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The map label for this gene is hdc

Identifier: 13475187

GI number: 13475187

Start: 5027871

End: 5028980

Strand: Direct

Name: hdc

Synonym: mlr6209

Alternate gene names: 13475187

Gene position: 5027871-5028980 (Clockwise)

Preceding gene: 13475183

Following gene: 13475188

Centisome position: 71.46

GC content: 51.53

Gene sequence:

>1110_bases
ATGCTGGAACCCCAAGATCAAAAAAAACTGGATGAACTATTCTCATCCATGCAGGAGGCAAATGGCTGCTTTCTAGGCTA
TCCGTTTGCGAAGGACTTCGATTATGAACCGTTGTGGCGGTTCATGAGCCTCACAGGCAACAACCTCGGAGATCCATTCG
AACCAGGGACCTATCGCGTAAACTCGCATGCTTTCGAATGCGACGTCGTCGATTTCTTTGCCAGGCTGTTTCGGGCATGT
TCTTGCGAAGTCTGGGGCTACGTGACAAATGGAGGGACCGAGGGGAACATCTACGGGTTGTACCTTGCCCGCGAGCTCTA
TCCAAATGCTGTCGCGTATTTTTCGCAGGACACTCACTATAGTGTGAGCAAAGGGGTTCGGCTGCTCCGGTTGGAACACT
CTGTGGTGCGTTCGCAATCCAATGGAGAAATAAACTATGACGATCTAGCCCAGAAGGCTACTCGTTACAGAACTCGCCCA
GCGGTGGTTGTTGCAAATATAGGCACTACAATGAAGGAAGGCAAAGATGATACGTTAAAAATTCGTGCGGTCCTTCACGA
TGTCGGTATCAGCGCGATCTATGTCCATTCCGACGCGGCACTATGCGGGCCATACGCGCCCCTCTTAAATCCCAAACCCG
CCTTCGATTTTGCGGATGGAGCGGACTCCATCACGCTAAGTGGACACAAGTTTCTCGGCGCGCCGATGCCTTGCGGGGTC
GTTCTCTCGCACAAACTTCACGTTCAACGTGTGATGCGCAATATCGATTACATCGGCAGCTCAGATACGACGTTGAGTGG
ATCGCGAAATGCCTTTACGCCGATCATCCTCTGGTATGCGATCCGTAGTCTGGGGATCGAAGGTATCAAACAGACTTTCC
AACAATGCGAGCGATTGGCGGCCTACACAGCCGATGAACTTAACGTTCGCGGCGTCAGCGCTTGGCGTAATCCCAATGCG
CTTACAGTTGTACTCCCTCCTGTCGAAGACAGCATCAAGACAAAGTGGCAAATTGCGACTCAGGACGTTAGCCATTTGGT
GGTCACGCCAGGCACGACCAAGCAACAGGCCGATGCGCTAATCGAAACTATCTCAAATAGAAACAGATAA

Upstream 100 bases:

>100_bases
CGGTGATAGTGCGCTCAAGGCAGGAGCTTTGTCCGCACGTGAACAAGAACCCGACTAGTTCGCAGGGTCTGTTAACTCCG
GGCCCCGGAGGGCGCTCATC

Downstream 100 bases:

>100_bases
ATTCGGAGGGGCAGCGGGCAACTGGGTCTTGGCACTAGTCAGGGCGTGAGTGCGATTGTTCGGTACCTTGCGGTTCAACA
GTTCAGGTGCGACCTCTTGC

Product: histidine decarboxylase

Products: NA

Alternate protein names: HDC

Number of amino acids: Translated: 369; Mature: 369

Protein sequence:

>369_residues
MLEPQDQKKLDELFSSMQEANGCFLGYPFAKDFDYEPLWRFMSLTGNNLGDPFEPGTYRVNSHAFECDVVDFFARLFRAC
SCEVWGYVTNGGTEGNIYGLYLARELYPNAVAYFSQDTHYSVSKGVRLLRLEHSVVRSQSNGEINYDDLAQKATRYRTRP
AVVVANIGTTMKEGKDDTLKIRAVLHDVGISAIYVHSDAALCGPYAPLLNPKPAFDFADGADSITLSGHKFLGAPMPCGV
VLSHKLHVQRVMRNIDYIGSSDTTLSGSRNAFTPIILWYAIRSLGIEGIKQTFQQCERLAAYTADELNVRGVSAWRNPNA
LTVVLPPVEDSIKTKWQIATQDVSHLVVTPGTTKQQADALIETISNRNR

Sequences:

>Translated_369_residues
MLEPQDQKKLDELFSSMQEANGCFLGYPFAKDFDYEPLWRFMSLTGNNLGDPFEPGTYRVNSHAFECDVVDFFARLFRAC
SCEVWGYVTNGGTEGNIYGLYLARELYPNAVAYFSQDTHYSVSKGVRLLRLEHSVVRSQSNGEINYDDLAQKATRYRTRP
AVVVANIGTTMKEGKDDTLKIRAVLHDVGISAIYVHSDAALCGPYAPLLNPKPAFDFADGADSITLSGHKFLGAPMPCGV
VLSHKLHVQRVMRNIDYIGSSDTTLSGSRNAFTPIILWYAIRSLGIEGIKQTFQQCERLAAYTADELNVRGVSAWRNPNA
LTVVLPPVEDSIKTKWQIATQDVSHLVVTPGTTKQQADALIETISNRNR
>Mature_369_residues
MLEPQDQKKLDELFSSMQEANGCFLGYPFAKDFDYEPLWRFMSLTGNNLGDPFEPGTYRVNSHAFECDVVDFFARLFRAC
SCEVWGYVTNGGTEGNIYGLYLARELYPNAVAYFSQDTHYSVSKGVRLLRLEHSVVRSQSNGEINYDDLAQKATRYRTRP
AVVVANIGTTMKEGKDDTLKIRAVLHDVGISAIYVHSDAALCGPYAPLLNPKPAFDFADGADSITLSGHKFLGAPMPCGV
VLSHKLHVQRVMRNIDYIGSSDTTLSGSRNAFTPIILWYAIRSLGIEGIKQTFQQCERLAAYTADELNVRGVSAWRNPNA
LTVVLPPVEDSIKTKWQIATQDVSHLVVTPGTTKQQADALIETISNRNR

Specific function: Catalyzes The Production Of Gaba. [C]

COG id: COG0076

COG function: function code E; Glutamate decarboxylase and related PLP-dependent proteins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the group II decarboxylase family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DCHS_RHILO (Q98A07)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_106751.1
- ProteinModelPortal:   Q98A07
- SMR:   Q98A07
- GeneID:   1229406
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mlr6209
- NMPDR:   fig|266835.1.peg.4852
- HOGENOM:   HBG320100
- OMA:   EFVRRWQ
- ProtClustDB:   PRK02769
- BRENDA:   4.1.1.22
- HAMAP:   MF_00609
- InterPro:   IPR002129
- InterPro:   IPR015424
- InterPro:   IPR015421
- Gene3D:   G3DSA:3.40.640.10
- PANTHER:   PTHR11999

Pfam domain/function: PF00282 Pyridoxal_deC; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =4.1.1.22

Molecular weight: Translated: 41035; Mature: 41035

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: PS00392 DDC_GAD_HDC_YDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEPQDQKKLDELFSSMQEANGCFLGYPFAKDFDYEPLWRFMSLTGNNLGDPFEPGTYRV
CCCCCHHHHHHHHHHHHHHCCCCEEECCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCEEE
NSHAFECDVVDFFARLFRACSCEVWGYVTNGGTEGNIYGLYLARELYPNAVAYFSQDTHY
CCCEEEECHHHHHHHHHHHHCCEEEEEEECCCCCCCEEEEEEEHHHCCCHHEEECCCCCE
SVSKGVRLLRLEHSVVRSQSNGEINYDDLAQKATRYRTRPAVVVANIGTTMKEGKDDTLK
EHHHCEEEEEHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCHHHCCCCCCEE
IRAVLHDVGISAIYVHSDAALCGPYAPLLNPKPAFDFADGADSITLSGHKFLGAPMPCGV
HHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCEEECCCCCCCH
VLSHKLHVQRVMRNIDYIGSSDTTLSGSRNAFTPIILWYAIRSLGIEGIKQTFQQCERLA
HHHHHHHHHHHHHHHHCCCCCCCEECCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHH
AYTADELNVRGVSAWRNPNALTVVLPPVEDSIKTKWQIATQDVSHLVVTPGTTKQQADAL
HHCCCCCCCEEEECCCCCCEEEEEECCCCCCCCCEEEEEECCCCEEEECCCCCHHHHHHH
IETISNRNR
HHHHHCCCC
>Mature Secondary Structure
MLEPQDQKKLDELFSSMQEANGCFLGYPFAKDFDYEPLWRFMSLTGNNLGDPFEPGTYRV
CCCCCHHHHHHHHHHHHHHCCCCEEECCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCEEE
NSHAFECDVVDFFARLFRACSCEVWGYVTNGGTEGNIYGLYLARELYPNAVAYFSQDTHY
CCCEEEECHHHHHHHHHHHHCCEEEEEEECCCCCCCEEEEEEEHHHCCCHHEEECCCCCE
SVSKGVRLLRLEHSVVRSQSNGEINYDDLAQKATRYRTRPAVVVANIGTTMKEGKDDTLK
EHHHCEEEEEHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCHHHCCCCCCEE
IRAVLHDVGISAIYVHSDAALCGPYAPLLNPKPAFDFADGADSITLSGHKFLGAPMPCGV
HHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCEEECCCCCCCH
VLSHKLHVQRVMRNIDYIGSSDTTLSGSRNAFTPIILWYAIRSLGIEGIKQTFQQCERLA
HHHHHHHHHHHHHHHHCCCCCCCEECCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHH
AYTADELNVRGVSAWRNPNALTVVLPPVEDSIKTKWQIATQDVSHLVVTPGTTKQQADAL
HHCCCCCCCEEEECCCCCCEEEEEECCCCCCCCCEEEEEECCCCEEEECCCCCHHHHHHH
IETISNRNR
HHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11214968