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The map label for this gene is cah [H]

Identifier: 13475340

GI number: 13475340

Start: 5206818

End: 5207570

Strand: Reverse

Name: cah [H]

Synonym: mll6384

Alternate gene names: 13475340

Gene position: 5207570-5206818 (Counterclockwise)

Preceding gene: 13475344

Following gene: 13475339

Centisome position: 74.01

GC content: 59.89

Gene sequence:

>753_bases
ATGCATCGTCGTAACCTGATTAGAGCATTCATCGCGCTGGGCGTGTGCCCGATCTGCGCCCAGACCGCGCGTGCGGCCAG
CGCCCATTGGGGATATGGCGGCTCGGTCGGGCCGGAGCATTGGGCCGATCTGGACACGAGAAATTTCGCCTGTTCGGCGG
GCAGGCAGCAGTCACCCATCGACATCGCCGGCACAGTAAAGGCGGATATACCGCGCATCGACATCAGTTGGCTCAAGGGC
GGCGGCAGGATGGTGAACAACGGCCACACCATTCAAATCAACATGCCGGAAGGCAGCACCTTGACCCGCGGGGATCGCGT
CTACCAACTGGCACAGTTGCATTTCCACGCGCCGAGCGAGCATCACGTGGCGGGCATGAGCTTCCCGATGGAAGCGCATT
TTGTCCATAAAGACACAAAGAGCGATACTCTGGGTGTGCTGAGCGCCCTTCTTATGCCTGGCGCGACAAATAACAGCTTT
GCCGGTCTCGCCAAGGTCTTTCCGGCCCGGCCCGGCGAGGAGATGGCAGTTGACGAGTTCGATCCCAACGGGCTTTTGCC
GGCCTCGCTCGGCTATTGGACCTATGAGGGATCATTAACGACTCCGCCCTGCACCGAAAACGTGGAGTGGATGGTTGCAA
TGGAACCGGTCGAGGTCGACACCGCAGACATCAAGCGGTTTACGACGCTTTACGCATCTAACGCGCGGTCGATCCGTCCC
TCCAATCGGCGCTTCATCCTAGGCCTCAGCTAA

Upstream 100 bases:

>100_bases
GCTGGTGGCGCGGCTCAACCTACGCCCGCCCTTGCGGCTGTGCCTTGACTGCACCAATTGGAAGCAAGGACATAAGGTTC
GCATCAAGGAGCGAGGCAAT

Downstream 100 bases:

>100_bases
GGTCATCGCGCGCGTCAAGCAAAACCGCGGTAACAATCGGGGGGTTTCGAACAGTACGACGGCACCCTGGTGGCGCTGGC
ATCGACCATAATGCCCTAGA

Product: a-type carbonic anhydrase

Products: NA

Alternate protein names: Carbonate dehydratase [H]

Number of amino acids: Translated: 250; Mature: 250

Protein sequence:

>250_residues
MHRRNLIRAFIALGVCPICAQTARAASAHWGYGGSVGPEHWADLDTRNFACSAGRQQSPIDIAGTVKADIPRIDISWLKG
GGRMVNNGHTIQINMPEGSTLTRGDRVYQLAQLHFHAPSEHHVAGMSFPMEAHFVHKDTKSDTLGVLSALLMPGATNNSF
AGLAKVFPARPGEEMAVDEFDPNGLLPASLGYWTYEGSLTTPPCTENVEWMVAMEPVEVDTADIKRFTTLYASNARSIRP
SNRRFILGLS

Sequences:

>Translated_250_residues
MHRRNLIRAFIALGVCPICAQTARAASAHWGYGGSVGPEHWADLDTRNFACSAGRQQSPIDIAGTVKADIPRIDISWLKG
GGRMVNNGHTIQINMPEGSTLTRGDRVYQLAQLHFHAPSEHHVAGMSFPMEAHFVHKDTKSDTLGVLSALLMPGATNNSF
AGLAKVFPARPGEEMAVDEFDPNGLLPASLGYWTYEGSLTTPPCTENVEWMVAMEPVEVDTADIKRFTTLYASNARSIRP
SNRRFILGLS
>Mature_250_residues
MHRRNLIRAFIALGVCPICAQTARAASAHWGYGGSVGPEHWADLDTRNFACSAGRQQSPIDIAGTVKADIPRIDISWLKG
GGRMVNNGHTIQINMPEGSTLTRGDRVYQLAQLHFHAPSEHHVAGMSFPMEAHFVHKDTKSDTLGVLSALLMPGATNNSF
AGLAKVFPARPGEEMAVDEFDPNGLLPASLGYWTYEGSLTTPPCTENVEWMVAMEPVEVDTADIKRFTTLYASNARSIRP
SNRRFILGLS

Specific function: Reversible hydration of carbon dioxide [H]

COG id: COG3338

COG function: function code P; Carbonic anhydrase

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the alpha-carbonic anhydrase family [H]

Homologues:

Organism=Homo sapiens, GI4557395, Length=231, Percent_Identity=35.4978354978355, Blast_Score=125, Evalue=3e-29,
Organism=Homo sapiens, GI4885101, Length=229, Percent_Identity=34.9344978165939, Blast_Score=112, Evalue=3e-25,
Organism=Homo sapiens, GI258679498, Length=250, Percent_Identity=31.2, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI192447434, Length=250, Percent_Identity=31.2, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI192447432, Length=250, Percent_Identity=31.2, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI192447430, Length=250, Percent_Identity=31.2, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI4502517, Length=250, Percent_Identity=31.2, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI4885099, Length=260, Percent_Identity=29.2307692307692, Blast_Score=105, Evalue=4e-23,
Organism=Homo sapiens, GI38348436, Length=229, Percent_Identity=31.0043668122271, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI70167127, Length=249, Percent_Identity=32.1285140562249, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI169636420, Length=258, Percent_Identity=33.7209302325581, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI4502521, Length=208, Percent_Identity=32.6923076923077, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI6912284, Length=260, Percent_Identity=29.6153846153846, Blast_Score=93, Evalue=2e-19,
Organism=Homo sapiens, GI62240989, Length=171, Percent_Identity=36.2573099415205, Blast_Score=92, Evalue=3e-19,
Organism=Homo sapiens, GI4502515, Length=285, Percent_Identity=30.5263157894737, Blast_Score=92, Evalue=4e-19,
Organism=Homo sapiens, GI45935383, Length=285, Percent_Identity=30.5263157894737, Blast_Score=92, Evalue=4e-19,
Organism=Homo sapiens, GI6005723, Length=205, Percent_Identity=30.7317073170732, Blast_Score=92, Evalue=5e-19,
Organism=Homo sapiens, GI194097398, Length=241, Percent_Identity=29.045643153527, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI22027500, Length=213, Percent_Identity=27.2300469483568, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI4502519, Length=248, Percent_Identity=27.8225806451613, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI91208428, Length=232, Percent_Identity=26.2931034482759, Blast_Score=72, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17568715, Length=239, Percent_Identity=30.5439330543933, Blast_Score=94, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI71995280, Length=266, Percent_Identity=26.6917293233083, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17569163, Length=228, Percent_Identity=28.9473684210526, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17569165, Length=225, Percent_Identity=28.8888888888889, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI17737413, Length=250, Percent_Identity=33.2, Blast_Score=110, Evalue=6e-25,
Organism=Drosophila melanogaster, GI24645604, Length=278, Percent_Identity=25.8992805755396, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI21358169, Length=276, Percent_Identity=26.0869565217391, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI161079350, Length=267, Percent_Identity=27.7153558052434, Blast_Score=87, Evalue=8e-18,
Organism=Drosophila melanogaster, GI18858185, Length=241, Percent_Identity=25.7261410788382, Blast_Score=68, Evalue=7e-12,
Organism=Drosophila melanogaster, GI221329761, Length=234, Percent_Identity=25.2136752136752, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001148
- InterPro:   IPR018338
- InterPro:   IPR018340 [H]

Pfam domain/function: PF00194 Carb_anhydrase [H]

EC number: =4.2.1.1 [H]

Molecular weight: Translated: 27259; Mature: 27259

Theoretical pI: Translated: 7.06; Mature: 7.06

Prosite motif: PS00162 ALPHA_CA_1 ; PS51144 ALPHA_CA_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHRRNLIRAFIALGVCPICAQTARAASAHWGYGGSVGPEHWADLDTRNFACSAGRQQSPI
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCCCCCEEECCCCCCCCC
DIAGTVKADIPRIDISWLKGGGRMVNNGHTIQINMPEGSTLTRGDRVYQLAQLHFHAPSE
EEEEEEECCCCEEEEEEECCCCEEECCCEEEEEECCCCCCCCCCHHHHEEEHHEECCCCC
HHVAGMSFPMEAHFVHKDTKSDTLGVLSALLMPGATNNSFAGLAKVFPARPGEEMAVDEF
CCEECCCCCCEEEEEECCCCCHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCCCCCCCCC
DPNGLLPASLGYWTYEGSLTTPPCTENVEWMVAMEPVEVDTADIKRFTTLYASNARSIRP
CCCCCCCCCCCEEEECCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCC
SNRRFILGLS
CCCEEEEEEC
>Mature Secondary Structure
MHRRNLIRAFIALGVCPICAQTARAASAHWGYGGSVGPEHWADLDTRNFACSAGRQQSPI
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCCCCCEEECCCCCCCCC
DIAGTVKADIPRIDISWLKGGGRMVNNGHTIQINMPEGSTLTRGDRVYQLAQLHFHAPSE
EEEEEEECCCCEEEEEEECCCCEEECCCEEEEEECCCCCCCCCCHHHHEEEHHEECCCCC
HHVAGMSFPMEAHFVHKDTKSDTLGVLSALLMPGATNNSFAGLAKVFPARPGEEMAVDEF
CCEECCCCCCEEEEEECCCCCHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCCCCCCCCC
DPNGLLPASLGYWTYEGSLTTPPCTENVEWMVAMEPVEVDTADIKRFTTLYASNARSIRP
CCCCCCCCCCCEEEECCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCC
SNRRFILGLS
CCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9108244; 7721686; 9761692 [H]