAAAGCCATCAATCGCGAGCAAAGCTTCCTGCTGACCAA
GAGCGTGGTGGATGCCGTGCGGGCGCGTGGCGTGAATTCGGTGAACCTCGACCTGCTCTACGGACTGCCGCACCAGACCC
TTGAGAGCGTTGCCCGGACCGTCGCCCAGGCGTTGACGTTGCGGCCCGACAGGCTGGCGCTGTTCGGCTATGCGCATGTG
CCCTGGTTCAAGAAACATCAGACCATGATCGACGAAGCATGGCTCCCCGATTCCGCCGGACGGCTGGCGCAATCGCAGAT
CGCCGCGCGGCTGATCGTGGACGCCGGATACGAGGCCTTGGGACTGGACCATTTCGCCAAGCCGGACGATACGCTCGCGA
TCTCGGCTCGCACCGGCAAGATCCGCCGCAATTTCCAGGGCTATACAGAGGACAATTGCGAGACGCTGATCGGTCTCGGG
CCCTCCGCGATCAGCCGATACCGCCAGGGCTATGCCCAGAACATCGTCGCGACCGGTGCATACGAGAAGGTCGTGGATTC
CGGACAGCTGGCAGTGGCCCGCGGCGTCGAGCTCAGCGTCGACGATCTGGCGAGAGGCTGGATCATCGAGCGTCTGATGT
GCCATTTCGCCTTCTCGGCGATCGAACTGGTCGAACGCTTCGGCGACGTCGGCCAGAGACTCCTGGCCATGGCAAGTCGA
CTTGCCGTCGGCGGCGGCGGCCTTTTGCTTCGGCTCGATGGTGAAAACTTCGTCGTACCGAAGGACAGCCGCCCGCTTGT
CAGGACGGTGGCAGCGAAATTCGACAAGTACCTCGAAGCCGGCACGGCCAGGCATTCGGTGGCGGTCTGA

Upstream 100 bases:

>100_bases
CCTTGTGACAGTTTGTCCGGTGCAAAGGCTTTGACCGAAATCAAGGCATTGGCGTGCGATTGCGGCCATTGCCTGACCTT
GCAAACACAAGGAAAGCGAC

Downstream 100 bases:

>100_bases
GCATCGGTCTGGTCAGAAGTGCTCGCCGACTCTGAAGGGGCCGATGCGCGTTCCCGCCGCGATCAGATAAGCGGTCGACC
AGCCGATGAGGAGAAATCCG

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MQPEAAARLGENVPRYTSYPTAPHFHPGVDAAVCRTWLEALKGDDEISLYLHIPYCDKLCWFCACHTKQTRHYQPVATFL
HSLHREIEAVGSLVRGKGRVRAIHFGGGSPTMLKPEDILSLGEALRDRFDVLDDASLSVEIDPSDMDEARLDALSAIGMT
RASLGVQDFDPKVQKAINREQSFLLTKSVVDAVRARGVNSVNLDLLYGLPHQTLESVARTVAQALTLRPDRLALFGYAHV
PWFKKHQTMIDEAWLPDSAGRLAQSQIAARLIVDAGYEALGLDHFAKPDDTLAISARTGKIRRNFQGYTEDNCETLIGLG
PSAISRYRQGYAQNIVATGAYEKVVDSGQLAVARGVELSVDDLARGWIIERLMCHFAFSAIELVERFGDVGQRLLAMASR
LAVGGGGLLLRLDGENFVVPKDSRPLVRTVAAKFDKYLEAGTARHSVAV

Sequences:

>Translated_449_residues
MQPEAAARLGENVPRYTSYPTAPHFHPGVDAAVCRTWLEALKGDDEISLYLHIPYCDKLCWFCACHTKQTRHYQPVATFL
HSLHREIEAVGSLVRGKGRVRAIHFGGGSPTMLKPEDILSLGEALRDRFDVLDDASLSVEIDPSDMDEARLDALSAIGMT
RASLGVQDFDPKVQKAINREQSFLLTKSVVDAVRARGVNSVNLDLLYGLPHQTLESVARTVAQALTLRPDRLALFGYAHV
PWFKKHQTMIDEAWLPDSAGRLAQSQIAARLIVDAGYEALGLDHFAKPDDTLAISARTGKIRRNFQGYTEDNCETLIGLG
PSAISRYRQGYAQNIVATGAYEKVVDSGQLAVARGVELSVDDLARGWIIERLMCHFAFSAIELVERFGDVGQRLLAMASR
LAVGGGGLLLRLDGENFVVPKDSRPLVRTVAAKFDKYLEAGTARHSVAV
>Mature_449_residues
MQPEAAARLGENVPRYTSYPTAPHFHPGVDAAVCRTWLEALKGDDEISLYLHIPYCDKLCWFCACHTKQTRHYQPVATFL
HSLHREIEAVGSLVRGKGRVRAIHFGGGSPTMLKPEDILSLGEALRDRFDVLDDASLSVEIDPSDMDEARLDALSAIGMT
RASLGVQDFDPKVQKAINREQSFLLTKSVVDAVRARGVNSVNLDLLYGLPHQTLESVARTVAQALTLRPDRLALFGYAHV
PWFKKHQTMIDEAWLPDSAGRLAQSQIAARLIVDAGYEALGLDHFAKPDDTLAISARTGKIRRNFQGYTEDNCETLIGLG
PSAISRYRQGYAQNIVATGAYEKVVDSGQLAVARGVELSVDDLARGWIIERLMCHFAFSAIELVERFGDVGQRLLAMASR
LAVGGGGLLLRLDGENFVVPKDSRPLVRTVAAKFDKYLEAGTARHSVAV

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=289, Percent_Identity=26.2975778546713, Blast_Score=82, Evalue=1e-15,
Organism=Escherichia coli, GI87082341, Length=431, Percent_Identity=38.5150812064965, Blast_Score=285, Evalue=5e-78,
Organism=Escherichia coli, GI1789325, Length=247, Percent_Identity=26.7206477732794, Blast_Score=100, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004558
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 49334; Mature: 49334

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQPEAAARLGENVPRYTSYPTAPHFHPGVDAAVCRTWLEALKGDDEISLYLHIPYCDKLC
CCCHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCHHHHHH
WFCACHTKQTRHYQPVATFLHSLHREIEAVGSLVRGKGRVRAIHFGGGSPTMLKPEDILS
HHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHHH
LGEALRDRFDVLDDASLSVEIDPSDMDEARLDALSAIGMTRASLGVQDFDPKVQKAINRE
HHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCHH
QSFLLTKSVVDAVRARGVNSVNLDLLYGLPHQTLESVARTVAQALTLRPDRLALFGYAHV
HHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCC
PWFKKHQTMIDEAWLPDSAGRLAQSQIAARLIVDAGYEALGLDHFAKPDDTLAISARTGK
CHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCCEEEEECCCH
IRRNFQGYTEDNCETLIGLGPSAISRYRQGYAQNIVATGAYEKVVDSGQLAVARGVELSV
HHHCCCCCCCCCCHHEECCCHHHHHHHHHHHHHHHHHCCHHHHHHCCCCEEEECCCCCCH
DDLARGWIIERLMCHFAFSAIELVERFGDVGQRLLAMASRLAVGGGGLLLRLDGENFVVP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEEEC
KDSRPLVRTVAAKFDKYLEAGTARHSVAV
CCCCHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MQPEAAARLGENVPRYTSYPTAPHFHPGVDAAVCRTWLEALKGDDEISLYLHIPYCDKLC
CCCHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCHHHHHH
WFCACHTKQTRHYQPVATFLHSLHREIEAVGSLVRGKGRVRAIHFGGGSPTMLKPEDILS
HHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHHH
LGEALRDRFDVLDDASLSVEIDPSDMDEARLDALSAIGMTRASLGVQDFDPKVQKAINRE
HHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCHH
QSFLLTKSVVDAVRARGVNSVNLDLLYGLPHQTLESVARTVAQALTLRPDRLALFGYAHV
HHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCC
PWFKKHQTMIDEAWLPDSAGRLAQSQIAARLIVDAGYEALGLDHFAKPDDTLAISARTGK
CHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCCEEEEECCCH
IRRNFQGYTEDNCETLIGLGPSAISRYRQGYAQNIVATGAYEKVVDSGQLAVARGVELSV
HHHCCCCCCCCCCHHEECCCHHHHHHHHHHHHHHHHHCCHHHHHHCCCCEEEECCCCCCH
DDLARGWIIERLMCHFAFSAIELVERFGDVGQRLLAMASRLAVGGGGLLLRLDGENFVVP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEEEC
KDSRPLVRTVAAKFDKYLEAGTARHSVAV
CCCCHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11157943; 12597275 [H]