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The map label for this gene is mco [H]

Identifier: 13475430

GI number: 13475430

Start: 5304766

End: 5306160

Strand: Direct

Name: mco [H]

Synonym: mlr6496

Alternate gene names: 13475430

Gene position: 5304766-5306160 (Clockwise)

Preceding gene: 13475429

Following gene: 13475431

Centisome position: 75.39

GC content: 63.23

Gene sequence:

>1395_bases
ATGACCGGATGGACACGCCGTGGGCTCTTGAAAACGGCCGCCGTCGCTGGCGCAACCGGAGTAGGGCTTTCGGCCATCGG
CAGGCTTGGCGGCCTCGCCGCCACCAGCCCCGAGCCGATGGTGCTGCAGACGGCCAAGATCCAGGCCAGGCTGATGGATA
TCGGCCCGACCAACAATGTGCTGACCTATGGCAATGCCGGAATGCCGCCAGTGCTGAGGATGAAGAAGGGCGAACCCTTC
GCGGCGCGCCTGGTCAACGCCATCGATGATCCCACGACCATCCATTGGCACGGCATTCGCCTGCCCAACAAGATGGATGG
CGTGCCCTTCCTGGTGCAGCCCTATGTCAACACCGGCGACCATTTCGACTACGCCTTCACGCCGCCCGACGCCGGCACCT
TCTGGTACCACCCGCATTGCAACACGCTGGAGCAGATGGGCCACGGCCTGACCGGCGTGATCGTTGTCGAAAACCCGAAT
GATCCGAAATTCGACGCCGAATTCGTCCTCAATCTGCGCGACTGGCGTCTTGGCGACGACGGCCAGTTCATCGACCAATT
CCGGCCGCGCGATGCCGCGAAAACCGGCACTTACGGCACGGTGCGCACCGCCAACTGGCTCGACCAGCCGCAATACGACG
CGCCGGCCGGAGGTCTGGTGCGGCTGCGCGTCGCCATCACCGATGTCACCCGCATCTATGCCTTTCGCGTCGACGGTGCC
GAGGCGATCGTGATGGCGCTTGACGGCAATCCGGTGCCTGAGCGCTTTTCACCCGATGCCTTGCTGCTTGGGCCGGGGCA
GCGCATGGAACTTGCCATCCGCATGCCAGACCGGGAAGGCGCGGTGGTGAGCCTGCGGGATGTCAGGGGCACCAAGCCCA
AGATCCTGGCGACCGTGCGGGCGACGGGCAGCTCGCTCAAACGGGATGTTCGCGATGTTGCGCCGCTGGAGGTCAATCCG
GTGGCGGAAGTGGACCTCAGCGCCGCCCAGCACATTTCGCTGGCTCTCAGCGCTACGGCGGAAAACGTACCGAGCGATGG
CATCTGCGGTTCGCTAGGCTACAGTTTCTGGGCCATCAACAAGGTGCCGTGGCCAGGCGATACATCCGATCCGACCGCGC
CGCTGGCCGAATTGAAGCTCGGCAAGAGCTATGTCATCGACATGGAGAACCTGACGCCGCAATCGCATCCGATGCATCTG
CACGGTATGGGCTTCAAGGTGCTGTCGTCCTCGACACGTCCGGTGCAGCCGCTGATTTCCGACACCTATCTTATCCAGCC
CAACGAAAAGGTTCAGCTCGGCTTCGTCGCCGACAATCCCGGTGACTGGCTGCTGCACTGCCACATCATCGAGCACCAGA
AATCGGGCATGACGAGCTACGTCCGGGTGGTTTGA

Upstream 100 bases:

>100_bases
CATTGGCGGGACGCGGTGTGCCAATATCGGCATTTGCACTGGCGGCTCGCCTGTGATCCAAGGCGACGACAAATCCCAGG
CTTTGCAGTTGGAGCGCTGA

Downstream 100 bases:

>100_bases
GCCAGGTTTGAACGGTTTCGTTGGCAAAAGCGGGTGGTTCCCTGCTATTGCCGCATCCAAAACCAAGAACCATGGACATC
TCACGCATGACCAATGTCGC

Product: metallo-oxidoreductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 464; Mature: 463

Protein sequence:

>464_residues
MTGWTRRGLLKTAAVAGATGVGLSAIGRLGGLAATSPEPMVLQTAKIQARLMDIGPTNNVLTYGNAGMPPVLRMKKGEPF
AARLVNAIDDPTTIHWHGIRLPNKMDGVPFLVQPYVNTGDHFDYAFTPPDAGTFWYHPHCNTLEQMGHGLTGVIVVENPN
DPKFDAEFVLNLRDWRLGDDGQFIDQFRPRDAAKTGTYGTVRTANWLDQPQYDAPAGGLVRLRVAITDVTRIYAFRVDGA
EAIVMALDGNPVPERFSPDALLLGPGQRMELAIRMPDREGAVVSLRDVRGTKPKILATVRATGSSLKRDVRDVAPLEVNP
VAEVDLSAAQHISLALSATAENVPSDGICGSLGYSFWAINKVPWPGDTSDPTAPLAELKLGKSYVIDMENLTPQSHPMHL
HGMGFKVLSSSTRPVQPLISDTYLIQPNEKVQLGFVADNPGDWLLHCHIIEHQKSGMTSYVRVV

Sequences:

>Translated_464_residues
MTGWTRRGLLKTAAVAGATGVGLSAIGRLGGLAATSPEPMVLQTAKIQARLMDIGPTNNVLTYGNAGMPPVLRMKKGEPF
AARLVNAIDDPTTIHWHGIRLPNKMDGVPFLVQPYVNTGDHFDYAFTPPDAGTFWYHPHCNTLEQMGHGLTGVIVVENPN
DPKFDAEFVLNLRDWRLGDDGQFIDQFRPRDAAKTGTYGTVRTANWLDQPQYDAPAGGLVRLRVAITDVTRIYAFRVDGA
EAIVMALDGNPVPERFSPDALLLGPGQRMELAIRMPDREGAVVSLRDVRGTKPKILATVRATGSSLKRDVRDVAPLEVNP
VAEVDLSAAQHISLALSATAENVPSDGICGSLGYSFWAINKVPWPGDTSDPTAPLAELKLGKSYVIDMENLTPQSHPMHL
HGMGFKVLSSSTRPVQPLISDTYLIQPNEKVQLGFVADNPGDWLLHCHIIEHQKSGMTSYVRVV
>Mature_463_residues
TGWTRRGLLKTAAVAGATGVGLSAIGRLGGLAATSPEPMVLQTAKIQARLMDIGPTNNVLTYGNAGMPPVLRMKKGEPFA
ARLVNAIDDPTTIHWHGIRLPNKMDGVPFLVQPYVNTGDHFDYAFTPPDAGTFWYHPHCNTLEQMGHGLTGVIVVENPND
PKFDAEFVLNLRDWRLGDDGQFIDQFRPRDAAKTGTYGTVRTANWLDQPQYDAPAGGLVRLRVAITDVTRIYAFRVDGAE
AIVMALDGNPVPERFSPDALLLGPGQRMELAIRMPDREGAVVSLRDVRGTKPKILATVRATGSSLKRDVRDVAPLEVNPV
AEVDLSAAQHISLALSATAENVPSDGICGSLGYSFWAINKVPWPGDTSDPTAPLAELKLGKSYVIDMENLTPQSHPMHLH
GMGFKVLSSSTRPVQPLISDTYLIQPNEKVQLGFVADNPGDWLLHCHIIEHQKSGMTSYVRVV

Specific function: May be involved in copper homeostasis and oxidative stress response [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family [H]

Homologues:

Organism=Escherichia coli, GI1786314, Length=523, Percent_Identity=25.6214149139579, Blast_Score=95, Evalue=9e-21,
Organism=Saccharomyces cerevisiae, GI6320714, Length=511, Percent_Identity=21.3307240704501, Blast_Score=91, Evalue=5e-19,
Organism=Drosophila melanogaster, GI18859919, Length=195, Percent_Identity=30.7692307692308, Blast_Score=76, Evalue=4e-14,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001117
- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR002355
- InterPro:   IPR008972 [H]

Pfam domain/function: PF00394 Cu-oxidase; PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 50444; Mature: 50313

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: PS00079 MULTICOPPER_OXIDASE1 ; PS00080 MULTICOPPER_OXIDASE2 ; PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGWTRRGLLKTAAVAGATGVGLSAIGRLGGLAATSPEPMVLQTAKIQARLMDIGPTNNV
CCCCCCCCHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCCEEEEEEEEEEEEEECCCCCCE
LTYGNAGMPPVLRMKKGEPFAARLVNAIDDPTTIHWHGIRLPNKMDGVPFLVQPYVNTGD
EEECCCCCCCEEEECCCCCHHHHHHHHCCCCCEEEEEEEECCCCCCCCCEEEECCCCCCC
HFDYAFTPPDAGTFWYHPHCNTLEQMGHGLTGVIVVENPNDPKFDAEFVLNLRDWRLGDD
CCCEEECCCCCCEEEECCCCCHHHHHCCCCEEEEEEECCCCCCCCEEEEEEEECCEECCC
GQFIDQFRPRDAAKTGTYGTVRTANWLDQPQYDAPAGGLVRLRVAITDVTRIYAFRVDGA
CHHHHHCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCEEEEEEEEEEEEEEEEEEECCC
EAIVMALDGNPVPERFSPDALLLGPGQRMELAIRMPDREGAVVSLRDVRGTKPKILATVR
EEEEEEECCCCCCCCCCCCEEEECCCCCEEEEEECCCCCCCEEEEECCCCCCCEEEEEEE
ATGSSLKRDVRDVAPLEVNPVAEVDLSAAQHISLALSATAENVPSDGICGSLGYSFWAIN
CCCHHHHHHHHHCCCCCCCCCHHCCCCCHHEEEEEEEEHHCCCCCCCCCCCCCCEEEEEC
KVPWPGDTSDPTAPLAELKLGKSYVIDMENLTPQSHPMHLHGMGFKVLSSSTRPVQPLIS
CCCCCCCCCCCCCCHHHHCCCCEEEEEHHHCCCCCCCEEEECCCEEEECCCCCCCCHHHC
DTYLIQPNEKVQLGFVADNPGDWLLHCHIIEHQKSGMTSYVRVV
CEEEECCCCEEEEEEEECCCCCEEEEEEEEECCCCCCCEEEEEC
>Mature Secondary Structure 
TGWTRRGLLKTAAVAGATGVGLSAIGRLGGLAATSPEPMVLQTAKIQARLMDIGPTNNV
CCCCCCCHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCCEEEEEEEEEEEEEECCCCCCE
LTYGNAGMPPVLRMKKGEPFAARLVNAIDDPTTIHWHGIRLPNKMDGVPFLVQPYVNTGD
EEECCCCCCCEEEECCCCCHHHHHHHHCCCCCEEEEEEEECCCCCCCCCEEEECCCCCCC
HFDYAFTPPDAGTFWYHPHCNTLEQMGHGLTGVIVVENPNDPKFDAEFVLNLRDWRLGDD
CCCEEECCCCCCEEEECCCCCHHHHHCCCCEEEEEEECCCCCCCCEEEEEEEECCEECCC
GQFIDQFRPRDAAKTGTYGTVRTANWLDQPQYDAPAGGLVRLRVAITDVTRIYAFRVDGA
CHHHHHCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCEEEEEEEEEEEEEEEEEEECCC
EAIVMALDGNPVPERFSPDALLLGPGQRMELAIRMPDREGAVVSLRDVRGTKPKILATVR
EEEEEEECCCCCCCCCCCCEEEECCCCCEEEEEECCCCCCCEEEEECCCCCCCEEEEEEE
ATGSSLKRDVRDVAPLEVNPVAEVDLSAAQHISLALSATAENVPSDGICGSLGYSFWAIN
CCCHHHHHHHHHCCCCCCCCCHHCCCCCHHEEEEEEEEHHCCCCCCCCCCCCCCEEEEEC
KVPWPGDTSDPTAPLAELKLGKSYVIDMENLTPQSHPMHLHGMGFKVLSSSTRPVQPLIS
CCCCCCCCCCCCCCHHHHCCCCEEEEEHHHCCCCCCCEEEECCCEEEECCCCCCCCHHHC
DTYLIQPNEKVQLGFVADNPGDWLLHCHIIEHQKSGMTSYVRVV
CEEEECCCCEEEEEEEECCCCCEEEEEEEEECCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12950922 [H]