Click here to switch to the map view.

The map label for this gene is bioF [H]

Identifier: 13475018

GI number: 13475018

Start: 4855456

End: 4856703

Strand: Reverse

Name: bioF [H]

Synonym: mll6006

Alternate gene names: 13475018

Gene position: 4856703-4855456 (Counterclockwise)

Preceding gene: 13475019

Following gene: 13475017

Centisome position: 69.03

GC content: 67.79

Gene sequence:

>1248_bases
GTGTTTCTTTGCCGGCGCCAATTCGATCTTCGTCGGCGACACGCTGCTGACGGCGGACAATCCCGGCGAGGACAAGGACA
TTCTGCTGTTTCGGCGCCTCGGCATGGAGCCAATGGGCGCAATGAACGGGGCGCTTCTTGCCCGGTATGGCCGGTCCTTG
CGCGGACTGGCGCGCAAGGACCGGCTGCGGACGCTGGCACCGCGCGCCGGGCTCGACTTCTCGTCGAACGACTATCTCGG
ACTTGCCTCCTGCAAAAGACTTGGCGAGGCGGTTGCGGCGGCGATTGCGCGGGGCACGCCGGTGGGCGCCACCGGATCGG
CAACGCGCCGGAACACGAGGCGCTGGAGTCGGACGCTGCGGCGTTTTTCGGAGCCGATCGCGCCCTGTTCTTCGGCAGCG
GCTACATCGCCAACTTCGCTCTGCTGACGGCCCTGCCGCAGAAGGGCGACCTGCTGGTGCTCGACCAGCTCGCCCATGCC
AGCATGCATGAGGGCGCGCAAGCCGGACGCGCCGAGTTCAAGCTCGCCGCGCATAACGACGTCGATGCTGTCGAGGATGC
GATCACGCGCTGGCGCGCCGAAGGCGGCATGGGGCGCGTCTGGATCGCGGTCGAAAGCCTCTACAGCATGGATGGCGACT
ACGCGCCGCTGGAGAGCCTGGTCGCGCTTGCCGATCGGCACGAGGCATTCCTTGTCGTCGGCGAGGCACATGCCACCGGC
GTCTGGGGACCGGATGGCCGCGGCCTTGCCACCGCGTTCGAGGGCAGCGACAACATCGTCGCGCTGCATACATGCGGCAA
GGCGCTCGGCGCGTCCGGCGCGCTCGTCACCGGGCCGGGAACGCTATGCGACTTTCTCGTCAACCGGTGCCGGCCGTTCA
TCTACGCCACCGCACCATCGCCGCTAATGGCGGTCGCGGCGCGCGAAGCGCTCACCATGCTGTCCGACGAGCCCACGCGT
CGCGTTCAGCTGCGTGAGCGTATCGCTTTCGCGGGCCGGCAATTGGCCGAGCGCTGCGGCGTGGTGCCCAGTTGCTCGCA
GATCCAGTCCTTTGTCATCGGCGACAACAGGCGCACCATGGCGGTGGCGGCGGCGCTCCAGGCGCGCGGCTTCGACATAC
GCGGCATTCGTCCGCCGACCGTACCCGAGGGCACATCGCGACTGCGCATTTCGCTGACGCTCAACGTCGACGAAGCCGAC
ATTTCGGCCATGCTCGAGGCGCTCGTCGAGGTGCTGGCCTCGACATGA

Upstream 100 bases:

>100_bases
AATTCGTGCGCGTGATCGCCCTGGCGCGCATCATGATGCCGAAATCGCATGTGCGTCTTTCCGCCGGCCGCACCGCCATG
ACCGACGAGATGCAGGCACT

Downstream 100 bases:

>100_bases
CCAAGCGCATCGTCATCACCGGAACAGATACCGGAATCGGCAAGACGGTGTTTTCGGCGGGATTGGCCGGCTTCCTCAAC
GGCTTCTACTGGAAGCCGGT

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 415; Mature: 415

Protein sequence:

>415_residues
MFLCRRQFDLRRRHAADGGQSRRGQGHSAVSAPRHGANGRNERGASCPVWPVLARTGAQGPAADAGTARRARLLVERLSR
TCLLQKTWRGGCGGDCAGHAGGRHRIGNAPEHEALESDAAAFFGADRALFFGSGYIANFALLTALPQKGDLLVLDQLAHA
SMHEGAQAGRAEFKLAAHNDVDAVEDAITRWRAEGGMGRVWIAVESLYSMDGDYAPLESLVALADRHEAFLVVGEAHATG
VWGPDGRGLATAFEGSDNIVALHTCGKALGASGALVTGPGTLCDFLVNRCRPFIYATAPSPLMAVAAREALTMLSDEPTR
RVQLRERIAFAGRQLAERCGVVPSCSQIQSFVIGDNRRTMAVAAALQARGFDIRGIRPPTVPEGTSRLRISLTLNVDEAD
ISAMLEALVEVLAST

Sequences:

>Translated_415_residues
MFLCRRQFDLRRRHAADGGQSRRGQGHSAVSAPRHGANGRNERGASCPVWPVLARTGAQGPAADAGTARRARLLVERLSR
TCLLQKTWRGGCGGDCAGHAGGRHRIGNAPEHEALESDAAAFFGADRALFFGSGYIANFALLTALPQKGDLLVLDQLAHA
SMHEGAQAGRAEFKLAAHNDVDAVEDAITRWRAEGGMGRVWIAVESLYSMDGDYAPLESLVALADRHEAFLVVGEAHATG
VWGPDGRGLATAFEGSDNIVALHTCGKALGASGALVTGPGTLCDFLVNRCRPFIYATAPSPLMAVAAREALTMLSDEPTR
RVQLRERIAFAGRQLAERCGVVPSCSQIQSFVIGDNRRTMAVAAALQARGFDIRGIRPPTVPEGTSRLRISLTLNVDEAD
ISAMLEALVEVLAST
>Mature_415_residues
MFLCRRQFDLRRRHAADGGQSRRGQGHSAVSAPRHGANGRNERGASCPVWPVLARTGAQGPAADAGTARRARLLVERLSR
TCLLQKTWRGGCGGDCAGHAGGRHRIGNAPEHEALESDAAAFFGADRALFFGSGYIANFALLTALPQKGDLLVLDQLAHA
SMHEGAQAGRAEFKLAAHNDVDAVEDAITRWRAEGGMGRVWIAVESLYSMDGDYAPLESLVALADRHEAFLVVGEAHATG
VWGPDGRGLATAFEGSDNIVALHTCGKALGASGALVTGPGTLCDFLVNRCRPFIYATAPSPLMAVAAREALTMLSDEPTR
RVQLRERIAFAGRQLAERCGVVPSCSQIQSFVIGDNRRTMAVAAALQARGFDIRGIRPPTVPEGTSRLRISLTLNVDEAD
ISAMLEALVEVLAST

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A, and carbon dioxide [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=319, Percent_Identity=31.974921630094, Blast_Score=139, Evalue=4e-33,
Organism=Homo sapiens, GI284448556, Length=319, Percent_Identity=31.974921630094, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI4758668, Length=213, Percent_Identity=35.6807511737089, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI119220554, Length=285, Percent_Identity=30.8771929824561, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI4502025, Length=322, Percent_Identity=29.1925465838509, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI40316939, Length=322, Percent_Identity=29.1925465838509, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI83977444, Length=327, Percent_Identity=29.0519877675841, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI83977440, Length=327, Percent_Identity=29.0519877675841, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI83977442, Length=327, Percent_Identity=29.0519877675841, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI5454084, Length=164, Percent_Identity=28.6585365853659, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1786993, Length=305, Percent_Identity=38.0327868852459, Blast_Score=176, Evalue=3e-45,
Organism=Escherichia coli, GI1790046, Length=327, Percent_Identity=29.9694189602446, Blast_Score=125, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI71994529, Length=323, Percent_Identity=28.4829721362229, Blast_Score=134, Evalue=6e-32,
Organism=Caenorhabditis elegans, GI32566772, Length=334, Percent_Identity=26.3473053892216, Blast_Score=109, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17560914, Length=219, Percent_Identity=26.9406392694064, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17560912, Length=219, Percent_Identity=26.9406392694064, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71982625, Length=253, Percent_Identity=26.0869565217391, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71982617, Length=253, Percent_Identity=26.0869565217391, Blast_Score=89, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6320438, Length=336, Percent_Identity=28.8690476190476, Blast_Score=108, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6320267, Length=328, Percent_Identity=27.4390243902439, Blast_Score=104, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6323954, Length=208, Percent_Identity=28.3653846153846, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24662918, Length=329, Percent_Identity=31.306990881459, Blast_Score=142, Evalue=4e-34,
Organism=Drosophila melanogaster, GI17137420, Length=308, Percent_Identity=30.5194805194805, Blast_Score=113, Evalue=3e-25,
Organism=Drosophila melanogaster, GI17136286, Length=331, Percent_Identity=25.6797583081571, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24653280, Length=263, Percent_Identity=25.4752851711027, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24653276, Length=263, Percent_Identity=25.4752851711027, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24653278, Length=263, Percent_Identity=25.4752851711027, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.47 [H]

Molecular weight: Translated: 44109; Mature: 44109

Theoretical pI: Translated: 7.95; Mature: 7.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFLCRRQFDLRRRHAADGGQSRRGQGHSAVSAPRHGANGRNERGASCPVWPVLARTGAQG
CCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCC
PAADAGTARRARLLVERLSRTCLLQKTWRGGCGGDCAGHAGGRHRIGNAPEHEALESDAA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
AFFGADRALFFGSGYIANFALLTALPQKGDLLVLDQLAHASMHEGAQAGRAEFKLAAHND
HHHCCCCEEEECCCHHHHHHHHHHCCCCCCEEEEHHHHHHHHHCCHHCCCCEEEEECCCC
VDAVEDAITRWRAEGGMGRVWIAVESLYSMDGDYAPLESLVALADRHEAFLVVGEAHATG
HHHHHHHHHHHHHCCCCCEEEEEEHHHHHCCCCCHHHHHHHHHHCCCCEEEEEECCCCCC
VWGPDGRGLATAFEGSDNIVALHTCGKALGASGALVTGPGTLCDFLVNRCRPFIYATAPS
CCCCCCCCEEEEECCCCCEEEEEECCHHHCCCCCEEECCHHHHHHHHHCCCCEEEECCCC
PLMAVAAREALTMLSDEPTRRVQLRERIAFAGRQLAERCGVVPSCSQIQSFVIGDNRRTM
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHH
AVAAALQARGFDIRGIRPPTVPEGTSRLRISLTLNVDEADISAMLEALVEVLAST
HHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEEEECCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MFLCRRQFDLRRRHAADGGQSRRGQGHSAVSAPRHGANGRNERGASCPVWPVLARTGAQG
CCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCC
PAADAGTARRARLLVERLSRTCLLQKTWRGGCGGDCAGHAGGRHRIGNAPEHEALESDAA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
AFFGADRALFFGSGYIANFALLTALPQKGDLLVLDQLAHASMHEGAQAGRAEFKLAAHND
HHHCCCCEEEECCCHHHHHHHHHHCCCCCCEEEEHHHHHHHHHCCHHCCCCEEEEECCCC
VDAVEDAITRWRAEGGMGRVWIAVESLYSMDGDYAPLESLVALADRHEAFLVVGEAHATG
HHHHHHHHHHHHHCCCCCEEEEEEHHHHHCCCCCHHHHHHHHHHCCCCEEEEEECCCCCC
VWGPDGRGLATAFEGSDNIVALHTCGKALGASGALVTGPGTLCDFLVNRCRPFIYATAPS
CCCCCCCCEEEEECCCCCEEEEEECCHHHCCCCCEEECCHHHHHHHHHCCCCEEEECCCC
PLMAVAAREALTMLSDEPTRRVQLRERIAFAGRQLAERCGVVPSCSQIQSFVIGDNRRTM
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHH
AVAAALQARGFDIRGIRPPTVPEGTSRLRISLTLNVDEADISAMLEALVEVLAST
HHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEEEECCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA