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The map label for this gene is bioF [C]

Identifier: 13474855

GI number: 13474855

Start: 4702711

End: 4703850

Strand: Reverse

Name: bioF [C]

Synonym: mll5830

Alternate gene names: 13474855

Gene position: 4703850-4702711 (Counterclockwise)

Preceding gene: 13474856

Following gene: 13474854

Centisome position: 66.85

GC content: 67.63

Gene sequence:

>1140_bases
ATGAACGAGGCACTTCTTGTCCGGTATGACGCGTCCTTGCGCGGACTGGCGCGCAAGGACCGGCTGCGCACACTTGCACC
GCGCGCCGGGCTCGACTTCTCGTCGAACGACTATCTCGGGCTTGCCGCCTCCAAAAGACTTGGCGAAGCGGTGGCGGCGG
CGATTGCGCGGGGGACGCCGGTCGGCGCGACCGGATCGCGGTTGTTAAGGGGCAACTCACCGGAGCACGAGGCTCTGGAG
GCAGACGCCGCGGCGTTCTTCGGCGCCGAACGCGCGCTGTTCTTCGGCAGCGGCTATATCGCCAACTTCGCTCTGCTGAC
GACGCTGCCGCAAAAGGGCGACCTCTTGATCCTCGACGACCTTGCTCATGCCAGTATGCATGAGGGGGCCCGCGCTGGCC
GCGCCGAGTTCAAGCTCGCCGCGCATAACGACATCGATGCTGTCGAGGATGCGATCACCCGCTGGCGCGCCGAAGGCGGC
ATGGGCCGCATCTGGATCGCGGTCGAAAGCCTCTACAGCATGGATGGCGACCGCGCCCCGATGGCCCGCCTTATCGCGCT
TGCCGATCGGCACGAGGCATTCCTCGTCGTCGACGAGGCGCATGCCACCGGCATCTGGGGACCGAACGGCCGCGGGCTGG
CCGCCGCTTTCGAGGGCCGCGACAACACTGTCGCACTTCACACATGCGGCAAGGCGCTCGGCGCGTCCGGCGCACTCGTC
ACCGGGCCGGGAACGCTATGCGACTATCTCGTCAACCGCTGCCGGCCATTCATCTACGCCACCGCGCCGTCGCCTCTGAT
GGCGGTGGCAGTGCGCGAAGCGCTGGCCATGCTGTCCGACGAGCCCCAACGCCGTGTCCAGCTGCAGGAGCGCGTAGCCT
TCGCGGGCCGCCAATTGGCCGAGCGCTGCGGCGTGAAGCCCAGCGGCTCGCAGATCCAGTCCTTTGTCATCGGCGACAAC
AGGCGCACCATGGCGGTGGCGGCGGCGCTGCAGACGCGCGGCTTCGACATACGCGGCATTCGTCCGCCGACCGTACCCGA
GGGCACATCGCGACTGCGCATTTCGCTGACGCTCAACGTCGACGAAGCCGACATTTCGGCCATGGTCGGGGCACTCGTCG
AGGTGCTGGCCTCGGCATGA

Upstream 100 bases:

>100_bases
TCGTCGGCGACACACTGCTGACGGCGGACAATCCCGGCGAAGACAAGGATACTCTGCTGTTCCAGCGTCTCGGCATCGAG
CCGATGGAAATCGGCACGCA

Downstream 100 bases:

>100_bases
CCAAGCGCATCGTTATCACCGGAACGGATACCGGCATCGGCAAGACGGTGTTTTCGGCCGGGCTCACCGGCCTGCTCGAC
GGCTTCTACTGGAAGCCGGT

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 379; Mature: 379

Protein sequence:

>379_residues
MNEALLVRYDASLRGLARKDRLRTLAPRAGLDFSSNDYLGLAASKRLGEAVAAAIARGTPVGATGSRLLRGNSPEHEALE
ADAAAFFGAERALFFGSGYIANFALLTTLPQKGDLLILDDLAHASMHEGARAGRAEFKLAAHNDIDAVEDAITRWRAEGG
MGRIWIAVESLYSMDGDRAPMARLIALADRHEAFLVVDEAHATGIWGPNGRGLAAAFEGRDNTVALHTCGKALGASGALV
TGPGTLCDYLVNRCRPFIYATAPSPLMAVAVREALAMLSDEPQRRVQLQERVAFAGRQLAERCGVKPSGSQIQSFVIGDN
RRTMAVAAALQTRGFDIRGIRPPTVPEGTSRLRISLTLNVDEADISAMVGALVEVLASA

Sequences:

>Translated_379_residues
MNEALLVRYDASLRGLARKDRLRTLAPRAGLDFSSNDYLGLAASKRLGEAVAAAIARGTPVGATGSRLLRGNSPEHEALE
ADAAAFFGAERALFFGSGYIANFALLTTLPQKGDLLILDDLAHASMHEGARAGRAEFKLAAHNDIDAVEDAITRWRAEGG
MGRIWIAVESLYSMDGDRAPMARLIALADRHEAFLVVDEAHATGIWGPNGRGLAAAFEGRDNTVALHTCGKALGASGALV
TGPGTLCDYLVNRCRPFIYATAPSPLMAVAVREALAMLSDEPQRRVQLQERVAFAGRQLAERCGVKPSGSQIQSFVIGDN
RRTMAVAAALQTRGFDIRGIRPPTVPEGTSRLRISLTLNVDEADISAMVGALVEVLASA
>Mature_379_residues
MNEALLVRYDASLRGLARKDRLRTLAPRAGLDFSSNDYLGLAASKRLGEAVAAAIARGTPVGATGSRLLRGNSPEHEALE
ADAAAFFGAERALFFGSGYIANFALLTTLPQKGDLLILDDLAHASMHEGARAGRAEFKLAAHNDIDAVEDAITRWRAEGG
MGRIWIAVESLYSMDGDRAPMARLIALADRHEAFLVVDEAHATGIWGPNGRGLAAAFEGRDNTVALHTCGKALGASGALV
TGPGTLCDYLVNRCRPFIYATAPSPLMAVAVREALAMLSDEPQRRVQLQERVAFAGRQLAERCGVKPSGSQIQSFVIGDN
RRTMAVAAALQTRGFDIRGIRPPTVPEGTSRLRISLTLNVDEADISAMVGALVEVLASA

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=350, Percent_Identity=33.1428571428571, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI284448556, Length=350, Percent_Identity=33.1428571428571, Blast_Score=150, Evalue=1e-36,
Organism=Homo sapiens, GI4758668, Length=243, Percent_Identity=34.9794238683128, Blast_Score=133, Evalue=2e-31,
Organism=Homo sapiens, GI119220554, Length=299, Percent_Identity=29.7658862876254, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI4502025, Length=333, Percent_Identity=30.3303303303303, Blast_Score=113, Evalue=4e-25,
Organism=Homo sapiens, GI40316939, Length=333, Percent_Identity=30.3303303303303, Blast_Score=113, Evalue=4e-25,
Organism=Homo sapiens, GI83977444, Length=335, Percent_Identity=29.5522388059701, Blast_Score=111, Evalue=9e-25,
Organism=Homo sapiens, GI83977442, Length=335, Percent_Identity=29.5522388059701, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI83977440, Length=335, Percent_Identity=29.5522388059701, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI5454084, Length=294, Percent_Identity=24.4897959183673, Blast_Score=86, Evalue=7e-17,
Organism=Escherichia coli, GI1786993, Length=353, Percent_Identity=36.5439093484419, Blast_Score=180, Evalue=1e-46,
Organism=Escherichia coli, GI1790046, Length=360, Percent_Identity=31.1111111111111, Blast_Score=144, Evalue=9e-36,
Organism=Caenorhabditis elegans, GI71994529, Length=350, Percent_Identity=29.4285714285714, Blast_Score=150, Evalue=9e-37,
Organism=Caenorhabditis elegans, GI32566772, Length=286, Percent_Identity=27.2727272727273, Blast_Score=112, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17560912, Length=275, Percent_Identity=30.1818181818182, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17560914, Length=275, Percent_Identity=30.1818181818182, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI71982625, Length=281, Percent_Identity=24.9110320284698, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI71982617, Length=281, Percent_Identity=24.9110320284698, Blast_Score=99, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6320438, Length=385, Percent_Identity=29.6103896103896, Blast_Score=124, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6320267, Length=364, Percent_Identity=27.1978021978022, Blast_Score=118, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6323954, Length=226, Percent_Identity=27.8761061946903, Blast_Score=109, Evalue=8e-25,
Organism=Drosophila melanogaster, GI24662918, Length=355, Percent_Identity=31.830985915493, Blast_Score=161, Evalue=6e-40,
Organism=Drosophila melanogaster, GI17137420, Length=384, Percent_Identity=30.9895833333333, Blast_Score=135, Evalue=6e-32,
Organism=Drosophila melanogaster, GI17136286, Length=345, Percent_Identity=28.1159420289855, Blast_Score=114, Evalue=7e-26,
Organism=Drosophila melanogaster, GI24653280, Length=270, Percent_Identity=23.7037037037037, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24653276, Length=270, Percent_Identity=23.7037037037037, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24653278, Length=270, Percent_Identity=23.7037037037037, Blast_Score=91, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 40272; Mature: 40272

Theoretical pI: Translated: 7.18; Mature: 7.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEALLVRYDASLRGLARKDRLRTLAPRAGLDFSSNDYLGLAASKRLGEAVAAAIARGTP
CCCCEEEEECCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHCCCC
VGATGSRLLRGNSPEHEALEADAAAFFGAERALFFGSGYIANFALLTTLPQKGDLLILDD
CCCCCCHHHCCCCCCHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHCCCCCCCEEEEEC
LAHASMHEGARAGRAEFKLAAHNDIDAVEDAITRWRAEGGMGRIWIAVESLYSMDGDRAP
HHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCCEEEEEEEHHHHCCCCCCH
MARLIALADRHEAFLVVDEAHATGIWGPNGRGLAAAFEGRDNTVALHTCGKALGASGALV
HHHHHHHHCCCCEEEEEECCCCCCCCCCCCCEEEEEECCCCCEEEEEECCHHHCCCCCEE
TGPGTLCDYLVNRCRPFIYATAPSPLMAVAVREALAMLSDEPQRRVQLQERVAFAGRQLA
ECCHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
ERCGVKPSGSQIQSFVIGDNRRTMAVAAALQTRGFDIRGIRPPTVPEGTSRLRISLTLNV
HHCCCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCEECCCCCCCCCCCCCEEEEEEEEEC
DEADISAMVGALVEVLASA
CHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNEALLVRYDASLRGLARKDRLRTLAPRAGLDFSSNDYLGLAASKRLGEAVAAAIARGTP
CCCCEEEEECCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHCCCC
VGATGSRLLRGNSPEHEALEADAAAFFGAERALFFGSGYIANFALLTTLPQKGDLLILDD
CCCCCCHHHCCCCCCHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHCCCCCCCEEEEEC
LAHASMHEGARAGRAEFKLAAHNDIDAVEDAITRWRAEGGMGRIWIAVESLYSMDGDRAP
HHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCCEEEEEEEHHHHCCCCCCH
MARLIALADRHEAFLVVDEAHATGIWGPNGRGLAAAFEGRDNTVALHTCGKALGASGALV
HHHHHHHHCCCCEEEEEECCCCCCCCCCCCCEEEEEECCCCCEEEEEECCHHHCCCCCEE
TGPGTLCDYLVNRCRPFIYATAPSPLMAVAVREALAMLSDEPQRRVQLQERVAFAGRQLA
ECCHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
ERCGVKPSGSQIQSFVIGDNRRTMAVAAALQTRGFDIRGIRPPTVPEGTSRLRISLTLNV
HHCCCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCEECCCCCCCCCCCCCEEEEEEEEEC
DEADISAMVGALVEVLASA
CHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA